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1. 发明授权

US09049782B2 Mobile device case with retractor reel assembly for user-provided headphones 有权
标题翻译：用于用户提供的耳机的牵引器卷轴组件的移动设备外壳
公开(公告)号：US09049782B2
公开(公告)日：2015-06-02
申请号：US14319821
申请日：2014-06-30
申请人： Scott Koenig
发明人： Scott Koenig , David Conroy
IPC分类号： H05K5/00 , H05K5/02 , B65H75/44 , H04R1/10 , H02G11/02 , H04M1/15 , H01R13/72
CPC分类号： H05K5/0247 , B65H75/4431 , B65H75/4449 , B65H2701/3919 , H01R13/72 , H02G11/02 , H04M1/15 , H04R1/1033 , H05K5/0217
摘要： A mobile device case includes a reel assembly, including a reel, a supporting plate, and a hub between the reel and the supporting plate. The hub includes a first cavity between the hub and the supporting plate for housing a spring, and a second cavity between the hub and the reel for housing a flat flexible cable (FFC). The spring is wound in a first direction, while the FFC is wound in a second direction. The FFC includes a first end for electrically coupling to a female jack connector of a device. A female connector is electrically coupled to a second end of the FFC for engaging a male jack connector of user-provided headphones. When the reel rotates in the first direction, the spring tightens and the FFC loosens. When the reel rotates in the second direction, the spring loosens and the FFC tightens.
摘要翻译：移动设备壳体包括卷轴组件，其包括卷轴，支撑板以及在卷轴和支撑板之间的轮毂。毂包括在毂和用于容纳弹簧的支撑板之间的第一空腔，以及在毂和卷轴之间的用于容纳扁平柔性电缆（FFC）的第二腔。弹簧沿第一方向缠绕，而FFC沿第二方向缠绕。 FFC包括用于电耦合到装置的母插座连接器的第一端。母连接器电耦合到FFC的第二端，用于接合用户提供的耳机的公插头连接器。当卷轴沿第一方向旋转时，弹簧收紧，FFC松动。当卷轴沿第二个方向旋转时，弹簧松开，FFC拉紧。

2. 发明申请

US20140134162A1 Methods for the Treatment of Disease Using Immunoglobulins Having Fc Regions with Altered Affinities for FcgammaRactivating and FcgammaRinhibiting 有权
标题翻译：使用具有Fcγ激活和Fcγ抑制具有改变亲和力的Fc区的免疫球蛋白治疗疾病的方法
公开(公告)号：US20140134162A1
公开(公告)日：2014-05-15
申请号：US14156747
申请日：2014-01-16
申请人： Jeffrey B. Stavenhagen , Scott Koenig
发明人： Jeffrey B. Stavenhagen , Scott Koenig
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2887 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to methods of treating or preventing cancer and other diseases using molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds an FcγR that activates a cellular effector (“FcγRActivating,” such as FcγRIIA or FcγRIIIA) and an FcγR that inhibits a cellular effector (“FcγRInhibiting,” such as FcγRIIA) with an altered Ratio of Affinities relative to the respective binding affinities of such FcγR for the Fc region of the wild-type immunoglobulin. The methods of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where either an enhanced efficacy of effector cell function mediated by FcγR is desired (e.g., cancer, infectious disease) or an inhibited effector cell response mediated by FcγR is desired (e.g., inflammation, autoimmunde disease).
摘要翻译：本发明涉及使用分子，特别是多肽，特别是包含变体Fc区的免疫球蛋白（例如抗体）治疗或预防癌症和其它疾病的方法，其中所述变体Fc区包含至少一个相对于野生型Fc区，该变体Fc区结合激活细胞效应子（“FcγRActivating”，例如FcγRIIA或FcγRIIIA）的FcγR）和抑制细胞效应子（“FcγR抑制”如FcγRIIA）的FcγR，其具有改变的比例的亲和力相对于野生型免疫球蛋白Fc区的FcγR各自的结合亲和力。本发明的方法特别可用于预防，治疗或改善与需要由FcγR介导的效应细胞功能的增强功效的疾病，病症或感染相关的一种或多种症状（例如癌症，感染性疾病）或由FcγR介导的受抑制的效应细胞反应是期望的（例如炎症，自身免疫疾病）。

3. 发明授权

US08530627B2 FcγRIIB specific antibodies and methods of use thereof 有权
标题翻译： FcγRIIB特异性抗体及其使用方法
公开(公告)号：US08530627B2
公开(公告)日：2013-09-10
申请号：US12167776
申请日：2008-07-03
申请人： Scott Koenig , Maria Concetta Veri
发明人： Scott Koenig , Maria Concetta Veri
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K1/00
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/732
摘要： The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.
摘要翻译：本发明涉及以比所述抗体或其片段更大的亲和力结合FcγRIIA，特别是人FcγRIIA的FcγRIIB特别是人FcγRIIB特异性结合的抗体或其片段。本发明提供了通过施用本发明的抗体来增强治疗性抗体的效应功能来增强治疗性抗体的治疗效果的方法。本发明还提供了通过施用本发明的抗体来增强疫苗组合物的功效的方法。

4. 发明授权

US08193318B2 FcγRIIB specific antibodies and methods of use thereof 有权
标题翻译： FcγRIIB特异性抗体及其使用方法
公开(公告)号：US08193318B2
公开(公告)日：2012-06-05
申请号：US12186058
申请日：2008-08-05
申请人： Scott Koenig , Maria Concetta Veri , Nadine Tuaillon , Ezio Bonvini
发明人： Scott Koenig , Maria Concetta Veri , Nadine Tuaillon , Ezio Bonvini
IPC分类号： C07K16/00 , C12P21/08 , C07K14/00
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/72 , C07K2317/732
摘要： The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB with greater affinity than said antibodies or fragments thereof bind FcγRIIA. The present invention also encompasses the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof for the treatment, prevention, management, or amelioration of a disease or disorder. The invention further provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention with a vaccine composition. The invention also provides methods of breaking tolerance to an antigen by administering an antigen-antibody complex and an antibody of the invention.
摘要翻译：本发明涉及以比所述抗体或其片段更大的亲和力结合FcγRIIA特异性结合FcγRIIB的抗体或其片段。本发明还包括抗FcγRIIB抗体或其抗原结合片段用于治疗，预防，治疗或改善疾病或病症的用途。本发明还提供了通过施用本发明的抗体来增强治疗性抗体的效应子功能来增强治疗性抗体的治疗效果的方法。本发明还提供了通过用疫苗组合物施用本发明的抗体来增强疫苗组合物的功效的方法。本发明还提供了通过施用本发明的抗原 - 抗体复合物和抗体来破坏对抗原的耐受性的方法。

5. 发明授权

US07635568B2 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 失效
公开(公告)号：US07635568B2
公开(公告)日：2009-12-22
申请号：US10900230
申请日：2004-07-26
申请人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
发明人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
IPC分类号： G01N33/53 , A61K39/12 , A61K39/42
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection.

6. 发明授权

US07553489B2 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 有权
标题翻译：给予/给予抗RSV抗体进行预防和治疗的方法
公开(公告)号：US07553489B2
公开(公告)日：2009-06-30
申请号：US11643982
申请日：2006-12-20
申请人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
发明人： James F. Young , Scott Koenig , Leslie S. Johnson , William D. Huse , Jeffrey D. Watkins , Herren Wu
IPC分类号： A61K39/42 , A61K39/155
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis of a RSV infection.
摘要翻译：本发明包括免疫特异性结合一种或多种RSV抗原的新型抗体及其片段，以及包含所述抗体和抗体片段的组合物。本发明包括预防人类呼吸道合胞病毒（RSV）感染的方法，包括向所述人施用预防有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定的血清滴度为所述抗体或抗体片段在所述人受试者中实现。本发明还包括用于治疗或改善与人类RSV感染有关的症状的方法，包括向所述人施用治疗有效量的一种或多种免疫特异性结合一种或多种RSV抗原的抗体或其片段，其中一定所述抗体或抗体片段的血清滴度在所述人受试者中实现。本发明还包括包含免疫特异性结合RSV抗原的抗体或其片段的组合物，以及使用所述组合物检测或诊断RSV感染的方法。

7. 发明授权

US07504107B2 Methods of priming the immunogenic activity of vaccines useful for eliciting a protective immune response 失效
标题翻译：引发用于引发保护性免疫应答的疫苗的免疫原性活性的方法
公开(公告)号：US07504107B2
公开(公告)日：2009-03-17
申请号：US11935188
申请日：2007-11-05
申请人： Scott Koenig
发明人： Scott Koenig
IPC分类号： A61K39/00
CPC分类号： C07K16/1027 , A61K39/00 , A61K39/395 , A61K39/40 , A61K39/42 , A61K2039/505 , A61K2039/545 , Y02A50/464 , Y02A50/466 , Y02A50/474
摘要： Disclosed are methods for vaccine priming, using co-treatment, at a temporally similar or at a previous time, with a priming antibody capable of priming, or enhancing, or potentiating the effects of a vaccine, or vaccine composition. Also disclosed are methods of using this process to prevent or treat disease.
摘要翻译：公开了疫苗引发的方法，其使用能够在时间上相似或以前的时间使用能够引发或增强或增强疫苗或疫苗组合物的作用的引发抗体进行共同治疗。还公开了使用该方法预防或治疗疾病的方法。

8. 发明申请

US20050260213A1 Fcgamma-RIIB-specific antibodies and methods of use thereof 审中-公开
标题翻译： FcγRIIB特异性抗体及其使用方法
公开(公告)号：US20050260213A1
公开(公告)日：2005-11-24
申请号：US11108135
申请日：2005-04-15
申请人： Scott Koenig , Maria Veri , Nadine Tuaillon , Ezio Bonvini , Jeffrey Stavenhagen , Christopher Rankin
发明人： Scott Koenig , Maria Veri , Nadine Tuaillon , Ezio Bonvini , Jeffrey Stavenhagen , Christopher Rankin
IPC分类号： A61K39/395 , C07K16/28 , C07K16/46
CPC分类号： C07K16/283 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/71 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The present invention also provides the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, as a single agent therapy for the treatment, prevention, management, or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chronic lymphocytic leukemia or non-Hodgkin's lymphoma, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.
摘要翻译：本发明涉及以比所述抗体或其片段更大的亲和力结合FcγRIIA，特别是人FcγRIIA的FcγRIIB特别是人FcγRIIB特异性结合的抗体或其片段。本发明还提供抗FcγRIIB抗体或其抗原结合片段作为单一药物治疗用于治疗，预防，治疗或改善癌症，优选B细胞恶性肿瘤，特别是B细胞细胞性慢性淋巴细胞白血病或非霍奇金淋巴瘤，自身免疫性疾病，炎症性疾病，IgE介导的过敏性疾病或其一种或多种症状。本发明提供了通过施用本发明的抗体来增强治疗性抗体的效应功能来增强治疗性抗体的治疗效果的方法。本发明还提供了通过施用本发明的抗体来增强疫苗组合物的功效的方法。

9. 发明申请

US20050196749A1 Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment 失效
公开(公告)号：US20050196749A1
公开(公告)日：2005-09-08
申请号：US10403180
申请日：2003-03-31
申请人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
发明人： James Young , Scott Koenig , Leslie Johnson , William Huse , Jeffrey Watkins , Herren Wu
IPC分类号： C07K16/10 , C12Q1/70 , C07K16/08
CPC分类号： C07K16/1027 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis a RSV infection

10. 外观设计

USD509065S1 Flexible personal property security strap 失效
标题翻译：灵活的个人财产安全带
公开(公告)号：USD509065S1
公开(公告)日：2005-09-06
申请号：US29172293
申请日：2002-12-10
申请人： Jeffrey Scott Koenig
设计人： Jeffrey Scott Koenig

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