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1. 发明授权

US09861636B2 Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors 有权
公开(公告)号：US09861636B2
公开(公告)日：2018-01-09
申请号：US15356014
申请日：2016-11-18
申请人： Wei He
发明人： Wei He
IPC分类号： A61K31/519 , C07D487/04 , C07C303/38 , C07C311/08 , C07D519/00 , C07F5/04 , C07F5/02
CPC分类号： A61K31/519 , C07C303/38 , C07C311/08 , C07D487/04 , C07D519/00 , C07F5/025 , C07F5/04
摘要： Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.

2. 发明授权

US09755315B2 Antenna arrangement 有权
公开(公告)号：US09755315B2
公开(公告)日：2017-09-05
申请号：US13984624
申请日：2011-02-10
申请人： Wanbo Xie , Jie Zhang , Wei He
发明人： Wanbo Xie , Jie Zhang , Wei He
IPC分类号： H01Q13/10 , H01Q1/48 , H01Q21/28
CPC分类号： H01Q13/106 , H01Q1/243 , H01Q1/48 , H01Q21/28 , H01Q21/30
摘要： The Figures illustrate an apparatus 2 comprising: a conductive element 4 comprising an area of conductive material 5 defined by a plurality of edges 6, 7 including a first edge 7 wherein the conductive element 4 comprises an interior aperture 12 in the area of conductive material 5 and an elongate portion 20 defined by a gap 14 at the first edge 7 of the conductive element 4 and by at least a portion of the interior aperture 12. The apparatus 2 may comprise a further interior aperture in the area of conductive material and a second elongate portion defined by a second gap, by at least a portion of the interior aperture and by at least a portion of the further interior aperture.

3. 发明授权

US09484577B2 Positive electrode materials for lithium ion batteries and process for preparing the same 有权
标题翻译：锂离子电池正极材料及其制备方法
公开(公告)号：US09484577B2
公开(公告)日：2016-11-01
申请号：US13141368
申请日：2009-12-22
申请人： Xin Teng , Wei He , Ming He , Ruyu Rao , Bin Xiao , Qiming Pan
发明人： Xin Teng , Wei He , Ming He , Ruyu Rao , Bin Xiao , Qiming Pan
IPC分类号： H01M4/131 , H01M4/1391 , H01M4/505 , H01M4/525 , H01M10/0525 , H01M4/36 , H01M4/485
CPC分类号： H01M4/505 , H01M4/1391 , H01M4/364 , H01M4/366 , H01M4/485 , H01M4/525 , H01M10/0525 , Y02E60/122 , Y02P70/54
摘要： Provided are a positive electrode material for lithium ion batteries and a process for preparing the same. The positive electrode material for lithium ion batteries comprises a composite positive electrode material consists of LiCoO2 and an auxiliary positive electrode material, the general formula of the auxiliary positive electrode material is LiCo1-x-yNixMnyO2, wherein 0
摘要翻译：提供了一种用于锂离子电池的正极材料及其制备方法。用于锂离子电池的正极材料包括由LiCoO 2和辅助正极材料组成的复合正极材料，辅助正极材料的通式为LiCo1-x-yNixMnyO2，其中0

4. 发明授权

US09331887B2 Peer-aware ranking of voice streams 有权
标题翻译：语音流的对等感知排名
公开(公告)号：US09331887B2
公开(公告)日：2016-05-03
申请号：US11277932
申请日：2006-03-29
申请人： Li-wei He , Dinei A. Florencio , Xun Xu
发明人： Li-wei He , Dinei A. Florencio , Xun Xu
IPC分类号： H04L12/16 , H04L29/06 , H04L12/66
CPC分类号： H04L29/06027 , H04L12/66 , H04L65/403 , H04L65/4038
摘要： A peer-aware voice stream ranking method that makes decisions based on information about participants of a voice conference over a network. Whether to send a participant's own audio packet out on the network is based both on information about the participant's own voice packet and voice packets that the participant receives from other clients. A Voice Activity Score (VAS) is computed for each frame of a particular voice stream. The VAS includes a voiceness component, indicating the likelihood that the audio frame contains speech or voice, and an energy level component that indicating the ratio of current frame energy to the long-term average of energy for a current speaker. Using the VAS from the participants, the method also ranks the client's voice stream as compared to other clients' voice streams in the voice conference. If there are participants higher ranking, the client's voice stream is not sent.
摘要翻译：基于通过网络进行语音会议的参与者的信息进行决策的对等感知语音流排序方法。是否在网络上发送参与者自己的音频数据包都是基于参与者自己的语音数据包和参与者从其他客户端收到的语音数据包的信息。为特定语音流的每个帧计算语音活动分数（VAS）。 VAS包括声音分量，指示音频帧包含语音或语音的可能性，以及指示当前帧能量与当前说话者的长期能量平均值的比率的能量分量。使用来自参与者的VAS，与语音会议中的其他客户端的语音流相比，该方法还对客户端的语音流进行排序。如果参与者排名较高，则不会发送客户端的语音流。

5. 发明授权

US08987779B2 Electrostatic discharge protection device 有权
标题翻译：静电放电保护装置
公开(公告)号：US08987779B2
公开(公告)日：2015-03-24
申请号：US13304383
申请日：2011-11-24
申请人： Qi-An Xu , Chieh-Wei He
发明人： Qi-An Xu , Chieh-Wei He
IPC分类号： H01L29/73 , H01L27/02 , H01L29/74
CPC分类号： H01L27/0262 , H01L29/7436
摘要： An ESD protection device including second P-type wells, first P+-type doped regions, first N+-type doped regions and a P-type substrate having a first P-type well, an N-type well and an N-type deep well is provided. The second P-type wells are disposed in the N-type deep well. The first P+-type doped regions and the first N+-type doped regions are respectively disposed in the first P-type well, the N-type well and the second P-type wells in alternation. The first P+-type doped region in the N-type well and the N-type deep well are electrically connected to the first connection terminal. The doped regions in the first P-type well and the P-type substrate are electrically connected to the second connection terminal. The second P-type wells and the first N+-type doped regions therein form a diode string connected in series between the first N+-type doped region of the N-type well and the second connection terminal.
摘要翻译：一种ESD保护装置，包括第二P型阱，第一P +型掺杂区，第一N +型掺杂区和具有第一P型阱，N型阱和N型阱的P型衬底被提供。第二个P型井设置在N型深井中。第一P +型掺杂区和第一N +型掺杂区分别设置在第一P型阱，N型阱和第二P型阱中。 N型阱和N型深阱中的第一P +型掺杂区域电连接到第一连接端子。第一P型阱和P型衬底中的掺杂区域电连接到第二连接端子。第二P型阱和其中的第一N +型掺杂区形成串联连接在N型阱的第一N +型掺杂区和第二连接端之间的二极管串。

6. 发明授权

US08942008B2 Electronic device with riser card 有权
标题翻译：带转接卡的电子设备
公开(公告)号：US08942008B2
公开(公告)日：2015-01-27
申请号：US13474810
申请日：2012-05-18
申请人： Yu-Wei He , Wen-Da Zhang
发明人： Yu-Wei He , Wen-Da Zhang
IPC分类号： H05K7/02 , G06F1/18 , H05K7/04 , H05K1/14
CPC分类号： G06F1/183
摘要： An electronic device includes a chassis, a mounting assembly, and an assisting member. The mounting assembly is secured to the chassis and includes a circuit board and a connector secured to the circuit board. The signal module is secured to the chassis and includes a signal card, and the signal card is engaged with the connector. The assisting member is secured to a first end of the mounting assembly and includes an assisting corner. The assisting corner abuts the signal module. The connector is located between the assisting corner and a second end of the mounting assembly, which is opposite to the first end. The second end rotates about the assisting corner, and the connector disengages from the signal card when the second end is rotated about the assisting corner.
摘要翻译：电子设备包括底盘，安装组件和辅助构件。安装组件固定到底盘，并且包括电路板和固定到电路板的连接器。信号模块固定在机箱上，并包括一个信号卡，信号卡与连接器接合。辅助构件被固定到安装组件的第一端并且包括辅助角。辅助转角邻接信号模块。连接器位于辅助角与安装组件的与第一端相对的第二端之间。第二端围绕辅助角旋转，并且当第二端围绕辅助角转动时，连接器与信号卡脱离。

7. 发明授权

US08902887B2 Load-balancing structure for packet switches and its constructing method 有权
标题翻译：分组交换机的负载均衡结构及其构建方法
公开(公告)号：US08902887B2
公开(公告)日：2014-12-02
申请号：US12739729
申请日：2009-10-31
申请人： Hui Li , Wei He , Shuoyan Li , Jiaqing Huang , Jian Chen , Kai Pan , Shuxin Zhang , Peng Yi , Binqiang Wang
发明人： Hui Li , Wei He , Shuoyan Li , Jiaqing Huang , Jian Chen , Kai Pan , Shuxin Zhang , Peng Yi , Binqiang Wang
IPC分类号： H04L12/28 , H04L12/939 , H04L12/933
CPC分类号： H04L49/101 , H04L49/552
摘要： This invention provides a load-balancing structure for packet switches and its constructing method. In this method, the structure based on self-routing concentrators is divided into two stages, that is, a first stage and a second stage fabric. A virtual output group queue (VOGQ) is appended to each input group port of the first stage fabric, and a reordering buffer (RB) is configured behind each output group port of the second stage fabric. Packets stored in the VOGQ are combined into data blocks with preset length, which is divided into data slices of fixed size, finally each data slice is added an address tag and is delivered to the first stage fabric for self-routing. Once reaching the RB, data slices are recombined into data blocks. This invention solves the packet out-of-sequence problem in the load-balancing Birkhoff-von Neumann switching structure and improves the end-to-end throughput.
摘要翻译：本发明提供了分组交换机的负载平衡结构及其构造方法。在这种方法中，基于自路由集中器的结构分为两个阶段，即第一阶段和第二阶段结构。将虚拟输出组队列（VOGQ）附加到第一级结构的每个输入组端口，并且在第二级结构的每个输出组端口之后配置重新排序缓冲器（RB）。存储在VOGQ中的数据包被组合成具有预设长度的数据块，其被划分为固定大小的数据片段，最后每个数据片段添加地址标签，并且被递送到第一级结构以进行自路由。一旦到达RB，数据切片被重新组合成数据块。本发明解决了负载平衡Birkhoff-von Neumann交换结构中的分组失序问题，提高了端到端吞吐量。

8. 发明申请

US20140288071A1 INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE 审中-公开
标题翻译：酚类化合物的抑制剂及其使用方法
公开(公告)号：US20140288071A1
公开(公告)日：2014-09-25
申请号：US14300281
申请日：2014-06-10
申请人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Wei HE , Victoria LOMBARDO , Praveen PABBA , James TARVER, JR.
发明人： Joseph BARBOSA , Kenneth Gordon CARSON , Michael Walter GARDYAN , Wei HE , Victoria LOMBARDO , Praveen PABBA , James TARVER, JR.
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein.
摘要翻译：公开了用于治疗，管理和预防影响骨骼的疾病和病症的化合物。特殊的化合物是Notum果胶乙酰酯酶的有效抑制剂，具有下式：其中E，G，Y，Z，R 1，R 2和R 3在本文中定义。

9. 发明授权

US08685752B2 Ex vivo flow cytometry method and device 有权
标题翻译：离体流式细胞术方法及装置
公开(公告)号：US08685752B2
公开(公告)日：2014-04-01
申请号：US12513028
申请日：2007-11-02
申请人： Philip Stewart Low , Wei He , Sumith A Kularatne
发明人： Philip Stewart Low , Wei He , Sumith A Kularatne
IPC分类号： G01N33/82 , G01N31/22 , A61K38/00
CPC分类号： G01N33/582 , G01N15/1459 , G01N15/1463 , G01N33/5091 , G01N33/574 , G01N33/57434 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2458/00
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X, wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
摘要翻译：本发明涉及诊断由致病细胞介导的疾病状态的方法。该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，并使用流式细胞术检测表达配体受体的致病细胞。

10. 发明授权

US08640330B2 Extracting apparatus for storage device module 有权
标题翻译：存储设备模块提取装置
公开(公告)号：US08640330B2
公开(公告)日：2014-02-04
申请号：US12608948
申请日：2009-10-29
申请人： Wen-Tang Peng , Mo-Ming Yu , Lei Zheng , Xiang-Wei He
发明人： Wen-Tang Peng , Mo-Ming Yu , Lei Zheng , Xiang-Wei He
IPC分类号： H05K7/14
CPC分类号： H05K7/1411 , G11B33/124 , Y10T29/53283
摘要： An extracting apparatus is disclosed. The extracting apparatus includes a mounting member, a handle pivotably connected to the mounting member, a latch member fixed to the mounting member and comprising a latch portion locked to the handle, and a release member slidably mounted to the mounting member and comprising an engaging portion for engaging with the latch member to deform the latch portion of the latch member, thereby releasing the latch portion from the handle.
摘要翻译：公开了一种提取装置。提取装置包括安装构件，可枢转地连接到安装构件的手柄，固定到安装构件的闩锁构件，并且包括锁定到手柄的闩锁部分，以及可滑动地安装到安装构件的释放构件，用于与闩锁构件接合以使闩锁构件的闩锁部分变形，从而将闩锁部分从手柄释放。

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