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1. 发明申请

US20110209248A1 NOVEL SUGAR TRANSPORTERS 有权
标题翻译：新糖运输机
公开(公告)号：US20110209248A1
公开(公告)日：2011-08-25
申请号：US12773500
申请日：2010-05-04
申请人： Wolf B. Frommer , Sylvie Lalonde
发明人： Wolf B. Frommer , Sylvie Lalonde
IPC分类号： C12N15/82 , C07H21/04 , C07K14/00 , A61K38/16 , A61K31/7088 , A61K39/00 , A61P31/00 , A61P37/00 , A61P7/00 , C12N15/63 , C12N5/10 , A01H5/00 , C12N5/07 , C12N5/04 , G01N33/53 , A01N37/18 , A01P21/00
CPC分类号： C12N15/8279 , C07K14/415 , C07K14/43545 , C07K14/47 , C12N15/8218 , C12N15/8245 , C12N15/8246
摘要： A novel class of transporter protein, referred to as SWEET, GLUE or Glü, is disclosed. These transporters provide a novel system for the transportation of sugars across membranes within a cell and between the inside and outside of a cell. Such transporters are useful for understanding and altering the sugar concentration within certain organs of an organism, and within certain organelles within the cell. These transporters are also useful in protecting plants from a pathogen attack.
摘要翻译：公开了一类新颖的转运蛋白，称为SWEET，GLUE或Glü。这些转运蛋白提供了一种用于在细胞内和细胞内部和外部的膜之间运输糖的新型系统。这样的转运蛋白可用于理解和改变生物体的某些器官内和细胞内的某些细胞器内的糖浓度。这些转运蛋白也可用于保护植物免受病原体攻击。

2. 发明授权

US09562081B2 Sugar transporters 有权
标题翻译：糖运输商
公开(公告)号：US09562081B2
公开(公告)日：2017-02-07
申请号：US12773500
申请日：2010-05-04
申请人： Wolf B. Frommer , Sylvie Lalonde
发明人： Wolf B. Frommer , Sylvie Lalonde
IPC分类号： C12N15/113 , C12N15/82 , C07K14/47 , C07K14/415 , C07K14/435
CPC分类号： C12N15/8279 , C07K14/415 , C07K14/43545 , C07K14/47 , C12N15/8218 , C12N15/8245 , C12N15/8246
摘要： A novel class of transporter protein, referred to as SWEET, GLUE or Glü, is disclosed. These transporters provide a novel system for the transportation of sugars across membranes within a cell and between the inside and outside of a cell. Such transporters are useful for understanding and altering the sugar concentration within certain organs of an organism, and within certain organelles within the cell. These transporters are also useful in protecting plants from a pathogen attack.
摘要翻译：公开了一类新颖的转运蛋白，称为SWEET，GLUE或Glü。这些转运蛋白提供了一种用于在细胞内和细胞内部和外部的膜之间运输糖的新型系统。这样的转运蛋白可用于理解和改变生物体的某些器官内和细胞内的某些细胞器内的糖浓度。这些转运蛋白也可用于保护植物免受病原体攻击。

3. 发明申请

US20090311674A1 Phosphate Biosensors and Methods of Using the Same 有权
标题翻译：磷酸盐生物传感器及其使用方法
公开(公告)号：US20090311674A1
公开(公告)日：2009-12-17
申请号：US12083267
申请日：2005-10-14
申请人： Wolf B. Frommer , Hong Gu , Sylvie Lalonde , Arthur Grossman
发明人： Wolf B. Frommer , Hong Gu , Sylvie Lalonde , Arthur Grossman
IPC分类号： C12Q1/68 , C07H21/04 , C12N1/19 , C12N5/10 , C12N15/63 , A01K67/00 , C07K14/435
CPC分类号： C07K14/195
摘要： Phosphate biosensors are disclosed, which comprise a phosphate binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon phosphate binding. Such biosensors are useful for real time monitoring of phosphate metabolism in living cells.
摘要翻译：公开了磷酸盐生物传感器，其包含与供体和荧光部分缀合的磷酸盐结合结构域，其允许在磷酸盐结合时检测和测量荧光共振能量转移。这种生物传感器可用于实时监测活细胞中的磷酸盐代谢。

4. 发明授权

US08846365B2 Nucleic acids encoding phosphate fluorescent indicators and methods of using the same 有权
标题翻译：编码磷酸荧光指示剂的核酸及其使用方法
公开(公告)号：US08846365B2
公开(公告)日：2014-09-30
申请号：US12083267
申请日：2005-10-14
申请人： Wolf B. Frommer , Hong Gu , Sylvie Lalonde , Arthur Grossman
发明人： Wolf B. Frommer , Hong Gu , Sylvie Lalonde , Arthur Grossman
IPC分类号： C12N9/30 , C07K14/195
CPC分类号： C07K14/195
摘要： Phosphate biosensors are disclosed, which comprise a phosphate binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon phosphate binding. Such biosensors are useful for real time monitoring of phosphate metabolism in living cells.
摘要翻译：公开了磷酸盐生物传感器，其包含与供体和荧光部分缀合的磷酸盐结合结构域，其允许在磷酸盐结合时检测和测量荧光共振能量转移。这种生物传感器可用于实时监测活细胞中的磷酸盐代谢。

5. 发明申请

US20090178149A1 Polyamine Sensors and Methods of Using the Same 审中-公开
标题翻译：多胺传感器及其使用方法
公开(公告)号：US20090178149A1
公开(公告)日：2009-07-09
申请号：US11817478
申请日：2005-10-14
申请人： Sylvie Lalonde , Wolf B. Frommer , Loren L. Looger
发明人： Sylvie Lalonde , Wolf B. Frommer , Loren L. Looger
IPC分类号： A01K67/027 , C12N15/11 , C12N15/00 , C12N1/21 , C12N1/19 , C12N5/06 , C12Q1/02
CPC分类号： C07K14/195 , C07K2319/60
摘要： Polyamine biosensors are disclosed, including putrescine binding biosensors, comprising a polyamine binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding polyamine. Such biosensors are useful for the detection of polyamine concentrations in vivo and in culture.
摘要翻译：公开了多胺生物传感器，包括腐胺结合生物传感器，其包含与供体结合的多胺结合结构域和荧光部分，其允许在结合多胺时检测和测量荧光共振能量转移。这种生物传感器可用于在体内和培养物中检测多胺浓度。

6. 发明申请

US20070136825A1 Fusion proteins useful for detecting analytes 审中-公开
标题翻译：用于检测分析物的融合蛋白
公开(公告)号：US20070136825A1
公开(公告)日：2007-06-14
申请号：US10490153
申请日：2002-09-13
申请人： Wolf-Bernd Frommer , Marcus Fehr , Sylvie Lalonde
发明人： Wolf-Bernd Frommer , Marcus Fehr , Sylvie Lalonde
IPC分类号： A01K67/027 , C07H21/04 , C12P21/04 , C12N15/82 , C12N5/04 , C07K14/435
CPC分类号： C07K14/43595 , A01K2217/05 , C07K2319/00 , C07K2319/20 , C07K2319/60 , G01N33/542
摘要： Disclosed are fusion proteins comprising two detection portions and a periplasmic binding protein (PBP) portion between this two detection portions which undergoes a conformational change upon binding of a compound. Also described are nucleic acid molecules comprising a nucleotide sequence encoding such a fusion protein as well as expression cassettes, vectors, transgenic plants and transgenic non-human animals comprising said nucleic acid molecules. In addition, described are methods for detecting an analyte in a sample or in a cell using said fusion protein, and optionally, a control sensor allowing a calibration of analyte detection made by said fusion protein. Also described are such control sensors and nucleic acid molecules encoding them, as well as diagnostic compositions, kits and uses of the fusion protein and the control sensor for in vitro or in vivo analyte detection and preparing a diagnostic composition.
摘要翻译：公开了在两个检测部分之间包含两个检测部分和周质结合蛋白（PBP）部分的融合蛋白，其在化合物结合时经历构象变化。还描述了包含编码这种融合蛋白的核苷酸序列以及包含所述核酸分子的表达盒，载体，转基因植物和转基因非人动物的核酸分子。此外，描述了使用所述融合蛋白检测样品或细胞中的分析物的方法，以及任选的允许校准由所述融合蛋白产生的分析物检测的控制传感器的方法。还描述了这样的控制传感器和编码它们的核酸分子，以及用于体外或体内分析物检测和制备诊断组合物的融合蛋白和控制传感器的诊断组合物，试剂盒和用途。

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