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1. 发明申请

US20110086058A1 Immunopotentiator-Linked Oligomeric Influenza Immunogenic Compositions 有权
标题翻译：免疫增强剂连接的低分子流感免疫原性组合物
公开(公告)号：US20110086058A1
公开(公告)日：2011-04-14
申请号：US12897997
申请日：2010-10-05
申请人： Shibo Jiang , Lanying Du
发明人： Shibo Jiang , Lanying Du
IPC分类号： A61K39/145 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K2039/55516 , A61K2039/58 , A61K2039/6056 , C07K2319/30 , C12N7/00 , C12N2760/16134 , C12Y302/01
摘要： Disclosed herein are immunogenic compositions for preventing infection with influenza viruses wherein the immunogenic compositions comprises an immunogen such as a hemagglutinin of an influenza virus, and an immunopotentiator such as an Fc fragment of human IgG and optionally a stabilization sequence. The immunogen is linked to the stabilization sequence which in turn is linked to the immunopotentiator.
摘要翻译：本文公开了用于预防感染流感病毒的免疫原性组合物，其中免疫原性组合物包含免疫原，例如流感病毒的血凝素，和免疫增强剂，例如人IgG的Fc片段和任选的稳定序列。免疫原与稳定序列连接，稳定序列又与免疫增强剂连接。

2. 发明申请

US20100021427A1 Use of Antiviral Peptides For Treatment of Infections Caused by Drug-Resistant HIV 审中-公开
标题翻译：使用抗病毒肽治疗由耐药性HIV引起的感染
公开(公告)号：US20100021427A1
公开(公告)日：2010-01-28
申请号：US12474702
申请日：2009-05-29
申请人： Xin Chen , Linqi Zhang , Shibo Jiang
发明人： Xin Chen , Linqi Zhang , Shibo Jiang
IPC分类号： A61K38/16 , A61P31/18 , A61K38/21
CPC分类号： A61K38/162
摘要： The present invention provides methods of treating drug-resistant HIV infections especially of HIV strains that are resistant to infusion inhibitors, such as T20.
摘要翻译：本发明提供了治疗耐药性HIV感染的方法，特别是对输注抑制剂如T20具有抗性的HIV毒株。

3. 发明授权

US07241803B2 Compounds for inhibition of HIV infection by blocking HIV entry 有权
标题翻译：通过阻止HIV进入来抑制HIV感染的化合物
公开(公告)号：US07241803B2
公开(公告)日：2007-07-10
申请号：US10706027
申请日：2003-11-12
申请人： Shibo Jiang , Asim Kumar Debnath
发明人： Shibo Jiang , Asim Kumar Debnath
IPC分类号： C07D207/327 , A61K31/402
CPC分类号： C07D207/327
摘要： A group of compounds that inhibit HIV replication by blocking HIV entry was identified. Two representative compounds, designated NB-2 and NB-64, inhibited HIV replication (p24 production) with IC50 values
摘要翻译：鉴定了一组通过阻断HIV进入而抑制HIV复制的化合物。两种代表性的化合物（称为NB-2和NB-64）抑制HIV复制（p24产生），IC <50μg/ ml。证明NB-2和NB-64是通过靶向HIV gp41的HIV进入抑制因子，因为：1）它们抑制HIV介导的细胞融合; 2）只有当病毒加入不到1小时后，才能抑制HIV复制; 3）它们不阻断gp120-CD4结合; 4）它们没有与共受体CXCR4相互作用，因为它们不能阻断抗CXCR4抗体结合CXCR4表达细胞; 5）它们阻断了使用构象特异性MAb NC-1通过夹心酶联免疫吸附测定（ELISA）检测到的gp41核心的形成; 6）它们抑制荧光天然 - 聚丙烯酰胺凝胶电泳（FN-PAGE）显示的gp41六螺旋束的形成; 和7）它们阻断了肽肽与肽IQN17模拟的gp41卷曲螺旋结构域内的疏水空穴的结合。这些结果表明NB-2和NB-64可能与疏水腔相互作用并阻断融合活性gp41卷曲螺旋结构域的形成，导致HIV-1介导的膜融合和病毒进入的抑制。

4. 发明申请

US20060240551A1 Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus 失效
公开(公告)号：US20060240551A1
公开(公告)日：2006-10-26
申请号：US11351108
申请日：2006-02-08
申请人： Shibo Jiang , Yuxian He
发明人： Shibo Jiang , Yuxian He
IPC分类号： C12Q1/68 , C12N5/06 , C12N5/16
CPC分类号： C07K16/10 , C07K2317/34 , C07K2317/76
摘要： The present invention provides an isolated antibody capable of binding to the receptor-binding domain of the spike protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) so as to competitively inhibit the binding of the SARS-CoV to host cells. These mAbs or substances can be used: 1) as passive-immunizing agents for prevention of SARS-CoV infection; 2) as biological reagents for diagnosis of SARS-CoV infection; 3) as immunotherapeutics for early treatment of SARS-CoV infection; and 4) as probes for studying the immunogenicity, antigenicity, structure, and function of the SARS-CoV S protein.

5. 发明授权

US5952009A Methods for preventing the transmission of or treating patients infected with herpesvirus 失效
标题翻译：防止感染疱疹病毒的患者传播或治疗方法
公开(公告)号：US5952009A
公开(公告)日：1999-09-14
申请号：US703925
申请日：1996-08-28
申请人： Alexander Robert Neurath , Asim Kumar Debnath , Shibo Jiang
发明人： Alexander Robert Neurath , Asim Kumar Debnath , Shibo Jiang
IPC分类号： A61K35/20 , A61K35/54 , A61K38/17
CPC分类号： A61K38/1709
摘要： A method of preventing the transmission of or treating herpesvirus, such as herpes simplex virus infection, or Chlamydia trachomatis comprising administering to a patient a composition which comprises: (i) a protein or peptide containing lysines and an N-terminal amino group, wherein at least one of the lysines or the N-terminal amino group of the protein or peptide, such as casein, .beta.-lactoglobulin, powdered milk or whey, is modified by contact with an aromatic acid anhydride compound, such as trimellitic anhydride, trimellitic anhydride chloride or 3-hydroxyphthalic anhydride and/or (ii) a protein or peptide containing arginines, which is modified by an arginine modifying agent containing at least one carboxyl group, such as p-carboxyphenylglyoxal.
摘要翻译：一种防止疱疹病毒如单纯疱疹病毒感染或沙眼衣原体的传播或治疗的方法，包括向患者施用包含以下物质的组合物：（i）含有赖氨酸和N-末端氨基的蛋白质或肽，其中在通过与芳族酸酐化合物如偏苯三酸酐，偏苯三酸酐氯化物接触来改变蛋白质或肽的赖氨酸或N-末端氨基中的至少一个，例如酪蛋白，β-乳球蛋白，奶粉或乳清，或3-羟基邻苯二甲酸酐和/或（ii）含有精氨酸改性剂（含有至少一个羧基）如对羧基苯基乙二醛的精氨酸的蛋白质或肽。

6. 发明授权

US5840843A Synthetic polypeptides as inhibitors of HIV-1 失效
标题翻译：作为HIV-1抑制剂的合成多肽
公开(公告)号：US5840843A
公开(公告)日：1998-11-24
申请号：US484107
申请日：1995-06-07
申请人： Shibo Jiang , Kang Lin , A. Robert Neurath
发明人： Shibo Jiang , Kang Lin , A. Robert Neurath
IPC分类号： A61K38/00 , A61K39/00 , A61P31/12 , C07K14/155 , C07K14/16 , C12N15/09 , C12P21/02 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
摘要： A synthetic HIV-1-based polypeptide as well as methods for treating HIV-1 infections are provided herein. The polypeptide of the present invention has an amino acid sequence substantially corresponding to a specified region of the HIV-1.sub.IIIB virus. The polypeptide of the present invention may be administered in effective amounts for preventing and treating HIV-1 infections. The polypeptide is useful for inhibiting the replication of the HIV-1 virus as well as HIV-1-mediated cytopathogenesis and cell fusion at levels which are within acceptable ranges of cytotoxicity.
摘要翻译：本文提供合成的基于HIV-1的多肽以及用于治疗HIV-1感染的方法。本发明的多肽具有基本对应于HIV-1IIIB病毒的特定区域的氨基酸序列。本发明的多肽可以以有效的量施用以预防和治疗HIV-1感染。该多肽可用于抑制HIV-1病毒的复制以及在可接受的细胞毒性范围内的HIV-1介导的细胞致病发生和细胞融合。

7. 发明授权

US08900585B2 Influenza hemagglutinin-specific monoclonal antibodies for preventing and treating influenza virus infection 有权
标题翻译：流感血凝素特异性单克隆抗体用于预防和治疗流感病毒感染
公开(公告)号：US08900585B2
公开(公告)日：2014-12-02
申请号：US13277515
申请日：2011-10-20
申请人： Shibo Jiang , Lanying Du , Yusen Zhou
发明人： Shibo Jiang , Lanying Du , Yusen Zhou
IPC分类号： C07K16/00 , A61K39/395 , C07K16/10 , A61K39/00
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76
摘要： Disclosed herein are neutralizing antibodies with cross-neutralizing activity and cross-protective effects against divergent stains of influenza virus, which are specific for an epitope having at least 90% homology to amino acids +72-115 of the HA1 domain of H5N1 influenza virus hemagglutinin.
摘要翻译：本文公开了具有交叉中和活性和针对流感病毒发散性污染物的交叉保护作用的中和抗体，其对于与H5N1流感病毒血凝素的HA1结构域的氨基酸+ 72-115具有至少90％同源性的表位是特异性的。

8. 发明申请

US20120100150A1 Influenza Hemagglutinin-Specific Monoclonal Antibodies for Preventing and Treating Influenza Virus Infection 有权
标题翻译：流感血凝素特异性单克隆抗体用于预防和治疗流感病毒感染
公开(公告)号：US20120100150A1
公开(公告)日：2012-04-26
申请号：US13277515
申请日：2011-10-20
申请人： Shibo Jiang , Lanying Du , Yusen Zhou
发明人： Shibo Jiang , Lanying Du , Yusen Zhou
IPC分类号： A61K39/42 , A61P31/16 , C07K16/10
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/34 , C07K2317/76
摘要： Disclosed herein are neutralizing antibodies with cross-neutralizing activity and cross-protective effects against divergent stains of influenza virus, which are specific for an epitope having at least 90% homology to amino acids +72-115 of the HA1 domain of H5N1 influenza virus hemagglutinin.
摘要翻译：本文公开了具有交叉中和活性和针对流感病毒发散性污染物的交叉保护作用的中和抗体，其对于与H5N1流感病毒血凝素的HA1结构域的氨基酸+ 72-115具有至少90％同源性的表位是特异性的。

9. 发明申请

US20120016639A1 OPTIMIZATION DESIGN METHOD FOR THE CHASSIS STRUCTURE OF AN ELECTRONIC DEVICE BASED ON MECHANICAL, ELECTRICAL AND THERMAL THREE-FIELD COUPLING 有权
标题翻译：基于机械，电和热三相耦合的电子设备底盘结构优化设计方法
公开(公告)号：US20120016639A1
公开(公告)日：2012-01-19
申请号：US13259262
申请日：2009-09-24
申请人： Baoyan Duan , Hui Qiao , Peng Li , Shibo Jiang , Boyuan Ma , Ning Han , Lizhi Zeng , Yu He
发明人： Baoyan Duan , Hui Qiao , Peng Li , Shibo Jiang , Boyuan Ma , Ning Han , Lizhi Zeng , Yu He
IPC分类号： G06F17/50 , G06F17/10
CPC分类号： G06F17/5018 , G06F2217/16 , G06F2217/80
摘要： An optimizing design method for a chassis structure of electronic equipment is disclosed, including: investigating from the point of view of mechanical, electric and thermal three-field coupling, determining the preliminary design size of the chassis, performing a mechanical analysis by using the software Ansys; converting the mesh model among the three-fields, obtaining the mesh model used for the electromagnetic and thermal analyses; setting the thermal analysis parameters, performing the thermal analysis by using the software IcePak; determining a resonance frequency of the chassis and an electric parameter of the absorbing material, performing an electromagnetic analysis by using the software FeKo; correcting the analysis result by sample testing; determining whether the chassis satisfies the design requirement, if it satisfies the requirement, the optimizing design will be finished, otherwise, modifying the preliminary CAD model, the electromagnetic analysis parameter and the thermal analysis parameter, repeating the above processes until the requirement is satisfied.
摘要翻译：公开了一种电子设备底盘结构的优化设计方法，包括：从机械，电和热三场耦合的角度考察，确定机箱的初步设计尺寸，使用软件进行机械分析安斯斯在三场中转换网格模型，获得用于电磁和热分析的网格模型; 设置热分析参数，使用IcePak软件执行热分析; 确定底盘的共振频率和吸收材料的电参数，使用软件FeKo执行电磁分析; 通过样本测试纠正分析结果; 确定底盘是否满足设计要求，如果满足要求，优化设计将完成，否则，修改初步CAD模型，电磁分析参数和热分析参数，重复上述过程直到满足要求。

10. 发明申请

US20100098724A1 IMMUNOENHACER-LINKED OLIGOMERIC HIV VACCINES 有权
标题翻译：免疫原性连接的低密度HIV疫苗
公开(公告)号：US20100098724A1
公开(公告)日：2010-04-22
申请号：US12581056
申请日：2009-10-16
申请人： Shibo Jiang , Zhi Qi , Chungen Pan
发明人： Shibo Jiang , Zhi Qi , Chungen Pan
IPC分类号： A61K39/21 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C07K2319/30 , C07K2319/40 , C12N2740/16122 , C12N2740/16134
摘要： Provided herein are immunogenic compositions comprising fusion proteins, the fusion proteins comprising lentivirus gp41 or a fragment thereof, a trimerization or oligomerization motif and an immunoenhancer that elicit potent and broad HIV neutralizing antibody responses in the immunized hosts. Also disclosed are methods of making and using the immunogenic compositions.
摘要翻译：本文提供包含融合蛋白的免疫原性组合物，包含慢病毒gp41或其片段的融合蛋白，三聚或寡聚化基序和在免疫宿主中引发有效和广泛的HIV中和抗体应答的免疫增强子。还公开了制备和使用免疫原性组合物的方法。

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