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1. 发明授权

US08165369B2 System and method for robust segmentation of pulmonary nodules of various densities 有权
标题翻译：用于各种密度的肺结节的鲁棒分割的系统和方法
公开(公告)号：US08165369B2
公开(公告)日：2012-04-24
申请号：US12243387
申请日：2008-10-01
申请人： Toshiro Kubota , Anna Jerebko , Marcos Salganicoff
发明人： Toshiro Kubota , Anna Jerebko , Marcos Salganicoff
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/187 , G06T2207/30064
摘要： A method for differentiating pulmonary nodules in digitized medical images includes identifying an object of interest from a digital image of the lungs, computing a first distance map of each point of the object of interest, determining a seed point from the first distance map, starting from the seed point, growing a first region by adding successive adjacent layers of points until a background point is reached, and partitioning the first region into a nodule region and a non-nodule region.
摘要翻译：用于区分数字化医学图像中的肺结节的方法包括从肺的数字图像识别感兴趣对象，计算感兴趣对象的每个点的第一距离图，从第一距离图确定种子点，从种子点，通过添加连续的相邻层点直到达到背景点来生长第一区域，并将第一区域划分成结节区域和非结节区域。

2. 发明授权

US07711172B2 Automatic nodule measurements 有权
标题翻译：自动结节测量
公开(公告)号：US07711172B2
公开(公告)日：2010-05-04
申请号：US11970899
申请日：2008-01-08
申请人： Toshiro Kubota
发明人： Toshiro Kubota
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/342 , G06K2209/05 , G06T7/11 , G06T7/194 , G06T7/62 , G06T2207/10081 , G06T2207/20101 , G06T2207/30064
摘要： A method for automatically estimating a measure of a nodule includes providing sliced image volume data comprising at least one marked position of the nodule, extracting a sub-volume from the sliced image volume data that includes the marked position, performing a figure-ground separation to determine a solid foreground of the sub-volume and a non-solid foreground of the sub-volume, determining a seed point corresponding to the nodule from each of the solid foreground and the non-solid foreground, selecting one of the seed point of the solid foreground or the seed point of the non-solid foreground, determining whether the selected seed point is solitary or non-solitary and performing region growing for non-solitary selected seed point, determining a segmentation of the selected seed point, estimating the measure of the nodule corresponding to the segmentation, and outputting the segmentation and an estimate of the measure of the nodule.
摘要翻译：用于自动估计结节的测量的方法包括提供包括结节的至少一个标记位置的切片图像体积数据，从包括标记位置的切片图像体积数据中提取子体积，执行图形分离确定子体积的固体前景和子体积的非固体前景，从固体前景和非固体前景中的每一个确定与结节相对应的种子点，选择一个种子点确定非固体前景的固定前景或种子点，确定选择的种子点是单独的还是非孤立的，并且对于非孤立选择的种子点执行区域生长，确定所选种子点的分割，估计所选种子点的度量所述结节对应于所述分割，并且输出所述分割和所述结节的度量的估计。

3. 发明授权

US07590273B2 Estimation of solitary pulmonary nodule diameters with a hybrid segmentation approach 有权
标题翻译：用混合分割方法估计孤立性肺结节直径
公开(公告)号：US07590273B2
公开(公告)日：2009-09-15
申请号：US11398099
申请日：2006-04-04
申请人： Toshiro Kubota , Kazunori Okada
发明人： Toshiro Kubota , Kazunori Okada
IPC分类号： G06K9/00
CPC分类号： G06K9/44 , G06K2209/053 , G06T7/0012 , G06T7/12 , G06T7/149 , G06T7/62 , G06T2207/10081 , G06T2207/20116 , G06T2207/30064 , Y10S378/901
摘要： A method for estimating a diameter of an object of interest, includes extracting a sub-volume of voxels around a marker identifying a location of the object of interest, and determining a segmentation result identifying an edge of the object of interest by a reactive-diffusion method. The method further includes performing a boundary check on the segmentation result to determine whether the object of interest is solitary, estimating a diameter of the object of interest from the segmentation result upon determining the object of interest to be solitary, and extracting the object of interest by performing ellipsoid fit on the sub-volume and estimating a diameter of the object of interest upon determining the object of interest to be non-solitary.
摘要翻译：一种用于估计感兴趣对象的直径的方法，包括提取识别感兴趣对象的位置的标记周围的体素的子体积，以及通过反应扩散来确定识别感兴趣对象的边缘的分割结果方法。所述方法还包括对所述分割结果执行边界检查以确定所述感兴趣对象是否是孤立的，在确定感兴趣的对象是单独的时，从所述分割结果估计所述对象的直径，以及提取所述感兴趣的对象通过在子体积上执行椭圆体拟合并且在确定感兴趣的对象是非孤立性时估计感兴趣对象的直径。

4. 发明申请

US20080137970A1 Automatic Nodule Measurements 有权
标题翻译：自动结节测量
公开(公告)号：US20080137970A1
公开(公告)日：2008-06-12
申请号：US11970899
申请日：2008-01-08
申请人： Toshiro Kubota
发明人： Toshiro Kubota
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/342 , G06K2209/05 , G06T7/11 , G06T7/194 , G06T7/62 , G06T2207/10081 , G06T2207/20101 , G06T2207/30064
摘要： A method for automatically estimating a measure of a nodule includes providing sliced image volume data comprising at least one marked position of the nodule, extracting a sub-volume from the sliced image volume data that includes the marked position, performing a figure-ground separation to determine a solid foreground of the sub-volume and a non-solid foreground of the sub-volume, determining a seed point corresponding to the nodule from each of the solid foreground and the non-solid foreground, selecting one of the seed point of the solid foreground or the seed point of the non-solid foreground, determining whether the selected seed point is solitary or non-solitary and performing region growing for non-solitary selected seed point, determining a segmentation of the selected seed point, estimating the measure of the nodule corresponding to the segmentation, and outputting the segmentation and an estimate of the measure of the nodule.
摘要翻译：用于自动估计结节的测量的方法包括提供包括结节的至少一个标记位置的切片图像体积数据，从包括标记位置的切片图像体积数据中提取子体积，执行图形分离确定子体积的固体前景和子体积的非固体前景，从固体前景和非固体前景中的每一个确定与结节相对应的种子点，选择一个种子点确定非固体前景的固定前景或种子点，确定选择的种子点是单独的还是非孤立的，并且对于非孤立选择的种子点执行区域生长，确定所选种子点的分割，估计所选种子点的度量所述结节对应于所述分割，并且输出所述分割和所述结节的度量的估计。

5. 发明申请

US20070081712A1 System and method for whole body landmark detection, segmentation and change quantification in digital images 有权
标题翻译：数字图像全身地标检测，分割和变化量化的系统和方法
公开(公告)号：US20070081712A1
公开(公告)日：2007-04-12
申请号：US11542477
申请日：2006-10-03
申请人： Xiaolei Huang , Xiang Zhou , Anna Jerebko , Arun Krishnan , Haiying Guan , Toshiro Kubota , Vaclav Potesil
发明人： Xiaolei Huang , Xiang Zhou , Anna Jerebko , Arun Krishnan , Haiying Guan , Toshiro Kubota , Vaclav Potesil
IPC分类号： G06K9/00
CPC分类号： G06T7/174 , G06T7/155 , G06T7/33 , G06T7/38 , G06T2207/10072 , G06T2207/20016 , G06T2207/20081 , G06T2207/20164 , G06T2207/30004 , G06T2207/30204
摘要： A method for segmenting digitized images includes providing a training set comprising a plurality of digitized whole-body images, providing labels on anatomical landmarks in each image of said training set, aligning each said training set image, generating positive and negative training examples for each landmark by cropping the aligned training volumes into one or more cropping windows of different spatial scales, and using said positive and negative examples to train a detector for each landmark at one or more spatial scales ranging from a coarse resolution to a fine resolution, wherein the spatial relationship between a cropping windows of a coarse resolution detector and a fine resolution detector is recorded.
摘要翻译：用于分割数字化图像的方法包括提供包括多个数字化的全身图像的训练集合，在所述训练集合的每个图像中的解剖学标志上提供标签，对准每个所述训练集合图像，为每个界标生成正和负训练样本通过将对准的训练量裁剪成不同空间尺度的一个或多个裁剪窗口，并且使用所述正和负的示例来在从粗分辨率到精细分辨率的一个或多个空间尺度上训练每个地标的检测器，其中空间记录粗分辨率检测器的裁切窗与精细分辨率检测器之间的关系。

6. 发明授权

US06388496B1 Semiconductor output circuit 失效
标题翻译：半导体输出电路
公开(公告)号：US06388496B1
公开(公告)日：2002-05-14
申请号：US09549512
申请日：2000-04-14
申请人： Hiroyuki Tsurumi , Toshiro Kubota
发明人： Hiroyuki Tsurumi , Toshiro Kubota
IPC分类号： H03K508
CPC分类号： H03F3/3081 , H03F3/3432 , H03F3/68 , H03K17/08112 , H03K17/663
摘要： The present invention relates to a semiconductor output circuit that protects a circuit including such a reverse operation as reverses the potentials of a collector and an emitter of a bipolar transistor. A cathode of a protective diode is connected to a P type side of a base-emitter PN junction of a bipolar transistor constituting a semiconductor output circuit, while an anode of the protective diode is connected to an N type side of the base-emitter PN junction. By positively operating the bipolar transistor in a reverse direction with a reverse current gain &bgr;R>1, a reverse voltage between a collector and an emitter of the bipolar transistor is precluded from exceeding Veco to prevent the transistor from being broken down due to its reverse operation. In addition, by connecting the anode of the protective diode to a P type side of a base-collector PN junction of the bipolar transistor constituting the semiconductor output circuit, while connecting the cathode of the protective diode to an N type side of the base-collector junction, Veco is increased to a higher level within the entire circuit to prevent the bipolar transistor from being broken down due to its reverse operation.
摘要翻译：本发明涉及一种半导体输出电路，其保护包括这样的反向操作的电路，以反转双极晶体管的集电极和发射极的电位。保护二极管的阴极连接到构成半导体输出电路的双极晶体管的基极 - 发射极PN结的P型侧，而保护二极管的阳极连接到基极 - 发射极PN的N型侧交界处通过在反向电流增益βR> 1的情况下以相反方向正极操作双极晶体管，双极晶体管的集电极和发射极之间的反向电压不会超过Veco，以防止晶体管由于其反向操作而分解。此外，通过将保护二极管的阳极连接到构成半导体输出电路的双极晶体管的基极集电极PN结的P型侧，同时将保护二极管的阴极连接到基极集电极PN结的N型侧，集电极结，Veco在整个电路内增加到更高的电平，以防止双极晶体管由于其反向操作而分解。

7. 发明授权

US6009447A Method and system for generating and implementing orientational filters for real-time computer vision applications 失效
标题翻译：用于生成和实现实时计算机视觉应用的定向滤波器的方法和系统
公开(公告)号：US6009447A
公开(公告)日：1999-12-28
申请号：US801602
申请日：1997-02-13
申请人： Toshiro Kubota , Cecil O. Alford
发明人： Toshiro Kubota , Cecil O. Alford
IPC分类号： G06T5/20 , G06F17/00
CPC分类号： G06T5/20
摘要： Methods for generating and implementing digital orientational filters. A first method of the present invention is provided for generating digital orientational filters of uniform size but each having a different fixed orientation. A second method provides for dilation of the digital orientation filters generated by the first method, both in a decimated and an undecimated format. A third method of the present invention provides for steering the orientation of the filters generated by the first method. Also, associated VLSI hardware based systems implementing the above methods are disclosed. The above methods and systems allow digital orientational filters to be utilized in computer vision and other applications requiring a large amount of video signal data to be processed in real-time.
摘要翻译：用于生成和实现数字定向滤波器的方法。提供本发明的第一种方法用于产生均匀尺寸的数字取向滤光片，但是每个具有不同的固定取向。第二种方法提供了通过第一种方法产生的数字方向滤波器的扩展，无论是抽取的还是未格式化的。本发明的第三种方法提供了转向由第一种方法产生的滤波器的取向。此外，公开了实现上述方法的相关联的基于VLSI硬件的系统。上述方法和系统允许数字取向滤波器用于需要大量视频信号数据被实时处理的计算机视觉和其它应用中。

8. 发明授权

US07720271B2 Estimation of solitary pulmonary nodule diameters with reaction-diffusion segmentation 有权
标题翻译：用反应扩散分割估计孤立性肺结节直径
公开(公告)号：US07720271B2
公开(公告)日：2010-05-18
申请号：US11398100
申请日：2006-04-04
申请人： Toshiro Kubota
发明人： Toshiro Kubota
IPC分类号： G06K9/00
CPC分类号： G06K9/34 , G06K9/38 , G06T7/12 , G06T7/149 , G06T7/62 , G06T2207/10081 , G06T2207/20116 , G06T2207/30064
摘要： A reactive-diffusion method for estimating a diameter of an object of interest includes providing a volume of interest including a plurality of voxels, initializing at least two volumes of the volume of interest, wherein each of the voxels has at least two values corresponding to the at least two volumes of the volume of interest, respectively, performing a diffusion operation and a reaction operation on the voxels to adjust the at least two values, comparing, for each voxel, the at least two values to a threshold to assign each voxel to one of the at least two volumes, wherein the assignment of the voxels is a segmentation result, and estimating a diameter of the object of interest from the segmentation result, wherein the object of interest is represented by at least one of the at least two volumes but less than all the volumes.
摘要翻译：用于估计感兴趣对象的直径的反应性扩散方法包括提供包括多个体素的兴趣体积，初始化感兴趣体积的至少两个体积，其中每个体素具有对应于至少两个体积的感兴趣的体积分别对体素执行扩散操作和反应操作以调整至少两个值，将每个体素比较所述至少两个值到阈值以将每个体素分配到所述至少两个体积中的一个，其中所述体素的分配是分割结果，以及从所述分割结果估计所述感兴趣对象的直径，其中所述感兴趣对象由所述至少两个体积中的至少一个表示但少于所有卷。

9. 发明申请

US20090092302A1 System and Method for Robust Segmentation of Pulmonary Nodules of Various Densities 有权
标题翻译：用于各种密度的肺结节的鲁棒分割的系统和方法
公开(公告)号：US20090092302A1
公开(公告)日：2009-04-09
申请号：US12243387
申请日：2008-10-01
申请人： Toshiro Kubota , Anna Jerebko , Marcos Salganicoff
发明人： Toshiro Kubota , Anna Jerebko , Marcos Salganicoff
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/11 , G06T7/187 , G06T2207/30064
摘要： A method for differentiating pulmonary nodules in digitized medical images includes identifying an object of interest from a digital image of the lungs, computing a first distance map of each point of the object of interest, determining a seed point from the first distance map, starting from the seed point, growing a first region by adding successive adjacent layers of points until a background point is reached, and partitioning the first region into a nodule region and a non-nodule region.
摘要翻译：用于区分数字化医学图像中的肺结节的方法包括从肺的数字图像识别感兴趣对象，计算感兴趣对象的每个点的第一距离图，从第一距离图确定种子点，从种子点，通过添加连续的相邻层点直到达到背景点来生长第一区域，并将第一区域划分成结节区域和非结节区域。

10. 发明授权

US06201137B1 Process for purifying tetrahydrofurans used as starting material for polyether polyols 有权
标题翻译：纯化用作聚醚多元醇原料的四氢呋喃的方法
公开(公告)号：US06201137B1
公开(公告)日：2001-03-13
申请号：US09319031
申请日：1999-08-11
申请人： Hiroshi Nakaoka , Toshiro Kubota
发明人： Hiroshi Nakaoka , Toshiro Kubota
IPC分类号： C07D30706
CPC分类号： C07D307/08
摘要： Tetrahydrofurans suitable for use as starting materials in the synthesis of polyether polyols without causing coloration in the product polyether polyols can be obtained by contacting crude tetrahydrofurans with a mineral acid or a strongly acidic cation-exchange resin, followed by isolation through a simple distillation and/or rectification to obtain purified tetrahydrofurans.
摘要翻译：可以通过使粗四氢呋喃与无机酸或强酸性阳离子交换树脂接触，然后通过简单的蒸馏和/或反应产物分离来获得适合用作聚醚多元醇合成中的原料而不引起产物聚醚多元醇着色的四氢呋喃，或精馏以获得纯化的四氢呋喃。

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