专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US10335233B2 Myoma/polyp in-office treatment with lasers 有权
公开(公告)号：US10335233B2
公开(公告)日：2019-07-02
申请号：US13931210
申请日：2013-06-28
申请人： Martin Sabado , Wolfgang Neuberger
发明人： Martin Sabado , Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B1/303 , A61B8/08 , A61B1/018 , A61B18/00 , A61B17/42 , A61B18/20
摘要： A noninvasive treatment of uterine growths such as myomas (fibroids) and polyps is presented. Treatment involves carrying out diagnostic hysteroscopy and ultrasound procedures to detect, measure, and evaluate unwanted uterine growths; then inserting optical fiber into a hysteroscope, reaching target tissue with optical fiber and eliminating said tissue or shrinking it to a size/shape for easy mechanical removal. Finally, ultrasound imaging is used to confirm success of procedure. In one embodiment, optical fiber has an off-axis firing end but can be inserted inside a conventional hysteroscopy device. In another embodiment, a laser interstitial thermal therapy (LITT) fiber is used to treat myomas found on the outside of the uterus. A high energy laser is used that can emit at wavelengths easily absorbed by water and blood, such as 980 nm and 1470 nm. Procedure is fast and can be done in the physician's office with little or no anesthesia used.

2. 发明申请

US20120283619A1 MINIMALLY INVASIVE CONTRACEPTION METHOD AND DEVICE 审中-公开
标题翻译：最小的入侵收缩方法和设备
公开(公告)号：US20120283619A1
公开(公告)日：2012-11-08
申请号：US13101873
申请日：2011-05-05
申请人： Martin Sabado , Wolfgang Neuberger
发明人： Martin Sabado , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61B18/20
CPC分类号： A61B18/22 , A61B18/24 , A61B2018/00559 , A61B2018/00642 , A61B2018/00702 , A61B2018/00791 , A61B2018/00982 , A61B2090/378 , A61B2218/001
摘要： Minimally invasive methods and devices for endoluminally treating female fallopian tubes or male vas deferens of mammals are presented as a permanent method of contraception. In preferred embodiments, medical devices for male and female sterilization comprise laser radiation source operating at one or more preselected wavelengths between about 980 nm and about 1950 nm, preferably at least one of 980 nm, 1470 nm and 1950 nm; treatment waveguide with a radial or cylindrical radiation emitting tip; viewing scope; and a temperature sensor. In another preferred embodiment, a minimally-invasive permanent contraception method for males and females comprises the steps of introducing at least one treatment waveguide in a body cavity; positioning the treatment waveguide inside a body cavity; irradiating; and repeating the procedure in companion body cavity to inhibit fertilization. In another embodiment, fluids are infused and/or extracted after, before or during the procedure to enhance laser energy absorption and enhance efficiency of laser treatment.
摘要翻译：作为永久避孕方法，提出了微创治疗哺乳动物雌激素输卵管或输精管输精管的微创方法和装置。在优选实施例中，用于男性和女性消毒的医疗装置包括在约980nm至约1950nm之间的一个或多个预选波长操作的激光辐射源，优选980nm，1470nm和1950nm中的至少一个; 具有径向或圆柱形辐射发射尖端的处理波导; 查看范围; 和温度传感器。在另一个优选实施例中，对于男性和女性的微创永久避孕方法包括以下步骤：在体腔内引入至少一个治疗波导; 将治疗波导定位在体腔内; 照射; 并重复同伴体腔中的手术以抑制受精。在另一个实施例中，流体在手术之后，之前或期间被输注和/或提取，以增强激光能量吸收并提高激光治疗的效率。

3. 发明授权

US10716624B2 Minimally invasive contraception method and device 有权
公开(公告)号：US10716624B2
公开(公告)日：2020-07-21
申请号：US13101873
申请日：2011-05-05
申请人： Martin Sabado , Wolfgang Neuberger
发明人： Martin Sabado , Wolfgang Neuberger
IPC分类号： A61M37/00 , A61B18/20 , A61B18/22 , A61B18/24 , A61B18/00 , A61B90/00
摘要： Minimally invasive methods and devices for endoluminally treating female fallopian tubes or male vas deferens of mammals are presented as a permanent method of contraception. In preferred embodiments, medical devices for male and female sterilization comprise laser radiation source operating at one or more preselected wavelengths between about 980 nm and about 1950 nm, preferably at least one of 980 nm, 1470 nm and 1950 nm; treatment waveguide with a radial or cylindrical radiation emitting tip; viewing scope; and a temperature sensor. In another preferred embodiment, a minimally-invasive permanent contraception method for males and females comprises the steps of introducing at least one treatment waveguide in a body cavity; positioning the treatment waveguide inside a body cavity; irradiating; and repeating the procedure in companion body cavity to inhibit fertilization. In another embodiment, fluids are infused and/or extracted after, before or during the procedure to enhance laser energy absorption and enhance efficiency of laser treatment.

4. 发明申请

US20150080867A1 Gastric Reflux Treatment with Lasers 审中-公开
标题翻译：用激光进行胃反流治疗
公开(公告)号：US20150080867A1
公开(公告)日：2015-03-19
申请号：US14030790
申请日：2013-09-18
申请人： Wolfgang Neuberger , Martin Sabado
发明人： Wolfgang Neuberger , Martin Sabado
IPC分类号： A61B18/20
CPC分类号： A61B18/22 , A61B2018/00494 , A61B2018/00982 , A61B2018/2261 , A61B2018/2285
摘要： Method/devices for endoscopic laser treatment of gastrointestinal disorders such as, gastro-esophageal reflux disorder (GERD) are disclosed. Treatment involves irradiating tissue of the digestive tract to strengthen muscle tone and shrink anatomical areas reducing occurrence of reflux of food/liquids from the stomach to the esophagus. In a preferred embodiment, equipment comprises a gastro-endoscope with a working channel for inserting an optical fiber. Laser device comprises a diode laser source emitting a suitable wavelength and wave pattern through optical fiber. Laser radiation is applied near the Z line at the esophago-gastric junction. Measures are taken to assure irradiation is very accurate. Injury to the mucosa and adjacent structures, e.g. nerves, are avoided by focusing at the muscularis layer while preventing thermal effects on mucosa. This is achieved using wavelengths of ca. 1470 nm or ca. 980 mm. Energy is emitted perpendicular to fiber axis using optical fibers with side fiber distal tips, radial fiber distal tips or twister fiber distal tips.
摘要翻译：公开了用于内窥镜激光治疗胃肠道疾病如胃食管反流障碍（GERD）的方法/装置。治疗包括照射消化道的组织以增强肌肉紧张度并缩小解剖面积，减少食物/液体从胃向食道的反流的发生。在优选实施例中，设备包括具有用于插入光纤的工作通道的胃内窥镜。激光装置包括通过光纤发射合适的波长和波形图案的二极管激光源。在食道 - 胃交界处的Z线附近施加激光辐射。采取措施确保照射非常准确。对粘膜和相邻结构的损伤，例如通过聚焦在肌层以避免对粘膜的热效应来避免神经。这是使用波长约 1470nm或约 980毫米。使用具有侧纤维远端头，径向纤维远端尖端或扭曲纤维远端尖端的光纤垂直于纤维轴发射能量。

5. 发明申请

US20150005577A1 Myoma/Polyp In-Office Treatment with Lasers 审中-公开
标题翻译：肌瘤/ Polyp在线治疗与激光
公开(公告)号：US20150005577A1
公开(公告)日：2015-01-01
申请号：US13931210
申请日：2013-06-28
申请人： Martin Sabado , Wolfgang Neuberger
发明人： Martin Sabado , Wolfgang Neuberger
IPC分类号： A61B18/22 , A61B1/303 , A61B17/42 , A61B1/018
CPC分类号： A61B1/303 , A61B1/018 , A61B8/085 , A61B18/22 , A61B2017/4216 , A61B2018/00559 , A61B2018/00589 , A61B2018/00625 , A61B2018/00982 , A61B2018/2005 , A61B2018/2025 , A61B2018/20361
摘要： A noninvasive treatment of uterine growths such as myomas (fibroids) and polyps is presented. Treatment involves carrying out diagnostic hysteroscopy and ultrasound procedures to detect, measure, and evaluate unwanted uterine growths; then inserting optical fiber into a hysteroscope, reaching target tissue with optical fiber and eliminating said tissue or shrinking it to a size/shape for easy mechanical removal. Finally, ultrasound imaging is used to confirm success of procedure. In one embodiment, optical fiber has an off-axis firing end but can be inserted inside a conventional hysteroscopy device. In another embodiment, a laser interstitial thermal therapy (LITT) fiber is used to treat myomas found on the outside of the uterus. A high energy laser is used that can emit at wavelengths easily absorbed by water and blood, such as 980 nm and 1470 nm. Procedure is fast and can be done in the physician's office with little or no anesthesia used.
摘要翻译：提出了非侵入性治疗子宫生长如肌瘤（肌瘤）和息肉。治疗包括进行诊断性宫腔镜检查和超声检查程序来检测，测量和评估不需要的子宫生长; 然后将光纤插入宫腔镜，用光纤到达目标组织，并消除所述组织或将其收缩至尺寸/形状以便于机械去除。最后，超声成像用于确认手术成功。在一个实施例中，光纤具有离轴点火端，但可插入传统的宫腔镜装置内。在另一个实施例中，使用激光间质热疗（LITT）纤维来治疗在子宫外部发现的肌瘤。使用能够以容易被水和血液吸收的波长（例如980nm和1470nm）发射的高能激光。程序很快，可以在医生的办公室进行很少或不用麻醉。

6. 发明授权

US10709896B2 System and method for treating hemorrhoids 有权
公开(公告)号：US10709896B2
公开(公告)日：2020-07-14
申请号：US12976484
申请日：2010-12-22
申请人： Wolfgang Neuberger , Endrick Groenhoff
发明人： Wolfgang Neuberger , Endrick Groenhoff
IPC分类号： A61N5/06 , A61B8/12 , A61N5/067 , A61B8/00
摘要： System and method for treating hemorrhoidal piles, addressing both cause and symptoms, by endoluminal/interstitial application of energy are disclosed. The dilated blood arteries in anal/rectal region are irradiated from inside the pile using (laser) energy for minimal pain/discomfort. The center of the pile is irradiated over a certain diameter, absorbing energy; and is denatured causing volume reduction. Central vessels located in the same diameter are obliterated immediately, relieving bleeding. During treatment, new connective tissue replaces the coagulated tissue. Closing inflowing arteries further shrinks piles in weeks to three months. Complications are highly diminished. A hand-piece and a fiber with a sharp distal tip are beneficial. Including an imaging system, (ultrasound imaging, optical coherence tomography) and an intelligent system to calculate necessary laser energy parameters help address each pile individually.

7. 发明授权

US09724069B2 Tissue resection under image guidance/control 有权
公开(公告)号：US09724069B2
公开(公告)日：2017-08-08
申请号：US12976337
申请日：2010-12-22
申请人： Wolfgang Neuberger , Manfred Kistner
发明人： Wolfgang Neuberger , Manfred Kistner
IPC分类号： A61B5/05 , A61B8/08 , A61N5/06 , A61B8/12 , A61B18/24 , A61B18/00 , A61B18/18 , A61B90/00
CPC分类号： A61B8/0841 , A61B8/12 , A61B18/24 , A61B2018/00547 , A61B2018/1807 , A61B2090/3762 , A61B2090/3764 , A61B2090/3784 , A61N5/0601
摘要： An improved method and device for accurate, efficient surgical procedures are disclosed. The disclosed system consists in simultaneously using an elongated member that conveys energy to a treatment site and imaging means to control position of the elongated member and monitor treatment progress in real-time. In a preferred embodiment, for BPH, a twister fiber with a fused cap is used and ultrasound image guidance is obtained using a rectal probe. The method consists in placing an ultrasound rectal probe, fixed by mechanical means, and an optical fiber inserted into urethra. Initial positioning of probe is done under endoscopic/ultrasound control. The twister fiber probe operates in contact-mode. Treatment is monitored, real-time, by the ultrasound device. Additional imaging technologies include Positron Emission Tomography (PET), Computed Tomography (CT) or Optical Coherence Tomography. Other applications include the removal of tumorous (hyperplasic) tissue. Sources include lasers, higher power LEDs or bright lamps and photodynamic therapy.

8. 发明授权

US08986731B2 Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy 有权
标题翻译：用于光动力学治疗的疏水性光敏剂的聚乙二醇化脂质体制剂
公开(公告)号：US08986731B2
公开(公告)日：2015-03-24
申请号：US11349405
申请日：2006-02-07
申请人： Volker Albrecht , Alfred Fahr , Dietrich Scheglmann , Susanna Gräfe , Wolfgang Neuberger
发明人： Volker Albrecht , Alfred Fahr , Dietrich Scheglmann , Susanna Gräfe , Wolfgang Neuberger
IPC分类号： A61K9/127 , A61K31/407 , A61K31/555 , A61K41/00
CPC分类号： A61K9/1271 , A61K31/407 , A61K31/555 , A61K41/0071
摘要： Pharmaceutical pegylated liposomal formulations for photodynamic therapy are presented. The pegylated liposomal formulation provides therapeutically effective amounts of the photosensitizer for intravenous administration. At least one of the phospholipids in the liposomes has been linked with poly ethylene glycol (PEG) as an integral part of the phospholipids. The formed pegylated liposomes contain the hydrophobic photosensitizer within the lipid bilayer membrane. Pegylation of liposomes carrying the hydrophobic photosensitizer helps to maintain the drug level within the therapeutic window for longer time periods and provides the drug a longer circulating half life in vivo. Further the pegylated formulation of hydrophobic photosensitizers shows improved pharmacokinetics over standard non-liposomal formulations thus enhancing the efficacy of PDT with the pegylated liposomal formulations.
摘要翻译：提出了用于光动力学治疗的药物聚乙二醇化脂质体制剂。聚乙二醇化脂质体制剂提供治疗有效量的用于静脉内施用的光敏剂。脂质体中的至少一种磷脂已经与作为磷脂的组成部分的聚乙二醇（PEG）连接。形成的聚乙二醇化脂质体在脂质双层膜内含有疏水性光敏剂。携带疏水性光敏剂的脂质体的聚乙二醇化有助于在治疗窗口内维持更长时间的药物水平，并使药物在体内延长循环半衰期。此外，疏水性光敏剂的聚乙二醇化制剂显示与标准非脂质体制剂相比改善的药物代谢动力学，从而增强PDT与聚乙二醇化脂质体制剂的功效。

9. 发明授权

US08827991B2 Medical laser treatment device and method utilizing total reflection induced by radiation 有权
标题翻译：医疗激光治疗装置及利用辐射引起的全反射的方法
公开(公告)号：US08827991B2
公开(公告)日：2014-09-09
申请号：US12756010
申请日：2010-04-07
申请人： Wolfgang Neuberger , Walter Cecchetti
发明人： Wolfgang Neuberger , Walter Cecchetti
IPC分类号： A61B18/18
CPC分类号： A61B18/22 , A61B2017/00274 , A61B2018/00005 , A61B2018/00547 , A61B2018/2272 , A61B2018/2288
摘要： A device for improved surgical procedures to remove unwanted or hyperplasic tissue from a patient during laser ablation, urological treatments, benign prostatic hyperplasia treatments and other applications. Specially prepared optical waveguide tips allow for enhanced irradiation of desired tissues with light sources including laser diodes, bright LEDs or lamps. A significant fraction of the optical radiation, being transported in the waveguide, is coupled out of the waveguide into the surrounding medium through a peripheral surface at or near the distal end. The optical radiation is chosen to have an appropriate wavelength and sufficient power density, so that the surrounding medium will be changed in the vicinity of at least a part of the peripheral surface area. The changes of the surrounding medium result in a change of its refractive index such that the optical radiation is redirected.
摘要翻译：一种用于在激光消融，泌尿系统治疗，良性前列腺增生治疗和其他应用中从患者中去除不需要的或超增生组织的外科手术的装置。特别制备的光波导尖端允许用包括激光二极管，亮LED或灯的光源对所需组织进行增强的照射。在波导中传输的光辐射的很大一部分通过远端处或附近的外围表面耦合到波导外部到周围介质中。选择光辐射具有适当的波长和足够的功率密度，使得周围介质将在周边表面区域的至少一部分附近改变。周围介质的变化导致其折射率的变化，使得光辐射被重定向。

10. 发明授权

US08721631B2 Twister fiber optic systems and their use in medical applications 有权
标题翻译：扭转光纤系统及其在医疗应用中的应用
公开(公告)号：US08721631B2
公开(公告)日：2014-05-13
申请号：US12714155
申请日：2010-02-26
申请人： Wolfgang Neuberger
发明人： Wolfgang Neuberger
IPC分类号： A61B18/16
CPC分类号： A61B18/22 , A61B2018/0019 , A61B2018/1861 , A61B2018/2211 , A61B2018/2272 , A61B2018/2288
摘要： An improved device and method for safe, accurate and efficient surgical procedures are disclosed. The disclosed device is an optical fiber set with an asymmetric distal end configuration, comprising a bent tip fiber with a fused sleeve as an integral part of it, placed at the fiber's distal (output) end and with a rotatable connector at the proximal (input) side. Fiber tip and tissue-contacting surface located at the distal end of the tip may be constructed with different shape configurations, such as convex tip to improve focusing characteristics, concave tip to achieve diverging irradiation or an expanded beam tip to achieve an effect similar to that obtained by electrosurgical tools. A grip guarantees and enhances the ability to twist and rotate it easily. In another preferred embodiment, twisting maneuvers are enhanced through a special configuration. Both special features (bent tip and rotatable connector), allow for improved and enhanced treatment of diverse pathologies, making possible to efficiently and easily reach and treat specific tissues. Optical fiber's steerability, twistability and rotation lead to a more precise and improved effect on tissues.
摘要翻译：公开了一种用于安全，准确和有效的外科手术的改进的装置和方法。所公开的装置是具有不对称远端构造的光纤组件，其包括具有作为其整体部分的熔融套筒的弯曲尖端纤维，放置在光纤的远端（输出端）处并且在近端（输入端）处具有可旋转连接器）侧。位于尖端远端处的纤维尖端和组织接触表面可以被构造成具有不同的形状构造，例如凸尖以改善聚焦特性，凹形尖端以实现发散照射或扩张的束尖以实现类似于通过电外科手术获得。抓地力保证并增强扭曲和旋转的能力。在另一优选实施例中，通过特殊配置来增强扭转机动。两个特殊功能（弯尖和可旋转连接器），可以改善和增强各种病态的治疗，使得有效和容易地达到和治疗特定组织成为可能。光纤的可操纵性，扭曲性和旋转性导致对组织的更精确和改善的影响。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式