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1. 发明授权

US09008613B2 Connection and data application billing 有权
标题翻译：连接和数据应用程序计费
公开(公告)号：US09008613B2
公开(公告)日：2015-04-14
申请号：US11176166
申请日：2005-07-06
申请人： Xiaohui Du
发明人： Xiaohui Du
IPC分类号： H04M11/00 , H04M15/00 , H04W4/24
CPC分类号： H04M15/00 , H04M15/8214 , H04M15/8228 , H04M2215/2013 , H04M2215/2026 , H04M2215/22 , H04M2215/32 , H04M2215/782 , H04M2215/7833 , H04W4/24
摘要： A server and related method embodiments for determining usage on a wireless network are described. The server includes a connection detector, a connection classifier connected with the connection detector, and a usage tracker connected with the connection classifier. The connection detector detects a connection from a mobile station. The connection classifier determines the type of the detected connection. The usage tracker determines usage for each detected connection based on the connection type. A connecting mobile station for accessing the server includes a session controller for controlling a session with the server, a connection controller for controlling a connection related to the session, and an application assigner for controlling assignment of an application executed by the client to a particular connection.
摘要翻译：描述了用于确定无线网络上的使用的服务器和相关方法实施例。服务器包括连接检测器，与连接检测器连接的连接分类器，以及与连接分类器连接的使用跟踪器。连接检测器检测来自移动台的连接。连接分类器确定检测到的连接的类型。使用情况跟踪器根据连接类型确定每个检测到的连接的使用情况。用于访问服务器的连接移动站包括用于控制与服务器的会话的会话控制器，用于控制与该会话有关的连接的连接控制器，以及用于控制由客户端执行的应用对特定连接的分配的应用分配器。

2. 发明授权

US07799795B2 Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders 有权
标题翻译：芳基腈化合物及其组合物及其在治疗炎症和相关疾病中的用途
公开(公告)号：US07799795B2
公开(公告)日：2010-09-21
申请号：US11475653
申请日：2006-06-26
申请人： Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Julio C. Medina , Jeffrey T. Mihalic , George R. Tonn
发明人： Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Julio C. Medina , Jeffrey T. Mihalic , George R. Tonn
IPC分类号： C07D471/04 , A61K31/519 , A61P29/00 , A61P11/06 , A61P27/14 , A61P19/02 , A61P9/10 , A61P17/06 , C07D487/04 , C07D513/04 , C07D239/26 , C07D233/22 , C07D495/04 , C07D491/04 , C07D233/68 , C07D235/10 , C07D239/90
CPC分类号： C07D233/64 , C07D235/14 , C07D239/26 , C07D239/90 , C07D401/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Provided herein are compounds of the formula where A1, A2, A3, A4, L, Q, R1, R2, R3, R4, Rx, Ry, Rz, X, Y1, Y2, Y4 and Z are as described herein, and compositions thereof that are useful in the treatment of inflammatory and immune conditions and diseases. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor.
摘要翻译：本文提供的化合物是其中A1，A2，A3，A4，L，Q，R1，R2，R3，R4，Rx，Ry，Rz，X，Y1，Y2，Y4和Z如本文所述，其可用于治疗炎症和免疫病症和疾病。特别地，本发明提供了调节趋化因子受体的表达和/或功能的芳基腈化合物。

3. 发明授权

US07375102B2 Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use 失效
标题翻译：四氢喹唑啉-4（3H） - 酮相关和四氢吡啶并[2,3-D]嘧啶-4（3H） - 酮相关化合物，其使用的组合物和方法
公开(公告)号：US07375102B2
公开(公告)日：2008-05-20
申请号：US11168006
申请日：2005-06-27
申请人： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
发明人： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
IPC分类号： C07D471/04 , C07D487/04 , C07D239/72 , A61K31/513 , A61K31/519 , A61P29/00
CPC分类号： C07D471/04 , C07D239/91 , C07D401/12 , C07D403/12 , C07D409/12
摘要： Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
摘要翻译：提供具有下式的化合物：其中变量A 1，A 2，A 3，A 4，R 4， R 1，R 2，R 3，R 4，Q和L如本文所述。本发明化合物可用于治疗炎症和免疫疾病和疾病。还提供了使用本发明化合物的组合物和治疗方法。例如，本发明的方法可用于治疗炎症和免疫疾病以及诸如多发性硬化症，类风湿性关节炎，牛皮癣和炎症性肠病等疾病。

4. 发明申请

US20060069127A1 Imidazolo-related compounds, compositions and methods for their use 失效
标题翻译：咪唑唑相关化合物，其使用的组合物和方法
公开(公告)号：US20060069127A1
公开(公告)日：2006-03-30
申请号：US11168193
申请日：2005-06-27
申请人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
发明人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
IPC分类号： A61K31/454 , A61K31/4439 , A61K31/4178 , C07D403/02
CPC分类号： C07D233/64 , C07D233/68 , C07D233/90 , C07D235/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12
摘要： Compounds are provided having the formula: wherein variables R0, R1, R2, R3, R4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
摘要翻译：提供具有下式的化合物：

5. 发明申请

US20060069106A1 Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use 失效
标题翻译：四氢喹唑啉-4（3H） - 酮相关和四氢吡啶并[2,3-D]嘧啶-4（3H） - 酮相关化合物，其使用的组合物和方法
公开(公告)号：US20060069106A1
公开(公告)日：2006-03-30
申请号：US11168006
申请日：2005-06-27
申请人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
发明人： Zice Fu , Michael Johnson , An-Rong Li , Andrew Marcus , Julio Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason Duquette , Darin Gustin , Jeffrey Mihalic
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04 , C07D239/91 , C07D401/12 , C07D403/12 , C07D409/12
摘要： Compounds are provided having the formula: wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
摘要翻译：提供具有下式的化合物：

6. 发明授权

US08785468B2 Phenylalanine amide derivatives useful for treating insulin-related diseases and conditions 有权
标题翻译：用于治疗胰岛素相关疾病和病症的苯丙氨酸酰胺衍生物
公开(公告)号：US08785468B2
公开(公告)日：2014-07-22
申请号：US13148296
申请日：2010-02-12
申请人： Xiaohui Du , Zice Fu , Jonathan B. Houze , XianYun Jiao , Yong-Jae Kim , Leping Li , Jinqian Liu , Mike Elias Lizarzaburu , Julio C. Medina , Wang Shen , Simon Turcotte , Ming Yu
发明人： Xiaohui Du , Zice Fu , Jonathan B. Houze , XianYun Jiao , Yong-Jae Kim , Leping Li , Jinqian Liu , Mike Elias Lizarzaburu , Julio C. Medina , Wang Shen , Simon Turcotte , Ming Yu
IPC分类号： C07D401/04 , A61K31/444
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds of formula I: wherein A, B, X, R1, R2 and subscript n are as defined in the following disclosure. Compositions comprising the compounds are also provided, as well as methods for their use, for example, in treatment of type 2 diabetes and type 2 diabetes-related conditions.
摘要翻译：本文提供了式I的化合物：其中A，B，X，R 1，R 2和下标n如以下公开内容所定义。还提供了包含该化合物的组合物，以及其用于例如治疗2型糖尿病和2型糖尿病相关病症的方法。

7. 发明授权

US08278325B2 Nitrogen-containing heteroaryl compounds and methods of use thereof 有权
标题翻译：含氮杂芳基化合物及其使用方法
公开(公告)号：US08278325B2
公开(公告)日：2012-10-02
申请号：US13186351
申请日：2011-07-19
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Wen-Bin Ho , Eric Turtle , Xiaohui Du
IPC分类号： C07D217/26 , A61K31/472
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译：本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。

8. 发明授权

US08030354B2 Substituted biphenyl GPR40 modulators 有权
标题翻译：取代的联苯GPR40调节剂
公开(公告)号：US08030354B2
公开(公告)日：2011-10-04
申请号：US12287036
申请日：2008-10-03
申请人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
发明人： Sean P. Brown , Qiong Cao , Paul John Dransfield , Xiaohui Du , Zice Fu , Jonathan Houze , Xian Yun Jiao , Yong-Jae Kim , Todd J. Kohn , SuJen Lai , An-Rong Li , Daniel Lin , Jiwen Liu , Jian Luo , Julio C. Medina , Jeffrey D. Reagan , Vatee Pattaropong , Margrit Schwarz , Wang Shen , Yongli Su , Gayathri Swaminath , Marc Vimolratana , Yingcai Wang , Yumei Xiong , Li Yang , Ming Yu , Jie Zhang , Liusheng Zhu
IPC分类号： A61K31/192 , C07C53/134
CPC分类号： C07C323/62 , C07C59/68 , C07C59/72 , C07C217/54 , C07C217/62 , C07C317/22 , C07C323/19 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D213/64 , C07D309/12
摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
摘要翻译：本发明提供了可用于例如治疗受试者的代谢紊乱的化合物。这些化合物具有通式I：其中本文提供变量的定义。本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病例如II型糖尿病中的使用方法。

9. 发明授权

US07939538B2 Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases 失效
标题翻译：用于预防和治疗炎性和免疫调节性疾病和疾病的化合物，组合物和方法
公开(公告)号：US07939538B2
公开(公告)日：2011-05-10
申请号：US11168005
申请日：2005-06-27
申请人： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
发明人： Zice Fu , Michael G. Johnson , An-Rong Li , Andrew P. Marcus , Julio C. Medina , Philippe Bergeron , Xiaoqi Chen , Xiaohui Du , Jeffrey Deignan , Jason A. Duquette , Darin Gustin , Jeffrey T. Mihalic , Jiwen Liu
IPC分类号： A61K31/519 , C07D471/04 , C07D239/90 , C07D239/91
CPC分类号： C07D471/04 , C07D239/91 , C07D401/12
摘要： Compounds are provided having the formula: wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
摘要翻译：提供具有下式的化合物：其中如本文所述的变量Ra，R1，R2，R3，R4，A1，A4，L，Q，X和下标n。本发明化合物可用于治疗炎症和免疫疾病和疾病。还提供了使用本发明化合物的组合物和治疗方法。例如，本发明的方法可用于治疗炎症和免疫疾病以及诸如多发性硬化症，类风湿性关节炎，牛皮癣和炎症性肠病等疾病。

10. 发明申请

US20080293763A1 NOVEL NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF 有权
标题翻译：新型含氮化合物的方法及其使用方法
公开(公告)号：US20080293763A1
公开(公告)日：2008-11-27
申请号：US12015275
申请日：2008-01-16
申请人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric D. Turtle , Xiaohui Du
发明人： Michael P. Arend , Lee A. Flippin , Volkmar Guenzler-Pukall , Web-Bin Ho , Eric D. Turtle , Xiaohui Du
IPC分类号： A61K31/472 , C12N9/99
CPC分类号： A61K31/472 , A61K31/4725 , A61K31/473 , A61K38/1816 , C07D217/24 , C07D217/26 , C07D221/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo.
摘要翻译：本发明涉及适用于介导缺氧诱导因子并通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的化合物。

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