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1. 发明授权

US08632286B2 Transportation unit for a wind turbine rotor blade 有权
标题翻译：风力发电机转子叶片的运输单元
公开(公告)号：US08632286B2
公开(公告)日：2014-01-21
申请号：US11380770
申请日：2006-04-28
申请人： Thomas Wessel , Dirk-Jan Kootstra
发明人： Thomas Wessel , Dirk-Jan Kootstra
IPC分类号： B60P7/08
CPC分类号： F03D80/00 , F03D13/40 , Y02E10/72
摘要： A transportation system for a wind turbine rotor blade is provided. The transportation system includes a root fixture adapted to receive the root end of the wind turbine rotor blade, and a tip end fixture adapted to receive a tip end of the wind turbine rotor blade. The root fixture and the tip end fixture are provided as separate transportable units.
摘要翻译：提供了一种用于风力涡轮机转子叶片的输送系统。运输系统包括适于接收风力涡轮机转子叶片的根部的根部固定装置，以及适于接收风力涡轮机转子叶片的尖端的末端夹具。根部固定装置和末端装置作为单独的运输装置提供。

2. 发明授权

US08329950B2 Process for preparation of trans 4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1Napthalenamine 有权
标题翻译：反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的制备方法
公开(公告)号：US08329950B2
公开(公告)日：2012-12-11
申请号：US13358155
申请日：2012-01-25
申请人： Judy Caron , Thomas Wessel , Karim Lalji , Mark Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Han , Stefan G. Koenig
发明人： Judy Caron , Thomas Wessel , Karim Lalji , Mark Varney , Roger P. Bakale , Surendra P. Singh , H. Scott Wilkinson , Xiping Su , Zhengxu Han , Stefan G. Koenig
IPC分类号： C07C209/62
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） 2,3,4-四氢-1-萘胺。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

3. 发明授权

US08186916B2 System and method for transporting wind turbine tower sections on a shipping vessel 有权
标题翻译：在运输船上运输风力涡轮机塔架段的系统和方法
公开(公告)号：US08186916B2
公开(公告)日：2012-05-29
申请号：US12135992
申请日：2008-06-09
申请人： Thomas Wessel , Peter Scott
发明人： Thomas Wessel , Peter Scott
IPC分类号： B60P7/12 , B60P1/00
CPC分类号： B63B35/003 , F03D13/40 , F05B2260/30 , Y02E10/727
摘要： In a system and method for transporting wind turbine tower sections on a shipping vessel a pair of support members is secured to a first wind turbine tower section generally at opposite ends of the first tower section. Another pair of support members is secured to a second wind turbine tower section generally at opposite ends of the second tower section. A pair of elongate mounting members is secured on a support surface of the shipping vessel in spaced relationship with each other. One of the support members of the first tower section and one of the support members of the second tower section are secured to one of the elongate mounting members. The other one of the support members of the first tower section and the other one of the support members of the second tower section are secured to the other one of the elongate mounting members.
摘要翻译：在用于在运输船上运输风力涡轮机塔架部分的系统和方法中，一对支撑构件通常在第一塔架部分的相对端固定到第一风力涡轮机塔架部分。另一对支撑构件通常在第二塔架部分的相对端固定到第二风力涡轮机塔架部分。一对细长的安装构件以彼此间隔开的关系固定在运输船的支撑表面上。第一塔架部分的支撑构件之一和第二塔架部分的支撑构件中的一个固定到细长安装构件中的一个。第一塔架段的另一个支撑构件和第二塔架段的另一个支撑构件固定到另一个细长安装构件。

4. 发明申请

US20120122874A1 COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR TREATING DEPRESSION 审中-公开
标题翻译：消融和神经递质调节剂的组合以及治疗衰老的方法
公开(公告)号：US20120122874A1
公开(公告)日：2012-05-17
申请号：US13305007
申请日：2011-11-28
申请人： Karim LALJI , Timothy J. BARBERICH , Judy CARON , Thomas WESSEL
发明人： Karim LALJI , Timothy J. BARBERICH , Judy CARON , Thomas WESSEL
IPC分类号： A61K31/4985 , A61P25/24
CPC分类号： A61K31/4985 , A61K31/137 , A61K31/138 , A61K31/495 , A61K31/724 , A61K45/06 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., insomnia and/or depression. The first component of the pharmaceutical composition is a GABA receptor modulating compound. The second component of the pharmaceutical composition is a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a 5-HT2A modulator, or dopamine reuptake inhibitor. In certain embodiments, the pharmaceutical composition comprises eszopiclone. In a preferred embodiment, the pharmaceutical composition comprises eszopiclone and fluoxetine. The present invention also relates to a method of treating a sleep abnormality, treating insomnia, treating depression, augmenting antidepressant therapy, eliciting a dose-sparing effect, reducing depression relapse, improving the efficacy of antidepressant therapy or improving the tolerability of antidepressant therapy, comprising co-administering to a patient in need thereof a GABA-receptor-modulating compound; and a SRI, NRI, 5-HT2A modulator or DRI.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，当它们一起被用于治疗，例如失眠和/或抑郁症时。药物组合物的第一组分是调节GABA受体的化合物。药物组合物的第二组分是5-羟色胺再摄取抑制剂，去甲肾上腺素再摄取抑制剂，5-HT2A调节剂或多巴胺再摄取抑制剂。在某些实施方案中，药物组合物包含依佐匹克。在优选的实施方案中，药物组合物包含依佐匹克和氟西汀。本发明还涉及一种治疗睡眠异常，治疗失眠，治疗抑郁症，增强抗抑郁药治疗，引发剂量保留作用，减少抑郁症复发，改善抗抑郁治疗疗效或提高抗抑郁治疗耐受性的方法，包括向有需要的患者共同施用GABA受体调节化合物; 和SRI，NRI，5-HT2A调节剂或DRI。

5. 发明申请

US20090111818A1 Combinations of Eszopiclone and O-Desmethylvenlafaxine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders 审中-公开
标题翻译：依曲替康和O-去甲基文拉法辛的组合以及更年期和心理，焦虑和认知障碍的治疗方法
公开(公告)号：US20090111818A1
公开(公告)日：2009-04-30
申请号：US11994638
申请日：2006-07-05
申请人： Judy Caron , Thomas Wessel , Karim Lalji , Mark A. Varney
发明人： Judy Caron , Thomas Wessel , Karim Lalji , Mark A. Varney
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985 , A61K31/137 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is O-desmethylvenlafaxine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，所述活性剂当一起用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是O-去甲基文拉法辛。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑障碍和认知障碍的方法。

6. 发明申请

US20070253829A1 TRANSPORTATION UNIT FOR A WIND TURBINE ROTOR BLADE 有权
标题翻译：风力涡轮机叶片运输单元
公开(公告)号：US20070253829A1
公开(公告)日：2007-11-01
申请号：US11380770
申请日：2006-04-28
申请人： Thomas Wessel , Dirk-Jan Kootstra
发明人： Thomas Wessel , Dirk-Jan Kootstra
IPC分类号： F04D29/00
CPC分类号： F03D80/00 , F03D13/40 , Y02E10/72
摘要： A transportation system for a wind turbine rotor blade is provided. The transportation system includes a root fixture adapted to receive the root end of the wind turbine rotor blade, and a tip end fixture adapted to receive a tip end of the wind turbine rotor blade. The root fixture and the tip end fixture are provided as separate transportable units.
摘要翻译：提供了一种用于风力涡轮机转子叶片的输送系统。运输系统包括适于接收风力涡轮机转子叶片的根部的根部固定装置，以及适于接收风力涡轮机转子叶片的尖端的末端夹具。根部固定装置和末端装置作为单独的运输装置提供。

7. 发明申请

US20060004224A1 Method of making halophthalic acids and halophthalic anhydrides 有权
公开(公告)号：US20060004224A1
公开(公告)日：2006-01-05
申请号：US11170708
申请日：2005-06-29
申请人： Robert Colborn , David Hall , Peter Koch , Bernd Demuth , Thomas Wessel , KarlErnst Mack , Prashant Tatake , Utpal Vakil , Shyamal Gondkar , John Pace , Kwang Won
发明人： Robert Colborn , David Hall , Peter Koch , Bernd Demuth , Thomas Wessel , KarlErnst Mack , Prashant Tatake , Utpal Vakil , Shyamal Gondkar , John Pace , Kwang Won
IPC分类号： C07C51/265
CPC分类号： C07C51/265 , C07C63/68
摘要： A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition methods for the preparation of halophthalic anhydride, and recovery of high purity acetic acid from an aqueous acetic acid stream comprising HCl, which is generated during the preparation of the halophthalic acid are also disclosed.

8. 发明申请

US20050176680A1 Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression 审中-公开
标题翻译：镇静剂和神经递质调节剂的组合，以及改善睡眠质量和治疗抑郁症的方法
公开(公告)号：US20050176680A1
公开(公告)日：2005-08-11
申请号：US11007795
申请日：2004-12-08
申请人： Karim Lalji , Timothy Barberich , Judy Caron , Thomas Wessel
发明人： Karim Lalji , Timothy Barberich , Judy Caron , Thomas Wessel
IPC分类号： A61K31/137 , A61K31/138 , A61K31/495 , A61K31/4985 , A61K31/724 , A61K45/06
CPC分类号： A61K31/4985 , A61K31/137 , A61K31/138 , A61K31/495 , A61K31/724 , A61K45/06 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., insomnia and/or depression. The first component of the pharmaceutical composition is a GABA receptor modulating compound. The second component of the pharmaceutical composition is a serotonin reuptake inhibitor, a norepinephrine reuptake inhibitor, a 5-HT2A modulator, or dopamine reuptake inhibitor. In certain embodiments, the pharmaceutical composition comprises eszopiclone. In a preferred embodiment, the pharmaceutical composition comprises eszopiclone and fluoxetine. The present invention also relates to a method of treating a sleep abnormality, treating insomnia, treating depression, augmenting antidepressant therapy, eliciting a dose-sparing effect, reducing depression relapse, improving the efficacy of antidepressant therapy or improving the tolerability of antidepressant therapy, comprising co-administering to a patient in need thereof a GABA-receptor-modulating compound; and a SRI, NRI, 5-HT2A modulator or DRI.
摘要翻译：本发明的一个方面涉及含有两种或更多种活性剂的药物组合物，当它们一起被用于治疗，例如失眠和/或抑郁症时。药物组合物的第一组分是调节GABA受体的化合物。药物组合物的第二组分是5-羟色胺再摄取抑制剂，去甲肾上腺素再摄取抑制剂，5-HT 2AA调节剂或多巴胺再摄取抑制剂。在某些实施方案中，药物组合物包含依佐匹克。在优选的实施方案中，药物组合物包含依佐匹克和氟西汀。本发明还涉及一种治疗睡眠异常，治疗失眠，治疗抑郁症，增强抗抑郁药治疗，引发剂量保留作用，减少抑郁症复发，改善抗抑郁治疗疗效或提高抗抑郁治疗耐受性的方法，包括向有需要的患者共同施用GABA受体调节化合物; 和SRI，NRI，5-HT 2A调节剂或DRI。

9. 发明授权

US6103659A Catalyst comprising an amidophosphonium salt for halex reactions 失效
标题翻译：包含用于halex反应的酰胺鏻盐的催化剂
公开(公告)号：US6103659A
公开(公告)日：2000-08-15
申请号：US341986
申请日：1999-07-21
申请人： Sergej Pasenok , Wolfgang Appel , Ralf Pfirmann , Thomas Wessel , Thomas Schach , Hans Schubert
发明人： Sergej Pasenok , Wolfgang Appel , Ralf Pfirmann , Thomas Wessel , Thomas Schach , Hans Schubert
IPC分类号： B01J31/02 , C07B39/00 , C07B61/00 , C07C17/20 , C07C25/02 , C07C45/63 , C07C47/55 , C07C201/12 , C07C205/12 , B01J27/14 , C07D211/72 , C07D239/02 , C07D241/02
CPC分类号： C07C205/12 , B01J31/0202 , B01J31/0204 , B01J31/0239 , B01J31/0268 , C07B39/00 , C07C17/208 , C07C45/63 , B01J2231/40
摘要： Catalyst for halogen-fluorine exchange reactions on aromatics, consisting essentially of a mixture of one or more compounds of the component a) plus at least one compound of the components b), c) and/or d), whereina) is an amidophosphonium salt of the formula (I) ##STR1## where A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6, A.sup.7, A.sup.8 are, independently of one another, identical or different and are each a straight-chain or branched alkyl or alkenyl having from 1 to 12 carbon atoms, cycloalkyl having from 4 to 8 carbon atoms, an aryl having from 6 to 12 carbon atoms, an aralkyl having from 7 to 12 carbon atoms, or A.sup.1 A.sup.2, A.sup.3 A.sup.4, A.sup.5 A.sup.6, A.sup.7 A.sup.8 are, independently of one another, identical or different and are in each case connected to one another either directly or via O or N--A.sup.9 to form a ring having from 3 to 7 ring atoms, A.sup.9 is an alkyl having from 1 to 4 carbon atoms and B.sup..crclbar. is a monovalent acid anion or the equivalent of a polyvalent acid anion,b) a quaternary ammonium salt,c) a quaternary phosphonium salt, andd) a crown ether or a polyether of the formula (IV):R.sup.10 --(O--O.sub.x H.sub.2x).sub.r --OR.sup.11 (IV).
摘要翻译： PCT No.PCT / EP90 / 00332 Sec。 371日期：1999年7月21日 102（e）日期1999年7月21日PCT提交1998年1月22日PCT公布。出版物WO98 / 32532 日期1998年7月30日关于芳族化合物的卤素 - 氟交换反应的催化剂，主要由一种或多种组分a）的化合物与至少一种组分b），c）和/或d）的化合物的混合物组成，其中 a）是式（I）的酰胺鏻盐，其中A1，A2，A3，A4，A5，A6，A7，A8彼此独立地相同或不同，并且各自是直链或支链烷基或烯基具有1至12个碳原子，具有4至8个碳原子的环烷基，具有6至12个碳原子的芳基，具有7至12个碳原子的芳烷基，或者A 1 A 2，A 3 A 4，A 5 A 6，A 7 A 8独立地为彼此相同或不同，并且各自直接或通过O或N-A9彼此连接以形成具有3至7个环原子的环，A 9是具有1至4个碳原子的烷基和B（ - ）是一价酸阴离子或多价酸阴离子当量，b）季铵盐，c）季鏻盐和d）冠醚或式（IV）的聚醚：R 10 - （O-OxH 2 x）r -OR 11（IV）。

10. 发明授权

US5424479A Process for the preparation of aromatic methyl methoxycarboxylates 失效
标题翻译：制备芳族甲基甲氧基羧酸酯的方法
公开(公告)号：US5424479A
公开(公告)日：1995-06-13
申请号：US294449
申请日：1994-08-23
申请人： Rolf Muller , Thomas Wessel
发明人： Rolf Muller , Thomas Wessel
IPC分类号： C07C67/11 , C07B61/00 , C07C65/05 , C07C65/11 , C07C67/31 , C07C69/92 , C07C69/76
CPC分类号： C07C67/31 , C07C65/05 , C07C65/11
摘要： The invention relates to a preparation process for aromatic methyl methoxycarboxylates by reaction of aromatic hydroxycarboxylic acids in the form of a mixture with the methoxycarboxylic acids with dimethyl sulphate in water.
摘要翻译：本发明涉及一种芳族甲基甲氧基羧酸甲酯的制备方法，该方法是将与甲氧基羧酸的混合物形式的芳族羟基羧酸与硫酸二甲酯在水中反应。

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