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1. 发明授权

US10709896B2 System and method for treating hemorrhoids 有权
公开(公告)号：US10709896B2
公开(公告)日：2020-07-14
申请号：US12976484
申请日：2010-12-22
申请人： Wolfgang Neuberger , Endrick Groenhoff
发明人： Wolfgang Neuberger , Endrick Groenhoff
IPC分类号： A61N5/06 , A61B8/12 , A61N5/067 , A61B8/00
摘要： System and method for treating hemorrhoidal piles, addressing both cause and symptoms, by endoluminal/interstitial application of energy are disclosed. The dilated blood arteries in anal/rectal region are irradiated from inside the pile using (laser) energy for minimal pain/discomfort. The center of the pile is irradiated over a certain diameter, absorbing energy; and is denatured causing volume reduction. Central vessels located in the same diameter are obliterated immediately, relieving bleeding. During treatment, new connective tissue replaces the coagulated tissue. Closing inflowing arteries further shrinks piles in weeks to three months. Complications are highly diminished. A hand-piece and a fiber with a sharp distal tip are beneficial. Including an imaging system, (ultrasound imaging, optical coherence tomography) and an intelligent system to calculate necessary laser energy parameters help address each pile individually.

2. 发明授权

US10335233B2 Myoma/polyp in-office treatment with lasers 有权
公开(公告)号：US10335233B2
公开(公告)日：2019-07-02
申请号：US13931210
申请日：2013-06-28
申请人： Martin Sabado , Wolfgang Neuberger
发明人： Martin Sabado , Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B1/303 , A61B8/08 , A61B1/018 , A61B18/00 , A61B17/42 , A61B18/20
摘要： A noninvasive treatment of uterine growths such as myomas (fibroids) and polyps is presented. Treatment involves carrying out diagnostic hysteroscopy and ultrasound procedures to detect, measure, and evaluate unwanted uterine growths; then inserting optical fiber into a hysteroscope, reaching target tissue with optical fiber and eliminating said tissue or shrinking it to a size/shape for easy mechanical removal. Finally, ultrasound imaging is used to confirm success of procedure. In one embodiment, optical fiber has an off-axis firing end but can be inserted inside a conventional hysteroscopy device. In another embodiment, a laser interstitial thermal therapy (LITT) fiber is used to treat myomas found on the outside of the uterus. A high energy laser is used that can emit at wavelengths easily absorbed by water and blood, such as 980 nm and 1470 nm. Procedure is fast and can be done in the physician's office with little or no anesthesia used.

3. 发明授权

US09724069B2 Tissue resection under image guidance/control 有权
公开(公告)号：US09724069B2
公开(公告)日：2017-08-08
申请号：US12976337
申请日：2010-12-22
申请人： Wolfgang Neuberger , Manfred Kistner
发明人： Wolfgang Neuberger , Manfred Kistner
IPC分类号： A61B5/05 , A61B8/08 , A61N5/06 , A61B8/12 , A61B18/24 , A61B18/00 , A61B18/18 , A61B90/00
CPC分类号： A61B8/0841 , A61B8/12 , A61B18/24 , A61B2018/00547 , A61B2018/1807 , A61B2090/3762 , A61B2090/3764 , A61B2090/3784 , A61N5/0601
摘要： An improved method and device for accurate, efficient surgical procedures are disclosed. The disclosed system consists in simultaneously using an elongated member that conveys energy to a treatment site and imaging means to control position of the elongated member and monitor treatment progress in real-time. In a preferred embodiment, for BPH, a twister fiber with a fused cap is used and ultrasound image guidance is obtained using a rectal probe. The method consists in placing an ultrasound rectal probe, fixed by mechanical means, and an optical fiber inserted into urethra. Initial positioning of probe is done under endoscopic/ultrasound control. The twister fiber probe operates in contact-mode. Treatment is monitored, real-time, by the ultrasound device. Additional imaging technologies include Positron Emission Tomography (PET), Computed Tomography (CT) or Optical Coherence Tomography. Other applications include the removal of tumorous (hyperplasic) tissue. Sources include lasers, higher power LEDs or bright lamps and photodynamic therapy.

4. 发明授权

US08986731B2 Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy 有权
标题翻译：用于光动力学治疗的疏水性光敏剂的聚乙二醇化脂质体制剂
公开(公告)号：US08986731B2
公开(公告)日：2015-03-24
申请号：US11349405
申请日：2006-02-07
申请人： Volker Albrecht , Alfred Fahr , Dietrich Scheglmann , Susanna Gräfe , Wolfgang Neuberger
发明人： Volker Albrecht , Alfred Fahr , Dietrich Scheglmann , Susanna Gräfe , Wolfgang Neuberger
IPC分类号： A61K9/127 , A61K31/407 , A61K31/555 , A61K41/00
CPC分类号： A61K9/1271 , A61K31/407 , A61K31/555 , A61K41/0071
摘要： Pharmaceutical pegylated liposomal formulations for photodynamic therapy are presented. The pegylated liposomal formulation provides therapeutically effective amounts of the photosensitizer for intravenous administration. At least one of the phospholipids in the liposomes has been linked with poly ethylene glycol (PEG) as an integral part of the phospholipids. The formed pegylated liposomes contain the hydrophobic photosensitizer within the lipid bilayer membrane. Pegylation of liposomes carrying the hydrophobic photosensitizer helps to maintain the drug level within the therapeutic window for longer time periods and provides the drug a longer circulating half life in vivo. Further the pegylated formulation of hydrophobic photosensitizers shows improved pharmacokinetics over standard non-liposomal formulations thus enhancing the efficacy of PDT with the pegylated liposomal formulations.
摘要翻译：提出了用于光动力学治疗的药物聚乙二醇化脂质体制剂。聚乙二醇化脂质体制剂提供治疗有效量的用于静脉内施用的光敏剂。脂质体中的至少一种磷脂已经与作为磷脂的组成部分的聚乙二醇（PEG）连接。形成的聚乙二醇化脂质体在脂质双层膜内含有疏水性光敏剂。携带疏水性光敏剂的脂质体的聚乙二醇化有助于在治疗窗口内维持更长时间的药物水平，并使药物在体内延长循环半衰期。此外，疏水性光敏剂的聚乙二醇化制剂显示与标准非脂质体制剂相比改善的药物代谢动力学，从而增强PDT与聚乙二醇化脂质体制剂的功效。

5. 发明授权

US08827991B2 Medical laser treatment device and method utilizing total reflection induced by radiation 有权
标题翻译：医疗激光治疗装置及利用辐射引起的全反射的方法
公开(公告)号：US08827991B2
公开(公告)日：2014-09-09
申请号：US12756010
申请日：2010-04-07
申请人： Wolfgang Neuberger , Walter Cecchetti
发明人： Wolfgang Neuberger , Walter Cecchetti
IPC分类号： A61B18/18
CPC分类号： A61B18/22 , A61B2017/00274 , A61B2018/00005 , A61B2018/00547 , A61B2018/2272 , A61B2018/2288
摘要： A device for improved surgical procedures to remove unwanted or hyperplasic tissue from a patient during laser ablation, urological treatments, benign prostatic hyperplasia treatments and other applications. Specially prepared optical waveguide tips allow for enhanced irradiation of desired tissues with light sources including laser diodes, bright LEDs or lamps. A significant fraction of the optical radiation, being transported in the waveguide, is coupled out of the waveguide into the surrounding medium through a peripheral surface at or near the distal end. The optical radiation is chosen to have an appropriate wavelength and sufficient power density, so that the surrounding medium will be changed in the vicinity of at least a part of the peripheral surface area. The changes of the surrounding medium result in a change of its refractive index such that the optical radiation is redirected.
摘要翻译：一种用于在激光消融，泌尿系统治疗，良性前列腺增生治疗和其他应用中从患者中去除不需要的或超增生组织的外科手术的装置。特别制备的光波导尖端允许用包括激光二极管，亮LED或灯的光源对所需组织进行增强的照射。在波导中传输的光辐射的很大一部分通过远端处或附近的外围表面耦合到波导外部到周围介质中。选择光辐射具有适当的波长和足够的功率密度，使得周围介质将在周边表面区域的至少一部分附近改变。周围介质的变化导致其折射率的变化，使得光辐射被重定向。

6. 发明授权

US08721631B2 Twister fiber optic systems and their use in medical applications 有权
标题翻译：扭转光纤系统及其在医疗应用中的应用
公开(公告)号：US08721631B2
公开(公告)日：2014-05-13
申请号：US12714155
申请日：2010-02-26
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/16
CPC分类号： A61B18/22 , A61B2018/0019 , A61B2018/1861 , A61B2018/2211 , A61B2018/2272 , A61B2018/2288
摘要： An improved device and method for safe, accurate and efficient surgical procedures are disclosed. The disclosed device is an optical fiber set with an asymmetric distal end configuration, comprising a bent tip fiber with a fused sleeve as an integral part of it, placed at the fiber's distal (output) end and with a rotatable connector at the proximal (input) side. Fiber tip and tissue-contacting surface located at the distal end of the tip may be constructed with different shape configurations, such as convex tip to improve focusing characteristics, concave tip to achieve diverging irradiation or an expanded beam tip to achieve an effect similar to that obtained by electrosurgical tools. A grip guarantees and enhances the ability to twist and rotate it easily. In another preferred embodiment, twisting maneuvers are enhanced through a special configuration. Both special features (bent tip and rotatable connector), allow for improved and enhanced treatment of diverse pathologies, making possible to efficiently and easily reach and treat specific tissues. Optical fiber's steerability, twistability and rotation lead to a more precise and improved effect on tissues.
摘要翻译：公开了一种用于安全，准确和有效的外科手术的改进的装置和方法。所公开的装置是具有不对称远端构造的光纤组件，其包括具有作为其整体部分的熔融套筒的弯曲尖端纤维，放置在光纤的远端（输出端）处并且在近端（输入端）处具有可旋转连接器）侧。位于尖端远端处的纤维尖端和组织接触表面可以被构造成具有不同的形状构造，例如凸尖以改善聚焦特性，凹形尖端以实现发散照射或扩张的束尖以实现类似于通过电外科手术获得。抓地力保证并增强扭曲和旋转的能力。在另一优选实施例中，通过特殊配置来增强扭转机动。两个特殊功能（弯尖和可旋转连接器），可以改善和增强各种病态的治疗，使得有效和容易地达到和治疗特定组织成为可能。光纤的可操纵性，扭曲性和旋转性导致对组织的更精确和改善的影响。

7. 发明授权

US08685072B2 Device and method for vessel treatment 有权
标题翻译：血管治疗的装置和方法
公开(公告)号：US08685072B2
公开(公告)日：2014-04-01
申请号：US12877721
申请日：2010-09-08
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61N5/06
CPC分类号： A61N5/0601 , A61B90/36 , A61N2005/063 , A61N2005/0659
摘要： A device and method for restoring functionality of blood vessels are disclosed. Laser energy is accurately and precisely applied in order to restore vessel functionality. This is accomplished by a controlled, reliable and specific shrinkage and/or strengthening of the vessel structure by controlled transport of laser radiation via an optical fiber to the treatment site. Laser wavelength is chosen according to the required penetration depth in tissue. In a preferred embodiment, wavelength of approximately 1470 nm is used. A mini-endoscope is preferably used to control the process by visual inspection from the inside of the vessel but other means may also be combined to control the procedure. Full 360° radial emission, i.e., delivery of laser radiation perpendicularly or fairly inclined relative to the veins axis, is beneficial, and is accomplished by means of a radial emitting fiber. In another preferred embodiment, a 360 degree radiation pattern can be achieved by using a twister or side-emitting fiber, along with rotational and sweeping movements to apply energy in an even, more-controlled, and guided manner. Valve function is restored to recover whole vein functionality, avoiding the need of closing it. In a preferred embodiment, energy is applied from the outside of the vessel, by inserting a device through the skin and tissue. In another preferred embodiment, specific radiation absorbers are located at suitable positions inside the vessel wall, to selectively target radiation to tagged locations. Vessel function is restored preserving its structure. A wide range of vessel diameters are effectively treated. Vessels include veins, arteries and fistulas.
摘要翻译：公开了恢复血管功能的装置和方法。激光能量准确而精确地应用于恢复血管功能。这是通过受控的，可靠的和具体的收缩和/或通过经由光纤将激光辐射控制传输到处理部位来加强容器结构来实现的。根据组织中所需的穿透深度选择激光波长。在优选实施例中，使用约1470nm的波长。微型内窥镜优选地用于通过目视检查从容器的内部控制过程，但也可以组合其它装置来控制该过程。完全360°径向辐射，即相对于静脉轴线垂直或相当倾斜的激光辐射的传送是有益的，并且通过径向发射光纤实现。在另一个优选实施例中，360度辐射图可以通过使用捻线机或侧发射光纤以及旋转和扫掠运动来实现，以以均匀，更受控制和引导的方式施加能量。阀功能恢复恢复整个静脉功能，避免了关闭它。在优选实施例中，通过将装置插入皮肤和组织，从容器的外部施加能量。在另一优选实施例中，特定的辐射吸收器位于血管壁内的适当位置，以选择性地将辐射靶向到标记位置。船舶功能恢复保存其结构。有效处理各种血管直径。血管包括静脉，动脉和瘘管。

8. 发明申请

US20120101427A1 NOVEL PHOTOSENSITIZER FORMULATIONS FOR ORAL ADMINISTRATION 审中-公开
标题翻译：用于口腔管理的新型光敏剂配方
公开(公告)号：US20120101427A1
公开(公告)日：2012-04-26
申请号：US13266056
申请日：2009-04-28
申请人： Gerard Farmer , Gerhard Wieland , Dietrich Scheglmann , Arno Wiehe , Susanna Gräfe , Nikolay E. Nufantiev , Volker Albrecht , Wolfgang Neuberger
发明人： Gerard Farmer , Gerhard Wieland , Dietrich Scheglmann , Arno Wiehe , Susanna Gräfe , Nikolay E. Nufantiev , Volker Albrecht , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61K31/498 , C07D487/22 , C07D241/46 , A61K9/127 , A61K38/02 , A61K31/7056 , A61K31/706 , A61K31/79 , A61P35/00 , A61P17/00 , A61P9/00 , A61P19/02 , A61P31/04 , A61P33/02 , A61P31/12 , A61P31/00 , A61K31/409 , B82Y5/00
CPC分类号： A61K31/122 , A61K31/40 , A61K31/498 , A61K41/0071
摘要： The present invention provides novel drug formulations for oral administration for diverse medical applications including anticancer, antimetastatic, antibacterial, antifungal, antiprotozoic, antiviral, antiprionic and PDT treatments for diagnostic and therapeutic purposes. In a preferred embodiment the oral drug formulation comprises a photosensitizer and suitable excipients and may be administered in multiple doses over an extended period of time with exposure to activating radiation occurring generally between individual doses or in a light-independent manner. In another preferred embodiment PDT methods for treating hyperplasia and neoplasia, for localizing hyperplasic and neoplasic tissues and pathogen bacteria by fluorescence, for treating infections caused by pathogen bacteria in complex body fluids and for fat reduction, skin disorders and vascular diseases are provided.
摘要翻译：本发明提供用于口服给药以用于各种医学应用的新型药物制剂，包括用于诊断和治疗目的的抗癌，抗转移，抗细菌，抗真菌，抗原生动脉，抗病毒，抗细胞和PDT治疗。在优选的实施方案中，口服药物制剂包含光敏剂和合适的赋形剂，并且可以在延长的时间段内以多个剂量施用，暴露于通常在单独剂量之间或以轻轻独立的方式发生的活化辐射。在另一个优选实施方案中，提供了用于治疗增生和瘤形成的PDT方法，用于通过荧光定位超基质和新生组织和病原体细菌，用于治疗复杂体液中由病原体引起的感染和用于减脂，皮肤病和血管疾病。

9. 发明申请

US20110213348A1 METHOD AND DEVICE FOR VALVE REPAIR 有权
标题翻译：阀门维修的方法和装置
公开(公告)号：US20110213348A1
公开(公告)日：2011-09-01
申请号：US13102830
申请日：2011-05-06
申请人： Enrique Ferracani , Wolfgang Neuberger
发明人： Enrique Ferracani , Wolfgang Neuberger
IPC分类号： A61B18/20 , A61B17/00
CPC分类号： A61B18/24 , A61B2018/00029 , A61B2018/00982
摘要： A method and a device for minimally invasive treatment of diseased deep and superficial venous valves are disclosed. Treatment seeks to repair/rejuvenate dysfunctional valve by reducing the circumference of dilated valve rings and by restoring their original shape and function using laser energy to make physical suture points and shrink collagen in selected points. Real time monitoring is by angioscopic view and endovenous echographic control. In a preferred embodiment, system comprises a specific catheter-like device for endovenous insertion that allows for real time view of energy emission and venous surface to be corrected. Catheter flexibility is such that viewing angle and direct energy emission can be oriented properly. Catheter can comprise channels for irrigation or for interchange of laser fibers according to desired irradiation pattern. A preferred embodiment of catheter device also comprises cuffs for temporary occlusion, by inflation and deflation. In preferred embodiments, 1470 nm, 1550 nm or 1900 nm laser energy is applied. This treatment can be applied to venous valves of the deep venous system, as well as valves of the sapheno-femoral junction, terminal valve and pre-terminal valve.
摘要翻译：公开了用于微创治疗患病深部和浅静脉瓣的方法和装置。治疗旨在通过减小扩张瓣环的周长并通过使用激光能量恢复其原始形状和功能来修复/恢复功能失调的瓣膜，以在选定的点产生物理缝合点和收缩胶原蛋白。实时监测是通过血管镜观察和静态回波控制。在优选实施例中，系统包括用于静脉内插入的特定导管状装置，其允许实时观察要校正的能量排出和静脉表面。导管的灵活性使得视角和直接能量发射可以适当地定向。导管可以包括根据所需照射模式进行冲洗或激光纤维交换的通道。导管装置的优选实施例还包括用于暂时闭塞的袖口，通过充气和放气。在优选实施例中，施加1470nm，1550nm或1900nm的激光能量。这种治疗可以应用于深静脉系统的静脉瓣膜，以及隐静脉股关节，终端阀和前端阀的阀门。

10. 发明申请

US20110034854A1 PDT ASSISTED VISION CORRECTION AND SCAR PREVENTION 审中-公开
标题翻译： PDT辅助视力矫正和防护
公开(公告)号：US20110034854A1
公开(公告)日：2011-02-10
申请号：US12743515
申请日：2008-11-20
申请人： Wolfgang Neuberger , Volker Albrecht
发明人： Wolfgang Neuberger , Volker Albrecht
IPC分类号： A61M37/00 , A61K31/409 , A61K9/127 , A61P17/02
CPC分类号： A61N5/062 , A61F9/00802 , A61F2009/00872
摘要： A method and formulation are disclosed for improving the results of corneal refractive surgery, and generally reducing post-operative scarring and scarring arising from other traumas. In the vision examples, after completion of a procedure, including Photorefractive Keratotomy (PRK) or Laser-In-Situ Keratomileusis (LASIK), a photosensitizer or photosensitizer precursor is applied to the treatment site. After allowing sufficient time for the photosensitizers to accumulate among proliferating cells that occur as a result of ablation, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is thus activated to destroy only those proliferating cells. In this way, proliferating tissue is eliminated and the cornea maintains the shape created during the surgery. As a result, instances of regression and the need for follow-up treatments, is minimized. This method is also useful for preventing post-surgical scarring that can lead to vision problems such as corneal haze. Likewise the method and formulations, presented here, are suitable for reducing post-operative scarring, and trauma cased scarring in general. For such scars, a photosensitizer or photosensitizer precursor is topically applied to the treatment site. After allowing sufficient time for the photosensitizers to attach to proliferating cells, radiation appropriate to activate the photosensitizers is administered to the treatment site. The photosensitizer is activated to destroy only those proliferating cells.
摘要翻译：公开了用于改善角膜屈光手术结果的方法和制剂，并且通常减少由其他创伤引起的术后瘢痕形成和瘢痕形成。在视觉实例中，在完成包括光折射角膜切开术（PRK）或激光原位角膜磨镶术（LASIK））的手术完成后，将光敏剂或光敏剂前体施用于治疗部位。在允许足够的时间使光敏剂在由于消融引起的增殖细胞之间累积，适当激活光敏剂的辐射被施用于治疗部位。因此，光敏剂被激活以仅破坏那些增殖细胞。以这种方式，消除增殖组织，并且角膜保持手术期间产生的形状。因此，尽可能减少了回归和后续治疗的需要。这种方法也可用于预防术后瘢痕形成，导致视力问题，如角膜混浊。同样地，这里给出的方法和制剂适用于减少手术后瘢痕形成和一般的外伤瘢痕形成。对于这种疤痕，将光敏剂或光敏剂前体局部施用于治疗部位。在允许足够的时间使光敏剂附着于增殖细胞之后，向治疗部位施用适于激活光敏剂的辐射。光敏剂被激活以仅破坏那些增殖细胞。

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