专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08648080B2 Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility 有权
标题翻译：酸泵拮抗剂用于治疗涉及胃肠蠕动异常的疾病
公开(公告)号：US08648080B2
公开(公告)日：2014-02-11
申请号：US13383056
申请日：2010-07-09
申请人： Nobuyuki Takahashi , Shinichi Koizumi
发明人： Nobuyuki Takahashi , Shinichi Koizumi
IPC分类号： A61K31/497 , A61K31/44
CPC分类号： A61K45/06 , A61K31/4184 , A61K31/4188 , A61K31/437 , A61K31/506 , A61K2300/00
摘要： The present invention relates to a use of a compound having an acid pump antagonistic activity, a pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof for the manufacture of a medicament for prevention or treatment of diseases in which abnormal gastrointestinal motility is involved. In addition, the present invention relates to the method of prevention or treatment including administering to a human or animal. The compound, the pharmaceutically acceptable salt thereof, or pharmaceutical compositions containing them, may be used in combination with one or more second active agent. Further, the present invention relates to pharmaceutical compositions and kits comprising a compound having an acid pump antagonistic activity or a pharmaceutically acceptable salt thereof for the prevention or treatment of said diseases.
摘要翻译：本发明涉及具有酸泵拮抗活性的化合物，其药学上可接受的盐或其药物组合物在制备用于预防或治疗其中涉及异常胃肠蠕动的疾病的药物中的用途。此外，本发明涉及预防或治疗方法，包括对人或动物施用。化合物，其药学上可接受的盐或含有它们的药物组合物可以与一种或多种第二活性剂组合使用。此外，本发明涉及药物组合物和试剂盒，其包含具有酸泵拮抗活性的化合物或其药学上可接受的盐，用于预防或治疗所述疾病。

2. 发明申请

US20080275127A1 Arylsulfonamido-substituted hydroxamic acid derivatives 失效
标题翻译：芳基磺酰氨基取代的异羟肟酸衍生物
公开(公告)号：US20080275127A1
公开(公告)日：2008-11-06
申请号：US11581524
申请日：2006-10-16
申请人： Werner Breitenstein , Kenji Hayakawa , Genji Iwasaki , Takanori Kanazawa , Tatsuhiko Kasaoka , Shinichi Koizumi , Shinichiro Matsunaga , Motowo Nakajima , Junichi Sakaki
发明人： Werner Breitenstein , Kenji Hayakawa , Genji Iwasaki , Takanori Kanazawa , Tatsuhiko Kasaoka , Shinichi Koizumi , Shinichiro Matsunaga , Motowo Nakajima , Junichi Sakaki
IPC分类号： A61K31/18 , C07C303/00
CPC分类号： C07D207/32 , C07C311/29 , C07D213/42 , C07D215/12 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/06 , C07D249/08 , C07D257/04 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/52 , C07D333/20
摘要： α-Amino hydroxamic acid derivative of the formula I, in which R is C2-C7-alkyl, which is mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C3-C5-cycloalkyl or unsubstituted or substituted C3-C6-heteroaryl comprising one or two heteroatoms selected from the group consisting of O, S and N; or C3-C7-alkenyl or C3-C7-alkynyl, which in each case is unsubstituted or mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C3-C5-cycloalkyl or unsubstituted or substituted C3-C6-heteroaryl comprising one or two heteroatoms selected from the group consisting of O, S and N; and the other symbols are as defined in claim 1, are described. These compounds are MMP and in particular MMP2 inhibitors and can be used for treatment of MMP dependent diseases, in particular inflammation conditions, rheumatoid arthritis, osteoarthritis, tumors (tumor growth, metastasis, progression or invasion) and pulmonary disorders (e.g. emphysema, COPD).
摘要翻译：式I的α-氨基异羟肟酸衍生物，其中R是C 2 -C 7 - 烷基，其被卤素，硝基的单，二或三取代，低级酰氧基，三氟甲氧基，氰基，C 3 -C 5 - 环烷基或未取代或取代的C 3 -C 6 - 包含一个或两个选自O，S和N的杂原子的杂芳基; 或C 3 -C 7 - 烯基或C 3 -C 7 - 炔基，其在每种情况下为未取代的或被卤素，硝基，低级酰氧基，三氟甲氧基，氰基，C 3 -C 5 - 环烷基或未取代或取代的C 1 - 3个-C 6 -C 6 - 杂芳基，其包含一个或两个选自O，S和N的杂原子; 并且其它符号如权利要求1中所定义。这些化合物是MMP，特别是MMP2抑制剂，可用于治疗MMP依赖性疾病，特别是炎症病症，类风湿性关节炎，骨关节炎，肿瘤（肿瘤生长，转移，进展或侵袭）和肺部疾病（例如肺气肿，COPD）。

3. 发明授权

US07138432B1 Arylsulfonamido-substituted hydroxamic acid derivatives 失效
标题翻译：芳基磺酰氨基取代的异羟肟酸衍生物
公开(公告)号：US07138432B1
公开(公告)日：2006-11-21
申请号：US10048932
申请日：2000-08-07
申请人： Werner Breitenstein , Kenji Hayakawa , Genji Iwasaki , Takanori Kanazawa , Tatsuhiko Kasaoka , Shinichi Koizumi , Shinichiro Matsunaga , Motowo Nakajima , Junichi Sakaki
发明人： Werner Breitenstein , Kenji Hayakawa , Genji Iwasaki , Takanori Kanazawa , Tatsuhiko Kasaoka , Shinichi Koizumi , Shinichiro Matsunaga , Motowo Nakajima , Junichi Sakaki
IPC分类号： A61K31/18 , C07C303/00
CPC分类号： C07D207/32 , C07C311/29 , C07D213/42 , C07D215/12 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/06 , C07D249/08 , C07D257/04 , C07D295/125 , C07D295/13 , C07D295/135 , C07D307/52 , C07D333/20
摘要： α-Amino hydroxamic acid derivative of formula (I), in which R is C2–C7-alkyl, which is mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C3–C5-cycloalkyl or unsubstituted or substituted C3–C4-heteroaryl comprising one or two heteroatoms selected from the group consisting of O, S and N; or C3–C7-alkenyl or C3–C7-alkynyl, which in each case is unsubstituted or mono-, di- or trisubstituted by halogen, nitro, lower acyloxy, trifluoromethoxy, cyano, C3–C5-cycloalkyl or unsubstituted or substituted C3–C6-heteroaryl comprising one or two heteroatoms selected from the group consisting of O, S and N; and the other symbols are as defined in claim 1, are described. These compounds are MMP and in particular MMP2 inhibitors and can be used for treatment of MMP dependent diseases, in particular inflammation conditions, rheumatoid arthritis, osteoarthritis, tumors (tumor growth, metastasis, progression or invasi n) and pulmonary disorders (e.g. emphysema, COPD).
摘要翻译：式（I）的α-氨基异羟肟酸衍生物，其中R为C 2 -C 7 -C 7 - 烷基，其被卤素单，二或三取代，硝基，低级酰氧基，三氟甲氧基，氰基，C 3 -C 5 - 环烷基或未取代或取代的C 3 -C 4 - 包含一个或两个选自O，S和N的杂原子的杂芳基; 或C 3 -C 7 - 烯基或C 3 -C 7 - 炔基，其在每种情况下为未取代的或被卤素，硝基，低级酰氧基，三氟甲氧基，氰基，C 3 -C 5 - 环烷基或未取代或取代的C 1 - 3个-C 6 -C 6 - 杂芳基，其包含一个或两个选自O，S和N的杂原子; 并且其它符号如权利要求1中所定义。这些化合物是MMP，特别是MMP2抑制剂，可用于治疗MMP依赖性疾病，特别是炎症病症，类风湿性关节炎，骨关节炎，肿瘤（肿瘤生长，转移，进展或侵袭性）和肺部疾病（例如肺气肿，COPD ）。

4. 发明授权

US5541310A Herbicide resistant plants 失效
标题翻译：除草剂抗性植物
公开(公告)号：US5541310A
公开(公告)日：1996-07-30
申请号：US236427
申请日：1994-04-29
申请人： Eric R. Ward , Sandra Volrath , Shinichi Koizumi , Sachiyo Tada , Ichiro Mori , Genji Iwasaki
发明人： Eric R. Ward , Sandra Volrath , Shinichi Koizumi , Sachiyo Tada , Ichiro Mori , Genji Iwasaki
IPC分类号： A01H5/00 , C12N5/10 , C12N9/88 , C12N15/09 , C12N15/60 , C12N15/82 , C12Q1/527 , C12N15/29 , C12N15/63
CPC分类号： C12N9/88 , C12N15/8278 , C12Q1/527
摘要： Disclosed are plants, plant tissue and plant seed, whose growth and development are tolerant of, or resistant to various imidazole and triazole herbicidal compounds, at levels which normally are inhibitory to the plants. The tolerance or resistance is conferred by an altered imidazoleglycerol phosphate dehydratase (IGPD). Plant genes encoding wild-type and altered IGPD, purified plant IGPD, methods of isolating IGPD from plants, and methods of using both purified IGPD and IGPD-encoding genes are also disclosed.
摘要翻译：公开了植物，植物组织和植物种子，其生长发育对各种咪唑和三唑除草化合物具有耐受性或耐受性，其水平通常对植物具有抑制作用。耐受性或抗性由改变的咪唑磷酸脱水酶（IGPD）赋予。还公开了编码野生型和改变的IGPD的植物基因，纯化植物IGPD，从植物分离IGPD的方法，以及使用纯化的IGPD和IGPD编码基因的方法。

5. 发明申请

US20120088723A1 SELECTIVE EP4 RECEPTOR AGONISTIC SUBSTANCE FOR TREATMENT OF CANCER 有权
标题翻译：选择性EP4受体激素治疗癌症的药物
公开(公告)号：US20120088723A1
公开(公告)日：2012-04-12
申请号：US13265216
申请日：2010-04-22
申请人： Yukinori Take , Shinichi Koizumi , Takako Okumura , Kazuhiko Nonomura
发明人： Yukinori Take , Shinichi Koizumi , Takako Okumura , Kazuhiko Nonomura
IPC分类号： A61K31/437 , C07C229/38 , A61K38/02 , C07D213/82 , A61K31/44 , A61P35/00 , C07D471/04 , A61K31/195
CPC分类号： C07D471/04 , A61K31/192 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K45/06 , C07C235/60 , C07D213/82
摘要： This invention provides a medicament for the treatment of cancer, which cause a reduction of cancer. This invention relates to use of a compound which has inhibitory activities against prostaglandin E2 receptor (EP4 receptor) and is represented by the following general formula (I), (II), (III), or (IV), or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the compound or the salt for the manufacture of a medicament for the treatment of cancer. The invention relates to a method for treatment of cancer comprising administering the compound or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the compound or the salt to humans or animals. The compound or a pharmaceutically acceptable salt thereof, or the pharmaceutical composition may be used in combination with one or more second active agents.
摘要翻译：本发明提供了用于治疗导致癌症减少的癌症的药物。本发明涉及对前列腺素E2受体（EP4受体）具有抑制活性且由以下通式（I），（II），（III）或（IV）表示的化合物或其药学上可接受的盐或包含该化合物或盐的药物组合物，用于制备用于治疗癌症的药物。本发明涉及一种治疗癌症的方法，其包括将化合物或其药学上可接受的盐或包含该化合物或盐的药物组合物给予人或动物。化合物或其药学上可接受的盐或药物组合物可以与一种或多种第二活性剂组合使用。

6. 发明授权

US07743642B2 Moisture absorbent material with indicator function, humidity indicator and packaging bag 有权
标题翻译：具有指示功能的吸湿材料，湿度指示器和包装袋
公开(公告)号：US07743642B2
公开(公告)日：2010-06-29
申请号：US10580933
申请日：2004-11-26
申请人： Eisuke Chiba , Tatsuya Ogawa , Shinichi Koizumi , Saori Takahashi
发明人： Eisuke Chiba , Tatsuya Ogawa , Shinichi Koizumi , Saori Takahashi
IPC分类号： G01N5/02
CPC分类号： G09F3/00 , B01D53/261 , B01D53/28 , B01D2253/108 , B32B15/08 , B32B15/085 , B32B15/20 , B32B27/08 , B32B27/20 , B32B27/32 , B32B27/36 , B32B2264/102 , B32B2307/4023 , B32B2307/412 , B32B2307/416 , B32B2307/7242 , B32B2307/7246 , B32B2307/726 , B32B2307/728 , B32B2307/75 , B32B2439/46 , B32B2439/70 , B32B2439/80 , B65D31/02 , B65D79/02 , B65D81/267 , G01N31/222
摘要： A moisture absorbent material (drying material) with an indicator function is provided without the use of cobalt chloride containing a heavy metal, low molecular organic substance and the like; and a humidity indicator permitting a state of humidity to be found in a simple manner is also provided. The moisture absorbent material with an indicator function (10) includes a resin layer (11) containing 5 to 80 wt % zeolite which is provided on at least one surface thereof with a printed layer including a character, shape, picture or the like, so that the printed layer may visibly appear due to the resin layer becoming transparent by moisture absorption. The humidity indicator (20) is formed by laminating a film (21) made of a zeolite-containing resin composition, a polyolefin film (22) having patterns (24) printed thereon that include characters, symbols, lines or the like, which are printed to have a difference in the print density, and an aluminum foil (26) through an adhesive, so that the patterns (24) may be made sequentially visible due to the film (21) made of the zeolite-containing resin composition becoming transparent by moisture absorption.
摘要翻译：提供具有指示功能的吸湿材料（干燥材料），而不使用含有重金属，低分子有机物质等的氯化钴; 并且还提供了以简单的方式找到允许湿度状态的湿度指示器。具有指示功能的吸湿材料（10）包括含有5至80重量％沸石的树脂层（11），其在其至少一个表面上设置有包括字符，形状，图片等的印刷层，因此由于树脂层通过吸湿而变得透明，所以印刷层可以看得见。湿度指示器（20）通过层压由含沸石的树脂组合物制成的膜（21），其上印有图案（24）的聚烯烃膜（22）形成，其包括字符，符号，线条等，它们是被印刷以具有印刷密度的差异，以及通过粘合剂的铝箔（26），使得由于含有沸石的树脂组合物形成的膜（21）变得透明，图案（24）可以依次可见通过吸湿。

7. 发明授权

US07659293B2 α-Amino-N-hydroxy-acetamide derivatives 失效
标题翻译： α-氨基-N-羟基 - 乙酰胺衍生物
公开(公告)号：US07659293B2
公开(公告)日：2010-02-09
申请号：US11868032
申请日：2007-10-05
申请人： Kenji Hayakawa , Genji Iwasaki , Shinichi Koizumi , Ichiro Umemura
发明人： Kenji Hayakawa , Genji Iwasaki , Shinichi Koizumi , Ichiro Umemura
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07D249/06 , C07C311/29 , C07C2601/02
摘要： The invention relates to α-amino-N-hydroxy-acetamide derivatives of formula I, wherein R is di-lower alkyl amino, 1,2,3-triazol-1-yl, 1,2,3-triazol-2-yl or 1,2,4-triazol-4-yl, m represents an integer from 1 up to and including 10, and n represents an integer from 0 up to and including 10, and salts thereof: to processes for their preparation, pharmaceutical compositions comprising said hydroxamic acid derivatives, the use of such hydroxamic acid derivatives as medicaments, and a method of treating conditions or diseases mediated by matrix-degrading metalloproteinases (MMP's) using said derivatives alone or in combination with one or more other therapeutic agents.
摘要翻译：本发明涉及式I的α-氨基-N-羟基 - 乙酰胺衍生物，其中R是二低级烷基氨基，1,2,3-三唑-1-基，1,2,3-三唑-2-基或1,2,4-三唑-4-基，m表示1以上且包括10的整数，n表示0以上且10以下的整数及其盐：其制备方法，药物组合物包括所述异羟肟酸衍生物，使用这种异羟肟酸衍生物作为药物，以及使用所述衍生物单独或与一种或多种其它治疗剂组合治疗由基质降解金属蛋白酶（MMP）介导的病症或疾病的方法。

8. 发明申请

US20090013760A1 Moisture Absorbent Material with Indicator Function, Humidity Indicator and Packaging Bag 有权
标题翻译：具有指示功能的湿度吸收材料，湿度指示器和包装袋
公开(公告)号：US20090013760A1
公开(公告)日：2009-01-15
申请号：US10580933
申请日：2004-11-26
申请人： Eisuke Chiba , Tatsuya Ogawa , Shinichi Koizumi , Saori Takahashi
发明人： Eisuke Chiba , Tatsuya Ogawa , Shinichi Koizumi , Saori Takahashi
IPC分类号： G01N19/10 , B01J29/04 , G01N5/02
CPC分类号： G09F3/00 , B01D53/261 , B01D53/28 , B01D2253/108 , B32B15/08 , B32B15/085 , B32B15/20 , B32B27/08 , B32B27/20 , B32B27/32 , B32B27/36 , B32B2264/102 , B32B2307/4023 , B32B2307/412 , B32B2307/416 , B32B2307/7242 , B32B2307/7246 , B32B2307/726 , B32B2307/728 , B32B2307/75 , B32B2439/46 , B32B2439/70 , B32B2439/80 , B65D31/02 , B65D79/02 , B65D81/267 , G01N31/222
摘要： A moisture absorbent material (drying material) with an indicator function is provided without the use of cobalt chloride containing a heavy metal, low molecular organic substance and the like; and a humidity indicator permitting a state of humidity to be found in a simple manner is also provided. The moisture absorbent material with an indicator function (10) includes a resin layer (11) containing 5 to 80 wt % zeolite which is provided on at least one surface thereof with a printed layer including a character, shape, picture or the like, so that the printed layer may visibly appear due to the resin layer becoming transparent by moisture absorption. The humidity indicator (20) is formed by laminating a film (21) made of a zeolite-containing resin composition, a polyolefin film (22) having patterns (24) printed thereon that include characters, symbols, lines or the like, which are printed to have a difference in the print density, and an aluminum foil (26) through an adhesive, so that the patterns (24) may be made sequentially visible due to the film (21) made of the zeolite-containing resin composition becoming transparent by moisture absorption.
摘要翻译：提供具有指示功能的吸湿材料（干燥材料），而不使用含有重金属，低分子有机物质等的氯化钴; 并且还提供了以简单的方式找到允许湿度状态的湿度指示器。具有指示功能的吸湿材料（10）包括含有5至80重量％沸石的树脂层（11），其在其至少一个表面上设置有包括字符，形状，图片等的印刷层，因此由于树脂层通过吸湿而变得透明，所以印刷层可以看得见。湿度指示器（20）通过层压由含沸石的树脂组合物制成的膜（21），其上印有图案（24）的聚烯烃膜（22）形成，其包括字符，符号，线条等，它们是被印刷以具有印刷密度的差异，以及通过粘合剂的铝箔（26），使得由于含有沸石的树脂组合物形成的膜（21）变得透明，图案（24）可以依次可见通过吸湿。

9. 发明授权

US5225909A Video signal reproducing system 失效
标题翻译：视频信号再生系统
公开(公告)号：US5225909A
公开(公告)日：1993-07-06
申请号：US690217
申请日：1991-04-24
申请人： Shinichi Koizumi
发明人： Shinichi Koizumi
IPC分类号： H04N5/937 , A63J17/00 , G11B19/02 , H04N7/18
CPC分类号： A63J17/00 , H04N7/188
摘要： A video signal reproducing system has a video memory for storing a video signal fed from a source, a memory controller for controlling production of a video signal stored in the video memory, and a display for reproducing a video signal produced from the video memory. Level of an audio signal applied to the display is detected. A detected level is compared with a reference value. A change signal is produced when the detected level is higher than the reference value. In response to the change signal, a video signal stored in the video memory is produced for the reproduction thereof.
摘要翻译：视频信号再现系统具有用于存储从源提供的视频信号的视频存储器，用于控制存储在视频存储器中的视频信号的产生的存储器控制器和用于再现从视频存储器产生的视频信号的显示器。检测到施加到显示器的音频信号的电平。将检测到的电平与参考值进行比较。当检测到的电平高于参考值时，产生变化信号。响应于改变信号，产生存储在视频存储器中的视频信号以用于其再现。

10. 发明申请

US20130153459A1 PACKAGE 审中-公开
标题翻译：包
公开(公告)号：US20130153459A1
公开(公告)日：2013-06-20
申请号：US13819133
申请日：2011-09-01
申请人： Tomohiro Yoshita , Fumi Izumi , Tatsuya Ogawa , Shinichi Koizumi , Hikaru Yamamoto
发明人： Tomohiro Yoshita , Fumi Izumi , Tatsuya Ogawa , Shinichi Koizumi , Hikaru Yamamoto
IPC分类号： B65D81/26
CPC分类号： B65D81/26 , A61J1/035 , B65D75/326 , B65D81/267 , B65D2585/56
摘要： Provided is a package that exhibits satisfactory moldability as well as moisture adsorption and gas adsorption properties.A package P includes a container sheet 6 in which a concave receptacle unit 5 that accommodates a solid preparation 8 containing solifenacin succinate or 1-{[α-isobutanoyloxyethoxy]carbonyl}aminomethyl}-1-cyclohexaneacetic acid is formed, and an airtight cover material sheet 7 for sealing the solid preparation 8. The container sheet 6 is formed by a package film F1 in which an adsorption layer 1, at least one or more substrate layers 2 formed by resins, an aluminum foil 3, and a barrier layer 4. The adsorption layer 1 is laminated with the substrate layer 2 while also being disposed on the side where the solid preparation 8 is accommodated, and contains at least zeolite.
摘要翻译：提供了具有令人满意的成型性以及水分吸附和气体吸附性能的包装。包装P包括容器片6，其中形成容纳含有琥珀酸solifenacin或1 - {[α-异丁酰氧基乙氧基]羰基}氨基甲基} -1-环己烷乙酸的固体制剂8的凹形容器单元5，并且形成气密覆盖材料用于密封固体制剂8的片材7.容器片材6由包装膜F1形成，其中吸附层1，至少一个或多个由树脂形成的基底层2，铝箔3和阻挡层4。吸附层1与基材层2层叠，同时也设置在容纳固体制剂8的一侧，并且至少含有沸石。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式