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1. 发明授权

US07805182B2 System and method for the guidance of a catheter in electrophysiologic interventions 有权
标题翻译：导管在电生理干预中的指导系统和方法
公开(公告)号：US07805182B2
公开(公告)日：2010-09-28
申请号：US11814821
申请日：2006-01-23
申请人： Juergen Weese , Sabine Mollus , Kai Eck , Joerg Bredno
发明人： Juergen Weese , Sabine Mollus , Kai Eck , Joerg Bredno
IPC分类号： A61B5/05 , A61B6/00 , A61B5/04 , A61N1/00
CPC分类号： A61B5/042 , A61B6/12 , A61B6/4441 , A61B6/487 , A61B6/503 , A61B6/5288
摘要： In a system and a method for the guidance of a catheter with an electrode in an electrophysiological procedure, sequence of images of the catheter and of a resting reference catheter is generated with an X-ray device and stored together with the associated electrographic recordings from the electrodes. A reference image may then be selected from said sequence that corresponds to a desired electrographic pattern. In a next step, the positions of the catheters are localized on the reference image. The position of the reference catheter can be identified with the position of this catheter on an actual image. Thus it is possible to determine on the actual image also a target position for the catheter that corresponds to the position of this catheter on the reference image. The target position may finally be indicated on a monitor to assist the guidance of the catheter to a desired location.
摘要翻译：在用于在电生理过程中引导具有电极的导管的系统和方法中，使用X射线装置产生导管和静息参考导管的图像序列，并与来自相关联的电摄影记录一起存储电极。然后可以从对应于期望的电泳图案的所述序列中选择参考图像。在下一步骤中，导管的位置被定位在参考图像上。可以使用该导管在实际图像上的位置来识别参考导管的位置。因此，可以在实际图像上确定与参考图像上的该导管的位置相对应的导管的目标位置。目标位置可以最终在监视器上指示以辅助将导管引导到期望的位置。

2. 发明申请

US20090216111A1 PROCESSING OF IMAGES OF INTERVENTIONAL INSTRUMENTS WITH MARKERS 有权
标题翻译：传统仪器与标记的图像处理
公开(公告)号：US20090216111A1
公开(公告)日：2009-08-27
申请号：US11573292
申请日：2005-07-21
申请人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
发明人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
IPC分类号： A61B6/12 , A61B19/00
CPC分类号： A61B34/20 , A61B90/39 , A61B90/90 , A61B2034/2065 , A61B2090/392
摘要： The invention relates to a method and an image processing system (20) for the evaluation of projection images (25) generated by an X-ray imaging system (10), wherein the images (25) may show different instruments (51, 52) of a given set of interventional instruments like catheters or guide wires. The instruments are equipped with markers such that their configuration is characteristic of the corresponding instrument (51, 52). Preferably three markers are arranged on a straight line, the ratio of the distances between them being characteristic for the corresponding instrument. The image processing system (20) may then identify the instruments (51, 52) present in a given projection (25) and provide functionalities for a user that correspond to said instruments. Moreover, the system may be used to locate an instrument (51, 52) of interest in a projection image (25) if the marker configuration of that instrument (51, 52) is known a priori.
摘要翻译：本发明涉及一种用于评估由X射线成像系统（10）产生的投影图像（25）的方法和图像处理系统（20），其中图像（25）可以显示不同的仪器（51,52）一套给定的介入仪器，如导管或导丝。仪器配备有标记，使得它们的配置是相应仪器（51,52）的特征。优选地，三个标记布置在直线上，它们之间的距离比对于相应的仪器是特征的。然后，图像处理系统（20）可以识别存在于给定投影（25）中的仪器（51,52），并为与用户对应的所述仪器提供功能。此外，如果先前已知该仪器（51,52）的标记结构，则该系统可用于在投影图像（25）中定位感兴趣的仪器（51,52）。

3. 发明授权

US07454043B2 Image processing unit and method of associating stored images with current images 失效
标题翻译：将存储的图像与当前图像相关联的图像处理单元和方法
公开(公告)号：US07454043B2
公开(公告)日：2008-11-18
申请号：US10530816
申请日：2003-10-02
申请人： Kai Eck , Geert Gijsbers , Sabine Mollus
发明人： Kai Eck , Geert Gijsbers , Sabine Mollus
IPC分类号： G06K9/00
CPC分类号： A61B6/481 , A61B5/7289 , A61B6/12 , A61B6/504 , A61B6/541 , G06T7/0016 , G06T7/246
摘要： The invention relates to the association of a current (X-ray image) image of a body volume with one of several stored previous images, the ECG and the respiratory cycle being determined each time together with the images. Using this data, that one of the previous images is chosen which is closest to the current image in respect of cardiac rhythm and respiratory cycle. The resultant association yields a very high accuracy enabling superposed reproduction of the current image and the associated previous image.
摘要翻译：本发明涉及身体体积的当前（X射线图像）图像与几个存储的先前图像之一的关联，ECG和呼吸周期每次与图像一起确定。使用该数据，选择与心律和呼吸周期相关的当前图像最接近的先前图像之一。所得到的关联产生非常高的精度，使得能够叠加当前图像和相关联的先前图像的再现。

4. 发明申请

US20110060755A1 METHOD OF SELECTIVELY AND INTERACTIVELY PROCESSING DATA SETS 审中-公开
标题翻译：选择性和交互式处理数据集的方法
公开(公告)号：US20110060755A1
公开(公告)日：2011-03-10
申请号：US12920327
申请日：2009-03-03
申请人： Sabine Mollus , Juergen Weese
发明人： Sabine Mollus , Juergen Weese
IPC分类号： G06F17/30
CPC分类号： A61B6/4464 , A61B6/4441 , A61B6/481 , A61B6/504 , A61B6/507 , A61B6/5235 , A61B6/5247 , G06T7/0012 , G06T7/38 , G06T2207/10072 , G06T2207/20104 , G06T2207/20128 , G06T2207/30104
摘要： A method and an apparatus for selectively and interactively processing data sets is proposed. A first data set is gathered and a second data set is gathered. A first feature is selected interactively from the first data set. After the selection, the first feature is brought in correspondence with a second feature in the second data set during an identification step. The first feature, the second feature and combinations thereof can be visualized.
摘要翻译：提出了一种用于选择性地和交互地处理数据集的方法和装置。收集第一数据集，并收集第二数据集。从第一数据集交互地选择第一特征。在选择之后，在识别步骤期间，第一特征与第二数据集中的第二特征相对应。第一特征，第二特征及其组合可以被可视化。

5. 发明授权

US07203534B2 Method of assisting orientation in a vascular system 失效
标题翻译：协助血管系统取向的方法
公开(公告)号：US07203534B2
公开(公告)日：2007-04-10
申请号：US10323145
申请日：2002-12-18
申请人： Sabine Mollus , Kai Eck
发明人： Sabine Mollus , Kai Eck
IPC分类号： A61B5/05
CPC分类号： A61B6/541 , A61B6/466 , A61B6/481 , A61B6/504
摘要： The invention relates to a method of forming a very accurate vascular map or road map to be associated with the current X-ray image during an invasive vascular intervention. The vascular map is derived from a four-dimensional model of the vascular tree, that is, from a spatially three-dimensional, time-dependent model, the time dependency relating to natural motions of the body such as notably the heartbeat and/or the respiration. In particular the rhythm of the heartbeat or the respiration can be determined by means of a sensor so as to be used for synchronized selection and display of the corresponding three-dimensional vascular model.
摘要翻译：本发明涉及在侵入性血管干预期间形成与当前X射线图像相关联的非常准确的血管图或路线图的方法。血管图源自维管结构的四维模型，即从空间三维的时间依赖模型中，与身体的自然运动相关的时间依赖性，例如心跳和/或呼吸。特别地，可以通过传感器来确定心跳或呼吸的节奏，以便用于相应的三维血管模型的同步选择和显示。

6. 发明申请

US20070071172A1 Device and method for adjusting imaging parameters of an x-ray apparatus 有权
标题翻译：用于调整X射线装置成像参数的装置和方法
公开(公告)号：US20070071172A1
公开(公告)日：2007-03-29
申请号：US10577098
申请日：2004-10-15
申请人： Sabine Mollus , Jurgen Weese
发明人： Sabine Mollus , Jurgen Weese
IPC分类号： H05G1/44
CPC分类号： A61B6/488 , A61B6/00 , A61B6/469 , A61B6/542 , A61B6/544
摘要： The invention relates to a device for adjusting imaging parameters of an X-ray apparatus (1), whereby a user pre-defines on a preliminary image an image region of interest (ROI) and a value of the contrast-to-noise ratio (CNRref) desired for this image region. Based on the current contrast-to-noise ratio (CNRm), new imaging parameters (I, V, L, f, Q0) are then calculated for a generator-control module (7) to control the X-ray apparatus (1) during an image. By means of the method, the X-ray dose may be reduced to a minimum, while at the same time the desired visibility of a region of interest is ensured.
摘要翻译：本发明涉及一种用于调整X射线设备（1）的成像参数的设备，由此用户在初步图像上预先定义感兴趣的图像区域（ROI）和对比度噪声比值（ CNR ）对于该图像区域是期望的。基于当前的对比噪声比（CNR），然后对于发生器计算新的成像参数（I，V，L，f，Q <0> 0）控制模块（7），以在图像期间控制X射线设备（1）。通过该方法，可以将X射线剂量降低到最小，同时确保感兴趣区域的期望的可见度。

7. 发明授权

US09393079B2 Processing of images of interventional instruments with markers 有权
标题翻译：用标记处理介入仪器的图像
公开(公告)号：US09393079B2
公开(公告)日：2016-07-19
申请号：US11573292
申请日：2005-07-21
申请人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
发明人： Juergen Weese , Sabine Mollus , Raoul Florent , Lucile Nosjean , Pierre Lelong , Peter Maria Johannes Rongen
IPC分类号： A61B5/05 , A61B19/00
CPC分类号： A61B34/20 , A61B90/39 , A61B90/90 , A61B2034/2065 , A61B2090/392
摘要： A method and an image processing system for the evaluation of projection images generated by an X-ray imaging system, wherein the images may show different instruments of a given set of interventional instruments like catheters or guide wires. The instruments are equipped with markers such that their configuration is characteristic of the corresponding instrument. Preferably three markers are arranged on a straight line, the ratio of the distances between them being characteristic for the corresponding instrument. The image processing system may then identify the instruments present in a given projection and provide functionalities for a user that correspond to said instruments. Moreover, the system may be used to locate an instrument of interest in a projection image if the marker configuration of that instrument is known a priori.
摘要翻译：一种用于评估由X射线成像系统产生的投影图像的方法和图像处理系统，其中所述图像可以显示给定的一组介入装置如导管或导丝的不同仪器。这些仪器配有标记，使得它们的配置是相应仪器的特征。优选地，三个标记布置在直线上，它们之间的距离比对于相应的仪器是特征的。然后，图像处理系统可以识别给定投影中存在的工具，并为与用户对应的功能提供功能。此外，如果该仪器的标记配置是先验已知的，则该系统可用于在投影图像中定位感兴趣的仪器。

8. 发明授权

US08086001B2 Utilizing physiological models to control functional acquisitions 有权
标题翻译：利用生理模型来控制功能收购
公开(公告)号：US08086001B2
公开(公告)日：2011-12-27
申请号：US12090359
申请日：2006-10-06
申请人： Joerg Bredno , Georg Rose , Juergen Weese , Alexandra Groth , Sabine Mollus , Matthias Bertram , Jens Wiegert , Christoph Neukirchen
发明人： Joerg Bredno , Georg Rose , Juergen Weese , Alexandra Groth , Sabine Mollus , Matthias Bertram , Jens Wiegert , Christoph Neukirchen
IPC分类号： G06K9/00
CPC分类号： A61B6/032 , A61B6/481 , A61B6/488 , A61B6/507 , A61B6/542
摘要： Adaptively controlling an imaging system (200, 205) includes constructing model feature characteristics (105) of a process over time, determining parameters and commands (110) for controlling the imaging system for each state of the process, performing data acquisition (120) for the process, extracting current features (130) of the process from the acquired data, matching (135) the current features (130) with the model feature characteristics (105) to determine a state of the process (140), and controlling the data acquisition based on the state of the process to produce optimized data.
摘要翻译：自适应地控制成像系统（200,205）包括构建处理过程的模型特征特征（105），确定参数和命令（110），以控制成像系统对于每个处理状态，执行数据采集（120）该过程从所获取的数据提取过程的当前特征（130），将当前特征（130）与模型特征特征（105）匹配（135）以确定过程（140）的状态，以及控制数据根据进程的状态获取生成优化数据。

9. 发明申请

US20090262886A1 ROTATIONAL X-RAY SCAN PLANNING SYSTEM 有权
标题翻译：旋转X射线扫描计划系统
公开(公告)号：US20090262886A1
公开(公告)日：2009-10-22
申请号：US12375573
申请日：2007-07-18
申请人： Sabine Mollus , Juergen Weese , Jens Wiegert , Robert Johannes Frederik Homan
发明人： Sabine Mollus , Juergen Weese , Jens Wiegert , Robert Johannes Frederik Homan
IPC分类号： H05G1/60 , G06T7/00 , H05G1/42
CPC分类号： A61B6/488 , A61B6/027 , A61B6/03 , A61B6/4441 , A61B6/469 , Y10S378/901
摘要： In three-dimensional X-ray imaging, with C-arm systems, scan setup has to be performed manually under fluoroscopic control. According to an exemplary embodiment of the present invention, a scan planning system for planning a data acquisition process is provided, which is adapted to predict a field of view to be reconstructed and an image quality in the field of view with respect to the actual three-dimensional scan parameter set and previously acquired images or other information. The scan planning system may be accomplished by a stand control unit.
摘要翻译：在三维X射线成像中，使用C臂系统，扫描设置必须在荧光镜控制下手动执行。根据本发明的示例性实施例，提供了一种用于规划数据获取过程的扫描计划系统，其适于预测要重构的视野和相对于实际三维的视场中的图像质量三维扫描参数集和先前获取的图像或其他信息。扫描计划系统可以由支架控制单元完成。

10. 发明授权

US07519155B2 Device and method for adjusting imaging parameters of an X-ray apparatus 有权
标题翻译：用于调整X射线装置的成像参数的装置和方法
公开(公告)号：US07519155B2
公开(公告)日：2009-04-14
申请号：US10577098
申请日：2004-10-15
申请人： Sabine Mollus , Jürgen Weese
发明人： Sabine Mollus , Jürgen Weese
IPC分类号： H05G1/44 , G21K1/12
CPC分类号： A61B6/488 , A61B6/00 , A61B6/469 , A61B6/542 , A61B6/544
摘要： The invention relates to a device for adjusting imaging parameters of an X-ray apparatus (1), whereby a user pre-defines on a preliminary image an image region of interest (ROI) and a value of the contrast-to-noise ratio (CNRref) desired for this image region. Based on the current contrast-to-noise ratio (CNRm), new imaging parameters (I, V, L, f, Q0) are then calculated for a generator-control module (7) to control the X-ray apparatus (1) during an image. By means of the method, the X-ray dose may be reduced to a minimum, while at the same time the desired visibility of a region of interest is ensured.
摘要翻译：本发明涉及一种用于调整X射线设备（1）的成像参数的设备，由此用户在初步图像上预先定义感兴趣的图像区域（ROI）和对比度噪声比值（ CNRref）对于该图像区域是期望的。基于目前的对比噪声比（CNRm），然后为发电机控制模块（7）计算新的成像参数（I，V，L，f，Q0）以控制X射线装置（1）在图像期间。通过该方法，可以将X射线剂量降低到最小，同时确保感兴趣区域的期望的可见度。

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