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1. 发明申请

US20160158840A1 USE OF SPARK PLASMA SINTERING FOR MANUFACTURING SUPERALLOY COMPOUND COMPONENTS 审中-公开
标题翻译：使用火花等离子体烧结制造超级合金化合物组分
公开(公告)号：US20160158840A1
公开(公告)日：2016-06-09
申请号：US14088791
申请日：2013-11-25
申请人： Marco Cologna , Anand A. Kulkarni , Stefan Lampenscherf , Gia Khanh Pham , Cora Schillig , Steffen Walter
发明人： Marco Cologna , Anand A. Kulkarni , Stefan Lampenscherf , Gia Khanh Pham , Cora Schillig , Steffen Walter
IPC分类号： B22F3/105 , B22F1/00
CPC分类号： B22F3/105 , B22F1/0003 , B22F5/009 , B22F5/04 , B22F7/062 , B22F2003/1051 , B22F2201/20 , B22F2202/13 , B22F2301/15 , B22F2999/00 , C22C1/0433 , C22C1/045
摘要： A method of manufacturing a superalloy compound component is provided. The component includes a first component portion primarily consisting of a first superalloy and a second component portion primarily consisting of a second superalloy or of a refractory metal. The method includes using Spark Plasma Sintering for forming the superalloy compound component.
摘要翻译：提供了制造超合金化合物成分的方法。该组件包括主要由第一高温合金和第二组分部分组成的第一组分部分和主要由第二超级合金或难熔金属组成的第二组分部分。该方法包括使用火花等离子体烧结来形成超合金化合物组分。

2. 发明授权

US09101585B2 Immunotherapy against several tumors including gastrointestinal and gastric cancer 有权
标题翻译：免疫治疗几种肿瘤，包括胃肠和胃癌
公开(公告)号：US09101585B2
公开(公告)日：2015-08-11
申请号：US13051665
申请日：2011-03-18
申请人： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
发明人： Jens Fritsche , Toni Weinschenk , Steffen Walter , Peter Lewandrowski , Harpreet Singh
IPC分类号： C07K7/06 , C07K14/00 , A61K38/00 , A61K38/17 , A61K39/00 , G01N33/50
CPC分类号： A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61P35/00 , C07K7/06 , C07K2319/00 , G01N33/505
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 95 novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译：本发明涉及用于免疫治疗方法的肽，核酸和细胞。特别地，本发明涉及癌症的免疫治疗。本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的95种新型肽序列及其衍生自人类肿瘤细胞HLA I类分子的变体。

3. 发明授权

US08846216B2 Cast piece and method for producing same 有权
标题翻译：铸件及其制造方法
公开(公告)号：US08846216B2
公开(公告)日：2014-09-30
申请号：US12308732
申请日：2007-06-19
申请人： Rene Jabado , Jens Dahl Jensen , Ursus Krüger , Daniel Körtvelyessy , Richard Matz , Ralph Reiche , Michael Rindler , Steffen Walter
发明人： Rene Jabado , Jens Dahl Jensen , Ursus Krüger , Daniel Körtvelyessy , Richard Matz , Ralph Reiche , Michael Rindler , Steffen Walter
IPC分类号： G11B5/74 , B22D27/02 , B22D19/00 , B22D46/00 , B22D45/00
CPC分类号： B22D19/00 , B22D45/00 , B22D46/00 , Y10T428/12097 , Y10T428/12458 , Y10T428/12465 , Y10T428/12493 , Y10T428/24942 , Y10T428/32
摘要： A method for producing a cast metal piece and a cast metal piece are provided. An information element includes at least one piece of information. The information element is produced from a magnetizable material and the information is deposited n the magnetizable material and is cast into the information element during casting of the price, the casting temperature being above the Curie temperature of the magnetizable material of the information element.
摘要翻译：提供了铸造金属件和铸造件的制造方法。信息元素包括至少一条信息。信息元素由可磁化材料产生，并且信息被沉积在可磁化材料上，并且在铸造价格期间被投入到信息元素中，铸造温度高于信息元素的可磁化材料的居里温度。

4. 发明申请

US20130087538A1 METHOD AND DEVICE FOR LASER-JOINING SHEET METAL PARTS 有权
标题翻译：激光焊接金属部件的方法和装置
公开(公告)号：US20130087538A1
公开(公告)日：2013-04-11
申请号：US13700700
申请日：2011-05-25
申请人： Steffen Walter , Igor Haschke
发明人： Steffen Walter , Igor Haschke
IPC分类号： B23K26/00 , B23K26/04 , B23K26/08 , B23K26/24
CPC分类号： B23K26/00 , B23K26/037 , B23K26/043 , B23K26/08 , B23K26/082 , B23K26/20 , B23K26/24 , B23K26/32 , B23K2101/34 , B23K2103/08 , B23K2103/50
摘要： The invention relates to a device and to an associated method for joining sheet metal parts, each with a flange, by laser, wherein the flanges of the sheet metal parts (2) are joined into one connecting flange. The device has a clamping device (5) for clamping the sheet metal parts (2) to be joined in a main clamping direction running transversely to the connecting flange and a beam guidance system for a laser beam (1). Moreover, the device has a compensation shaft (9) which tracks the laser beam (1) according to a relative movement between the connecting flange and a guidance apparatus.
摘要翻译：本发明涉及一种用于通过激光连接每个具有凸缘的金属片部件的装置和相关联的方法，其中金属片部件（2）的凸缘接合成一个连接凸缘。该装置具有夹紧装置（5），用于沿横向于连接凸缘的主夹紧方向夹紧待连接的金属片（2）和用于激光束（1）的光束引导系统。此外，该装置具有根据连接凸缘和引导装置之间的相对运动跟踪激光束（1）的补偿轴（9）。

5. 发明授权

US08390195B2 High pressure discharge lamp 有权
标题翻译：高压放电灯
公开(公告)号：US08390195B2
公开(公告)日：2013-03-05
申请号：US13201225
申请日：2010-02-02
申请人： Roland Huettinger , Stefan Juengst , Stefan Kotter , Steffen Walter
发明人： Roland Huettinger , Stefan Juengst , Stefan Kotter , Steffen Walter
IPC分类号： H01J17/16 , H01J61/30
CPC分类号： H01J61/366 , H01J9/323
摘要： A high pressure discharge lamp may include a ceramic discharge vessel and a longitudinal axis, wherein at least one electrode is led out of the discharge vessel by means of a metal-containing feed-through, wherein the feed-through is connected to one end of the discharge vessel by way of a ceramic-containing adjustment part, wherein the adjustment part is tubular and consists of individual layers with different compositions, at least two materials A and B forming a plurality of layers of the adjustment part, these materials being chosen such that their coefficient of thermal expansion is between that of the feed-through and that of the end of the discharge vessel or at most is just outside, the layer thickness of each layer being so low that no shearing forces can occur, and the layer thickness of each layer of the same material being different.
摘要翻译：高压放电灯可以包括陶瓷放电容器和纵向轴线，其中至少一个电极通过含金属的馈通引出放电容器，其中馈通连接到所述放电容器通过含陶瓷的调节部件，其中所述调节部件是管状的，并且由具有不同成分的各个层组成，至少两种材料A和B形成所述调节部件的多个层，这些材料被选择为它们的热膨胀系数在馈通和放电容器末端的热膨胀系数之间，或者至多在外侧，每层的层厚度如此之低，不会产生剪切力，层厚度相同材料的每层不同。

6. 发明申请

US20130004456A1 COMPOSITION OF TUMOR-ASSOCIATED PEPTIDES AND RELATED ANTI-CANCER VACCINE FOR THE TREATMENT OF GLIOBLASTOMA (GBM) AND OTHER CANCERS 有权
公开(公告)号：US20130004456A1
公开(公告)日：2013-01-03
申请号：US13588206
申请日：2012-08-17
申请人： Toni WEINSCHENK , Oliver SCHOOR , Claudia TRAUTWEIN , Norbert HILF , Steffen WALTER , Harpreet SINGH
发明人： Toni WEINSCHENK , Oliver SCHOOR , Claudia TRAUTWEIN , Norbert HILF , Steffen WALTER , Harpreet SINGH
IPC分类号： A61K39/00 , A61P35/00 , A61K39/39
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against gliomas.

7. 发明申请

US20120229026A1 HIGH-PRESSURE DISCHARGE LAMP WITH IMPROVED IGNITABILITY AND HIGH-VOLTAGE PULSE GENERATOR 审中-公开
标题翻译：高压放电灯，具有改进的可燃性和高电压脉冲发生器
公开(公告)号：US20120229026A1
公开(公告)日：2012-09-13
申请号：US13450595
申请日：2012-04-19
申请人： Andreas Kloss , Ute Liepold , Carsten Schuh , Thorsten Steinkopff , Klaus Stockwald , Steffen Walter
发明人： Andreas Kloss , Ute Liepold , Carsten Schuh , Thorsten Steinkopff , Klaus Stockwald , Steffen Walter
IPC分类号： H01J61/54 , H01J61/56
CPC分类号： H05B41/042 , H01F27/323 , H01F41/061 , H01J61/34 , H01J61/547 , H01J61/56 , H03K3/537
摘要： High pressure discharge lamp (20) with improved ignitability. A spiral pulse generator (1) that is directly mounted inside the outer piston (12) of the lamp is used for igniting the high pressure discharge lamp.
摘要翻译：高压放电灯（20）具有改善的点火性能。直接安装在灯的外活塞（12）内的螺旋脉冲发生器（1）用于点燃高压放电灯。

8. 发明申请

US20110229505A1 Methods for the diagnosis and treatment of cancer based on AVL9 审中-公开
标题翻译：基于AVL9诊断和治疗癌症的方法
公开(公告)号：US20110229505A1
公开(公告)日：2011-09-22
申请号：US13051701
申请日：2011-03-18
申请人： Jens FRITSCHE , Toni WEINSCHENK , Steffen WALTER , Peter LEWANDROWSKI , Harpreet SINGH , Oliver SCHOOR
发明人： Jens FRITSCHE , Toni WEINSCHENK , Steffen WALTER , Peter LEWANDROWSKI , Harpreet SINGH , Oliver SCHOOR
IPC分类号： A61K39/00 , C12N15/63 , C12N5/0783 , C12N5/10 , C12N1/00 , C12Q1/68 , G01N33/574 , C07K14/47 , C07K7/06 , C07K7/08 , C07K19/00 , C07H21/00 , A61K38/17 , C07K16/18 , A61K48/00 , A61K35/00 , A61P35/00 , A61P37/04
CPC分类号： A61K38/1709 , A61K39/0011 , C07K14/4748 , G01N33/57492 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods for the diagnosis and treatment of cancer in mammals, in particular gastric cancer, based on the new target AVL9. The present invention thus relates to diagnostic methods and related components to be used in such methods. Furthermore, the present invention relates to the treatment of cancer in mammals, in particular gastric cancer, based on AVL9 as a target. Specifically, the present invention relates to the immunotherapy of cancer using AVL9 tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides, and respective pharmaceutical compositions, in particular vaccine compositions.
摘要翻译：本发明涉及基于新靶标AVL9来诊断和治疗哺乳动物癌症，特别是胃癌的方法。因此，本发明涉及用于这些方法的诊断方法和相关组件。此外，本发明涉及以AVL9为靶标的哺乳动物癌症，特别是胃癌的治疗。具体地，本发明涉及使用AVL9肿瘤相关的细胞毒性T细胞（CTL）肽表位的癌症的免疫治疗，其单独或与其它肿瘤相关肽组合，以及各自的药物组合物，特别是疫苗组合物。

9. 发明申请

US20110229504A1 Novel immunotherapy against several tumors including gastrointestinal and gastric cancer 有权
标题翻译：对几种肿瘤的新型免疫治疗，包括胃肠和胃癌
公开(公告)号：US20110229504A1
公开(公告)日：2011-09-22
申请号：US13051665
申请日：2011-03-18
申请人： Jens FRITSCHE , Toni WEINSCHENK , Steffen WALTER , Peter LEWANDROWSKI , Harpreet SINGH
发明人： Jens FRITSCHE , Toni WEINSCHENK , Steffen WALTER , Peter LEWANDROWSKI , Harpreet SINGH
IPC分类号： A61K39/00 , C07K7/06 , C07H21/02 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/02 , C12N5/0783 , A61K35/12 , A61K31/7088 , A61P35/00 , A61P37/04
CPC分类号： A61K38/1709 , A61K39/0011 , A61K2039/5158 , A61K2039/572 , A61K2039/585 , A61P35/00 , C07K7/06 , C07K2319/00 , G01N33/505
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 95 novel peptide sequences and their variants derived from HLA class I molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译：本发明涉及用于免疫治疗方法的肽，核酸和细胞。特别地，本发明涉及癌症的免疫治疗。本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的95种新型肽序列及其衍生自人类肿瘤细胞HLA I类分子的变体。

10. 发明申请

US20110089826A1 HALOGEN INCANDESCENT LAMP 审中-公开
标题翻译：卤素不良灯
公开(公告)号：US20110089826A1
公开(公告)日：2011-04-21
申请号：US12908960
申请日：2010-10-21
申请人： Janbernd Hentschel , Ute Liepold , Khanh Pham Gia , Steffen Walter , Raquel de la Pena Alonso
发明人： Janbernd Hentschel , Ute Liepold , Khanh Pham Gia , Steffen Walter , Raquel de la Pena Alonso
IPC分类号： H01K1/50
CPC分类号： H01K1/32 , H01K1/50 , Y02B20/12
摘要： A halogen incandescent lamp may include a bulb, in which a light-emitting element and a fill with a halogen-containing additive is accommodated, the halogen containing F, wherein a fluorine-resistant layer which is passive at suitable temperatures is accommodated in the interior of the bulb and completely covers the inner wall.
摘要翻译：卤素白炽灯可以包括其中容纳有发光元件和填充含卤素添加剂的灯泡，含有F的卤素，其中在适当温度下被动的耐氟层被容纳在内部的灯泡，并完全覆盖内壁。

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