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1. 发明申请

US20110104714A1 NON-PROTEOLYTIC METHOD FOR THE DETERMINATION OF ANALYTES IN KERATINIZED STRUCTURES 有权
标题翻译：用于确定克服结构中分析物的非防腐方法
公开(公告)号：US20110104714A1
公开(公告)日：2011-05-05
申请号：US12990447
申请日：2009-04-29
申请人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
发明人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
IPC分类号： G01N33/53
CPC分类号： G01N33/9486 , Y10S435/962 , Y10T436/10
摘要： Methods that permit the rapid release of one or more analytes from head or body hair or other keratinized structures of an individual (who may previously have ingested one or more of the analytes) are provided. The methods can include contacting the keratinized structure with a reducing agent but not with a proteolytic agent. The methods can further include identification and quantification of the one or more analytes by known analytical techniques such as immunoassays. The described methods do not damage the analyte and do not cause harmful effects on a subsequently-used analyte detection probe (e.g., an antibody).
摘要翻译：提供允许一种或多种分析物从头部或身体毛发或其他角质化结构（可能预先摄入一种或多种分析物）的其他角质化结构的快速释放的方法。所述方法可包括使角化结构与还原剂接触，但不与蛋白水解剂接触。所述方法还可以包括通过已知的分析技术如免疫测定来鉴定和定量一种或多种分析物。所描述的方法不会损害分析物，并且不会对随后使用的分析物检测探针（例如抗体）产生有害影响。

2. 发明申请

US20090269791A1 NON-PROTEOLYTIC METHOD FOR THE DETERMINATION OF ANALYTES IN KERATINIZED STRUCTURES 有权
标题翻译：用于确定克服结构中分析物的非防腐方法
公开(公告)号：US20090269791A1
公开(公告)日：2009-10-29
申请号：US12111914
申请日：2008-04-29
申请人： Virginia Hill , Mohammed Atefi , Michael I. Schaffer
发明人： Virginia Hill , Mohammed Atefi , Michael I. Schaffer
IPC分类号： G01N33/53 , G01N31/00 , G01N33/536
CPC分类号： G01N33/9486 , Y10S435/962 , Y10T436/10
摘要： Methods that permit the rapid release of one or more analytes from head or body hair or other keratinized structures of an individual (who may previously have ingested one or more of the analytes) are provided. The methods can include contacting the keratinized structure with a reducing agent but not with a proteolytic agent. The methods can further include identification and quantification of the one or more analytes by known analytical techniques such as immunoassays. The described methods do not damage the analyte and do not cause harmful effects on a subsequently-used analyte detection probe (e.g., an antibody).
摘要翻译：提供允许一种或多种分析物从头部或身体毛发或其他角质化结构（可能预先摄入一种或多种分析物）的其他角质化结构的快速释放的方法。所述方法可包括使角化结构与还原剂接触，但不与蛋白水解剂接触。所述方法还可以包括通过已知的分析技术如免疫测定来鉴定和定量一种或多种分析物。所描述的方法不会损害分析物，并且不会对随后使用的分析物检测探针（例如抗体）产生有害影响。

3. 发明申请

US20070260588A1 Selective, contextual review for documents 审中-公开
标题翻译：文件的选择性，背景审查
公开(公告)号：US20070260588A1
公开(公告)日：2007-11-08
申请号：US11430709
申请日：2006-05-08
申请人： Ana Biazetti , Virginia Hill , Mary Sturgeon
发明人： Ana Biazetti , Virginia Hill , Mary Sturgeon
IPC分类号： G06F17/30
CPC分类号： G06F16/3338 , G06F16/3344
摘要： A method, apparatus and computer-usable medium for the selective, contextual retrieval and presentation of information used in review processes. Search criteria is entered for information to be retrieved for review and information source documents are then searched, maintaining references to the contextual levels encountered (e.g., chapter, section, sub-section, etc.). Once the search is completed, a hierarchical list of sentence extracts matching the search criteria and indicating their location in their respective source document is presented to the reviewer. The user can then select any level of the hierarchical view, which then displays an expanded view of the related section of the source document. The retrieved information can be exported to a plurality of formats, which are annotatable by the reviewer. Users are thereby provided with information relevant to the subject under review, structured and presented in the context of its usage within its associated source document.
摘要翻译：用于在审查过程中使用的信息的选择性，上下文检索和呈现的方法，装置和计算机可用介质。输入要检索的信息以进行审查的搜索标准，然后搜索信息源文档，保持对遇到的上下文级别（例如，章节，部分，子部分等）的引用。一旦搜索完成，就将与搜索条件匹配的句子提取的分层列表以及它们各自的源文档中的位置提供给审阅者。然后，用户可以选择任何级别的分层视图，然后显示源文档的相关部分的扩展视图。检索到的信息可以被导出为多个格式，这些格式可由审阅者注释。从而向用户提供与被审查对象有关的信息，在其相关源文档中的使用情况下进行结构化和呈现。

4. 外观设计

USD484341S1 Portable tissue holder 失效
标题翻译：便携式纸巾架
公开(公告)号：USD484341S1
公开(公告)日：2003-12-30
申请号：US29181201
申请日：2003-05-08
申请人： Lafayette Hill , Virginia Hill
设计人： Lafayette Hill , Virginia Hill

5. 发明授权

US10539580B2 Solid phase multi-analyte assay 有权
公开(公告)号：US10539580B2
公开(公告)日：2020-01-21
申请号：US12990451
申请日：2009-04-29
申请人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
发明人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
IPC分类号： G01N33/94
摘要： Compositions and methods for detecting the presence and/or amount of one or more analytes, including analytes such as drugs of abuse, are provided. The compositions include two or more analytes associated with a solid phase, e.g., a particle or a multiwell plate. The compositions and methods also allow the simultaneous, tandem, or serial determination of the presence and/or amount of two or more analytes of interest in a sample.

6. 发明授权

US08084215B2 Non-proteolytic method for the determination of analytes in keratinized structures 有权
标题翻译：用于测定角化结构中分析物的非蛋白水解方法
公开(公告)号：US08084215B2
公开(公告)日：2011-12-27
申请号：US12111914
申请日：2008-04-29
申请人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
发明人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
IPC分类号： G01N33/53
CPC分类号： G01N33/9486 , Y10S435/962 , Y10T436/10
摘要： Methods that permit the rapid release of one or more analytes from head or body hair or other keratinized structures of an individual (who may previously have ingested one or more of the analytes) are provided. The methods can include contacting the keratinized structure with a reducing agent but not with a proteolytic agent. The methods can further include identification and quantification of the one or more analytes by known analytical techniques such as immunoassays. The described methods do not damage the analyte and do not cause harmful effects on a subsequently-used analyte detection probe (e.g., an antibody).
摘要翻译：提供允许一种或多种分析物从头部或身体毛发或其他角质化结构（可能预先摄入一种或多种分析物）的其他角质化结构的快速释放的方法。所述方法可包括使角化结构与还原剂接触，但不与蛋白水解剂接触。所述方法还可以包括通过已知的分析技术如免疫测定来鉴定和定量一种或多种分析物。所描述的方法不会损害分析物，并且不会对随后使用的分析物检测探针（例如抗体）产生有害影响。

7. 发明授权

US08329417B2 Non-proteolytic method for the determination of analytes in keratinized structures 有权
标题翻译：用于测定角化结构中分析物的非蛋白水解方法
公开(公告)号：US08329417B2
公开(公告)日：2012-12-11
申请号：US13336119
申请日：2011-12-23
申请人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
发明人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
IPC分类号： G01N33/53
CPC分类号： G01N33/9486 , Y10S435/962 , Y10T436/10
摘要： Methods that permit the rapid release of one or more analytes from head or body hair or other keratinized structures of an individual (who may previously have ingested one or more of the analytes) are provided. The methods can include contacting the keratinized structure with a reducing agent but not with a proteolytic agent. The methods can further include identification and quantification of the one or more analytes by known analytical techniques such as immunoassays. The described methods do not damage the analyte and do not cause harmful effects on a subsequently-used analyte detection probe (e.g., an antibody).
摘要翻译：提供允许一种或多种分析物从头部或身体毛发或其他角质化结构（可能预先摄入一种或多种分析物）的其他角质化结构的快速释放的方法。所述方法可包括使角化结构与还原剂接触，但不与蛋白水解剂接触。所述方法还可以包括通过已知的分析技术如免疫测定来鉴定和定量一种或多种分析物。所描述的方法不会损害分析物，并且不会对随后使用的分析物检测探针（例如抗体）产生有害影响。

8. 发明申请

US20120094309A1 NON-PROTEOLYTIC METHOD FOR THE DETERMINATION OF ANALYTES IN KERATINIZED STRUCTURES 有权
标题翻译：用于确定克服结构中分析物的非防腐方法
公开(公告)号：US20120094309A1
公开(公告)日：2012-04-19
申请号：US13336119
申请日：2011-12-23
申请人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
发明人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
IPC分类号： G01N33/53
CPC分类号： G01N33/9486 , Y10S435/962 , Y10T436/10
摘要： Methods that permit the rapid release of one or more analytes from head or body hair or other keratinized structures of an individual (who may previously have ingested one or more of the analytes) are provided. The methods can include contacting the keratinized structure with a reducing agent but not with a proteolytic agent. The methods can further include identification and quantification of the one or more analytes by known analytical techniques such as immunoassays. The described methods do not damage the analyte and do not cause harmful effects on a subsequently-used analyte detection probe (e.g., an antibody).
摘要翻译：提供允许一种或多种分析物从头部或身体毛发或其他角质化结构（可能预先摄入一种或多种分析物）的其他角质化结构的快速释放的方法。所述方法可包括使角化结构与还原剂接触，但不与蛋白水解剂接触。所述方法还可以包括通过已知的分析技术如免疫测定来鉴定和定量一种或多种分析物。所描述的方法不会损害分析物，并且不会对随后使用的分析物检测探针（例如抗体）产生有害影响。

9. 发明申请

US20110118138A1 SOLID PHASE MULTI-ANALYTE ASSAY 审中-公开
标题翻译：固相多分析测定
公开(公告)号：US20110118138A1
公开(公告)日：2011-05-19
申请号：US12990451
申请日：2009-04-29
申请人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
发明人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
IPC分类号： C40B30/04 , G01N33/543 , G01N33/53 , C40B40/00 , C40B40/04
摘要： Compositions and methods for detecting the presence and/or amount of one or more analytes, including analytes such as drugs of abuse, are provided. The compositions include two or more analytes associated with a solid phase, e.g., a particle or a multiwell plate. The compositions and methods also allow the simultaneous, tandem, or serial determination of the presence and/or amount of two or more analytes of interest in a sample.
摘要翻译：提供了用于检测一种或多种分析物（包括分析物例如滥用药物）的存在和/或量的组合物和方法。组合物包括与固相相关的两种或多种分析物，例如颗粒或多孔板。组合物和方法还允许同时，串联或连续测定样品中两种或多种感兴趣的分析物的存在和/或量。

10. 发明授权

US08435747B2 Non-proteolytic method for the determination of analytes in keratinized structures 有权
标题翻译：用于测定角化结构中分析物的非蛋白水解方法
公开(公告)号：US08435747B2
公开(公告)日：2013-05-07
申请号：US12990447
申请日：2009-04-29
申请人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
发明人： Virginia Hill , Mohammad Atefi , Michael I. Schaffer
IPC分类号： G01N33/53
CPC分类号： G01N33/9486 , Y10S435/962 , Y10T436/10
摘要： Methods that permit the rapid release of one or more analytes from head or body hair or other keratinized structures of an individual (who may previously have ingested one or more of the analytes) are provided. The methods can include contacting the keratinized structure with a reducing agent but not with a proteolytic agent. The methods can further include identification and quantification of the one or more analytes by known analytical techniques such as immunoassays. The described methods do not damage the analyte and do not cause harmful effects on a subsequently-used analyte detection probe (e.g., an antibody).
摘要翻译：提供允许一种或多种分析物从头部或身体毛发或其他角质化结构（可能预先摄入一种或多种分析物）的其他角质化结构的快速释放的方法。所述方法可包括使角化结构与还原剂接触，但不与蛋白水解剂接触。所述方法还可以包括通过已知的分析技术如免疫测定来鉴定和定量一种或多种分析物。所描述的方法不会损害分析物，并且不会对随后使用的分析物检测探针（例如抗体）产生有害影响。

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