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1. 发明授权

US10071956B2 Process for the preparation of dibenzenesulfonimide 有权
公开(公告)号：US10071956B2
公开(公告)日：2018-09-11
申请号：US15326379
申请日：2015-07-15
申请人： SRF Limited
发明人： Thirupathi Arumugam , Mariano Patrick Philips , Dilli Babu , Maheshwaran Chellaiah , Sarathy Iyengar , Rajdeep Anand
IPC分类号： C07C303/38 , C07C311/48
CPC分类号： C07C303/38 , C07C311/48
摘要： The present invention provides a process for the preparation of dibenzenesulfonimide.

2. 发明申请

US20180251423A1 1-SULFONAMIDO-4-ARYLOXY COMPOUNDS, AND PREPARATION METHOD AND MEDICINAL APPLICATION THEREOF 审中-公开
公开(公告)号：US20180251423A1
公开(公告)日：2018-09-06
申请号：US15755356
申请日：2016-11-25
申请人： CHINA PHARMACEUTICAL UNIVERSITY
发明人： Qidong YOU , Zhengyu JIANG , Mengchen LU , Zhiyun CHEN , Haopeng SUN , Xiaojin ZHANG , Xiaoke GUO , Xiaoli XU
IPC分类号： C07C311/21 , C07C303/08 , A61P3/10 , A61P9/10 , A61P11/00 , A61P25/16 , A61P25/28
CPC分类号： C07C311/21 , A61P3/10 , A61P9/10 , A61P11/00 , A61P25/16 , A61P25/28 , C07C303/08 , C07C303/38 , C07C311/29 , C07C311/46 , C07D257/04
摘要： Compounds of formula (I) having 1-sulfonamido-4-aryloxy as a basic backbone. A preliminary activity test showed that the compounds provide excellent interference of a binding of Nrf2 by Keap1, thereby activating Nrf2. The compounds have a potential anti-inflammatory activity and can be used to treat a plurality of inflammation-associated diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, gastroenteritis, rheumatoid arthritis, and the like.

3. 发明授权

US09861977B2 Multi-acid polymers and methods of making the same 有权
公开(公告)号：US09861977B2
公开(公告)日：2018-01-09
申请号：US15078209
申请日：2016-03-23
申请人： NISSAN NORTH AMERICA, INC.
发明人： Rameshwar Yadav
IPC分类号： H01M8/10 , C08G75/30 , B01J39/18 , C07C311/09 , C07C303/38 , C07C311/11 , C08G61/12 , C08F114/26 , B01J39/04 , B01J39/20 , H01M8/0239
CPC分类号： B01J39/20 , B01J39/05 , B01J41/12 , C07C303/38 , C07C303/40 , C07C311/09 , C07C311/11 , C08F8/30 , C08F8/34 , C08F114/26 , C08G61/121 , C08G2261/1452 , C08G2261/334 , C08G2261/516 , C08G2261/74 , H01M8/0239 , H01M8/103 , H01M8/1032 , H01M8/1039 , H01M2250/20 , Y02T90/32 , C07C311/48
摘要： A multi-acid monomer disclosed herein has the formula wherein R is one or more units of a non-SO2F or non-SO2Cl portion of a polymer precursor in sulfonyl fluoride or sulfonyl chloride form, X is a non-sulfonyl halide group of a multi-sulfonyl halide compound having a minimum of two acid giving groups, and Y is remaining sulfonyl halide groups of the multi-sulfonyl halide compound.

4. 发明申请

US20170210912A1 HYDROPHILIC OIL REPELLENT AND PRODUCTION METHOD OF SAME, SURFACE COATING MATERIAL, COATING FILM, RESIN COMPOSITION, OIL-WATER SEPARATION FILTER MATERIAL, AND POROUS BODY 审中-公开
公开(公告)号：US20170210912A1
公开(公告)日：2017-07-27
申请号：US15329408
申请日：2015-07-29
申请人： MITSUBISHI MATERIALS CORPORATION , Mitsubishi Materials Electronic Chemicals Co., Ltd.
发明人： Masato Fujita , Masakazu Uotani , Takeshi Kamiya , Tsunetoshi Honda , Daisuke Takano
IPC分类号： C09D5/16 , B01D17/02 , C09D7/00 , C07C229/12 , C07C227/16 , C07C233/05 , C07C231/02 , C07C311/05 , C07C303/38 , C07C309/13 , C07C303/02 , C07D211/38 , C07D265/30 , C07D207/10 , C07D241/04 , C02F1/40
CPC分类号： C09D5/1625 , B01D17/02 , C02F1/40 , C07C227/06 , C07C227/08 , C07C227/16 , C07C227/18 , C07C229/06 , C07C229/12 , C07C231/02 , C07C231/12 , C07C233/05 , C07C233/08 , C07C303/02 , C07C303/22 , C07C303/38 , C07C303/40 , C07C309/04 , C07C309/13 , C07C309/29 , C07C311/03 , C07C311/05 , C07D207/10 , C07D211/38 , C07D241/04 , C07D265/30 , C08K5/17 , C08L101/00 , C09D5/16 , C09D7/20 , C09D7/40 , C09D201/00 , C09K3/00 , Y02W10/37
摘要： The hydrophilic oil repellent includes one or more types of nitrogen-containing fluorine-based compounds. The nitrogen-containing fluorine-based compound includes any one hydrophilicity imparting group selected from the group consisting of anion type hydrophilicity imparting groups, cation type hydrophilicity imparting groups, and amphoteric type hydrophilicity imparting groups in the molecule.

5. 发明申请

US20160200730A1 POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS 有权
标题翻译：作为BRUTON酪氨酸激酶抑制剂的多氟化合物
公开(公告)号：US20160200730A1
公开(公告)日：2016-07-14
申请号：US15075033
申请日：2016-03-18
申请人： Wei He
发明人： Wei He
IPC分类号： C07D487/04
CPC分类号： A61K31/519 , C07C303/38 , C07C311/08 , C07D487/04 , C07D519/00 , C07F5/025 , C07F5/04
摘要： Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.
摘要翻译：本文描述了一系列新的多氟取代的吡唑并嘧啶化合物或其盐。这些化合物是Bruton的酪氨酸激酶（BTK）抑制剂。这些化合物可具有更好的BTK抑制选择性和药代动力学性质。本文公开了这些化合物的合成方法。本文公开了多氟取代的二苯甲酮和取代的苯氧基苯的新型合成方法。还公开了包含本文所述的BTK抑制剂的药物组合物。本发明还涉及包含本文所述的化合物作为活性成分的药物制剂。本发明还包括通过施用BTK抑制剂及其制剂来治疗和抑制自身免疫性疾病，超敏反应性疾病，炎性疾病和癌症的治疗方法。

6. 发明申请

US20140200362A1 A NOVEL PROCESS FOR THE PREPARATION OF N-(4-NITRO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER AND N-(4-AMINO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER 有权
标题翻译：制备N-（4-硝基-2-磺酰基 - 苯基） - 马来酸甲酯和N-（4-氨基-2-磺酰基 - 苯基） - 马来酸甲酯的新方法
公开(公告)号：US20140200362A1
公开(公告)日：2014-07-17
申请号：US14153878
申请日：2014-01-13
申请人： Hoffmann-La Roche Inc.
发明人： Jiang Zhu
IPC分类号： C07C303/40
CPC分类号： C07C303/40 , C07C303/38 , C07C311/46 , C07C311/39
摘要： The present invention provides a novel method for preparing compounds N-(4-nitro-2-sulfamoyl-phenyl)-malonamic acid methyl ester and N-(4-amino-2-sulfamoyl-phenyl)-malonamic acid methyl ester, which are novel intermediates for preparing a key intermediate N-(4-methanesulfonylamino-2-sulfamoyl-phenyl)-malonamic acid methyl ester, for the preparation of N-(3-{(1R,2S,7R,8S)-3-[(4-fluorophenyl)methyl]-6-hydroxy-4-oxo-3-azatricyclo [6.2.1.02,7]undec-5-en-5-yl}-1,1-dioxo-1,4-dihydro-1λ6,2,4-benzothiadiazin-7-yl)methanesulfonamide, also known commercially as Setrobuvir, a compound useful in treating hepatitis C.
摘要翻译：本发明提供了制备化合物N-（4-硝基-2-氨磺酰基 - 苯基） - 丙酰甲酸甲酯和N-（4-氨基-2-氨磺酰基 - 苯基） - 丙酰甲酸甲酯的新方法，它们是用于制备N-（3 - {（1R，2S，7R，8S）-3 - [（1R，2R）-3-甲氧基苯基） - 丙酰胺酸甲酯的关键中间体N-（4-甲磺酰氨基-2-氨磺酰基 - 苯基） 4-氟苯基）甲基] -6-羟基-4-氧代-3-氮杂三环[6.2.1.02,7]十一碳-5-烯-5-基} -1,1-二氧代-1,4-二氢-1λ6， 2,4-苯并噻二嗪-7-基）甲磺酰胺，也称为Setrobuvir，一种可用于治疗丙型肝炎的化合物。

7. 发明授权

US08685616B2 Photoacid generators and lithographic resists comprising the same 有权
标题翻译：光生酸产生剂和包含其的光刻抗蚀剂
公开(公告)号：US08685616B2
公开(公告)日：2014-04-01
申请号：US12997132
申请日：2009-06-10
申请人： Kenneth E. Gonsalves , Mingxing Wang
发明人： Kenneth E. Gonsalves , Mingxing Wang
IPC分类号： G03F7/004 , C07C303/38 , G03F7/039
CPC分类号： G03F7/027 , C07C303/38 , C07C309/65 , C07C309/73 , C07C309/75 , C07C311/48 , C07C381/12 , C07C2602/42 , C07D333/46 , G03F7/0045 , G03F7/0046 , G03F7/039 , G03F7/0397 , Y10S430/106 , Y10S430/12 , Y10S430/122 , Y10S430/123
摘要： The present invention provides photoacid generators for use in chemically amplified resists and lithographic processes using the same.
摘要翻译：本发明提供用于化学放大抗蚀剂的光酸产生剂和使用其的光刻法。

8. 发明授权

US08513443B2 Preparation of (R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)-N-3,4-difluoro-2(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide 有权
标题翻译：（R）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（2,3-二羟基丙基）环丙烷-1-磺酰胺和（S） -N-3,4-二氟-2（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（2,3-二羟基丙基）环丙烷-1-磺酰胺
公开(公告)号：US08513443B2
公开(公告)日：2013-08-20
申请号：US13386519
申请日：2010-07-10
申请人： Andreas Maderna , Jean-Michel Vernier
发明人： Andreas Maderna , Jean-Michel Vernier
IPC分类号： C07D317/10
CPC分类号： C07C303/38 , C07C317/18 , C07C2601/02 , C07D317/18 , C07D317/26 , C07C311/28
摘要： The present invention relates to the preparation of (R)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide.
摘要翻译：本发明涉及制备（R）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（2,3-二羟基丙基）环丙烷-1 - 磺酰胺和（S）-N-（3,4-二氟-2-（2-氟-4-碘苯基氨基）-6-甲氧基苯基）-1-（2,3-二羟丙基）环丙烷-1-磺酰胺。

9. 发明申请

US20130172295A1 PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS 审中-公开
标题翻译：制备HIV蛋白酶抑制剂的方法
公开(公告)号：US20130172295A1
公开(公告)日：2013-07-04
申请号：US13779188
申请日：2013-02-27
申请人： Gilead Sciences, Inc.
发明人： Kenneth R. Crawford , Eric D. Dowdy , Arnold Gutierrez , Richard P. Polniaszek , Richard Hung Chiu Yu
IPC分类号： C07F9/6561 , A61K31/665 , C07C311/29 , C07D493/04 , C07C51/41
CPC分类号： C07F9/6561 , A61K31/665 , C07C51/412 , C07C253/30 , C07C303/38 , C07C303/40 , C07C311/29 , C07D493/04 , C07F9/4006 , C07F9/4075 , C07F9/4084 , C07C255/60
摘要： A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed
摘要翻译：因此公开了用于制备抗病毒HIV蛋白酶抑制剂化合物的双呋喃中间体的合成方法

10. 发明申请

US20120258935A1 PROCESS FOR PREPARATION OF HIV PROTEASE INHBITORS 有权
标题翻译：制备艾滋病毒蛋白酶抑制剂的方法
公开(公告)号：US20120258935A1
公开(公告)日：2012-10-11
申请号：US13401659
申请日：2012-02-21
申请人： Kenneth R. Crawford , Eric D. Dowdy , Arnold Gutierrez , Richard P. Polniaszek , Richard Hung Chiu Yu
发明人： Kenneth R. Crawford , Eric D. Dowdy , Arnold Gutierrez , Richard P. Polniaszek , Richard Hung Chiu Yu
IPC分类号： C07F9/655 , A61P31/18 , A61K31/665 , A61P31/12 , C07C311/47 , C07C311/37
CPC分类号： C07F9/6561 , A61K31/665 , C07C51/412 , C07C253/30 , C07C303/38 , C07C303/40 , C07C311/29 , C07D493/04 , C07F9/4006 , C07F9/4075 , C07F9/4084 , C07C255/60
摘要： A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed
摘要翻译：因此公开了用于制备抗病毒HIV蛋白酶抑制剂化合物的双呋喃中间体的合成方法

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