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1. 发明授权

US09757188B2 Tissue treatment system and method for tissue perfusion using feedback control 有权
公开(公告)号：US09757188B2
公开(公告)日：2017-09-12
申请号：US12037882
申请日：2008-02-26
申请人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
发明人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
IPC分类号： A61B18/14 , A61B18/00
CPC分类号： A61B18/0206 , A61B18/12 , A61B18/1477 , A61B18/148 , A61B2018/00005 , A61B2018/00035 , A61B2018/00071 , A61B2018/00577 , A61B2018/00595 , A61B2018/00702 , A61B2018/00875 , A61B2018/00916 , A61B2018/00934 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1472 , A61B2018/1475 , A61B2218/002
摘要： A system, ablation probe, and method is provided for treating tissue, e.g., tissue having tumors. The treatment system is configured to automatically deliver infusaid to tissue when needed and comprises an ablation probe having an ablative element and at least one perfusion exit port. The system further comprises an ablation source operably coupled to the ablative element, and a pump assembly operably coupled to the perfusion exit pots). The pump assembly is configured for pumping infusaid out through the perfusion exit port(s), preferably during the ablation process. The system further comprises a feedback device configured for controlling the amount of infusaid displaced by the pump assembly based on a sensed tissue parameter, e.g., tissue temperature or tissue impedance.

2. 发明授权

US08185208B2 Modular stimulation lead network 失效
标题翻译：模块化刺激引线网络
公开(公告)号：US08185208B2
公开(公告)日：2012-05-22
申请号：US12549223
申请日：2009-08-27
申请人： Robert J. Garabedian , Michael P. Wallace
发明人： Robert J. Garabedian , Michael P. Wallace
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021
摘要： A medical kit and method for treating an ailment, such as chronic pain is provided. The kit comprises first and second medical leads, e.g., stimulation leads. Each lead comprises an elongated body and at least one operative element. The first medical lead comprises a coupling mechanism, such as a slot, and the second medical lead comprises a complementary mechanism, such as a rail, that slidably engages the coupling mechanism of the first medical lead. The method may comprise delivering the first medical lead into a patient's body, e.g., into the epidural space of the patient, and delivering the second medical lead into the patient's body by sliding the complementary coupling mechanism of the second medical lead along the coupling mechanism of the first medical lead.
摘要翻译：提供了用于治疗诸如慢性疼痛之类的疾病的医疗用具和方法。该试剂盒包括第一和第二医疗引线，例如刺激引线。每个引线包括细长主体和至少一个操作元件。第一医疗引线包括诸如槽的联接机构，并且第二医疗引线包括可滑动地接合第一医疗引线的联接机构的互补机构，例如轨道。该方法可以包括将第一医疗引线输送到患者体内，例如进入患者的硬膜外腔，并且通过沿第二医疗引线的联接机构滑动第二医疗引线的互补联接机构，将第二医疗引线输送到患者体内第一个医疗领导。

3. 发明申请

US20120059446A1 COLLAPSIBLE/EXPANDABLE TUBULAR ELECTRODE LEADS 审中-公开
标题翻译：可拆卸/可扩展的管状电极引线
公开(公告)号：US20120059446A1
公开(公告)日：2012-03-08
申请号：US13230410
申请日：2011-09-12
申请人： Michael P. Wallace , Robert J. Garabedian
发明人： Michael P. Wallace , Robert J. Garabedian
IPC分类号： A61N1/375 , A61N1/36
CPC分类号： A61N1/0553
摘要： A medical lead and method of treating a patient are provided. The medical lead comprises an electrically insulative tubular membrane, a resilient spring element associated with the insulative membrane, and at least one electrode associated with the insulative membrane. The medical lead is configured to be collapsed into a compact form for percutaneous delivery into the patient, thereby obviating the need to perform an invasive surgical procedure on the patient. The body formed by these elements, when expanded, can be sized to fit within the epidural space of a patient. The patient can be treated by placing the medical lead into a collapsed state by applying a compressive force to the medical lead, percutaneously delivering the collapsed medical lead into the patient adjacent tissue to be treated, and placing the medical lead into an expanded state by releasing the compressive force.
摘要翻译：提供医疗用铅和治疗患者的方法。医用引线包括电绝缘管状膜，与绝缘膜相关联的弹性弹簧元件以及与绝缘膜相关联的至少一个电极。医疗用引线被构造成塌缩成紧密形式用于经皮输送到患者体内，从而避免了对患者执行侵入性外科手术的需要。由这些元件形成的身体，当扩张时，其尺寸可以适合于患者的硬膜外腔内。可以通过向医用引线施加压缩力将医用引线置于折叠状态来将患者放置在患者身体中，将经塌陷的医用导管经皮递送到邻近被治疗组织的患者中，并通过释放将医用引线放入扩张状态压缩力。

4. 发明授权

US07818063B2 Method of intravascularly delivering stimulation leads into brain to stimulate the SPG 有权
标题翻译：血管内传递刺激的方法导致大脑刺激SPG
公开(公告)号：US07818063B2
公开(公告)日：2010-10-19
申请号：US11627359
申请日：2007-01-25
申请人： Michael P. Wallace , Robert J. Garabedian , Robert M. Abrams
发明人： Michael P. Wallace , Robert J. Garabedian , Robert M. Abrams
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method of treating a neurological disorder in a patient is provided. The method comprises intravascularly delivering a stimulation lead within the head of the patient, and placing the stimulation lead adjacent brain tissue (e.g., cortical brain tissue or deep brain tissue), the stimulation of which will treat the neurological disorder. The stimulation lead can be placed into indirect contact with the brain tissue (e.g., through a blood vessel) or indirect contact with the brain tissue (e.g., when placed within the ventricular cavity or by being introduced through an exit point within a vessel wall). Optionally, the method comprises implanting a source of stimulation within the patient's body, and then electrically coupling the proximal end of the stimulation lead, which conveniently extends from the access point within the circulatory system, to the implanted stimulation source. Using the stimulation lead, the brain tissue can then be stimulated in order to treat the neurological disorder.
摘要翻译：提供了治疗患者神经障碍的方法。该方法包括血管内递送患者头部内的刺激引线，并将刺激引导线邻近脑组织（例如皮质脑组织或深部脑组织）放置，其刺激将治疗神经障碍。刺激引线可以与脑组织（例如，通过血管）间接接触或与脑组织间接接触（例如当放置在心室内或通过血管壁内的出口点引入时）。可选地，该方法包括将刺激源植入患者体内，然后将刺激引线的近端电连接，其方便地从循环系统内的接入点延伸到植入的刺激源。使用刺激引线，可以刺激脑组织以治疗神经系统疾病。

5. 发明授权

US07771423B2 Surface electrode multiple mode operation 失效
标题翻译：表面电极多模式操作
公开(公告)号：US07771423B2
公开(公告)日：2010-08-10
申请号：US12271738
申请日：2008-11-14
申请人： Amy C. Kelly , Steven K. Landreville , Robert J. Garabedian
发明人： Amy C. Kelly , Steven K. Landreville , Robert J. Garabedian
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/1425 , A61B2018/143 , A61B2018/1475
摘要： A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.
摘要翻译：提供用于烧伤组织的表面电极。所述表面电极包括基底，从所述基底的表面延伸可调节距离的多个组织穿透针电极以及耦合到所述多个针电极的电接口。针电极的可调性允许针电极穿透组织的深度被调整。

6. 发明申请

US20090319012A1 MODULAR STIMULATION LEAD NETWORK 失效
标题翻译：模块化刺激网络
公开(公告)号：US20090319012A1
公开(公告)日：2009-12-24
申请号：US12549223
申请日：2009-08-27
申请人： Robert J. Garabedian , Michael P. Wallace
发明人： Robert J. Garabedian , Michael P. Wallace
IPC分类号： A61N1/04
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021
摘要： A medical kit and method for treating an ailment, such as chronic pain is provided. The kit comprises first and second medical leads, e.g., stimulation leads. Each lead comprises an elongated body and at least one operative element. The first medical lead comprises a coupling mechanism, such as a slot, and the second medical lead comprises a complementary mechanism, such as a rail, that slidably engages the coupling mechanism of the first medical lead. The method may comprise delivering the first medical lead into a patient's body, e.g., into the epidural space of the patient, and delivering the second medical lead into the patient's body by sliding the complementary coupling mechanism of the second medical lead along the coupling mechanism of the first medical lead.
摘要翻译：提供了用于治疗诸如慢性疼痛之类的疾病的医疗用具和方法。该试剂盒包括第一和第二医疗引线，例如刺激引线。每个引线包括细长主体和至少一个操作元件。第一医疗引线包括诸如槽的联接机构，并且第二医疗引线包括可滑动地接合第一医疗引线的联接机构的互补机构，例如轨道。该方法可以包括将第一医疗引线输送到患者体内，例如进入患者的硬膜外腔，并且通过沿第二医疗引线的联接机构滑动第二医疗引线的互补联接机构，将第二医疗引线输送到患者体内第一个医疗领导。

7. 发明授权

US07590454B2 Modular stimulation lead network 失效
标题翻译：模块化刺激引线网络
公开(公告)号：US07590454B2
公开(公告)日：2009-09-15
申请号：US10799271
申请日：2004-03-12
申请人： Robert J. Garabedian , Michael P. Wallace
发明人： Robert J. Garabedian , Michael P. Wallace
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/36021
摘要： A medical kit and method for treating an ailment, such as chronic pain is provided. The kit comprises first and second medical leads, e.g., stimulation leads. Each lead comprises an elongated body and at least one operative element. The first medical lead comprises a coupling mechanism, such as a slot, and the second medical lead comprises a complementary mechanism, such as a rail, that slidably engages the coupling mechanism of the first medical lead. The method may comprise delivering the first medical lead into a patient's body, e.g., into the epidural space of the patient, and delivering the second medical lead into the patient's body by sliding the complementary coupling mechanism of the second medical lead along the coupling mechanism of the first medical lead.
摘要翻译：提供了用于治疗诸如慢性疼痛之类的疾病的医疗用具和方法。该试剂盒包括第一和第二医疗引线，例如刺激引线。每个引线包括细长主体和至少一个操作元件。第一医疗引线包括诸如槽的联接机构，并且第二医疗引线包括可滑动地接合第一医疗引线的联接机构的互补机构，例如轨道。该方法可以包括将第一医疗引线输送到患者体内，例如进入患者的硬膜外腔，并且通过沿着第二医疗引线的联接机构滑动第二医疗引线的互补联接机构，将第二医疗引线输送到患者体内第一个医疗领导。

8. 发明申请

US20090069800A1 SURFACE ELECTRODE MULTIPLE MODE OPERATION 失效
标题翻译：表面电极多模式操作
公开(公告)号：US20090069800A1
公开(公告)日：2009-03-12
申请号：US12271738
申请日：2008-11-14
申请人： Amy C. Kelly , Steven K. Landreville , Robert J. Garabedian
发明人： Amy C. Kelly , Steven K. Landreville , Robert J. Garabedian
IPC分类号： A61B18/18 , A61B18/14
CPC分类号： A61B18/1477 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/1425 , A61B2018/143 , A61B2018/1475
摘要： A surface electrode for ablating tissue is provided. The surface electrode comprises a base, a plurality of tissue penetrating needle electrodes extending from the surface of the base an adjustable distance, and an electrical interface coupled to the plurality of needle electrodes. The adjustability of the needle electrodes allows the depth that the needle electrodes penetrate through tissue to be adjusted.
摘要翻译：提供用于烧伤组织的表面电极。所述表面电极包括基底，从所述基底的表面延伸可调节距离的多个组织穿透针电极以及耦合到所述多个针电极的电接口。针电极的可调性允许针电极穿透组织的深度被调整。

9. 发明申请

US20080221562A1 TISSUE TREATMENT SYSTEM AND METHOD FOR TISSUE PERFUSION USING FEEDBACK CONTROL 有权
公开(公告)号：US20080221562A1
公开(公告)日：2008-09-11
申请号：US12037882
申请日：2008-02-26
申请人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
发明人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
IPC分类号： A61B18/14 , A61B18/12
CPC分类号： A61B18/0206 , A61B18/12 , A61B18/1477 , A61B18/148 , A61B2018/00005 , A61B2018/00035 , A61B2018/00071 , A61B2018/00577 , A61B2018/00595 , A61B2018/00702 , A61B2018/00875 , A61B2018/00916 , A61B2018/00934 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1472 , A61B2018/1475 , A61B2218/002
摘要： A system, ablation probe, and method is provided for treating tissue, e.g., tissue having tumors. The treatment system is configured to automatically deliver infusaid to tissue when needed and comprises an ablation probe having an ablative element and at least one perfusion exit port. The system further comprises an ablation source operably coupled to the ablative element, and a pump assembly operably coupled to the perfusion exit port(s). The pump assembly is configured for pumping infusaid out through the perfusion exit port(s), preferably during the ablation process. The system further comprises a feedback device configured for controlling the amount of infusaid displaced by the pump assembly based on a sensed tissue parameter, e.g., tissue temperature or tissue impedance. For example, the feedback device can comprise a sensor configured for sensing the tissue parameter, and a perfusion controller configured for controlling the pump assembly based on the sensed tissue parameter. As another example, the feedback device can comprise a perfusion valve associated with the distal end of the shaft. In this case, the perfusion valve forms the perfusion exit port, wherein the perfusion valve changes the size of the perfusion exit port based on tissue temperature.An ablation probe is provided for treating tissue, e.g., tissue having a tumor. The ablation comprises an elongated shaft, an ablative element, a perfusion lumen that extends through the probe shaft, and a perfusion control valve associated with the distal end of the shaft. The perfusion control valve has a port, the size of which changes with temperature. In one embodiment, the perfusion control valve comprises a reed valve having at least one reed, e.g., a pair of opposing reeds, or even four reeds. The reeds are configured change shape in order to control the size of the port. For example, each reed can comprise a bimetallic flange or a nitinol flange that bends in the presence of a temperature change.Ablation probes and systems are provided for treating tissue, e.g., tissue having a tumor. The ablation comprises an elongated shaft, an ablative element, a perfusion lumen that extends through the probe shaft, and at least one perfusion exit port in fluid communication with the perfusion lumen. The perfusion lumen can be used to deliver an infusaid to the perfusion exit port(s) for perfusion of the surrounding tissue. The ablation probe further comprises a wicking material, e.g., cotton or fabric, disposed in the perfusion lumen. In this manner, the infusaid that travels through the perfusion lumen can be controlled without regard to the size of the perfusion exit port(s).An ablation probe is provided for treating tissue, e.g., tissue having a tumor. The ablation probe comprises an elongated shaft, an ablative element, a perfusion lumen that extends through the probe shaft, and at least one perfusion exit port in fluid communication with the perfusion lumen. The ablation probe further comprises a pump assembly carried by the proximal end of the shaft. The pump assembly is configured for pumping infusaid through the perfusion lumen and out the perfusion exit port(s). In one embodiment, the pump assembly comprises a reservoir for storing the infusaid, and a perfusion inlet port configured for transferring infusaid from an external source into the reservoir. The pump assembly can be variously configured. For example, the pump assembly may comprise a diaphragm adjacent the reservoir. In this case, the diaphragm has pumping stroke that displaces the infusaid from the reservoir into the perfusion lumen. As another example, the pump assembly comprises a diaphragm adjacent the reservoir, wherein the diaphragm is configured for expanding to pressurize the reservoir in response to the conveyance of infusaid into the reservoir. As still another example, the pump assembly comprises a plunger disposed in the reservoir and a spring configured to urge the plunger within the reservoir in one direction to pressurize the reservoir.

10. 发明授权

US07347859B2 Tissue treatment system and method for tissue perfusion using feedback control 有权
标题翻译：使用反馈控制的组织灌注组织治疗系统和方法
公开(公告)号：US07347859B2
公开(公告)日：2008-03-25
申请号：US10740692
申请日：2003-12-18
申请人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
发明人： Robert J. Garabedian , Amy C. Kelly , Steve K. Landreville
IPC分类号： A61B18/18
CPC分类号： A61B18/0206 , A61B18/12 , A61B18/1477 , A61B18/148 , A61B2018/00005 , A61B2018/00035 , A61B2018/00071 , A61B2018/00577 , A61B2018/00595 , A61B2018/00702 , A61B2018/00875 , A61B2018/00916 , A61B2018/00934 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1472 , A61B2018/1475 , A61B2218/002
摘要： A system, ablation probe, and method is provided for treating tissue, e.g., tissue having tumors. The treatment system is configured to automatically deliver infusaid to tissue when needed and comprises an ablation probe having an ablative element and at least one perfusion exit port. The system further comprises an ablation source operably coupled to the ablative element, and a pump assembly operably coupled to the perfusion exit port(s). The pump assembly is configured for pumping infusaid out through the perfusion exit port(s), preferably during the ablation process. The system further comprises a feedback device configured for controlling the amount of infusaid displaced by the pump assembly based on a sensed tissue parameter, e.g., tissue temperature or tissue impedance.
摘要翻译：提供了一种用于治疗组织，例如具有肿瘤的组织的系统，消融探针和方法。治疗系统被配置为在需要时自动地输送到组织，并且包括具有消融元件和至少一个灌注出口的消融探针。该系统还包括可操作地联接到消融元件的消融源，以及可操作地连接到灌注出口的泵组件。泵组件被配置为优选在消融过程期间通过灌注出口端口进行泵送。该系统还包括反馈装置，该反馈装置被配置为基于感测到的组织参数（例如组织温度或组织阻抗）来控制由泵组件移位的内注量。

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