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1. 发明授权

US09089422B2 Markers for prosthetic heart valves 有权
标题翻译：假体心脏瓣膜的标记
公开(公告)号：US09089422B2
公开(公告)日：2015-07-28
申请号：US12358765
申请日：2009-01-23
申请人： Timothy R. Ryan , Charles Tabor
发明人： Timothy R. Ryan , Charles Tabor
IPC分类号： A61F2/82 , A61F2/24 , A61F2/95
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2002/9505 , A61F2002/9511 , A61F2250/0098
摘要： A replacement prosthetic heart valve for engagement with a structure of an original prosthetic heart valve that includes at least one visually detectable marker. The replacement heart valve includes a stent structure having a generally tubular body portion and at least one visually detectable marker on a portion of the stent structure, and at least two leaflets attached within the interior area of the tubular body portion of the stent structure. At least one visually detectable marker of the stent structure is alignable with at least one visually detectable marker of the original prosthetic heart valve.
摘要翻译：一种替换假体心脏瓣膜，用于与包括至少一个视觉上可检测的标记物的原始假体心脏瓣膜的结构接合。置换心脏瓣膜包括支架结构，该支架结构具有大致管状主体部分和在支架结构的一部分上的至少一个视觉上可检测的标记，以及附接在支架结构的管状主体部分的内部区域内的至少两个小叶。支架结构的至少一个视觉上可检测的标记可与原始假体心脏瓣膜的至少一个视觉上可检测的标记物对准。

2. 发明授权

US08454684B2 Heart valve holder for use in valve implantation procedures 有权
标题翻译：用于阀门植入程序的心脏瓣膜支架
公开(公告)号：US08454684B2
公开(公告)日：2013-06-04
申请号：US11888915
申请日：2007-08-02
申请人： Cathleen A. Bergin , Timothy R. Ryan
发明人： Cathleen A. Bergin , Timothy R. Ryan
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/243
摘要： A valve holder for a prosthetic valve having a stent comprising a stent base and multiple commissure posts projecting from the stent base, the valve holder including a connector hub, a plurality of legs connected to the connector hub, each leg having an elongate portion and a commissure post engaging plate, a sliding member slideably connected to each leg of the plurality of legs and positioned between the connector hub and the commissure post engaging plates of the plurality of legs and slideably positionable at a first position relative to the connector hub with the commissure post engaging plates in an uncompressed configuration and a second position relative to the connector hub with the commissure post engaging plates in a compressed configuration, and a handle extending from the connector hub.
摘要翻译：一种用于人造瓣膜的瓣膜支架，其具有支架，所述支架包括支架基座和从所述支架基座突出的多个连合柱，所述阀保持器包括连接器毂，连接到所述连接器毂的多个支腿，每个支腿具有细长部分和连接柱接合板，滑动构件，其滑动地连接到所述多个腿的每个腿部并且定位在所述连接器毂和所述多个腿的连接柱接合板之间，并且可相对于所述连接器毂在第一位置处具有所述连接部后接合板处于未压缩构型和相对于连接器毂的第二位置，其中接合柱接合板处于压缩构型，以及从连接器毂延伸的手柄。

3. 发明申请

US20130072786A1 IMAGE-GUIDED HEART VALVE PLACEMENT OR REPAIR 审中-公开
标题翻译：图像导向心脏放置或修复
公开(公告)号：US20130072786A1
公开(公告)日：2013-03-21
申请号：US13585622
申请日：2012-08-14
申请人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
发明人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
IPC分类号： A61B6/12
CPC分类号： A61F2/2496 , A61B5/0044 , A61B5/1076 , A61B5/6853 , A61B8/445 , A61B18/1442 , A61B34/20 , A61B90/37 , A61B90/39 , A61B2017/00243 , A61B2018/00291 , A61B2018/00351 , A61B2018/00577 , A61B2034/2051 , A61B2034/2063 , A61B2090/378 , A61B2090/397 , A61F2/2433 , A61F2210/009 , A61F2250/0096 , A61N7/02
摘要： A device and method for valve replacement or valve repair is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding a valve replacement delivery member or a valve repair delivery member within the patient while tracking the position of the delivery member in the patient, positioning the valve replacement member or valve repair member in a desired position to replace a valve or repair valve and removing the delivery member from the patient.
摘要翻译：公开了一种用于瓣膜置换或瓣膜修复的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪位置的同时引导患者内的瓣膜置换输送构件或瓣膜修复递送构件的患者中的输送构件，将瓣膜置换构件或瓣膜修复构件定位在期望位置以更换瓣膜或修复瓣膜并从患者移除输送构件。

4. 发明授权

US08246677B2 Delivery systems and methods of implantation for replacement prosthetic heart valves 有权
标题翻译：更换假体心脏瓣膜的输送系统和植入方法
公开(公告)号：US08246677B2
公开(公告)日：2012-08-21
申请号：US12070382
申请日：2008-02-15
申请人： Timothy R. Ryan
发明人： Timothy R. Ryan
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2409 , A61F2/2433 , A61F2/2436 , A61F2/958 , A61F2210/0014 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , A61F2230/0069 , A61F2310/00023
摘要： A method of delivering a replacement prosthetic valve to a previously implanted prosthetic valve including the steps of compressing a replacement prosthetic valve having an expandable stent within a sheath of a delivery system, wherein the delivery system comprises a proximal end, a distal end, and a centering structure positioned between the proximal and distal ends, advancing the delivery system and compressed replacement prosthetic valve into a vessel of a patient until the distal end of the delivery system is positioned adjacent to a second side of a previously implanted prosthetic valve, deploying the centering structure to radially reposition the distal end of the delivery system, further advancing the delivery system toward the previously implanted prosthetic valve, and deploying the replacement prosthetic valve.
摘要翻译：将置换的人工瓣膜递送到先前植入的假体瓣膜的方法，包括以下步骤：在输送系统的护套内压缩具有可扩张支架的置换假体瓣膜，其中所述输送系统包括近端，远端和定心结构定位在近端和远端之间，使输送系统和压缩的替代假体瓣进入患者血管，直到输送系统的远端邻近先前植入的假性瓣膜的第二侧定位，展开定心结构以径向地重新定位输送系统的远端，进一步使输送系统朝向先前植入的假体瓣膜前进，并展开置换的人造瓣膜。

5. 发明申请

US20120022643A1 Set of Annuloplasty Devices with Varying Anterior-Posterior Ratios and Related Methods 有权
标题翻译：一套具有不同前后比的瓣膜成形术装置及相关方法
公开(公告)号：US20120022643A1
公开(公告)日：2012-01-26
申请号：US13206355
申请日：2011-08-09
申请人： Hugo Vanermen , Timothy R. Ryan , Michael A. Gloss , Stephen Kuehn
发明人： Hugo Vanermen , Timothy R. Ryan , Michael A. Gloss , Stephen Kuehn
IPC分类号： A61F2/24
CPC分类号： A61B5/1076 , A61F2/2448 , A61F2/2496
摘要： Described is a set of at least two annuloplasty devices having a particular size that corresponds to an inter-trigonal or inter-commissural distance of a heart valve annulus, wherein the at least two annuloplasty devices have different anterior-posterior ratios. Also, described is a kit for annuloplasty repair of a heart valve annulus including a plurality of annuloplasty devices each comprising one of a plurality of different sizes, wherein the different sizes each correspond to a different inter-trigonal or inter-commissural distance of a heart valve annulus, and for each of the plurality of different sizes there are at least two devices each having the same size but having different anterior-posterior ratios. Additionally, a method of choosing an annuloplasty device for implantation in a valve annulus is described.
摘要翻译：描述了一组具有对应于心脏瓣膜环的三角形或相互间距离的特定尺寸的瓣膜成形术装置，其中至少两个瓣环成形术装置具有不同的前后比。此外，描述了一种用于心瓣膜环的瓣膜成形术修复的套件，其包括多个瓣膜成形术装置，每个瓣膜成形术装置各自包括多个不同尺寸的瓣膜成形术装置，其中不同的尺寸各自对应于心脏的不同的三角形或相互间的距离阀环，并且对于多个不同尺寸的每一个，存在至少两个具有相同尺寸但具有不同前后比的装置。另外，描述了一种选择用于植入瓣膜环的瓣膜成形术装置的方法。

6. 发明授权

US07993395B2 Set of annuloplasty devices with varying anterior-posterior ratios and related methods 有权
标题翻译：具有前后比变化和相关方法的瓣环成形装置
公开(公告)号：US07993395B2
公开(公告)日：2011-08-09
申请号：US12357551
申请日：2009-01-22
申请人： Hugo Vanermen , Timothy R. Ryan , Michael A. Gloss , Stephen Kuehn
发明人： Hugo Vanermen , Timothy R. Ryan , Michael A. Gloss , Stephen Kuehn
IPC分类号： A61F2/24
CPC分类号： A61B5/1076 , A61F2/2448 , A61F2/2496
摘要： Described is a set of at least two annuloplasty devices having a particular size that corresponds to an inter-trigonal or inter-commissural distance of a heart valve annulus, wherein the at least two annuloplasty devices have different anterior-posterior ratios. Also, described is a kit for annuloplasty repair of a heart valve annulus including a plurality of annuloplasty devices each comprising one of a plurality of different sizes, wherein the different sizes each correspond to a different inter-trigonal or inter-commissural distance of a heart valve annulus, and for each of the plurality of different sizes there are at least two devices each having the same size but having different anterior-posterior ratios. Additionally, a method of choosing an annuloplasty device for implantation in a valve annulus is described.
摘要翻译：描述了一组具有对应于心脏瓣膜环的三角形或相互间距离的特定尺寸的瓣膜成形术装置，其中至少两个瓣环成形术装置具有不同的前后比。此外，描述了一种用于心瓣膜环的瓣膜成形术修复的套件，其包括多个瓣膜成形术装置，每个瓣膜成形术装置各自包括多个不同尺寸的瓣膜成形术装置，其中不同的尺寸各自对应于心脏的不同的三角形或相互间的距离阀环，并且对于多个不同尺寸的每一个，存在至少两个具有相同尺寸但具有不同前后比的装置。另外，描述了一种选择用于植入瓣膜环的瓣膜成形术装置的方法。

7. 发明授权

US07972378B2 Stents for prosthetic heart valves 有权
标题翻译：假体心脏瓣膜支架
公开(公告)号：US07972378B2
公开(公告)日：2011-07-05
申请号：US12321760
申请日：2009-01-23
申请人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
发明人： Charles Tabor , Carol E. Eberhardt , Timothy G. Laske , Timothy R. Ryan , Joseph C. Morrow , Tammy Y. Tam , Brian A. Glynn , Anne L. Brody Rubin , J. Michael Tuchek
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/013 , A61F2/07 , A61F2/2433 , A61F2/2436 , A61F2/89 , A61F2/90 , A61F2002/016 , A61F2220/0058 , A61F2220/0075 , A61F2220/0091 , A61F2230/0006 , A61F2230/0054 , A61F2230/008 , A61F2250/0018 , A61F2250/003 , A61F2250/0039
摘要： A stented valve including a stent structure including a generally tubular body portion that has a first end and a second end, wherein an area adjacent the first end has a first stiffness, an area adjacent the second end has a second stiffness, and a central region between the areas at the first and second ends has a third stiffness that is less than the stiffness adjacent the first and second ends, wherein the stent structure can be reconfigured in its central area to match a curved patient anatomical region. The stented valve further includes a valve structure attached within the generally tubular portion.
摘要翻译：一种支架式阀，包括支架结构，其包括具有第一端和第二端的大体管状体部，其中与第一端相邻的区域具有第一刚度，与第二端相邻的区域具有第二刚度，以及中心区域在第一和第二端之间的区域之间具有小于邻近第一和第二端的刚度的第三刚度，其中支架结构可以在其中心区域重新配置以匹配弯曲的患者解剖区域。支架瓣膜还包括附接在大致管状部分内的阀结构。

8. 发明申请

US20110022169A1 Annuloplasty Device for Tricuspid Valve Repair 有权
标题翻译：用于三尖瓣修复的瓣膜成形术装置
公开(公告)号：US20110022169A1
公开(公告)日：2011-01-27
申请号：US12847655
申请日：2010-07-30
申请人： Timothy R. Ryan , Alexander J. Hill , Jason L. Quill , Jerald L. Redmond , Stephen Kuehn , Eugene Grossi , Aubrey Galloway , Hugo Vanermen , Rudiger Lange
发明人： Timothy R. Ryan , Alexander J. Hill , Jason L. Quill , Jerald L. Redmond , Stephen Kuehn , Eugene Grossi , Aubrey Galloway , Hugo Vanermen , Rudiger Lange
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61B17/06066 , A61F2/2448 , A61F2230/0013
摘要： Annuloplasty device for implantation adjacent an annulus of a tricuspid valve, the annulus comprising anterior, posterior and septal aspects adjacent anterior, posterior and septal leaflets, respectively, of the tricuspid valve, the device comprising: a ring body comprising: an anterior portion, a posterior portion and a septal portion shaped to conform to, and for implantation adjacent, the anterior, posterior and septal aspects of the annulus, respectively; and first and second end portions that are more flexible than a remainder of the ring body to provide a gradual transition from the remainder of the ring body to tissue of the tricuspid valve annulus; wherein the ring body is curvilinear, with substantially no flat portions, and forming a shape. Related devices, kits and sizer devices.
摘要翻译：用于植入邻近三尖瓣环的瓣膜成形术装置，所述瓣环分别包括邻近所述三尖瓣的前，后和间隔小叶的前部，后部和隔膜方面，所述装置包括：环体，包括：前部，后部和间隔部分，其分别成形为分别与环的前部，后部和间隔方面相邻并用于邻近; 以及第一和第二端部，其比环体的其余部分更柔性，以提供从环体的其余部分到三尖瓣瓣环的组织的逐渐过渡; 其中所述环体是曲线形的，基本上没有平坦部分，并且形成形状。相关设备，套件和分级设备。

9. 发明申请

US20100198346A1 Method for Guiding a Medical Device 有权
标题翻译：引导医疗器械的方法
公开(公告)号：US20100198346A1
公开(公告)日：2010-08-05
申请号：US12570888
申请日：2009-09-30
申请人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
发明人： James R. Keogh , Timothy R. Ryan , Carol E. Eberhardt , Mark T. Stewart , James R. Skarda , Timothy G. Laske , Alexander J. Hill , Jack D. Lemmon , David E. Francischelli
IPC分类号： A61F2/24
CPC分类号： A61F2/2496 , A61B5/0044 , A61B5/1076 , A61B5/6853 , A61B8/445 , A61B18/1442 , A61B34/20 , A61B90/37 , A61B90/39 , A61B2017/00243 , A61B2018/00291 , A61B2018/00351 , A61B2018/00577 , A61B2034/2051 , A61B2034/2063 , A61B2090/378 , A61B2090/397 , A61F2/2433 , A61F2210/009 , A61F2250/0096 , A61N7/02
摘要： A device and method for valve replacement or valve repair is disclosed comprising the steps of acquiring an anatomical image of a patient, correlating the image to the patient, guiding a valve replacement delivery member or a valve repair delivery member within the patient while tracking the position of the delivery member in the patient, positioning the valve replacement member or valve repair member in a desired position to place a valve or repair valve and removing the delivery member from the patient. In one aspect of the invention, a delivery system is provided for percutaneous delivery of a heart valve to a predetermined position in the heart of a patient, where the delivery system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a delivery system is provided for percutaneous repair of a heart valve in the heart of a patient, where the repair system itself includes features that allow it to be accurately positioned in the heart. In another aspect of the invention, a method and device are provided that involve imaging a native root using an interoperative technique, then introducing a device that is easily visualized in a chosen imaging modality.
摘要翻译：公开了一种用于瓣膜置换或瓣膜修复的装置和方法，包括以下步骤：获取患者的解剖图像，将图像与患者相关联，在跟踪位置的同时引导患者内的瓣膜置换输送构件或瓣膜修复递送构件的患者中的输送构件，将瓣膜置换构件或瓣膜修复构件定位在期望的位置以放置瓣膜或修复瓣膜并从患者移除输送构件。在本发明的一个方面，提供一种用于将心脏瓣膜经皮递送到患者心脏中的预定位置的递送系统，其中递送系统本身包括允许其准确地定位在心脏中的特征。在本发明的另一方面，提供一种用于经皮修复患者心脏中的心脏瓣膜的递送系统，其中所述修复系统本身包括允许其准确地定位在心脏中的特征。在本发明的另一方面，提供了一种方法和装置，其涉及使用手术技术对本地根进行成像，然后引入在选择的成像模式中容易可视化的装置。

10. 发明申请

US20100179641A1 MULTI-LAYERED STENTS AND METHODS OF IMPLANTING 审中-公开
标题翻译：多层手术和植入方法
公开(公告)号：US20100179641A1
公开(公告)日：2010-07-15
申请号：US12732329
申请日：2010-03-26
申请人： Timothy R. Ryan , Timothy G. Laske , Philipp Bonhoeffer , Silvia Schievano
发明人： Timothy R. Ryan , Timothy G. Laske , Philipp Bonhoeffer , Silvia Schievano
IPC分类号： A61F2/82
CPC分类号： A61F2/852 , A61F2/2418 , A61F2/2475 , A61F2/90 , A61F2/915 , A61F2/958 , A61F2002/826 , A61F2002/828 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/0025 , A61F2220/0058 , A61F2230/0054 , A61F2240/001 , A61F2250/0015 , A61F2250/0018 , A61F2250/006 , Y10T29/49
摘要： A method of percutaneously delivering a multi-layered stent assembly to a desired implantation location of a patient including the steps of radially compressing a multi-layered stent assembly to a compressed size for implantation in a patient, the multi-layered stent assembly including a first stent, a second stent coaxially positioned within at least a portion of a length of the first stent, and a valve, wherein the first stent comprises at least one different material property than the second stent. The method further includes delivering the multi-layered stent assembly to the desired implantation location of the patient using a delivery system and substantially simultaneously expanding the first stent and the second stent of the multi-layered stent assembly at the desired implantation location to a radially expanded size that is larger than the compressed size.
摘要翻译：一种将多层支架组件经皮递送到患者期望的植入位置的方法，包括将多层支架组件径向压缩至压缩尺寸以便植入患者的步骤，所述多层支架组件包括第一支架，同轴地定位在第一支架的长度的至少一部分中的第二支架和阀，其中第一支架包括与第二支架相比的至少一种不同的材料特性。该方法还包括使用递送系统将多层支架组件递送到患者的期望植入位置，并且将所述多层支架组件的第一支架和第二支架基本上同时地扩展到期望的植入位置，以径向扩张尺寸大于压缩尺寸。

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