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1. 发明授权

US5254575A 4-aryl-thiazole derivatives 失效
标题翻译： 4-芳基 - 噻唑衍生物
公开(公告)号：US5254575A
公开(公告)日：1993-10-19
申请号：US857526
申请日：1992-03-25
申请人： John H. Pick , Robert T. Logan
发明人： John H. Pick , Robert T. Logan
IPC分类号： A61K31/415 , A61K31/425 , A61K31/426 , A61P9/04 , A61P11/08 , A61P43/00 , C07D233/90 , C07D277/20 , C07D277/56 , A01K31/425
CPC分类号： C07D277/56 , C07D233/90
摘要： The invention concerns a 4-aryl-thiazole or imidazole derivative having the formula I ##STR1## wherein X is 0 or NOH,Y is S or NR.sub.3,Ar is a group selected from phenyl, naphthyl, tetrahydronaphthyl, and biphenyl,R is one to four substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower thioalkyl, cycloalkyl, halogen, CF.sub.3, NO.sub.2, and O-ALK-NR.sub.1 R.sub.2, in which ALK is a saturated aliphatic hydrocarbon group having 2-6 carbon atoms, and R.sub.1 and R.sub.2 are independently hydrogen or lower alkyl, or form, together with the nitrogen atom to which they are bonded, a heterocyclic ring, andR.sub.3 is hydrogen or a lower alkyl; or a pharmaceutically acceptable salt thereof, with the proviso that 4-(4-chlorophenyl)-thiazole-2-carboxamide is excluded.The compounds according to the invention increase the sensitivity of cardiac myofibrils to calcium and possess phosphodiesterase inhibitory activity and bronchodilator activity, and are useful for the treatment of patients suffering from heart failure and asthma.

2. 发明授权

US4665206A Benzothiophene derivatives 失效
标题翻译：苯并噻吩衍生物
公开(公告)号：US4665206A
公开(公告)日：1987-05-12
申请号：US709396
申请日：1985-03-07
申请人： James Redpath , Robert T. Logan , David B. McFadzen , Robert G. Roy
发明人： James Redpath , Robert T. Logan , David B. McFadzen , Robert G. Roy
IPC分类号： A61K31/38 , A61K31/381 , A61P9/04 , C07D277/64 , C07D277/68 , C07D333/24 , C07D333/32 , C07D333/38 , C07D333/42 , C07D333/56 , C07D333/58 , C07D333/60 , C07D333/62 , C07D333/66 , C07D333/68 , C07D333/70 , C07D495/04
CPC分类号： C07D277/68 , C07D333/56 , C07D333/58 , C07D333/60 , C07D333/70 , C07D495/04
摘要： The invention relates to compounds of the general formula I ##STR1## wherein R.sub.1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO.sub.2 CF.sub.3 or the group --NR.sub.5 R.sub.6, whereby two substituents taken together may also represent a methylene-dioxy group,X represents nitrogen or the group ##STR2## n has the value 0, 1 or 2, R.sub.3 represents one of the moieties: ##STR3## the latter meaning of R.sub.3 (amide) only under the condition that for X is nitrogen the meaning of R.sub.1 is limited to substituents selected from hydroxy, alkoxy(1-6 C) and methylenedioxy, and R.sub.4, R.sub.5 and R.sub.6 represent hydrogen or alkyl(1-6 C), and pharmaceutically acceptable salts thereof, suitable in the treatment of heart failure.
摘要翻译：本发明涉及通式Ⅰ的化合物，其中R 1代表一个至多并包括四个相同或不同的选自烷基（1-6C），烷氧基（1-6C），羟基，卤素， NO 2 + L，CF 3或基团-NR 5 R 6，其中两个取代基一起也可以表示亚甲基 - 二氧基，X表示氮或基团n具有值0,1或2，R 3表示部分仅在X为氮的条件下，R 3（酰胺）的后面含义限于R 1的含义，限于选自羟基，烷氧基（1-6C）和亚甲二氧基的取代基，R4，R5 和R6代表适合于治疗心力衰竭的氢或烷基（1-6C）及其药学上可接受的盐。

3. 发明授权

US07834851B1 Computer mouse that prevents or treats carpal tunnel syndrome and methods of use 有权
标题翻译：防止或治疗腕管综合征和使用方法的电脑鼠标
公开(公告)号：US07834851B1
公开(公告)日：2010-11-16
申请号：US12830117
申请日：2010-07-02
申请人： Wlodzimierz Fidali , Robert T. Logan
发明人： Wlodzimierz Fidali , Robert T. Logan
IPC分类号： G06F3/033 , B68G5/00
CPC分类号： G06F3/03543 , G06F3/039
摘要： A new computer mouse is disclosed to prevent strain injuries to the hand and wrist and prevent or alleviate the symptoms associated with Carpel Tunnel Syndrome (CTS) for those who are repetitive users of computer mouse devices. The mouse is designed to leave the carpal tunnel of a user of the mouse substantially open, thus precluding tunnel narrowing and the symptoms resulting therefrom. The mouse is also designed to maximize comfort of the user, alleviate wrist bend associated with use of the mouse, and is adaptable to different size hands.
摘要翻译：公开了一种新的计算机鼠标，以防止手腕和手腕的应变损伤，并防止或减轻与皮肤隧道综合征（CTS）相关的症状，使其成为计算机鼠标设备重复使用者。鼠标被设计为使鼠标的使用者的腕管基本上打开，从而排除了隧道变窄以及由此导致的症状。鼠标也被设计成使用户的舒适度最大化，减轻与使用鼠标相关的手腕弯曲，并适应不同尺寸的手。

4. 发明授权

US5462959A 4-aryl-imidazole derivatives 失效
标题翻译： 4-芳基 - 咪唑衍生物
公开(公告)号：US5462959A
公开(公告)日：1995-10-31
申请号：US136530
申请日：1993-10-14
申请人： John H. Pick , Robert T. Logan
发明人： John H. Pick , Robert T. Logan
IPC分类号： A61K31/415 , A61K31/425 , A61K31/426 , A61P9/04 , A61P11/08 , A61P43/00 , C07D233/90 , C07D277/20 , C07D277/56
CPC分类号： C07D277/56 , C07D233/90
摘要： The invention concerns a 4-aryl-imidazole derivative having the formula I ##STR1## wherein X is 0 or NOH,Y is NR.sub.3,Ar is a group selected from phenyl, naphthyl, tetrahydronaphthyl, and biphenyl,R is one to four substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower thioalkyl, cycloalkyl, halogen, CF.sub.3, NO.sub.2, and O--ALK--NR.sub.1 R.sub.2, in which ALK is a saturated aliphatic hydrocarbon group having 2-6 carbon atoms, and R.sub.1 and R.sub.2 are independently hydrogen or lower alkyl, or form, together with the nitrogen atom to which they are bonded, a heterocyclic ring, andR.sub.3 is hydrogen or a lower alkyl; or a pharmaceutically acceptable salt thereof, with the proviso that 4-(4-chlorophenyl)-thiazole-2-carboxamide is excluded. The compounds according to the invention increase the sensitivity of cardiac myofibrils to calcium and possess phosphodiesterase inhibitory activity and bronchodilator activity, and are useful for the treatment of patients suffering from heart failure and asthma.
摘要翻译：本发明涉及具有式I的4-芳基 - 咪唑衍生物，其中X为0或NOH，Y为NR3，Ar为选自苯基，萘基，四氢萘基和联苯基的基团，R为1-4个取代基独立地选自氢，羟基，低级烷基，低级烷氧基，低级硫代烷基，环烷基，卤素，CF 3，NO 2和O-ALK-NR 1 R 2，其中ALK是具有2-6个碳原子的饱和脂族烃基， R2独立地为氢或低级烷基，或与它们所键合的氮原子一起形成杂环，并且R 3为氢或低级烷基; 或其药学上可接受的盐，条件是不包括4-（4-氯苯基） - 噻唑-2-甲酰胺。根据本发明的化合物增加心脏肌原纤维对钙的敏感性并具有磷酸二酯酶抑制活性和支气管扩张剂活性，并且可用于治疗患有心力衰竭和哮喘的患者。

5. 发明授权

US4929636A Positive inotrophic benzothiazole and benzothiophene compositions and method of use therefor 失效
标题翻译：阳性营养型苯并噻唑和苯并噻吩组合物及其使用方法
公开(公告)号：US4929636A
公开(公告)日：1990-05-29
申请号：US333806
申请日：1989-04-06
申请人： James Redpath , Robert T. Logan , David B. McFadzen , Robert G. Roy
发明人： James Redpath , Robert T. Logan , David B. McFadzen , Robert G. Roy
IPC分类号： A61K31/38 , A61K31/381 , A61P9/04 , C07D277/64 , C07D277/68 , C07D333/24 , C07D333/32 , C07D333/38 , C07D333/42 , C07D333/56 , C07D333/58 , C07D333/60 , C07D333/62 , C07D333/66 , C07D333/68 , C07D333/70 , C07D495/04
CPC分类号： C07D277/68 , C07D333/56 , C07D333/58 , C07D333/60 , C07D333/70 , C07D495/04
摘要： The invention relates to compounds of the general formula I ##STR1## wherein R.sub.1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO.sub.2, CF.sub.3 or the group --NR.sub.5 R.sub.6, whereby two substituents taken together may also represent a methylene-dioxy group,X represents nitrogen or the group ##STR2## n has the value 0, 1 or 2, R.sub.3 represents one of the moieties: ##STR3## the latter meaning of R.sub.3 (amide) only under the condition that for X is nitrogen the meaning of R.sub.1 is limited to substituents selected from hydroxy, alkoxy(1-6 C) and methylenedioxy, and R.sub.4, R.sub.5 and R.sub.6 represent hydrogen or alkyl(1-6 C), and pharmaceutically acceptable salts thereof, suitable in the treatment of heart failure.

6. 发明授权

US07757998B1 Computer mouse accoutrement (attachment) and method of preventing or alleviating carpel tunnel syndrome (CTS) 有权
标题翻译：电脑鼠标配件（附件）及预防或减轻心皮管隧道综合征（CTS）的方法
公开(公告)号：US07757998B1
公开(公告)日：2010-07-20
申请号：US12637518
申请日：2009-12-14
申请人： Wlodzimierz Fidali , Robert T. Logan
发明人： Wlodzimierz Fidali , Robert T. Logan
IPC分类号： B68G5/00 , A47G29/00 , G09G5/08
CPC分类号： G06F3/03543 , G06F2203/0333
摘要： A new ergonomic accoutrement adapted to be attached to a computer mouse was developed to prevent strain injuries to the hand and wrist and prevent or alleviate the symptoms associated with Carpel Tunnel Syndrome (CTS) for those who are repetitive users of computer mouse devices. The accoutrement is designed to leave the carpal tunnel of the user of a computer mouse substantially open, thus precluding tunnel narrowing and the symptoms resulting therefrom. The accoutrement is also designed to maximize comfort of the user, alleviate wrist bend associated with use of the mouse, and be adaptable to different size hands.
摘要翻译：开发了适用于计算机鼠标的新型符合人体工学原理的配件，以防止手腕和手腕的应变损伤，并防止或减轻与皮肤隧道综合征（CTS）相关的症状，为那些重复使用电脑鼠标设备的用户。该装置旨在使计算机鼠标的使用者的腕管基本上敞开，从而排除隧道变窄以及由此引起的症状。该设备还被设计成使用户的舒适度最大化，减轻与使用鼠标相关联的腕部弯曲，并适应不同尺寸的手。

7. 发明授权

US5276052A Use of a benzo[b]thiopene-2-carboximidamide derivative 失效
标题翻译：苯并[b]噻吩-2-甲脒类衍生物的应用
公开(公告)号：US5276052A
公开(公告)日：1994-01-04
申请号：US032759
申请日：1993-03-16
申请人： Robert T. Logan , James Redpath , George McGarry , Robert G. Roy
发明人： Robert T. Logan , James Redpath , George McGarry , Robert G. Roy
IPC分类号： A61K31/38
CPC分类号： A61K31/38
摘要： The invention relates to the use of the benzo[b]-thiophene-2-carboximidamide derivative having formula I ##STR1## or pharmaceutically acceptable salts thereof, for the preparation of a medicament which is suitable for the treatment of heart failure, having high bioavailability without inducing nausea, vomiting and/or restlessness.
摘要翻译：本发明涉及具有式I的苯并[b] - 噻吩-2-亚甲代酰胺衍生物或其药学上可接受的盐在制备适于治疗心力衰竭的药物中的应用，其具有高生物利用度不引起恶心，呕吐和/或不安。

8. 发明授权

US5192755A Pregnane derivatives as immunomodulators 失效
标题翻译：妊娠衍生物作为免疫调节剂
公开(公告)号：US5192755A
公开(公告)日：1993-03-09
申请号：US525299
申请日：1990-05-17
申请人： Robert T. Logan , Gilbert F. Woods
发明人： Robert T. Logan , Gilbert F. Woods
IPC分类号： C07J7/00 , C07J31/00
CPC分类号： C07J7/0085 , C07J31/006 , Y10S514/885
摘要： The invention provides novel pregnane derivatives having the formula: ##STR1## wherein X=F, Cl or Br; R.sub.1 =F or Cl; R.sub.2 =H(.beta.OH) or O; R.sub.3 =alkyl(1-4 C); R.sub.4 =alkyl(1-4 C); and the dotted line indicates the optional presence of a double bond.The novel compounds have been found to possess immunomodulating properties.
摘要翻译：本发明提供具有下式的新颖的孕烷衍生物：其中X = F，Cl或Br; R1 = F或Cl; R2 = H（βOH）或O; R3 =烷基（1-4C）; R4 =烷基（1-4C）; 虚线表示双键的任选存在。已经发现新化合物具有免疫调节特性。

9. 发明授权

US5026724A Compounds with bronchodilator activity 失效
标题翻译：具有支气管扩张剂活性的化合物
公开(公告)号：US5026724A
公开(公告)日：1991-06-25
申请号：US375654
申请日：1989-07-05
申请人： Robert T. Logan , James Redpath , George McGarry , Robert G. Roy
发明人： Robert T. Logan , James Redpath , George McGarry , Robert G. Roy
IPC分类号： A61K31/15 , A61K31/155 , A61K31/34 , A61K31/343 , A61K31/38 , A61K31/381 , A61P11/08 , C07C67/00 , C07C241/00 , C07C251/18 , C07C251/42 , C07C251/66 , C07C257/06 , C07C259/16 , C07D307/81 , C07D307/85 , C07D333/58 , C07D333/70 , C07D493/04
CPC分类号： C07D333/58 , A61K31/15 , A61K31/155 , A61K31/34 , A61K31/38 , C07C259/16 , C07D307/81 , C07D307/85 , C07D333/70 , Y10S514/826
摘要： A method is provided for treating patients suffering from or susceptible to bronchoconstriction, particularly for patients suffering from an asthmatic attach which comprises the use of benzothiophene, benzofuran, dihydronaphthalene or indene derivatives represented by formula I ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is independently H, (1-4C) alkyl, (1-4C) halogen substituted alkyl, OH, (1-4C) alkoxy, (1-4C) halogen substituted alkoxy, NO.sub.2, CN, halogen, an unsubstituted or (1-4C) alkyl substituted amino group, or wherein two adjacent groups R.sup.1, R.sup.2, R.sup.3 or R.sup.4 together form methylenedioxy;X is S, O or (CH.sub.2).sub.m in which m is 1 or 2;R.sup.5 is H or (1-4C) alkyl;R.sup.6 is H, NH.sub.2 or (1-4C) alkyl;R.sup.7 is H, (1-4C) alkyl or OR.sup.8 in whichR.sup.8 is H, (1-4C) alkyl or (1-8C) acyl;and its pharmaceutically acceptable salts for the preparation of a medicament with bronchodilator activity.

10. 发明授权

US07360804B1 Articles, systems, and methods for suppressing noise and/or vibrations in hotel/motel doors 有权
标题翻译：用于抑制酒店/汽车旅馆门噪声和/或震动的文章，系统和方法
公开(公告)号：US07360804B1
公开(公告)日：2008-04-22
申请号：US11610843
申请日：2006-12-14
申请人： Wlodzimierz Fidali , Robert T. Logan
发明人： Wlodzimierz Fidali , Robert T. Logan
IPC分类号： E05C17/04 , E05C19/18
CPC分类号： E05C17/166 , E05F5/02 , E05F5/04 , E05F2005/046 , E05Y2900/132 , Y10S292/15 , Y10S292/56 , Y10T16/61 , Y10T292/03 , Y10T292/28 , Y10T292/34
摘要： A door guard for hotel/motel doors comprises two articles, one article to be attached to a door, and another article to be attached to a door frame. One article is attached to the door, including a hook element adapted to receive a latch member of the door guard and attached to an inside surface of the door; and a damping element, composed of a sound dampening material, attached to an outside surface of the door. Another article is attached to the door frame, including a hinge element for connecting the article to the door frame; and a latch member pivotally connected to the hinge element. Another sound damping element, also composed of a sound dampening material, is disposed between the hinge element and the latch member. When the door guard is released and the door closes, the attached articles reduce the sound and/or vibrations, which are disturbing to hotel/motel guests, that occur when the closing door impacts the door guard and door frame.
摘要翻译：酒店/汽车旅馆门的门卫包括两个物品，一个要附在门上的物品，另一个物品要附在门框上。一个物品连接到门上，包括适于接收门护罩的闩锁构件并附接到门的内表面的钩元件; 以及由声音衰减材料构成的阻尼元件，其附接到门的外表面。另一个物品连接在门框上，包括用于将物品连接到门框的铰链元件; 以及枢转地连接到所述铰链元件的闩锁构件。另外由声音衰减材料组成的隔音元件设置在铰链元件和闩锁构件之间。当门禁器被释放并且门关闭时，附接的物品减少当关闭门撞击门保护和门框时发生的对酒店/汽车旅馆客人的噪音和/或振动。

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