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1. 发明授权

US11559521B2 Analgesic formulations and methods for reduced postoperative nausea and vomiting and enhanced postoperative pain relief 有权
公开(公告)号：US11559521B2
公开(公告)日：2023-01-24
申请号：US16834863
申请日：2020-03-30
申请人： William Bradley Worthington
发明人： William Bradley Worthington
IPC分类号： A61K31/135 , A61P23/02 , A61K31/445 , A61M25/00 , A61K31/407 , A61P29/00
摘要： A multimodal anti-emetic anesthetic/analgesic formulation for pain control not limited to postoperative pain control is described herein. The opioid-free/sparing anesthetic/analgesic formulation comprises a local anesthetic, an N-methyl-D-aspartate (NMDA) receptor antagonist, and a cyclooxygenase (COX) inhibitor such as Bupivacaine Hydrochloride, Ketamine Hydrochloride, and Ketorolac Tromethamine, which is effective to significantly reduce postoperative nausea and vomiting and enhance postoperative pain relief as compared to existing prior art anesthetics/analgesics. The formulation is administered to a mammal in need of anesthesia/analgesia and can be used as a preemptive and preventative multimodal analgesic. The formulation may have a buffer to enhance its shelf life and improve pharmacokinetics. The formulation may further comprise an alpha agonist, a steroid, a Transient Receptor Potential Channel agonist or antagonist, a beta-lactam antibiotic, a protein kinase inhibitor, a competitive or non-competitive glycine or glutamate antagonist, a glutamate or glycine inhibitor, a cyclooxygenase 3 inhibitor, or combinations thereof.

2. 发明申请

US20200230120A1 ANALGESIC FORMULATIONS AND METHODS FOR REDUCED POSTOPERATIVE NAUSEA AND VOMITING AND ENHANCED POSTOPERATIVE PAIN RELIEF 审中-公开
公开(公告)号：US20200230120A1
公开(公告)日：2020-07-23
申请号：US16834863
申请日：2020-03-30
申请人： William Bradley Worthington
发明人： William Bradley Worthington
IPC分类号： A61K31/445 , A61K31/135 , A61K31/407 , A61M25/00
摘要： A multimodal anti-emetic anesthetic/analgesic formulation for pain control not limited to postoperative pain control is described herein. The opioid-free/sparing anesthetic/analgesic formulation comprises a local anesthetic, an N-methyl-D-aspartate (NMDA) receptor antagonist, and a cyclooxygenase (COX) inhibitor such as Bupivacaine Hydrochloride, Ketamine Hydrochloride, and Ketorolac Tromethamine, which is effective to significantly reduce postoperative nausea and vomiting and enhance postoperative pain relief as compared to existing prior art anesthetics/analgesics. The formulation is administered to a mammal in need of anesthesia/analgesia and can be used as a preemptive and preventative multimodal analgesic. The formulation may have a buffer to enhance its shelf life and improve pharmacokinetics. The formulation may further comprise an alpha agonist, a steroid, a Transient Receptor Potential Channel agonist or antagonist, a beta-lactam antibiotic, a protein kinase inhibitor, a competitive or non-competitive glycine or glutamate antagonist, a glutamate or glycine inhibitor, a cyclooxygenase 3 inhibitor, or combinations thereof.

3. 发明授权

US09689207B2 Systems and methods for wellbore optimization 有权
公开(公告)号：US09689207B2
公开(公告)日：2017-06-27
申请号：US13805257
申请日：2010-06-18
申请人： Xinpu Shen , Mao Bai , William Bradley Standifird
发明人： Xinpu Shen , Mao Bai , William Bradley Standifird
IPC分类号： G06G7/48 , E21B7/04 , G06F17/50 , E21B47/00
CPC分类号： E21B7/04 , E21B47/0006 , G06F17/5009
摘要： Systems and methods for wellbore optimization, which include numerical procedures for selecting an optimal wellbore trajectory and casing strength based on Formation Loading Potential.

4. 发明授权

US09466054B1 Interoperable systems and methods for peer-to-peer service orchestration 有权
公开(公告)号：US09466054B1
公开(公告)日：2016-10-11
申请号：US11829837
申请日：2007-07-27
申请人： William Bradley , David Maher , Gilles Boccon-Gibod
发明人： William Bradley , David Maher , Gilles Boccon-Gibod
IPC分类号： G06Q20/00 , G06Q20/12 , H04L29/06 , H04L29/08 , H04L9/08 , H04L9/32 , G06F21/10
CPC分类号： H04L63/10 , G06F17/30864 , G06F21/10 , G06F2221/0759 , G06F2221/0786 , G06F2221/0788 , G06Q20/1235 , G06Q2220/10 , G06Q2220/18 , H04L9/0822 , H04L9/0825 , H04L9/0861 , H04L9/3263 , H04L9/3271 , H04L63/0281 , H04L63/0428 , H04L63/061 , H04L63/08 , H04L63/0823 , H04L63/20 , H04L67/1061 , H04L67/16 , H04L2209/603 , H04L2463/101 , H04L2463/102
摘要： Systems and methods are described for performing policy-managed, peer-to-peer service orchestration in a manner that supports the formation of self-organizing service networks that enable rich media experiences. In one embodiment, services are distributed across peer-to-peer communicating nodes, and each node provides message routing and orchestration using a message pump and workflow collator. Distributed policy management of service interfaces helps to provide trust and security, supporting commercial exchange of value. Peer-to-peer messaging and workflow collation allow services to be dynamically created from a heterogeneous set of primitive services. The shared resources are services of many different types, using different service interface bindings beyond those typically supported in a web service deployments built on UDDI, SOAP, and WSDL. In a preferred embodiment, a media services framework is provided that enables nodes to find one another, interact, exchange value, and cooperate across tiers of networks from WANs to PANs.

5. 发明授权

US09425192B2 Integrated circuit decoupling capacitors 有权
标题翻译：集成电路去耦电容
公开(公告)号：US09425192B2
公开(公告)日：2016-08-23
申请号：US12332928
申请日：2008-12-11
申请人： Irfan Rahim , William Bradley Vest , Myron Wai Wong
发明人： Irfan Rahim , William Bradley Vest , Myron Wai Wong
IPC分类号： H01L29/00 , H01L27/08 , H01L23/522 , H01L23/528
CPC分类号： H01L27/0805 , H01L23/5223 , H01L23/5286 , H01L2924/0002 , H01L2924/00
摘要： Power supply decoupling capacitors are provided for integrated circuits. The decoupling capacitors may be distributed in clusters amongst powered circuit components. Each cluster may contain a number of individual capacitor cells that are connected in parallel. Each capacitor cell may contain a capacitor and a resistor connected in series with the capacitor. The capacitors may be metal-insulator-metal (MIM) capacitors. The resistor in each cell may limit the current through an individual capacitor in the event of a short in the capacitor due to a dielectric defect.
摘要翻译：为集成电路提供电源去耦电容。去耦电容器可以在电源电路组件之间分布成簇。每个集群可以包含并联连接的多个单独的电容器单元。每个电容器单元可以包含与电容器串联的电容器和电阻器。电容器可以是金属 - 绝缘体 - 金属（MIM）电容器。由于电介质缺陷，每个电池中的电阻可能会限制在电容器短路的情况下单个电容器的电流。

6. 发明授权

US09328573B2 Integrated geomechanics determinations and wellbore pressure control 有权
标题翻译：综合地质力学测定和井筒压力控制
公开(公告)号：US09328573B2
公开(公告)日：2016-05-03
申请号：US13144321
申请日：2009-10-05
申请人： William Bradley Standifird , Syed AiJaz Rizvi , Xiaomin Hu , James R. Lovorn , Sara Shayegi , Nancy Davis , Jeremy Greenwood
发明人： William Bradley Standifird , Syed AiJaz Rizvi , Xiaomin Hu , James R. Lovorn , Sara Shayegi , Nancy Davis , Jeremy Greenwood
IPC分类号： E21B21/08
CPC分类号： E21B21/08 , E21B44/00 , E21B2021/006
摘要： Well pressure control is integrated in real time with geomechanics determinations made during drilling. A well drilling method includes updating determinations of properties of a formation surrounding a wellbore in real time as the wellbore is being drilled; and controlling wellbore pressure in real time as the wellbore is being drilled, in response to the updated determinations of the formation properties. Another well drilling method includes obtaining sensor measurements in a well drilling system in real time as a wellbore is being drilled; transmitting the sensor measurements to a control system in real time; the control system determining in real time properties of a formation surrounding the wellbore based on the sensor measurements, and the control system transmitting in real time a pressure setpoint to a controller; and the controller controlling operation of at least one flow control device, thereby influencing a well pressure toward the pressure setpoint.
摘要翻译：良好的压力控制与钻井过程中的地质力学测量实时整合。钻井方法包括在钻井时更新实时测量围绕井身的地层的性质; 并且响应于更新的地层性质的确定，在钻井时实时地控制井筒压力。另一种钻井方法包括在钻井时实时地在钻井系统中获得传感器测量值; 将传感器测量实时传输到控制系统; 所述控制系统基于所述传感器测量值确定围绕所述井筒的地层的实时性质，以及所述控制系统实时地将压力设定点传送到控制器; 并且控制器控制至少一个流量控制装置的操作，从而影响朝向压力设定点的井压力。

7. 发明授权

US09031284B2 Implant identification system and method 有权
标题翻译：种植体识别系统及方法
公开(公告)号：US09031284B2
公开(公告)日：2015-05-12
申请号：US13730038
申请日：2012-12-28
申请人： William Bradley Spath
发明人： William Bradley Spath
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/004 , G06T7/593 , G06T7/70 , G06T2207/10012 , G06T2207/10116 , G06T2207/30052
摘要： Objects implanted in a being are identified by acquiring a first internal medical image of the object from a first perspective; acquiring a second internal medical image of the object from a second perspective different than the first perspective; and receiving descriptive information about the object that is in addition to the first and second internal medical images. The object is identified based on the first internal medical image, the second internal medical image, and the descriptive information; one or more operational characteristics of the object are then determined and transmitted to a remote requestor that provided the first and second internal medical images.
摘要翻译：通过从第一角度获取对象的第一内部医学图像来识别植入在身体中的对象; 从与第一视角不同的第二透视图获取对象的第二内部医学图像; 以及接收除了第一和第二内部医学图像之外的关于对象的描述性信息。基于第一内部医学图像，第二内部医学图像和描述信息来识别对象; 然后确定对象的一个或多个操作特征并将其发送到提供第一和第二内部医学图像的远程请求者。

8. 发明授权

US08792602B2 Mixed signal stochastic belief propagation 有权
标题翻译：混合信号随机信念传播
公开(公告)号：US08792602B2
公开(公告)日：2014-07-29
申请号：US13032520
申请日：2011-02-22
申请人： Jeffrey Bernstein , Benjamin Vigoda , David Reynolds , Alexander Alexeyev , William Bradley
发明人： Jeffrey Bernstein , Benjamin Vigoda , David Reynolds , Alexander Alexeyev , William Bradley
IPC分类号： H04L7/00 , H03M13/11 , H03M13/00
CPC分类号： H03M13/6597 , H03M13/1111
摘要： A processor implements a network of functional nodes and communication paths between the nodes. The processor includes a plurality of circuit implementations of the functional nodes of the processor; and a plurality of signal paths implementing the communication paths linking the circuit implementations of the nodes. At least some of the signal paths are configured to pass signal values represented according to temporal patterns of signal levels on the signal paths. The processor also includes a plurality of circuit components for conversion between a signal value represented as a signal level (e.g., voltage or current level) and a signal value represented as a temporal pattern.
摘要翻译：处理器实现节点之间的功能节点和通信路径的网络。处理器包括处理器的功能节点的多个电路实现; 以及实现链接节点的电路实现的通信路径的多个信号路径。至少一些信号路径被配置为传递根据信号路径上的信号电平的时间模式表示的信号值。处理器还包括用于在表示为信号电平（例如，电压或电流电平）的信号值和表示为时间模式的信号值之间进行转换的多个电路部件。

9. 发明授权

US08458114B2 Analog computation using numerical representations with uncertainty 有权
标题翻译：使用具有不确定性的数值表示的模拟计算
公开(公告)号：US08458114B2
公开(公告)日：2013-06-04
申请号：US12716155
申请日：2010-03-02
申请人： Benjamin Vigoda , William Bradley , Shawn Hershey , Jeffrey Bernstein
发明人： Benjamin Vigoda , William Bradley , Shawn Hershey , Jeffrey Bernstein
IPC分类号： G06F9/44 , G06N7/02 , G06N7/06
CPC分类号： G06N7/005
摘要： Some general aspects relate to systems and methods of analog computation using numerical representation with uncertainty. For example, a specification of a group of variables is accepted, with each variable having a set of at least N possible values. The group of variables satisfies a set of one or more constraints, and each variable is specified as a decomposition into a group of constituents, with each constituent having a set of M (e.g., M
摘要翻译：一些一般方面涉及使用具有不确定性的数值表示的模拟计算的系统和方法。例如，接受一组变量的规范，每个变量具有至少N个可能值的集合。变量组满足一个或多个约束的集合，并且每个变量被指定为分组成一组成分，其中每个组成部分具有一组M（例如，M

10. 发明申请

US20130094298A1 STORAGE DEVICES WITH SOFT PROCESSING 有权
标题翻译：具有软处理的存储设备
公开(公告)号：US20130094298A1
公开(公告)日：2013-04-18
申请号：US13471816
申请日：2012-05-15
申请人： Benjamin Vigoda , Eric Nestler , Jeffrey Bernstein , David Reynolds , Alexander Alexeyev , Jeffrey Venuti , William Bradley , Vladimir Ziatkovic
发明人： Benjamin Vigoda , Eric Nestler , Jeffrey Bernstein , David Reynolds , Alexander Alexeyev , Jeffrey Venuti , William Bradley , Vladimir Ziatkovic
IPC分类号： G11C7/00 , G11C16/04 , G11C11/24
CPC分类号： G11C7/00 , G11C7/1006 , G11C7/16 , G11C11/24 , G11C11/5642 , G11C16/04 , G11C27/005 , G11C29/00
摘要： A storage device includes a storage array having a group of storage elements. Each storage element can written to a discrete set of physical states. A read circuit selects one or more storage elements and generates, for each selected storage element, an analog signal representative of the physical state of the selected storage element. A signal processing circuit processes the analog signal to generate a plurality of outputs, with each output representing a degree of an association of the selected storage element with a different subset of one or more of the discrete set of physical states.
摘要翻译：存储装置包括具有一组存储元件的存储阵列。每个存储元件可以写入一组离散的物理状态。读取电路选择一个或多个存储元件，并为每个选定的存储元件生成表示所选存储元件的物理状态的模拟信号。信号处理电路处理模拟信号以产生多个输出，其中每个输出表示所选择的存储元件与离散的物理状态集合中的一个或多个的不同子集的关联程度。

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