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1. 发明授权

US08182845B2 Ghrelin production promoter 有权
标题翻译：生长素释放肽生产促进剂
公开(公告)号：US08182845B2
公开(公告)日：2012-05-22
申请号：US12876476
申请日：2010-09-07
申请人： Masahiro Asaka , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
发明人： Masahiro Asaka , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
IPC分类号： A61K61/00 , A61K36/284 , A61K36/25 , A61K36/8888 , A61K36/076 , A61K36/484 , A61K36/725 , A61K36/752 , A61K36/258 , A61K36/48 , A61K36/906
CPC分类号： A61K36/28 , A61K36/07 , A61K36/23 , A61K36/48 , A61K36/75 , A61K2300/00
摘要： The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient.
摘要翻译：其目的是找到能够促进生长激素分泌作用等生理活性促进生长素释放肽的物质或组合物，提供含有作为活性成分的药物。药物是含有Rikkunshi的生长素释放肽生产促进剂作为活性成分。

2. 发明授权

US08741358B2 Ghrelin production promoter 有权
标题翻译：生长素释放肽生产促进剂
公开(公告)号：US08741358B2
公开(公告)日：2014-06-03
申请号：US13345826
申请日：2012-01-09
申请人： Masahiro Asaka , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
发明人： Masahiro Asaka , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
IPC分类号： A61K36/00 , A61K36/284 , A61K36/25 , A61K36/8888 , A61K36/076 , A61K36/484 , A61K36/725 , A61K36/752 , A61K36/258 , A61K36/48 , A61K36/906
CPC分类号： A61K36/28 , A61K36/07 , A61K36/23 , A61K36/48 , A61K36/75 , A61K2300/00
摘要： The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient.
摘要翻译：其目的是找到能够促进生长激素分泌作用等生理活性促进生长素释放肽的物质或组合物，提供含有作为活性成分的药物。药物是含有Rikkunshi的生长素释放肽生产促进剂作为活性成分。

3. 发明申请

US20100330210A1 GHRELIN PRODUCTION PROMOTER 有权
标题翻译： GHRELIN生产促销
公开(公告)号：US20100330210A1
公开(公告)日：2010-12-30
申请号：US12876476
申请日：2010-09-07
申请人： Masahiro ASAKA , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
发明人： Masahiro ASAKA , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
IPC分类号： A61K36/258 , A61P25/28 , A61P9/10 , A61P9/00 , A61P11/00 , A61P5/00
CPC分类号： A61K36/28 , A61K36/07 , A61K36/23 , A61K36/48 , A61K36/75 , A61K2300/00
摘要： The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient.
摘要翻译：其目的是找到能够促进生长激素分泌作用等生理活性促进生长素释放肽的物质或组合物，提供含有作为活性成分的药物。药物是含有Rikkunshi的生长素释放肽生产促进剂作为活性成分。

4. 发明申请

US20050187264A1 Phosphodiesterase iv inhibitor containing pyridylacrylamide derivative 审中-公开
标题翻译：含有吡啶基丙烯酰胺衍生物的磷酸二酯酶iv抑制剂
公开(公告)号：US20050187264A1
公开(公告)日：2005-08-25
申请号：US10510053
申请日：2003-04-02
申请人： Tomohisa Hattori , Toshinobu Sasaki , Yoshihiro Hasegawa , Tatsuhiro Obata
发明人： Tomohisa Hattori , Toshinobu Sasaki , Yoshihiro Hasegawa , Tatsuhiro Obata
IPC分类号： A61K31/4406 , A61P1/04 , A61P11/06 , A61P11/08 , A61P17/00 , A61P17/04 , A61P19/02 , A61P25/18 , A61P25/24 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P37/08 , A61P43/00 , C07D213/56 , C07D213/57 , C07D213/59 , C07D213/61 , C07D213/65 , C07D213/80 , C07D405/12 , A61K31/44
CPC分类号： C07D213/80 , C07D213/56 , C07D213/57 , C07D213/59 , C07D213/61 , C07D213/65 , C07D405/12
摘要： This invention relates to a phosphodiesterase IV inhibitor containing as an active ingredient a pyridylacrylamide derivative represented by the following formula (I): (wherein Ar1 represents substituted or unsubstituted pyridyl; Ar2 represents phenyl substituted by alkoxy, etc.; R1 represents hydrogen, alkyl, or aryl; R2 represents hydrogen, alkyl, cyano, or alkoxycarbonyl; R3 represents hydrogen or optionally substituted alkyl; X represents oxygen or sulfur; A and B are the same or different and each independently represents hydrogen, hydroxyl, alkoxy, or alkylthio, or A and B together represent oxo, thioxo, etc., or A may be hydroxyl and B may be 1-alkylimidazol-2-yl; and n is an integer from 1 to 3) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及含有下式（I）表示的吡啶基丙烯酰胺衍生物作为活性成分的磷酸二酯酶IV抑制剂：其中Ar 1表示取代或未取代的吡啶基; Ar 2 O 表示被烷氧基取代的苯基等; R 1表示氢，烷基或芳基; R 2表示氢，烷基，氰基或烷氧基羰基; R 1， 3表示氢或任选取代的烷基; X表示氧或硫; A和B相同或不同，各自独立地表示氢，羟基，烷氧基或烷硫基，或A和B一起代表氧代，硫代等或A可以是羟基，B可以是1-烷基咪唑-2-基; n是1至3的整数）或其药学上可接受的盐。

5. 发明授权

US06413995B1 Cinnamamide derivatives and drug compositions containing the same 失效
标题翻译：肉桂酰胺衍生物和含有它们的药物组合物
公开(公告)号：US06413995B1
公开(公告)日：2002-07-02
申请号：US09856419
申请日：2001-05-21
申请人： Yoshihiro Hasegawa , Shouichirou Shindou , Tomohisa Hattori , Tatsuhiro Obata , Fumiko Horiuchi , Hiroyuki Hayakawa , Hiroaki Kumazawa
发明人： Yoshihiro Hasegawa , Shouichirou Shindou , Tomohisa Hattori , Tatsuhiro Obata , Fumiko Horiuchi , Hiroyuki Hayakawa , Hiroaki Kumazawa
IPC分类号： C07D21340
CPC分类号： C07D213/40
摘要： The invention relates to cinnamamide derivatives having the following formula wherein R1 represents a hydroxyl group, a C1-6-alkoxy group, an arylalkoxy group or a substituted or unsubstituted amino group; R2 and R3 are same or different, each of which represents a hydrogen atom, a halogen atom or a C1-4-alkyl group; R4 represents a hydrogen atom or a C1-6-alkyl group; R5 represents a hydrogen atom, a C1-6-alkyl group or an aryl group; R6 represents a hydrogen atom, a C1-6-alkyl group, a cyano group or a C1-6-alkoxy-carbonyl group; W represents an oxygen atom, a sulfur atom, an imino group, a methylene group, a hydroxymethylene group or a carbonyl group; X and Y are same or different, each of which represents an oxygen atom or a sulfur atom; m represents an integer of 0 to 2; n represents an integer of 1 to 3; and when m is 0, a group: —C(R2)(R3)—W— may represent a vinylene group; or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the above compound, in particular, an immunomodulatory agent and a prophylactic or therapeutic agent for nephrotic syndrome, circulatory disorders or respiratory diseases.
摘要翻译：本发明涉及具有下列化学式的肉桂酰胺衍生物：R1表示羟基，C1-6-烷氧基，芳基烷氧基或取代或未取代的氨基; R2和R3相同或不同，各自表示氢原子，卤素原子或C 1-4 - 烷基; R 4表示氢原子或C 1-6 - 烷基; R 5表示氢原子，C 1-6 - 烷基或芳基; R 6表示氢原子， C 1-6 - 烷基，氰基或C 1-6 - 烷氧基 - 羰基; W表示氧原子，硫原子，亚氨基，亚甲基，羟基亚甲基或羰基; X和 Y相同或不同，各自表示氧原子或硫原子; m表示0〜2的整数，n表示1〜3的整数，并且当m为0时，基团-C（R 2）（R 3）-W-可以表示亚乙烯基;或其药学上可接受的盐; 以及含有上述化合物，特别是免疫调节剂，肾病综合征，循环障碍或呼吸系统疾病的预防或治疗剂的药物组合物。

6. 发明申请

US20120107426A1 GHRELIN PRODUCTION PROMOTER 有权
标题翻译： GHRELIN生产促销
公开(公告)号：US20120107426A1
公开(公告)日：2012-05-03
申请号：US13345826
申请日：2012-01-09
申请人： Masahiro ASAKA , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
发明人： Masahiro ASAKA , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
IPC分类号： A61K36/258 , A61P5/00
CPC分类号： A61K36/28 , A61K36/07 , A61K36/23 , A61K36/48 , A61K36/75 , A61K2300/00
摘要： The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient.
摘要翻译：其目的是找到能够促进生长激素分泌作用等生理活性促进生长素释放肽的物质或组合物，提供含有作为活性成分的药物。药物是含有Rikkunshi的生长素释放肽生产促进剂作为活性成分。

7. 发明申请

US20090053334A1 GHRELIN PRODUCTION PROMOTER 审中-公开
标题翻译： GHRELIN生产促销
公开(公告)号：US20090053334A1
公开(公告)日：2009-02-26
申请号：US12162864
申请日：2006-12-18
申请人： Masahiro Asaka , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
发明人： Masahiro Asaka , Hiroshi Takeda , Ryuuji Takasaki , Tomohisa Hattori
IPC分类号： A61K36/258 , A61P25/28 , A61P9/10 , A61P11/00
CPC分类号： A61K36/28 , A61K36/07 , A61K36/23 , A61K36/48 , A61K36/75 , A61K2300/00
摘要： The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient.
摘要翻译：其目的是找到能够促进生长激素分泌作用等生理活性促进生长素释放肽的物质或组合物，提供含有作为活性成分的药物。药物是含有Rikkunshi的生长素释放肽生产促进剂作为活性成分。

8. 发明授权

US06313153B1 Compositions and methods for treating nephritis and inhibiting TGF -&bgr; related conditions using pyridylacrylamide derivatives 失效
标题翻译：使用吡啶基丙烯酰胺衍生物治疗肾炎和抑制TGF-β相关病症的组合物和方法
公开(公告)号：US06313153B1
公开(公告)日：2001-11-06
申请号：US09463511
申请日：2000-01-21
申请人： Yoshihiro Hasegawa , Shouichirou Shindou , Tomohisa Hattori , Yousuke Yamazaki , Tatsuhiro Obata , Fumiko Horiuchi , Hiroyuki Hayakawa , Hiroaki Kumazawa
发明人： Yoshihiro Hasegawa , Shouichirou Shindou , Tomohisa Hattori , Yousuke Yamazaki , Tatsuhiro Obata , Fumiko Horiuchi , Hiroyuki Hayakawa , Hiroaki Kumazawa
IPC分类号： C07D21342
CPC分类号： C07D213/56
摘要： The present invention relates to an agent for treating nephritis and a TGF-&bgr; inhibiting agent comprising as an effective ingredient a pyridylacrylamide derivative represented by the following formula (I): wherein Ar1 is a substituted or unsubstituted pyridyl group, Ar2 is a substituted or unsubstituted phenyl group, R1 is a hydrogen atom, an alkyl group or an aryl group, R2 is a hydrogen atom, an alkyl group, a cyano group or an alkoxycarbonyl group, R3 is a hydrogen atom or an optionally substituted alkyl group, X is an oxygen or sulfur atom, A and B are same or different and each represent a hydrogen atom, a hydroxyl group, an alkoxy group or an alkylthio group, or A and B together form an oxo or thioxo group, or a group represented by the formula: ═N—Y in which Y is a dialkylamino, hydroxyl, aralkyloxy or alkoxy group, or a group represented by the formula: —Z1—M—Z2— which Z1 and Z2 are same or different and each represent an oxygen or sulfur atom or an imino group optionally substituted by an alkyl group, and M is an alkylene group or a 1,2-phenylene group, or A is a hydroxyl group and B is a 1-alkylimidazol-2-yl group, and n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof; as well as the pyridylacrylamide derivatives.
摘要翻译：本发明涉及治疗肾炎的药剂和TGF-β抑制剂，其包含作为有效成分的下式（I）表示的吡啶基丙烯酰胺衍生物：其中Ar1为取代或未取代的吡啶基，Ar2为取代或未取代的苯基，R 1为氢原子，烷基或芳基，R 2为氢原子，烷基，氰基或烷氧基羰基，R 3为氢原子或任选取代的烷基，X为氧或硫原子，A和B相同或不同，各自表示氢原子，羟基，烷氧基或烷硫基，或A和B一起形成氧代或硫代基，或由式：= NY，其中Y是二烷基氨基，羟基，芳烷氧基或烷氧基，或由式-Z1-M-Z2-表示的基团，其中Z1和Z2相同或不同，各自表示氧或硫原子或亚胺基可选择地由烷基取代，M为亚烷基或1,2-亚苯基，或A为羟基，B为1-烷基咪唑-2-基，n为1〜3的整数，或其药学上可接受的盐; 以及吡啶基丙烯酰胺衍生物。

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