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1. 发明申请

US20130040946A1 SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES 有权
标题翻译：取代的咪唑并嘧啶和三唑并嘧啶
公开(公告)号：US20130040946A1
公开(公告)日：2013-02-14
申请号：US13625086
申请日：2012-09-24
申请人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
发明人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
IPC分类号： A61K31/519 , C12N5/0775 , A61P7/00 , C12N5/0789 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to substituted imidazo- and triazolopyrimidines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of haematological disorders, preferably of leucopenias and neutropenias.
摘要翻译：本发明涉及取代的咪唑并 - 三唑并嘧啶类及其制备方法及其制备用于治疗和/或预防疾病，特别是血液病，优选白细胞减少和中性粒细胞减少症的药物的用途。

2. 发明申请

US20100105663A1 2-(HETEROARYL) ALKYL INDAZOLE 6-PHENYL AND THIENYL METHYL AMIDE AS THROMBIN INHIBITORS 审中-公开
标题翻译： 2-（异丁基）烷基吲唑6-苯乙烯和甲苯磺酰胺作为硫蛋白抑制剂
公开(公告)号：US20100105663A1
公开(公告)日：2010-04-29
申请号：US12373677
申请日：2007-07-02
申请人： Stephan Siegel , Dirk Schneider , Anja Buchmüller , Elke Dittrich-Wengenroth , Chrisstoph Gerdes , Mark Jean Gnoth , Stefan Heitmeier , Martin Hendrix , Ulrich Rester , Uwe Saatmann
发明人： Stephan Siegel , Dirk Schneider , Anja Buchmüller , Elke Dittrich-Wengenroth , Chrisstoph Gerdes , Mark Jean Gnoth , Stefan Heitmeier , Martin Hendrix , Ulrich Rester , Uwe Saatmann
IPC分类号： A61K31/55 , C07D231/56 , A61K31/416 , C07D277/20 , A61K31/426 , C07D401/02 , A61K31/4439 , C07D263/04 , A61K31/421 , C07D249/08 , A61K31/4196 , C07D413/02 , A61K31/5377 , C07D401/14 , A61K31/444 , C07D403/02 , A61K31/496 , A61P9/00
CPC分类号： C07D403/06 , C07D231/52 , C07D231/56 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The invention relates to substituted indazoles and methods for production thereof and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, especially of cardiovascular diseases, preferably of thromboembolic diseases.
摘要翻译：本发明涉及取代的吲唑及其生产方法及其用于生产用于治疗和/或预防疾病，特别是心血管疾病，优选血栓栓塞性疾病的药物的用途。

3. 发明申请

US20100092966A1 METHOD FOR DETECTING PYROPHOSPHATE BY MEANS OF BIOLUMINESCENCE DETECTION 有权
标题翻译：通过生物荧光检测方法检测磷酸酯的方法
公开(公告)号：US20100092966A1
公开(公告)日：2010-04-15
申请号：US12515218
申请日：2007-11-07
申请人： Nils Burkhardt , Stefan Heitmeier
发明人： Nils Burkhardt , Stefan Heitmeier
IPC分类号： C12Q1/66 , C40B30/08 , C12Q1/68 , C12M1/34
CPC分类号： C12Q1/66 , G01N2333/90241 , G01N2333/91171 , G01N2333/988
摘要： The invention relates to methods for detecting pyrophosphate by means of bioluminescence detection. In addition, methods for measuring chemical, especially enzyme-catalyzed, reactions in which pyrophosphate is formed or consumed are described. Such reactions are catalyzed for example by guanylyl cyclases, adenylyl cyclases, DNA polymerases or RNA polymerases.The novel methods are distinguished by high sensitivity and low susceptibility to interference, can easily be automated and miniaturized and are additionally suitable for carrying out continuous measurements. The methods can be employed particularly advantageously in the area of medical diagnosis and biomedical research, including pharmaceutical active ingredient research.
摘要翻译：本发明涉及通过生物发光检测法检测焦磷酸盐的方法。此外，还描述了测量化学，特别是酶催化的焦磷酸盐形成或消耗的反应的方法。这样的反应例如通过鸟苷酸环化酶，腺苷酸环化酶，DNA聚合酶或RNA聚合酶催化。新颖的方法的特征在于高灵敏度和低干扰敏感性，可以容易地自动化和小型化，并且还适用于进行连续测量。该方法可以特别有利地用于医学诊断和生物医学研究领域，包括药物活性成分研究。

4. 发明授权

US08273752B2 Substituted imidazopyrimidines and triazolopyrimidines 有权
标题翻译：取代的咪唑并嘧啶和三唑并嘧啶
公开(公告)号：US08273752B2
公开(公告)日：2012-09-25
申请号：US12529711
申请日：2008-03-04
申请人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
发明人： Stephan Siegel , Andreas Wilmen , Susanne Röhrig , Niels Svenstrup , Mark Jean Gnoth , Stefan Heitmeier , Ulrich Rester , Dmitry Zubov , Jochen Strayle , Michael Sperzel
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to substituted imidazo- and triazolopyrimidines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of haematological disorders, preferably of leucopenias and neutropenias.
摘要翻译：本发明涉及取代的咪唑并 - 三唑并嘧啶类及其制备方法及其制备用于治疗和/或预防疾病，特别是血液病，优选白细胞减少和中性粒细胞减少症的药物的用途。

5. 发明申请

US20100261759A1 SUBSTITUTED OXAZOLIDINONES AND THEIR USE 有权
公开(公告)号：US20100261759A1
公开(公告)日：2010-10-14
申请号：US12665718
申请日：2008-06-07
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Ulrich Rester , Stefan Heitmeier , Christoph Gerdes , Georges Von Degenfeld , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Klaus Münter , Mark Jean Gnoth , Dieter Lang
IPC分类号： A61K31/4439 , C07D413/14 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.

6. 发明申请

US20100004235A1 Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses 审中-公开
标题翻译：杂环取代的，苯并吡唑衍生物及其用途
公开(公告)号：US20100004235A1
公开(公告)日：2010-01-07
申请号：US12298532
申请日：2007-04-17
申请人： Hartmut Schirok , Nils Griebenow , Chantal Fürstner , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder , Karl-Heinz Schlemmer , Stefan Heitmeier , Friederike Stoll
发明人： Hartmut Schirok , Nils Griebenow , Chantal Fürstner , Joachim Mittendorf , Johannes-Peter Stasch , Frank Wunder , Karl-Heinz Schlemmer , Stefan Heitmeier , Friederike Stoll
IPC分类号： A61K31/5377 , C07D471/02 , A61K31/437 , C07D413/14 , A61P9/00
CPC分类号： C07D471/04
摘要： The present application relates to novel heterocyclyl-substituted fused pyrazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译：本申请涉及新的杂环基取代的稠合吡唑衍生物，其制备方法，其单独或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或治疗的药物的用途预防疾病，特别是用于治疗和/或预防心血管疾病。

7. 发明授权

US08969045B2 Method for detecting pyrophosphate by means of bioluminescence detection 有权
标题翻译：通过生物发光检测法检测焦磷酸盐的方法
公开(公告)号：US08969045B2
公开(公告)日：2015-03-03
申请号：US12515218
申请日：2007-11-07
申请人： Nils Burkhardt , Stefan Heitmeier
发明人： Nils Burkhardt , Stefan Heitmeier
IPC分类号： C12P19/34 , C12Q1/66
CPC分类号： C12Q1/66 , G01N2333/90241 , G01N2333/91171 , G01N2333/988
摘要： The invention relates to methods for detecting pyrophosphate by means of bioluminescence detection. In addition, methods for measuring chemical, especially enzyme-catalyzed, reactions in which pyrophosphate is formed or consumed are described. Such reactions are catalyzed for example by guanylyl cyclases, adenylyl cyclases, DNA polymerases or RNA polymerases.The novel methods are distinguished by high sensitivity and low susceptibility to interference, can easily be automated and miniaturized and are additionally suitable for carrying out continuous measurements. The methods can be employed particularly advantageously in the area of medical diagnosis and biomedical research, including pharmaceutical active ingredient research.
摘要翻译：本发明涉及通过生物发光检测法检测焦磷酸盐的方法。此外，还描述了测量化学，特别是酶催化的焦磷酸盐形成或消耗的反应的方法。这样的反应例如通过鸟苷酸环化酶，腺苷酸环化酶，DNA聚合酶或RNA聚合酶催化。新颖的方法的特征在于高灵敏度和低干扰敏感性，可以容易地自动化和小型化，并且还适用于进行连续测量。该方法可以特别有利地用于医学诊断和生物医学研究领域，包括药物活性成分研究。

8. 发明授权

US08198267B2 Substituted oxazolidinones and their use 失效
标题翻译：取代恶唑烷酮及其用途
公开(公告)号：US08198267B2
公开(公告)日：2012-06-12
申请号：US12665728
申请日：2008-06-13
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
IPC分类号： C07D413/14 , A61K31/4439 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译：本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

9. 发明申请

US20100298293A1 SUBSTITUTED OXAZOLIDINONES AND THEIR USE 失效
标题翻译：替代奥昔洛芬及其使用
公开(公告)号：US20100298293A1
公开(公告)日：2010-11-25
申请号：US12665728
申请日：2008-06-13
申请人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
发明人： Swen Allerheiligen , Marcus Bauser , Hartmut Schirok , Michael Härter , Stephan Siegel , Ulrich Rester , Christoph Gerdes , Stefan Heitmeier , Georges Von Degenfeld , Anja Buchmüller , Elke Dittrich-Wengenroth , Uwe Saatman , Julia Strassburger , Mark Jean Gnoth , Dieter Lang
IPC分类号： A61K31/553 , A01N1/02 , A61K31/5377 , A61K31/497 , A61K31/513 , A61K31/454 , A61K31/4439 , C07D413/12 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for preparation thereof, to the use thereof for treatment and/or prophylaxis of diseases, and to the use thereof for producing medicaments for treatment and/or prophylaxis of diseases, especially of thromboembolic disorders.
摘要翻译：本发明涉及新型取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

10. 发明申请

US20100184740A1 SUBSTITUTED OXAZOLIDINONES AND THEIR USE 有权
标题翻译：替代奥昔洛芬及其使用
公开(公告)号：US20100184740A1
公开(公告)日：2010-07-22
申请号：US12665729
申请日：2008-06-07
申请人： Swen Allerheiligen , Marcus Bauser , Dirk Heimbach , Stefan Heitmeier , Mark Jean Gnoth , Christoph Gerdes , Georges Von Degenfeld , Susanne Röhrig , Ulrich Rester , Elke Dittrich-Wengenroth , Uwe Saatman , Adrian Tersteegen
发明人： Swen Allerheiligen , Marcus Bauser , Dirk Heimbach , Stefan Heitmeier , Mark Jean Gnoth , Christoph Gerdes , Georges Von Degenfeld , Susanne Röhrig , Ulrich Rester , Elke Dittrich-Wengenroth , Uwe Saatman , Adrian Tersteegen
IPC分类号： A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/496 , C07D417/14 , A61K31/541 , A61K31/553 , A61P7/02 , A61P7/00 , A61P9/12 , A61P29/00
CPC分类号： C07D413/14
摘要： The invention relates to novel substituted oxazolidinones, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of thromboembolic disorders.
摘要翻译：本发明涉及新的取代的恶唑烷酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是血栓栓塞性疾病的药物的用途。

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