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1. 发明授权

US08415334B2 Method of combating infection 失效
标题翻译：抗感染方法
公开(公告)号：US08415334B2
公开(公告)日：2013-04-09
申请号：US11991080
申请日：2006-09-04
申请人： Philip John Burke , Roger Melton , Richard John Knox
发明人： Philip John Burke , Roger Melton , Richard John Knox
IPC分类号： A61K31/33
CPC分类号： A61K31/396 , Y02A50/409 , Y02A50/414 , Y02A50/488
摘要： Method of combating a parasitic protozoal infection of a host organism, wherein the parasite causing the infection is associated with an enzyme system capable of activating tretazicar into a cytotoxic form. The method is carried out by administering tretazicar to the host organism.
摘要翻译：抵抗宿主生物体的寄生性原虫感染的方法，其中引起感染的寄生虫与能够将赖氨酸转化为细胞毒性形式的酶系统相关联。该方法通过对宿主生物体施用噻托他汀来进行。

2. 发明授权

US08018870B2 Method and apparatus for simply configuring a subscriber appliance for performing a service controlled by a separate service provider 有权
标题翻译：用于简单地配置用户设备以执行由单独服务提供商控制的服务的方法和装置
公开(公告)号：US08018870B2
公开(公告)日：2011-09-13
申请号：US12785274
申请日：2010-05-21
申请人： Roger Melton , John Toebes
发明人： Roger Melton , John Toebes
IPC分类号： H04J1/16
CPC分类号： H04L41/5054 , H04L41/0213 , H04L41/082 , H04L41/0886 , H04L41/5029 , H04L63/08
摘要： A method and apparatus for configuring an appliance, such as a network node, for performing s service, such as communicating with a network, controlled by a service provider include inserting into an Ethernet port on the appliance an Ethernet couple on a device that is usually small compared to the appliance. The device is configured to send through the Ethernet couple without human intervention an Internet Protocol (IP) data packet that is directed to a logical port of an established standard, such as Hypertext Transfer Protocol (HTTP) port 80. The IP data packet includes appliance configuration data in a message form for the established standard, such as an HTTP POST. As a result, the appliance is configured automatically for performing the service controlled by the service provider.
摘要翻译：用于配置用于执行由服务提供商控制的诸如与网络通信的服务的设备（诸如网络节点）的方法和装置包括在设备上的以太网端口插入通常在以太网上的以太网耦合与家电相比较小。该设备被配置为通过以太网耦合发送，而无需人为干预，将指向已建立标准的逻辑端口（例如超文本传输协议（HTTP））端口80的因特网协议（IP）数据分组.IP数据分组包括设备用于建立标准的消息表单中的配置数据，例如HTTP POST。因此，自动配置设备以执行由服务提供商控制的服务。

3. 发明申请

US20070268837A1 Method and apparatus for simply configuring a subscriber appliance for performing a service controlled by a separate service provider 有权
标题翻译：用于简单地配置用户设备以执行由单独服务提供商控制的服务的方法和装置
公开(公告)号：US20070268837A1
公开(公告)日：2007-11-22
申请号：US11437930
申请日：2006-05-19
申请人： Roger Melton , John Toebes
发明人： Roger Melton , John Toebes
IPC分类号： H04J1/16 , H04L12/56
CPC分类号： H04L41/5054 , H04L41/0213 , H04L41/082 , H04L41/0886 , H04L41/5029 , H04L63/08
摘要： A method and apparatus for configuring an appliance, such as a network node, for performing s service, such as communicating with a network, controlled by a service provider include inserting into an Ethernet port on the appliance an Ethernet couple on a device that is usually small compared to the appliance. The device is configured to send through the Ethernet couple without human intervention an Internet Protocol (IP) data packet that is directed to a logical port of an established standard, such as Hypertext Transfer Protocol (HTTP) port 80. The IP data packet includes appliance configuration data in a message form for the established standard, such as an HTTP POST. As a result, the appliance is configured automatically for performing the service controlled by the service provider.
摘要翻译：用于配置用于执行由服务提供商控制的诸如与网络通信的服务的设备（诸如网络节点）的方法和装置包括在设备上的以太网端口插入通常在以太网上的以太网耦合与家电相比较小。该设备被配置为通过以太网耦合发送，而无需人为干预，将指向已建立标准的逻辑端口（例如超文本传输协议（HTTP））端口80的因特网协议（IP）数据分组.IP数据分组包括设备用于建立标准的消息表单中的配置数据，例如HTTP POST。因此，自动配置设备以执行由服务提供商控制的服务。

4. 发明授权

US5977065A Bacterial nitroreductase for the reduction of CB1954 and analogues thereof to a cytotoxic form 失效
标题翻译：用于将CB1954及其类似物还原成细胞毒性形式的细菌硝基还原酶
公开(公告)号：US5977065A
公开(公告)日：1999-11-02
申请号：US87855
申请日：1998-06-01
申请人： Gillian Anlezark , Roger Melton , Roger Sherwood , Thomas Connors , Frank Friedlos , Michael Jarman , Richard Knox , Anthony Mauger , Caroline Joy Springer
发明人： Gillian Anlezark , Roger Melton , Roger Sherwood , Thomas Connors , Frank Friedlos , Michael Jarman , Richard Knox , Anthony Mauger , Caroline Joy Springer
IPC分类号： C12N9/12 , A61K38/00 , C07C219/34 , C07C271/18 , C07D203/14 , C07D487/14 , C07H15/252 , C07H19/048 , C07K7/06 , C12N9/02 , C12N15/00 , C12N15/09 , C12N15/53 , C12P17/10 , C12P21/08 , C12R1/01 , C12R1/07 , C12R1/19 , G01N33/53 , G01N33/573 , A61K38/12 , C07K5/00 , C07K7/00
CPC分类号： C07D203/14 , C07C219/34 , C07C271/18 , C07D487/14 , C07H15/252 , C07H19/048 , C07K7/06 , C12N9/0036 , C12P17/10 , C12Y101/01284 , A61K38/00 , Y02E50/16
摘要： A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R.sup.1 NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.2 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.
摘要翻译：式（I）的前药：其中R1是使化合物R1NH2表示放线菌素D，多柔比星，丝裂霉素C或式（IV）的氮芥的基团：式（II）的前药：其中R 2 是化合物R 2 OH是酚氮芥的基团; 以及其中制备前述前药的方法，其中前药前体化合物与无水条件下的氯甲酸4-硝基苄酯反应。

5. 发明授权

US08785428B2 Vermin poison 有权
标题翻译：害虫毒
公开(公告)号：US08785428B2
公开(公告)日：2014-07-22
申请号：US12443447
申请日：2007-09-28
申请人： Richard J. Knox , Roger Melton , Philip Burke
发明人： Richard J. Knox , Roger Melton , Philip Burke
IPC分类号： A01N43/00
CPC分类号： A01N43/44 , A01N25/004 , A01N2300/00
摘要： Use of an orally or nasally available formulation of Tretazicar for poisoning vermin. An orally available or nasally available formulation of Tretazicar, wherein in the orally available formulation the Tretazicar is protected from acid hydrolysis, and provided that the formulation is not solid Tretazicar in a gelatin capsule. A formulation of Tretazicar in which the Tretazicar is protected from acid hydrolysis, wherein the formulation is present in a liquid form. A combination of Tretazicar and bait. A method of poisoning vermin comprising making available to the vermin an orally or nasally available formulation of Tretazicar and allowing the vermin to ingest or inhale the formulation of Tretazicar.
摘要翻译：使用口服或经鼻给予的Tretazicar制剂中毒害虫。一种口服或经鼻给药的妥他唑（Tretazicar）制剂，其中在口服可用的制剂中，保护Tretazicar免受酸水解，并且前提是该制剂在明胶胶囊中不是固体的替罗非那唑。一种Tretazicar的制剂，其中保护Tretazicar不受酸水解，其中制剂以液体形式存在。组合Tretazicar和诱饵。一种使害虫中毒的方法，包括向灭虫虫提供口服或经鼻给药的Tretazicar制剂，并允许害虫摄入或吸入Tretazicar的制剂。

6. 发明授权

US5780585A Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form 失效
标题翻译：用于将CB 1954及其类似物还原成细胞毒性形式的细菌硝基还原酶
公开(公告)号：US5780585A
公开(公告)日：1998-07-14
申请号：US504047
申请日：1995-06-07
申请人： Gillian Anlezark , Roger Melton , Roger Sherwood , Thomas Connors , Frank Friedlos , Michael Jarman , Richard Knox , Anthony Mauger , Caroline Joy Springer
发明人： Gillian Anlezark , Roger Melton , Roger Sherwood , Thomas Connors , Frank Friedlos , Michael Jarman , Richard Knox , Anthony Mauger , Caroline Joy Springer
IPC分类号： C12N9/12 , A61K38/00 , C07C219/34 , C07C271/18 , C07D203/14 , C07D487/14 , C07H15/252 , C07H19/048 , C07K7/06 , C12N9/02 , C12N15/00 , C12N15/09 , C12N15/53 , C12P17/10 , C12P21/08 , C12R1/01 , C12R1/07 , C12R1/19 , G01N33/53 , G01N33/573 , C07K7/56 , C07C68/00 , C07C69/96 , C07C269/04 , C07C271/28 , C07H15/24
CPC分类号： C07D203/14 , C07C219/34 , C07C271/18 , C07D487/14 , C07H15/252 , C07H19/048 , C07K7/06 , C12N9/0036 , C12P17/10 , C12Y101/01284 , A61K38/00 , Y02E50/16
摘要： A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R--NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.1 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.
摘要翻译：式（I）的前药：其中R 1是使得化合物R-NH 2表示放线菌素D，多柔比星，丝裂霉素C或式（IV）的氮芥的基团：式（II）的前药：其中R 1是使化合物R 2 OH是酚氮芥的基团; 以及其中制备前述前药的方法，其中前药前体化合物与无水条件下的氯甲酸4-硝基苄酯反应。

7. 发明申请

US20100166871A1 VERMIN POISON 有权
公开(公告)号：US20100166871A1
公开(公告)日：2010-07-01
申请号：US12443447
申请日：2007-09-28
申请人： Richard J. Knox , Roger Melton , Philip Burke
发明人： Richard J. Knox , Roger Melton , Philip Burke
IPC分类号： A01N43/44 , A01N25/00 , A01N25/28 , C07D203/14 , A01P15/00
CPC分类号： A01N43/44 , A01N25/004 , A01N2300/00
摘要： Use of an orally or nasally available formulation of Tretazicar for poisoning vermin. An orally available or nasally available formulation of Tretazicar, wherein in the orally available formulation the Tretazicar is protected from acid hydrolysis, and provided that the formulation is not solid Tretazicar in a gelatin capsule. A formulation of Tretazicar in which the Tretazicar is protected from acid hydrolysis, wherein the formulation is present in a liquid form. A combination of Tretazicar and bait. A method of poisoning vermin comprising making available to the vermin an orally or nasally available formulation of Tretazicar and allowing the vermin to ingest or inhale the formulation of Tretazicar.
摘要翻译：使用口服或经鼻给予的Tretazicar制剂中毒害虫。一种口服或经鼻给药的妥他唑（Tretazicar）制剂，其中在口服可用的制剂中，保护Tretazicar免受酸水解，并且前提是该制剂在明胶胶囊中不是固体的替罗非那唑。一种Tretazicar的制剂，其中保护Tretazicar不受酸水解，其中制剂以液体形式存在。组合Tretazicar和诱饵。一种使害虫中毒的方法，包括向灭虫虫提供口服或经鼻给药的Tretazicar制剂，并允许害虫摄入或吸入Tretazicar的制剂。

8. 发明申请

US20070243182A1 Use of Carboxypeptidease G for Combating Antifolate Toxicity 审中-公开
标题翻译：使用羧肽酶G来抵抗抗叶酸毒性
公开(公告)号：US20070243182A1
公开(公告)日：2007-10-18
申请号：US10590789
申请日：2005-02-28
申请人： Roger Melton , Anthony Atkinson
发明人： Roger Melton , Anthony Atkinson
IPC分类号： A61K38/48 , C12N9/14 , C12Q1/34
CPC分类号： A61K38/4813 , A61K31/519
摘要： A method of combating toxicity caused by an antifolate compound of Formula I, in an individual who has been administered the compound. The method comprises administering an enzyme that has carboxypeptidase G activity to the individual.
摘要翻译：在给予该化合物的个体中，对抗由式I的抗叶酸化合物引起的毒性的方法。该方法包括向个体施用具有羧肽酶G活性的酶。

9. 发明授权

US08634320B2 Method and apparatus for simply configuring a subscriber appliance for performing a service controlled by a separate service provider 有权
标题翻译：用于简单地配置用户设备以执行由单独服务提供商控制的服务的方法和装置
公开(公告)号：US08634320B2
公开(公告)日：2014-01-21
申请号：US13205538
申请日：2011-08-08
申请人： Roger Melton , John Toebes
发明人： Roger Melton , John Toebes
IPC分类号： H04J1/16
CPC分类号： H04L41/5054 , H04L41/0213 , H04L41/082 , H04L41/0886 , H04L41/5029 , H04L63/08
摘要： A method and apparatus for configuring an appliance, such as a network node, for performing a service, such as communicating with a network, controlled by a service provider include inserting into an Ethernet port on the appliance an Ethernet couple on a device that is usually small compared to the appliance. The device is configured to send through the Ethernet couple without human intervention an Internet Protocol (IP) data packet that is directed to a logical port of an established standard, such as Hypertext Transfer Protocol (HTTP) port 80. The IP data packet includes appliance configuration data in a message form for the established standard, such as an HTTP POST. As a result, the appliance is configured automatically for performing the service controlled by the service provider.
摘要翻译：用于配置用于执行由服务提供商控制的诸如与网络通信的服务的设备（诸如网络节点）的方法和装置包括在设备上的以太网端口插入通常在以太网上的以太网耦合与家电相比较小。该设备被配置为通过以太网耦合发送，而无需人为干预，将指向已建立标准的逻辑端口（例如超文本传输协议（HTTP））端口80的因特网协议（IP）数据分组.IP数据分组包括设备用于建立标准的消息表单中的配置数据，例如HTTP POST。因此，自动配置设备以执行由服务提供商控制的服务。

10. 发明申请

US20100273762A1 Method of combating infection 失效
标题翻译：抗感染方法
公开(公告)号：US20100273762A1
公开(公告)日：2010-10-28
申请号：US11991080
申请日：2006-09-04
申请人： Philip John Burke , Roger Melton , Richard John Knox
发明人： Philip John Burke , Roger Melton , Richard John Knox
IPC分类号： A61K31/396 , C07D203/04 , A61P33/02
CPC分类号： A61K31/396 , Y02A50/409 , Y02A50/414 , Y02A50/488
摘要： A method of combating a parasitic protozoal infection of a host organism, the method comprising administering tretazicar to the host organism. Tretazicar is the compound 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954), and the parasitic infection is preferably an infection of Trypanosoma cruzi, T. b. brucei, Leishmania spp. particularly L. infantum, Cryptosporidium or Giardia spp.
摘要翻译：一种抵抗宿主生物体的寄生原虫感染的方法，所述方法包括向所述宿主生物体施用噻托他汀。 Tretazicar是5-（吖啶啶-1-基）-2,4-二硝基苯甲酰胺（CB 1954）的化合物，寄生虫感染优选为克氏锥虫感染T. 布鲁斯，利什曼原虫属特别是婴幼儿，隐孢子虫或贾第虫属。

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