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1. 发明申请

US20170197968A1 Compositions and Methods for Inhibiting BMP 审中-公开
公开(公告)号：US20170197968A1
公开(公告)日：2017-07-13
申请号：US15326262
申请日：2015-07-14
申请人： Arthur LEE , John C. MCKEW , Paresma R. PATEL , Paul B. YU , Agustin H. MOHEADS , Philip E. SANDERSON , Wei ZHENG , Xiuli HUANG , THE BRIGHAM AND WOMEN'S HOSPITLAL, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN , UNIVERSITY OF HOUSTON SYSTEM
发明人： Arthur Lee , John C. McKew , Paresma R. Patel , Paul B. Yu , Agustin H. Mohedas , Philip E. Sanderson , Gregory D. Cuny , Wei Zheng , Xiuli Huang
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.

2. 发明申请

US20170190582A1 Novel Methods To Grow Two Dimensional Nano-Materials By Using Solid-State Materials as Feedstock 审中-公开
公开(公告)号：US20170190582A1
公开(公告)日：2017-07-06
申请号：US15396740
申请日：2017-01-02
申请人： Wenjie Fu , Wei Zheng
发明人： Wenjie Fu , Wei Zheng
IPC分类号： C01B31/02 , C23C16/511 , C23C16/26
CPC分类号： C23C14/0605 , B82Y30/00 , B82Y40/00 , C01B32/184 , C01B32/20 , C23C14/32 , H01J37/32091 , H01J37/321 , H01J37/32192 , H01J37/3414 , H01J37/3426 , Y10S977/734 , Y10S977/843
摘要： This invention is particularly addressing a novel method to grow two dimensional carbon nanomaterials. Using our technologies, only solid state carbon sources are used as feedstock to grow this kind of carbon nanomaterials, while no hydrocarbon gases or other carbon contained gases are required as feedstock. This invention can also be applied to grow non-carbon-based two dimensional nanomaterials, with obvious advantages of reducing manufacturing cost and enhancing growth rate.

3. 发明申请

US20170170486A1 Fuel Cells Using Vertically Free Standing Graphene and Carbon Nanosheets 审中-公开
公开(公告)号：US20170170486A1
公开(公告)日：2017-06-15
申请号：US15374712
申请日：2016-12-09
申请人： Wei Zheng , Xin Zhao
发明人： Wei Zheng , Xin Zhao
IPC分类号： H01M4/92 , H01M4/96 , H01M4/86
CPC分类号： H01M4/926 , H01M4/8673 , H01M8/0213 , H01M8/0234 , H01M8/1051
摘要： This disclosure is about invention of fuel cells comprising vertically free-standing graphene and carbon nanosheets in the components, and methods of making thereof. Performance enhancement effect of the fuel cell is achieved by using: an electrically conducting component whose surface is covered by vertically free-standing graphene and carbon nanosheets; and/or a catalyst supporting structure made of vertically free-standing graphene and carbon nanosheets; and/or a catalyst based on vertically free-standing graphene and carbon nanosheets. Layers of fuel cells embedded with vertically free-standing graphene and carbon nanosheets can be mechanically strengthened. Vertically free-standing graphene and carbon nanosheets embedded in the electrodes can also enhance the electrical conductivity.

4. 发明授权

US09075692B2 Method, device and system for activating on-line patch 有权
标题翻译：用于激活在线补丁的方法，设备和系统
公开(公告)号：US09075692B2
公开(公告)日：2015-07-07
申请号：US13336227
申请日：2011-12-23
申请人： Jiaqiang Yu , Wei Zheng
发明人： Jiaqiang Yu , Wei Zheng
IPC分类号： G06F9/445
CPC分类号： G06F8/67 , G06F8/656
摘要： Embodiments of the present invention provide a method, a device and a system for activating an on-line patch. The method comprises: positioning an address of a patch function and an entry address of a to-be-patched function; writing, in a middle segment, a long-jump instruction for jumping to the patch function based on the address of the patch function and the entry address of the to-be-patched function, where the middle segment is a storage space, which is located before or after the entry position of the to-be-patched function and can at least store one long-jump instruction; and modifying an instruction at the entry position of the to-be-patched function to a short-jump instruction for jumping to the middle segment, so as to jump to the middle segment after the short jump instruction is executed, and then to jump to and execute the patch function through that instructions in the middle segment are executed.
摘要翻译：本发明的实施例提供一种用于激活在线补丁的方法，装置和系统。该方法包括：定位补丁功能的地址和待修补功能的入口地址; 在中间段中，根据补丁功能的地址和待修补功能的入口地址写入跳转到补丁功能的长跳转指令，其中中间段是存储空间，其中位于待修补功能的入口位置之前或之后，并且可以至少存储一个长跳转指令; 并且将待修补功能的入口位置处的指令修改为跳转到中间段的短跳转指令，以便在执行短跳转指令之后跳转到中间段，然后跳转到并通过中间段的指令执行补丁功能。

5. 发明授权

US09044451B2 Use of delta tocopherol for the treatment of lysosomal storage disorders 有权
标题翻译：使用δ生育酚来治疗溶酶体贮积病
公开(公告)号：US09044451B2
公开(公告)日：2015-06-02
申请号：US13810774
申请日：2011-07-19
申请人： Wei Zheng , Juan Jose Marugan , Ke Liu , Noel Terrence Southall , Christopher P Austin
发明人： Wei Zheng , Juan Jose Marugan , Ke Liu , Noel Terrence Southall , Christopher P Austin
IPC分类号： A61K31/355 , A61K31/724 , A61K45/06 , A61K31/36 , A61K31/496 , A61K36/185
CPC分类号： A61K31/355 , A61K31/36 , A61K31/496 , A61K31/724 , A61K36/185 , A61K45/06 , A61K2300/00
摘要： This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of delta tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol in combination with cyclodextrin to a patient in need thereof.
摘要翻译：本公开一般涉及溶酶体储存障碍的治疗。具体地，本公开涉及δ生育酚在治疗与溶酶体贮积障碍相关的疾病和病症中的新用途。本公开内容包括调节胆固醇回收的方法。此外，本公开涉及诸如Niemann-Pick C型疾病，Farber病，Niemann-Pick型A型疾病，Wolman病和Tay Sachs病的病症。本公开内容中还包括用于治疗包括施用δ-生育酚的溶酶体储存障碍的方法。本公开内容中还包括用于治疗溶酶体贮积障碍的方法，其包括与需要的患者一起向环糊精施用δ-生育酚。

6. 发明申请

US20140249145A1 SUBSTITUTED PYRAZOLOPYRIMIDINES AS GLUCOCEREBROSIDASE ACTIVATORS 有权
标题翻译：取代的吡唑并嘧啶作为葡萄糖激酶
公开(公告)号：US20140249145A1
公开(公告)日：2014-09-04
申请号：US13991816
申请日：2011-12-08
申请人： Juan Jose Marugan , Noel Southall , Ehud Goldin , Wei Zheng , Samarjit Patnaik , Ellen Sidransky , Omid Motabar , Wendy Westbroek
发明人： Juan Jose Marugan , Noel Southall , Ehud Goldin , Wei Zheng , Samarjit Patnaik , Ellen Sidransky , Omid Motabar , Wendy Westbroek
IPC分类号： C07D487/04
CPC分类号： A61K31/519 , A61K31/5377 , A61P43/00 , C07D487/04
摘要： Substituted pyrazolopyrimidines and dihydropyrazolopyrimidines and related compounds, their methods of manufacture, compositions containing these compounds, and methods of use of these compounds in treating lysosomal storage disorders such as Gaucher disease are described herein. The compounds are of general Formula (I) in which variables R1-R7 and X are described in the application.
摘要翻译：本文描述了取代的吡唑并嘧啶和二氢吡唑并嘧啶及其相关化合物，其制备方法，含有这些化合物的组合物，以及这些化合物在治疗溶酶体贮积症如戈谢病中的应用方法。化合物是通式（I），其中变量R1-R7和X在本申请中描述。

7. 发明授权

US08705563B2 Method, combiner and system for transmitting signals 有权
标题翻译：用于发送信号的方法，组合器和系统
公开(公告)号：US08705563B2
公开(公告)日：2014-04-22
申请号：US13529956
申请日：2012-06-21
申请人： Pingjing Wang , Wei Zheng , Jian Shen , Jianjun Chen
发明人： Pingjing Wang , Wei Zheng , Jian Shen , Jianjun Chen
IPC分类号： H04J3/16
CPC分类号： H04L41/0213 , H04L41/06 , H04L69/324 , H04W88/085
摘要： Methods and apparatus are provided for receiving AISG protocol signals sent by one or more local devices and adding corresponding labels to the AISG protocol signals, where the labels are used to identify mapping relationships between the local devices that send the AISG protocol signals and peer devices. The AISG protocol signals to which the labels have been added are packed into data packet and sent to a peer combiner through a shared feeder. The peer combiner unpacks the data packet and sends the AISG protocol signals to corresponding peer devices according to the labels added to the AISG protocol signals.
摘要翻译：提供了用于接收由一个或多个本地设备发送的AISG协议信号的方法和装置，并向AISG协议信号添加相应的标签，其中标签用于标识发送AISG协议信号的本地设备和对等设备之间的映射关系。已经添加了标签的AISG协议信号被打包到数据分组中，并通过共享馈线发送到对等体组合器。对等组合器根据添加到AISG协议信号的标签，对数据包进行解包，并将AISG协议信号发送给相应的对等设备。

8. 发明授权

US08691647B1 Memory devices containing a high-K dielectric layer 有权
标题翻译：包含高K电介质层的存储器件
公开(公告)号：US08691647B1
公开(公告)日：2014-04-08
申请号：US10927692
申请日：2004-08-27
申请人： Wei Zheng , Arvind Halliyal , Mark T. Ramsbey , Jack F. Thomas
发明人： Wei Zheng , Arvind Halliyal , Mark T. Ramsbey , Jack F. Thomas
IPC分类号： H01L21/336
CPC分类号： H01L21/28273 , H01L21/28282 , H01L29/513 , H01L29/517 , H01L29/7881
摘要： In one embodiment, a semiconductor device is disclosed. The semiconductor device is formed on a semiconductor substrate having an active region, the semiconductor device comprising: a gate dielectric layer disposed on the semiconductor substrate, the gate dielectric layer having at least two sub-layers with at least one sub-layer having a dielectric constant greater than SiO2; a floating gate formed on the gate dielectric layer defining a channel interposed between a source and a drain formed within the active region of the semiconductor substrate; a control gate formed above the floating gate; and an intergate dielectric layer interposed between the floating gate and the control gate, the intergate dielectric layer comprising: a first layer formed on the floating gate; a second layer formed on the first layer; and a third layer formed on the second layer, wherein each of the first, second and third layers has a dielectric constant greater than SiO2.
摘要翻译：在一个实施例中，公开了一种半导体器件。所述半导体器件形成在具有有源区的半导体衬底上，所述半导体器件包括：栅极电介质层，其设置在所述半导体衬底上，所述栅极电介质层具有至少两个具有至少一个具有电介质的子层的子层常数大于SiO2; 形成在所述栅介质层上的浮置栅极，限定插入在所述半导体衬底的有源区域内形成的源极和漏极之间的沟道; 形成在浮动栅极上方的控制栅极; 以及插入在所述浮置栅极和所述控制栅极之间的隔间介电层，所述栅极间介电层包括：形成在所述浮动栅极上的第一层; 形成在所述第一层上的第二层; 以及形成在第二层上的第三层，其中第一层，第二层和第三层中的每一层具有大于SiO 2的介电常数。

9. 发明申请

US20140004082A1 METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBFBETA AND RUNX1 PROTEINS 有权
标题翻译：治疗由CBFBETA和RUNX1蛋白介导的白血病和疾病的方法
公开(公告)号：US20140004082A1
公开(公告)日：2014-01-02
申请号：US14005534
申请日：2012-03-15
申请人： Pu Liu , Wei Zheng , Juan Marugan , Noel T. Southall , Lea Cunningham
发明人： Pu Liu , Wei Zheng , Juan Marugan , Noel T. Southall , Lea Cunningham
IPC分类号： A61K31/5513 , A61K45/06 , A61K31/40
CPC分类号： A61K31/5513 , A61K31/203 , A61K31/40 , A61K31/417 , A61K31/704 , A61K31/7068 , A61K31/7076 , A61K38/2013 , A61K45/06 , Y10S514/908 , A61K2300/00
摘要： A method for treating core binding factor (CBF) leukemia in a subject, comprising administering to a subject having CBF leukemia a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt or ester thereof, that inhibits CBFβ and RUNX1 binding in the subject, thereby treating the CBF leukemia.
摘要翻译：一种用于治疗受试者中的核心结合因子（CBF）白血病的方法，包括向具有CBF白血病的受试者施用治疗有效量的抑制受试者中CBFbeta和RUNX1结合的化合物或其药学上可接受的盐或酯，从而治疗CBF白血病。

10. 发明申请

US20130123214A1 USE OF DELTA TOCOPHEROL FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS 有权
标题翻译：使用DELTA TOCOPHEROL治疗LYSOSOMAL存活障碍
公开(公告)号：US20130123214A1
公开(公告)日：2013-05-16
申请号：US13810774
申请日：2011-07-19
申请人： Wei Zheng , Juan Jose Marugan , Ke Liu , Noel Terrence Southall , Christopher P. Austin
发明人： Wei Zheng , Juan Jose Marugan , Ke Liu , Noel Terrence Southall , Christopher P. Austin
IPC分类号： A61K31/355 , A61K31/724 , A61K45/06
CPC分类号： A61K31/355 , A61K31/36 , A61K31/496 , A61K31/724 , A61K36/185 , A61K45/06 , A61K2300/00
摘要： This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of delta tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of delta tocopherol in combination with cyclodextrin to a patient in need thereof.
摘要翻译：本公开一般涉及溶酶体储存障碍的治疗。具体地，本公开涉及δ生育酚在治疗与溶酶体贮积障碍相关的疾病和病症中的新用途。本公开内容包括调节胆固醇回收的方法。此外，本公开涉及诸如Niemann-Pick C型疾病，Farber病，Niemann-Pick型A型疾病，Wolman病和Tay Sachs病的病症。本公开内容中还包括用于治疗包括施用δ-生育酚的溶酶体储存障碍的方法。本公开内容中还包括用于治疗溶酶体贮积障碍的方法，其包括与需要的患者一起向环糊精施用δ-生育酚。

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