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1. 发明申请

US20060279274A1 Sampling apparatus, and testing apparatus 审中-公开
标题翻译：取样装置和检测装置
公开(公告)号：US20060279274A1
公开(公告)日：2006-12-14
申请号：US11387445
申请日：2006-03-23
申请人： Tsutomu Yamanaka
发明人： Tsutomu Yamanaka
IPC分类号： G01R31/28
CPC分类号： G01R31/31922 , G01R31/31928
摘要： Each channel comprises: an AD converter which converts a signal value of a corresponding input signal into a digital value in response to a received sampling clock; a counter which counts the pulses of the sampling clock; memory which sequentially stores the digital values at addresses corresponding to the counted values of the counter; a transmission/reception unit which outputs the counted value of the counter at a point in time at which acquisition of the waveform of the input signal is to be started in a case that the channel is set to be a main channel beforehand, and which receives the start data counted value from the main channel in a case that the channel is set to be a sub-channel; and an output unit which sequentially outputs the digital values stored in the memory with the digital value stored at the address corresponding to the start data counted value as the start data.
摘要翻译：每个通道包括：AD转换器，其响应于接收到的采样时钟将相应输入信号的信号值转换成数字值; 计数采样时钟脉冲的计数器; 存储器，其顺序地将数字值存储在与计数器的计数值对应的地址处; 在通道被预先设定为主通道的情况下，在输入信号的波形的获取的时间点输出计数器的计数值的发送/接收单元，并且接收在将信道设置为子信道的情况下，来自主信道的起始数据计数值; 以及输出单元，其以存储在与开始数据计数值相对应的地址的数字值作为开始数据顺序输出存储在存储器中的数字值。

2. 发明授权

US5318969A Benzopyran compound and its pharmaceutical use 失效
标题翻译：苯并吡喃化合物及其药物用途
公开(公告)号：US5318969A
公开(公告)日：1994-06-07
申请号：US897253
申请日：1992-06-11
申请人： Tsutomu Yamanaka , Toshio Seki , Tohru Nakajima , Osamu Yaoka
发明人： Tsutomu Yamanaka , Toshio Seki , Tohru Nakajima , Osamu Yaoka
IPC分类号： C07D311/68 , A61K31/35 , A61K31/352 , A61K31/443 , A61K31/4433 , A61K31/455 , A61K31/50 , A61K31/535 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07D311/70 , C07D311/96 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12
CPC分类号： C07D405/12 , C07D311/68 , C07D407/12
摘要： A benzopyran compound of the general formula (I) ##STR1## wherein A represents --OR.sup.1 or --NH--COR.sup.2 ; R.sup.3 represents hydrogen, a lower alkyl, a lower alkoxy, amino, a mono- or di-lower alkylamino, an amino-lower alkyl, a hydroxy-lower alkyl, a halo-lower alkyl, a lower alkoxy-lower alkyl, an acyloxy-lower alkyl, a lower alkoxycarbonyl-lower alkyl, an aryl or a heteroaryl, or R.sup.2 and R.sup.3 combinedly together form an alkylene having 1 to 2 carbon atoms; R.sup.4 and R.sup.5 are the same or different, and respectively represent hydrogen or a lower alkyl, or combinedly together form an alkylene having 2 to 5 carbon atoms; R.sup.6 represents hydroxyl group, formyloxy, an alkanoyloxy, a haloalkanoyloxy, a lower alkoxycarbonyloxy, an aroyloxy, a heteroaroyloxy, carbamoyloxy, a mono- or di-lower alkylcarbamoyloxy and R.sup.7 represents hydrogen, or R.sup.6 and R.sup.7 combinedly together form a bond and X and Y are the same or different, and respectively represent hydrogen, halogen, nitro, cyano, a lower alkyl, a lower alkoxy, a halo-lower alkyl, carboxyl, formyl, an alkanoyl, an aroyl, a halo-alkanoyl, carbamoyl, a lower alkylsulfinyl, an arylsulfinyl, a lower alkylsulfonyl, an arylsulfonyl, sulfonamido or a mono- or di-lower alkylsulfonamido, or their pharmaceutically acceptable salts and its pharmaceutical use.
摘要翻译：通式（I）的苯并吡喃化合物其中A表示-OR1或-NH-COR2; R 3表示氢，低级烷基，低级烷氧基，氨基，一或二低级烷基氨基，氨基 - 低级烷基，羟基 - 低级烷基，卤代低级烷基，低级烷氧基 - 低级烷基，酰氧基低级烷基，低级烷氧基羰基 - 低级烷基，芳基或杂芳基，或R2和R3组合在一起形成具有1至2个碳原子的亚烷基; R4和R5相同或不同，分别表示氢或低级烷基，或者组合在一起形成具有2-5个碳原子的亚烷基; R6表示羟基，甲酰氧基，烷酰氧基，卤代烷酰氧基，低级烷氧基羰氧基，芳酰氧基，杂芳氧基，氨基甲酰氧基，一或二低级烷基氨基甲酰氧基，R7表示氢，或R6和R7组合在一起形成键，X和 Y分别相同或不同，分别表示氢，卤素，硝基，氰基，低级烷基，低级烷氧基，卤代低级烷基，羧基，甲酰基，烷酰基，芳酰基，卤代烷酰基，氨基甲酰基，低级烷基亚磺酰基，芳基亚磺酰基，低级烷基磺酰基，芳基磺酰基，亚磺酰氨基或单 - 或二 - 低级烷基亚磺酰氨基，或其药学上可接受的盐及其药物用途。

3. 发明授权

US5273998A Process for making an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound 失效
标题翻译：制备光学活性3,4-二氢-3,4-环氧-2H-1-苯并吡喃化合物的方法
公开(公告)号：US5273998A
公开(公告)日：1993-12-28
申请号：US963383
申请日：1992-10-19
申请人： Tsutomu Yamanaka
发明人： Tsutomu Yamanaka
IPC分类号： C07D405/12 , C07D493/04 , A61K31/335
CPC分类号： C07D405/12 , C07D493/04
摘要： The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coronary blood flow-increasing activities and the like, provides a diastereomeric ester compound which is useful as an intermediate for said epoxy compound and also provides a use of said diastereomeric ester compound in making of said epoxy compound, and further an optically active benzopyran compound which is useful as medicine.
摘要翻译：本发明提供了一种工业上有价值的制备光学活性3,4-二氢-3,4-环氧-2H-1-苯并吡喃化合物的方法，其可用作具有抗高血压，冠状动脉血流的光学活性苯并吡喃化合物的起始物质 - 增加活性等，提供了可用作所述环氧化合物的中间体的非对映异构体酯化合物，并且还提供所述非对映体酯化合物在制备所述环氧化合物中的用途，以及可用作以下的光学活性苯并吡喃化合物医学。

4. 发明授权

US5177216A Diastereomeric ester compound useful as an intermediate in the making of an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound 失效
标题翻译：作为制备光活性3,4-二氢-3,4-环氧-2H-1-苯并噻吩化合物的中间体有用的二异氰酸酯化合物
公开(公告)号：US5177216A
公开(公告)日：1993-01-05
申请号：US698775
申请日：1991-05-13
申请人： Tsutomu Yamanaka
发明人： Tsutomu Yamanaka
IPC分类号： C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04
CPC分类号： C07D405/12 , C07D493/04
摘要： The present invention provides a new diastereomer ester compound which is useful as an intermediate in the making of an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound.

5. 发明授权

US5162553A Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compounds and intermediates therefor 失效
标题翻译：光学活性3,4-二氢-3,4-环氧-2H-1-苯并吡喃化合物及其中间体的制备方法
公开(公告)号：US5162553A
公开(公告)日：1992-11-10
申请号：US717813
申请日：1991-06-19
申请人： Shinro Setoguchi , Mineo Tsuruda , Chiaki Kitami , Tsutomu Yamanaka
发明人： Shinro Setoguchi , Mineo Tsuruda , Chiaki Kitami , Tsutomu Yamanaka
IPC分类号： C07D311/22 , C07D493/04
CPC分类号： C07D493/04 , C07D311/22
摘要： The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coronary blood flow-increasing activities and the like, and also provides a diastereometric ester compound with a 3-halo-4-hydroxy-2H-1-benzopyran compound which is useful as an intermediate for said epoxy compound.
摘要翻译：本发明提供了一种工业上有价值的制备光学活性3,4-二氢-3,4-环氧-2H-1-苯并吡喃化合物的方法，其可用作具有抗高血压，冠状动脉血流的光学活性苯并吡喃化合物的起始物质 - 增加活性等，并且还提供了可用作所述环氧化合物的中间体的3-卤代-4-羟基-2H-1-苯并吡喃化合物的非对映酯化合物。

6. 发明授权

US5143936A Benzopyran compound and its pharmaceutical use 失效
公开(公告)号：US5143936A
公开(公告)日：1992-09-01
申请号：US672657
申请日：1991-03-21
申请人： Tsutomu Yamanaka , Toshio Seki , Tohru Nakajima , Osamu Yaoka
发明人： Tsutomu Yamanaka , Toshio Seki , Tohru Nakajima , Osamu Yaoka
IPC分类号： C07D311/68 , A61K31/35 , A61K31/352 , A61K31/443 , A61K31/4433 , A61K31/455 , A61K31/50 , A61K31/535 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07D311/70 , C07D311/96 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12
CPC分类号： C07D405/12 , C07D311/68 , C07D407/12
摘要： A benzopyran compound of the general formula (I) ##STR1## wherein A represents --OR.sup.1 or --NH--COR.sup.2 (wherein R.sup.1 represents hydrogen, a lower alkyl, formyl, an alkanoyl, an aroyl or an aralkyl and R.sup.2 represents hydrogen, a lower alkyl, a lower alkoxy, amino, mono- or di-lower alkylamino, an amino-lower alkyl, a hydroxy-lower alkyl, a halo-lower alkyl, a lower alkoxy-lower alkyl, an acyloxy-lower alkyl, a lower alkoxycarbonyl-lower alkyl, an aryl or a heteroaryl); R.sup.3 represents hydrogen, a lower alkyl, a lower alkoxy, amino, a mono- or di-lower alkylamino, an amino-lower alkyl, a hydroxy-lower alkyl, a halo-lower alkyl, a lower alkoxy-lower alkyl, an acyloxy-lower alkyl, a lower alkoxycarbonyl-lower alkyl, an aryl or a heteroaryl, or R.sup.2 and R.sup.3 combinedly together form an alkylene having 1 to 2 carbon atoms; R.sup.4 and R.sup.5 are the same or different, and respectively represent hydrogen or a lower alkyl, or combinedly together form an alkylene having 2 to 5 carbon atoms; R.sup.6 represents hydroxyl group, formyloxy, an alkanoyloxy, a haloalkanoyloxy, a lower alkoxycarbonyloxy, an aroyloxy, a heteroaroyloxy, carbamoyloxy, a mono- or di-lower alkycarbamoyloxy and R.sup.7 represents hydrogen, or R.sup.6 and R.sup.7 combinedly together form a bond and X and Y are the same or different, and respectively represent hydrogen, halogen, nitro, cyano, a lower alkyl, a lower alkoxy, a halo-lower alkyl, carboxyl, formyl, an alkanoyl, an aroyl, a halo-alkanoyl, carbamoyl, a lower alkylsulfinyl, an arylsulfinyl, a lower alkylsulfonyl, an arylsulfonyl, sulfonamido or a mono- or di-lower alkylsulfonamido, or their pharmaceutically acceptable salts and its pharmaceutical use.The compounds of the present invention exhibit remarkable and long lasting antihypertensive actions and peripheral vascular relaxant actions and therefore are useful as therapeutic medicines for hypertensive. Since they also display selective coronary vasodilating actions and the duration of actions are very long, they are of use as therapeutic medicines for cardiovascular disturbances such as angina pectoris and cardiac insufficiency.

7. 发明授权

US4709095A Ortho-aminomethylphenol compounds 失效
标题翻译：邻氨基甲基苯酚化合物
公开(公告)号：US4709095A
公开(公告)日：1987-11-24
申请号：US853809
申请日：1986-03-25
申请人： Tsutomu Yamanaka , Osamu Yaoka
发明人： Tsutomu Yamanaka , Osamu Yaoka
IPC分类号： A61K31/15 , A61K31/35 , A61K31/352 , A61K31/47 , A61P7/10 , A61P9/12 , A61P25/04 , A61P29/00 , C07C67/00 , C07C239/00 , C07C251/48 , C07D215/42 , C07D311/68 , C07C131/00
CPC分类号： C07D311/68
摘要： Ortho-aminomethylphenol compounds of the formula: ##STR1## wherein X is hydrogen or halogen, R is hydrogen or alkyl having 1 to 4 carbon atoms and A is alkyl having 1 to 4 carbon atoms, phenyl, benzyl or a bivalent radical selected from --(CH.sub.2).sub.3 -- and --O(CH.sub.2).sub.2 -- and joined together with the 3 or 5 position of the benzene nucleus to form a bicycle, or pharmaceutically acceptable salts thereof, a method of preparing said compounds and a pharmaceutical composition containing said compounds, are disclosed.Such compounds exhibit antiinflammatory, analgesic, diuretic and antihypertensive activities, so they are useful in the treatment for diseases caused by inflammation, edema or hypertension.
摘要翻译： PCT No.PCT / JP85 / 00440 Sec。 371日期：1986年3月25日 102（e）日期1986年3月25日PCT提交1985年8月2日PCT公布。出版物WO86 / 01201 日本：1986年2月27日。下式的邻氨基甲基苯酚化合物：其中X是氢或卤素，R是氢或具有1至4个碳原子的烷基，A是具有1至4个碳原子的烷基，苯基，苄基或选自 - （CH 2）3 - 和-O（CH 2）2 - 的二价基团并且与苯核的3或5位相连接以形成自行车或其药学上可接受的盐，制备所述化合物的方法和含有所述化合物的药物组合物。这些化合物表现出抗炎，止痛，利尿和抗高血压活性，因此它们可用于治疗由炎症，水肿或高血压引起的疾病。

8. 发明授权

US5066816A Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compounds and intermediates therefor 失效
标题翻译：制备光学活性3,4-二氢-3,4-环氧-2H-1-苯并噻吩化合物及其中间体的方法
公开(公告)号：US5066816A
公开(公告)日：1991-11-19
申请号：US486100
申请日：1990-02-28
申请人： Shinro Setoguchi , Mineo Tsuruda , Chiaki Kitami , Tsutomu Yamanaka
发明人： Shinro Setoguchi , Mineo Tsuruda , Chiaki Kitami , Tsutomu Yamanaka
IPC分类号： C07D311/22 , C07D493/04
CPC分类号： C07D493/04 , C07D311/22
摘要： The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coronary blood flow-increasing activities and the like, and also provides a diastereomeric ester compound with a 3-halo-4-hydroxy-2H-1-benzopyran compound which is useful as an intermediate for said epoxy compound.

9. 发明授权

US06805989B2 Separator for solid polymer electrolyte fuel cell and process for producing the same 失效
标题翻译：固体高分子电解质燃料电池用分离器及其制造方法
公开(公告)号：US06805989B2
公开(公告)日：2004-10-19
申请号：US10105944
申请日：2002-03-26
申请人： Masahiro Seido , Tatsuya Tonogi , Tsutomu Yamanaka
发明人： Masahiro Seido , Tatsuya Tonogi , Tsutomu Yamanaka
IPC分类号： H01M200
CPC分类号： H01M8/0213 , H01M8/0206 , H01M8/0228 , Y02P70/56
摘要： The surface of highly conductive iron, copper, aluminum, magnesium, or alloy thereof is covered with highly corrosion-resistant titanium or titanium alloy through plastic working by rolling or extrusion to form a cladding material. At least one surface of the cladding material is covered with a carbon material to form a separator for a solid polymer electrolyte fuel cell. By virtue of the above constitution, the separator for a solid polymer electrolyte fuel cell has good workability and, at the same time, can surely maintain or improve electrical conductivity and corrosion resistance.
摘要翻译：高导电性铁，铜，铝，镁或其合金的表面通过轧制或挤出的塑性加工被高度耐腐蚀的钛或钛合金覆盖，形成包层材料。包层材料的至少一个表面被碳材料覆盖以形成用于固体聚合物电解质燃料电池的隔板。根据上述结构，固体高分子电解质型燃料电池用隔膜具有良好的加工性，同时能够可靠地维持或提高导电性和耐腐蚀性。

10. 发明授权

US5021432A Benzopyran compound and its pharmaceutical use 失效
标题翻译：苯并吡喃化合物及其药物用途
公开(公告)号：US5021432A
公开(公告)日：1991-06-04
申请号：US340271
申请日：1989-04-19
申请人： Tsutomu Yamanaka , Toshio Seki , Tohru Nakajima , Osamu Yaoka
发明人： Tsutomu Yamanaka , Toshio Seki , Tohru Nakajima , Osamu Yaoka
IPC分类号： C07D311/68 , A61K31/35 , A61K31/352 , A61K31/443 , A61K31/4433 , A61K31/455 , A61K31/50 , A61K31/535 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07D311/70 , C07D311/96 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/12
CPC分类号： C07D405/12 , C07D311/68 , C07D407/12
摘要： A benzopyran compound of the general formula (I) ##STR1## wherein A represents --OR.sup.1 or --NH--COR.sup.2 (wherein R.sup.1 represents hydrogen, a lower alkyl, formyl, an alkanoyl, an aroyl or an aralkyl and R.sup.2 represents hydrogen, a lower alkyl, a lower alkoxy, amino, mono- or di-lower alkylamino, an amino-lower alkyl, a hydroxy-lower alkyl, a halo-lower alkyl, a lower alkoxy-lower alkyl, an acyloxy-lower alkyl, a lower alkoxy-carbonyl-lower alkyl, an aryl or a heteroaryl); R.sup.3 represents hydrogen, a lower alkyl, a lower alkoxy, amino, a mono- or di-lower alkylamino, an amino-lower alkyl, a hydroxy-lower alkyl, a halo-lower alkyl, a lower alkoxy-lower alkyl, an acyloxy-lower alkyl, a lower alkoxycarbonyl-lower alkyl, an aryl or a heteroaryl, or R.sup.2 and R.sup.3 combinedly together form an alkylene having 1 to 2 carbon atoms; R.sup.4 and R.sup.5 are the same or different, and respectively represent hydrogen or a lower alkyl, or combinedly together form an alkylene having 2 to 5 carbon atoms; R.sup.6 represents hydroxyl group, formyloxy, an alkanoyloxy, a haloalkanoyloxy, a lower alkoxycarbonyloxy, an aroyloxy, a heteroaroyloxy, carbamoyloxy, a mono- or di-lower alkylcarbamoyloxy and R.sup.7 represents hydrogen, or R.sup.6 and R.sup.7 combinedly together form a bond and X and Y are the same or different, and respectively represent hydrogen, halogen, nitro, cyano, a lower alkyl, a lower alkoxy, a halo-lower alkyl, carboxyl, formyl, and alkanoyl, an aroyl, a halo-alkanoyl, carbamoyl, a lower alkylsulfinyl, an arylsulfinyl, a lower alkylsulfonyl, and arylsulfonyl, sulfonamido or a mono- or di-lower alkylsulfonamido, or their pharmaceutically acceptable salts and its pharmaceutical use.The compounds of the present invention exhibit remarkable and long lasting antihypertensive actions and peripheral vascular relaxant actions and therefore are useful as therapeutic medicines for hypertensive. Since they also display selective coronary vasodilating actions and the duration of actions are very long, they are of use as therapeutic medicines for cardiovascular disturbances such as angina pectoris and cardiac insufficiency.

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