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1. 发明授权

US09739745B2 System and method for measuring an analyte in a sample 有权
公开(公告)号：US09739745B2
公开(公告)日：2017-08-22
申请号：US13620448
申请日：2012-09-14
申请人： Alastair M. Hodges , Ronald C. Chatelier
发明人： Alastair M. Hodges , Ronald C. Chatelier
IPC分类号： G01N27/327
摘要： Methods for calculating an analyte concentration of a sample are provided. In one exemplary embodiment the method includes steps that are directed toward accounting for inaccuracies that occur as a result of temperature variations in a sample, a meter, or the surrounding environment. In another exemplary embodiment the method includes steps that are directed toward determining whether an adequate sample is provided in a meter because insufficient samples can result in inaccuracies. The methods that are provided can be incorporated into a variety of mechanisms, but they are primarily directed toward glucose meters for blood samples and toward meters for controls solutions.

2. 发明授权

US08877034B2 Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity 有权
标题翻译：基于初始填充速度测量全血血细胞比容的系统，装置和方法
公开(公告)号：US08877034B2
公开(公告)日：2014-11-04
申请号：US12649509
申请日：2009-12-30
申请人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
发明人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
IPC分类号： G01N33/49 , G01N33/80 , G01N33/48 , G01N27/48
CPC分类号： G01N27/3272 , G01N27/3273 , G01N27/3274 , G01N27/48 , G01N33/49 , G01N33/80 , G01N2333/4737
摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.
摘要翻译：用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。在电极之间施加电位，并计算样品进入器件的初始填充速度。然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

3. 发明申请

US20130306493A1 SYSTEMS AND METHODS FOR HIGH ACCURACY ANALYTE MEASUREMENT 有权
标题翻译：用于高精度分析测量的系统和方法
公开(公告)号：US20130306493A1
公开(公告)日：2013-11-21
申请号：US13824308
申请日：2010-12-31
申请人： Ronald C. Chatelier , Alastair M. Hodges
发明人： Ronald C. Chatelier , Alastair M. Hodges
IPC分类号： G01N27/327
CPC分类号： G01N27/4163 , C12Q1/006 , C12Q1/025 , G01N27/30 , G01N27/327 , G01N27/3272 , G01N27/3274 , G01N27/413 , G01N33/49
摘要： Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a first analyte concentration is determined. A second analyte concentration value is calculated from the first analyte concentration value and corrected for temperature effects, fill time and capacitance to provide for a final analyte concentration value.
摘要翻译：本文提供了用于确定样品中分析物浓度的方法以及与其一起使用的装置和系统。在用于确定样品中分析物浓度的方法的一个示例性实施方案中，在具有工作电极和对电极的样品分析装置中提供包括分析物的样品。在电极之间施加电位，并确定第一分析物浓度。根据第一分析物浓度值计算第二分析物浓度值，并对温度影响，填充时间和电容进行校正以提供最终分析物浓度值。

4. 发明申请

US20130098763A1 SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE 有权
公开(公告)号：US20130098763A1
公开(公告)日：2013-04-25
申请号：US13619241
申请日：2012-09-14
申请人： Ronald C. Chatelier , Alastair M. Hodges , Santhanagopalan Nandagopalan
发明人： Ronald C. Chatelier , Alastair M. Hodges , Santhanagopalan Nandagopalan
IPC分类号： C12Q1/00
CPC分类号： G01N27/4163 , C12Q1/006 , G01N27/3274
摘要： Methods of determining a corrected analyte concentration in view of some error source are provided herein. The methods can be utilized for the determination of various analytes and/or various sources of error. In one example, the method can be configured to determine a corrected glucose concentration in view of an extreme level of hematocrit found within the sample. In other embodiments, methods are provided for identifying various system errors and/or defects. For example, such errors can include partial-fill or double-fill situations, high track resistance, and/or sample leakage. Systems are also provided for determining a corrected analyte concentration and/or detecting some system error.

5. 发明申请

US20130008804A1 SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE 有权
公开(公告)号：US20130008804A1
公开(公告)日：2013-01-10
申请号：US13620448
申请日：2012-09-14
申请人： Alastair M. Hodges , Ronald C. Chatelier
发明人： Alastair M. Hodges , Ronald C. Chatelier
IPC分类号： G01N27/26
CPC分类号： G01N27/3274
摘要： Methods for calculating an analyte concentration of a sample are provided. In one exemplary embodiment the method includes steps that are directed toward accounting for inaccuracies that occur as a result of temperature variations in a sample, a meter, or the surrounding environment. In another exemplary embodiment the method includes steps that are directed toward determining whether an adequate sample is provided in a meter because insufficient samples can result in inaccuracies. The methods that are provided can be incorporated into a variety of mechanisms, but they are primarily directed toward glucose meters for blood samples and toward meters for controls solutions.

6. 发明申请

US20110155584A1 Systems, Devices, and Methods for Measuring Whole Blood Hematocrit Based on Initial Fill Velocity 有权
标题翻译：基于初始填充速度测量全血血细胞比容的系统，设备和方法
公开(公告)号：US20110155584A1
公开(公告)日：2011-06-30
申请号：US12649509
申请日：2009-12-30
申请人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
发明人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
IPC分类号： G01N27/26
CPC分类号： G01N27/3272 , G01N27/3273 , G01N27/3274 , G01N27/48 , G01N33/49 , G01N33/80 , G01N2333/4737
摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.
摘要翻译：用于确定血液样本的血细胞比容的方法，以及与之一起使用的装置和系统。血细胞比容值可以单独测定，而且还可以用于确定样品中分析物的浓度。在用于确定血液样品中的血细胞比容值的方法的一个示例性实施方案中，在具有工作和对电极的样品分析装置中提供体积的血液。在电极之间施加电位，并计算样品进入器件的初始填充速度。然后可以确定血液的血细胞比容，以及考虑到初始填充速度的分析物的浓度。还提供利用初始填充速度来确定血细胞比容水平并进行分析物浓度测定的系统和装置。

7. 发明申请

US20090301899A1 SYSTEM AND METHOD FOR MEASURING AN ANALYTE IN A SAMPLE 有权
标题翻译：用于测量样品中分析物的系统和方法
公开(公告)号：US20090301899A1
公开(公告)日：2009-12-10
申请号：US12464935
申请日：2009-05-13
申请人： Alastair M. Hodges , Ronald C. Chatelier
发明人： Alastair M. Hodges , Ronald C. Chatelier
IPC分类号： G01N27/26
CPC分类号： G01N27/3274
摘要： Methods for calculating an analyte concentration of a sample are provided. In one exemplary embodiment the method includes steps that are directed toward accounting for inaccuracies that occur as a result of temperature variations in a sample, a meter, or the surrounding environment. In another exemplary embodiment the method includes steps that are directed toward determining whether an adequate sample is provided in a meter because insufficient samples can result in inaccuracies. The methods that are provided can be incorporated into a variety of mechanisms, but they are primarily directed toward glucose meters for blood samples and toward meters for controls solutions.
摘要翻译：提供了用于计算样品的分析物浓度的方法。在一个示例性实施例中，该方法包括针对由于样品，仪表或周围环境中的温度变化而发生的不准确性的步骤。在另一示例性实施例中，该方法包括以下步骤：针对确定在仪表中是否提供了足够的样品，因为不足的样品可导致不准确。所提供的方法可以并入多种机制中，但是它们主要针对血液样品的血糖仪和用于对照溶液的米。

8. 发明授权

US5449383A Cell growth substrates 失效
标题翻译：细胞生长底物
公开(公告)号：US5449383A
公开(公告)日：1995-09-12
申请号：US70049
申请日：1993-06-01
申请人： Ronald C. Chatelier , Hans J. Griesser , John G. Steele , Graham Johnson
发明人： Ronald C. Chatelier , Hans J. Griesser , John G. Steele , Graham Johnson
IPC分类号： A61F2/02 , A61F2/06 , A61L27/34 , C12N5/00 , A61F2/54 , C08J7/18 , C12N11/08
CPC分类号： C08J7/123 , A61L27/34 , C12N5/0068 , A61F2/06 , C12N2533/30 , Y10T428/2998 , Y10T428/31562
摘要： A process for producing a polymeric surface coating which faciliates attachment of cells on a polymeric substrate. The coating is deposited by plasma deposition of an amide monomer vapour. The coated product is suitable for use in tissue culture trays and biomedical implants.
摘要翻译：一种制造聚合物表面涂层的方法，其使细胞附着在聚合物基材上。通过等离子体沉积酰胺单体蒸气沉积涂层。涂层产品适用于组织培养托盘和生物医学植入物。

9. 发明授权

US08932445B2 Systems and methods for improved stability of electrochemical sensors 有权
标题翻译：用于改善电化学传感器稳定性的系统和方法
公开(公告)号：US08932445B2
公开(公告)日：2015-01-13
申请号：US12895168
申请日：2010-09-30
申请人： Ronald C. Chatelier , Alastair M. Hodges
发明人： Ronald C. Chatelier , Alastair M. Hodges
IPC分类号： G01N33/487 , G01N33/543 , C12Q1/00 , C12Q1/54 , G01N27/327
CPC分类号： G01N27/3274 , C12Q1/001 , C12Q1/54 , G01N27/3272 , G01N27/3273 , G01N33/5438
摘要： Methods for determining a concentration of an analyte in a sample, and the devices and systems used in conjunction with the same, are provided herein. In one exemplary embodiment of a method for determining a concentration of an analyte in a sample, a sample including an analyte is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and a measurement of a parameter correlating to changes in a physical property of the sample analyzing device is calculated. A concentration of the analyte in view of the parameter correlating to a change in the physical property can then be determined Systems and devices that take advantage of the parameter correlating to changes in a physical property to make analyte concentration determinations are also provided.
摘要翻译：本文提供了用于确定样品中分析物浓度的方法以及与其一起使用的装置和系统。在用于确定样品中分析物浓度的方法的一个示例性实施方案中，在具有工作电极和对电极的样品分析装置中提供包括分析物的样品。在电极之间施加电位，并且计算与样品分析装置的物理性质的变化相关的参数的测量。然后可以确定鉴于与物理性质的变化相关的参数的分析物的浓度。还提供利用与物理性质的变化相关的参数的优点的系统和装置，以进行分析物浓度测定。

10. 发明授权

US08758592B2 Adhesive composition for use in an immunosensor 有权
标题翻译：用于免疫传感器的粘合剂组合物
公开(公告)号：US08758592B2
公开(公告)日：2014-06-24
申请号：US13550176
申请日：2012-07-16
申请人： Ronald C. Chatelier , Dennis Rylatt
发明人： Ronald C. Chatelier , Dennis Rylatt
IPC分类号： G01N27/327
CPC分类号： G01N33/54326 , G01N33/5438
摘要： An adhesive composition for use in devices and methods for measuring a presence or a concentration of a particular component, such as an antigen, in a sample, such as blood, are provided. In one exemplary embodiment of an adhesive composition, the composition includes an adhesive, water, a poloxamer, and an anticoagulant. The adhesive can include particular properties, such as being hydrophilic, pressure-sensitive, heat-activated, and/or water soluble. The adhesive is particularly useful because it can help improve the flow of sample a device. For example, when the device is an immunosensor, the adhesive can help prevent the blood from clotting in chambers of the immunosensor. This results in a more efficient and accurate determination of the concentration of the sample. Methods of making the composition and device in which the composition can be used are provided, as are methods of using the same.
摘要翻译：提供了用于测量样品（例如血液）中特定成分（例如抗原）的存在或浓度的装置和方法中的粘合剂组合物。在粘合剂组合物的一个示例性实施方案中，组合物包括粘合剂，水，泊洛沙姆和抗凝血剂。粘合剂可以包括特定的性质，例如亲水的，压敏的，热活化的和/或水溶性的。粘合剂是特别有用的，因为它可以帮助改善样品的流动。例如，当该装置是免疫传感器时，粘合剂可以帮助防止血液在免疫传感器的腔室内凝结。这样可以更有效和准确地测定样品的浓度。提供可以使用组合物的组合物和装置的方法，以及使用该组合物的方法。

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