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1. 发明授权

US11597917B2 In vitro and in vivo enrichment strategy targeting lymphocytes derived from vector transduced HSCs for therapy of disorders 有权
公开(公告)号：US11597917B2
公开(公告)日：2023-03-07
申请号：US16619883
申请日：2018-06-06
申请人： THE MEDICAL COLLEGE OF WISCONSIN, INC. , UNIVERSITY HEALTH NETWORK , WASHINGTON UNIVERSITY IN ST. LOUIS
发明人： Jeffrey A. Medin , John F. Dipersio , Murtaza S. Nagree
IPC分类号： C12N9/04 , A61P43/00 , A61K9/00 , A61K35/28 , C12N5/0789 , C12N7/00 , C12N9/40 , C12N9/24 , C12N9/80 , C12N15/86
摘要： The present invention is related to a dual promoter lentiviral vector and methods of use for the treatment of diseases and disorders, specifically lysosomal storage disorders.

2. 发明授权

US11085933B2 Neurofibromin/dopamine signaling as a biomarker for cognitive and behavioral problems in children with neurofibromatosis type 1 (NF1 ) 有权
公开(公告)号：US11085933B2
公开(公告)日：2021-08-10
申请号：US16593316
申请日：2019-10-04
申请人： Washington University in St. Louis
发明人： David H. Gutmann , Corina Anastasaki
IPC分类号： G01N33/53 , G01N33/68 , C12Q1/6883
摘要： The present disclosure is generally related to neurofibromatosis type 1. More particularly, disclosed herein are methods for detecting behavioral disorders, methods for detecting cognitive impairment, and methods for detecting brain neurofibromin-dependent dopaminergic signaling associated with neurofibromatosis type 1.

3. 发明授权

US10467741B2 CT simulation optimization for radiation therapy contouring tasks 有权
公开(公告)号：US10467741B2
公开(公告)日：2019-11-05
申请号：US15054215
申请日：2016-02-26
申请人： Washington University in St. Louis
发明人： Hua Li , Sasa Mutic , Mark Anastasio
IPC分类号： G06T7/00 , G06F19/00 , G16H50/50
摘要： A method for optimizing a CT simulation protocol for different size patients for contouring and segmentation of organs and tumors. The method scanning different size phantoms, cadavers, or patients with a CT scanning x-ray tube to create a set of images and to create data sets for each different size phantoms, cadavers, or patients and then calculating an image quality index (IQI) as a benchmark for contouring accuracy. Finding an optimal IQI that characterizes patients of different sizes and using the optimal IQI to determine the accuracy of the contouring and segmentation of A CT simulation protocol for a patient.

4. 发明申请

US20180310869A1 MRI METHOD FOR IN VIVO DETECTION OF AMYLOID AND PATHLOGY IN THE ALZHEIMER BRAIN 审中-公开
公开(公告)号：US20180310869A1
公开(公告)日：2018-11-01
申请号：US15770127
申请日：2016-10-19
申请人： Washington University in St. Louis
发明人： Dmitriy Yablonskiy , Yue Zhao
IPC分类号： A61B5/00 , G01R33/56 , G01R33/50 , G01R33/561 , A61B5/055 , A61B5/145
CPC分类号： A61B5/4088 , A61B5/0042 , A61B5/055 , A61B5/14542 , G01R33/50 , G01R33/5601 , G01R33/5608 , G01R33/5616 , G01R33/56366
摘要： Disclosed are systems, biomarkers, and methods for the diagnosis of Alzheimer's Disease.

5. 发明申请

US20150297916A1 System and Method for the Validation and Quality Assurance of Computerized Contours of Human Anatomy 审中-公开
标题翻译：人体解剖学电脑轮廓的验证和质量保证体系与方法
公开(公告)号：US20150297916A1
公开(公告)日：2015-10-22
申请号：US14700592
申请日：2015-04-30
申请人： Washington University in St. Louis
发明人： Hsin-Chen Chen , Sasa Mutic , Jun Tan , Michael Altman , James Kavanaugh , Hua Li
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , G06T7/13 , G06T2207/10081 , G06T2207/10116 , G06T2207/20081 , G06T2207/30004
摘要： A system and method for validating the accuracy of delineated contours in computerized imaging using statistical data for generating assessment criterion that define acceptable tolerances for delineated contours, with the statistical data being conditionally updated and/or refined between individual processes for validating delineated contours to thereby adjust the tolerances defined by the assessment criterion in the stored statistical data, such that the stored statistical data is more closely representative of a target population. In an alternative embodiment, a system and method for validating the accuracy of delineated contours in computerized imaging using machine learning for assessing delineated contours, with the machine learning training data being used to generate geometric attributes, and the geometric attributes used to construct intra- and interstructural geometric attribute distribution models to automatically detect contouring errors. The present invention may be used to facilitate, as one example, radiation therapy.
摘要翻译：用于使用用于生成评估标准的统计数据来验证计算机化成像中的描绘轮廓的准确度的系统和方法，所述评估标准定义了描绘轮廓的可接受公差，其中统计数据在用于验证所描绘的轮廓之间的各个过程之间有条件地更新和/或改进以由此调整在所存储的统计数据中由评估标准定义的公差，使得存储的统计数据更接近于目标群体的代表。在替代实施例中，一种系统和方法，用于使用机器学习来评估计算机化学习中描绘的轮廓的准确性的系统和方法，其中机器学习训练数据用于生成几何属性，以及用于构建内部和内部结构几何属性分布模型自动检测轮廓误差。作为一个示例，本发明可以用于促进放射治疗。

6. 发明申请

US20210000821A1 USE OF FATTY ACID OXIDATION INHIBITORS AS ANTIMICROBIALS 有权
公开(公告)号：US20210000821A1
公开(公告)日：2021-01-07
申请号：US16979443
申请日：2019-03-15
申请人： Washington University in St. Louis , New York University
发明人： Jennifer A. Philips , Kathryn Moore , Pallavi Chandra , Mireille Ouimet
IPC分类号： A61K31/495 , A61K31/336
摘要： Methods of using small molecule inhibitors of fatty acid oxidation (FAO) as antimicrobials against intracellular Mycobacteria are disclosed. FAO inhibitors including etomoxir, trimetazidine, oxfenicine perhexeline and/or can be used alone, or in combination with known as antimycobacterial agents against intracellular Mycobacteria.

7. 发明授权

US09980660B2 Systems and methods for on-site and real-time electrocardiographic imaging (ECGI) 有权
公开(公告)号：US09980660B2
公开(公告)日：2018-05-29
申请号：US14990469
申请日：2016-01-07
申请人： WASHINGTON UNIVERSITY IN ST. LOUIS
发明人： Yoram Rudy , Yong Wang
IPC分类号： A61B5/0408 , A61B5/04 , A61B5/00 , A61B6/00 , A61B8/08 , A61B18/00
CPC分类号： A61B5/04085 , A61B5/04012 , A61B5/6805 , A61B6/503 , A61B6/5247 , A61B8/0883 , A61B8/5261 , A61B2018/00839
摘要： A non-transitory computer readable medium stores instructions that, when executed by at least one processor, cause the at least one processor to perform a method that includes computing a transfer matrix representing a relative influence that each respective electrode location for measuring electrical potentials on a patient's body has on an estimation of electrical potentials for locations on a surface of interest prior to the measuring of electrical potentials at the respective electrode locations and receiving electrical potential measurements measured via a plurality of electrodes at respective electrode locations on the patient's body. The method also includes computing the estimation of electrical potentials for the locations on the surface of interest based at least in part on the received electrical potential measurements and the computed transfer matrix and generating image data representing the estimation of electrical potentials.

8. 发明申请

US20180014971A1 THERMALLY CONDUCTIVE GRAFT 审中-公开
公开(公告)号：US20180014971A1
公开(公告)日：2018-01-18
申请号：US15714518
申请日：2017-09-25
申请人： University of Washington , Washington University in St. Louis
发明人： Raimondo D'Ambrosio , Samuel R. Browd , John W. Miller , Jeffrey G. Ojemann , Clifford L. Eastman , Matthew Smyth , Steven M. Rothman , Jason Fender
IPC分类号： A61F7/12 , A61F7/00
CPC分类号： A61F7/12 , A61F2007/0002
摘要： The present disclosure provides thermally conductive grafts and methods of passively cooling a hyperthermic region and preventing epilepsy, neural inflammation, and other neurological abnormalities using a thermally conductive graft including a thermally conductive matrix disposed between two opposed surfaces.

9. 发明申请

US20170342436A1 TRANSGENIC PLANTS EXHIBITING ENHANCED PHYTOCHELATIN-BASED HEAVY METAL TOLERANCE AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20170342436A1
公开(公告)日：2017-11-30
申请号：US15602757
申请日：2017-05-23
申请人： The Trustees of the University of Pennsylvania , Washington University in St. Louis , Donald Danforth Plant Science Center
发明人： Philip A. Rea , Joseph Jez , Rebecca Cahoon
IPC分类号： C12N15/82 , C12N9/10 , C02F3/32 , C02F103/06 , C02F101/20
CPC分类号： C12N15/8271 , C02F3/32 , C02F2101/20 , C02F2103/06 , C12N9/104 , C12Y203/02015
摘要： Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.

10. 发明申请

US20160299081A1 BIO-ENABLED PLASMONIC SUPERSTRUCTURES WITH BUILT-IN AND ACCESSIBLE HOTSPOTS 审中-公开
标题翻译：具有内置和可访问性的生物启发的等离子体超声波
公开(公告)号：US20160299081A1
公开(公告)日：2016-10-13
申请号：US15096505
申请日：2016-04-12
申请人： Washington University in St. Louis
发明人： Srikanth Singamaneni , Limei Tian
IPC分类号： G01N21/65 , A61K9/51 , A61K41/00 , G01N33/574 , G01N33/58
CPC分类号： G01N21/658 , A61K9/5146 , A61K9/5192 , A61K41/0052 , B82Y5/00 , G01N33/5005 , G01N33/57438 , G01N33/587 , G01N2800/7028
摘要： The present disclosure relates generally to plasmonic superstructures having a nanostructure core and a plurality of nanoparticle satellites and methods for preparing plasmonic superstructures. The present disclosure is further directed to methods of bioimaging, biosensing and therapeutic applications using the plasmonic superstructures.
摘要翻译：本公开一般涉及具有纳米结构核和多个纳米颗粒卫星的等离子体激元上层结构以及用于制备等离子体激元上层建筑的方法。本公开进一步涉及使用等离子体激元上层结构的生物成像，生物感测和治疗应用的方法。

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