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1. 发明授权

US11543638B2 Dark-field microscope apparatus utilizing portable electronic communication device 有权
公开(公告)号：US11543638B2
公开(公告)日：2023-01-03
申请号：US16637733
申请日：2018-08-09
申请人： Ye Hu , Dali Sun
发明人： Ye Hu , Dali Sun
IPC分类号： G02B21/00 , G01N21/51 , G01N33/58 , G02B21/02 , G02B21/10 , G02B21/26
摘要： A mobile phone-based dark field microscope (MDFM) apparatus suitable for quantifying nanoparticle signals is provided. The MDFM apparatus includes an electrically operated light source, a dark-field condenser, a slide housing configured to receive an analytical slide, and an adapter housing configured to receive an objective lens and receive a portable electronic communication device. The slide housing positions the analytical slide between the objective lens and the dark-field condenser. The adapter housing registers the objective lens with a camera lens of the portable electronic communication device. A method for performing a biological quantitative study using the dark-field microscope apparatus is further provided.

2. 发明申请

US20230138519A1 DARK-FIELD MICROSCOPE APPARATUS UTILIZING PORTABLE ELECTRONIC COMMUNICATION DEVICE 有权
公开(公告)号：US20230138519A1
公开(公告)日：2023-05-04
申请号：US18069572
申请日：2022-12-21
申请人： Ye Hu , Dali Sun
发明人： Ye Hu , Dali Sun
IPC分类号： G02B21/00 , G01N21/51 , G01N33/58 , G02B21/02 , G02B21/10 , G02B21/26
摘要： A mobile phone-based dark field microscope (MDFM) apparatus suitable for quantifying nanoparticle signals is provided. The MDFM apparatus includes an electrically operated light source, a dark-field condenser, a slide housing configured to receive an analytical slide, and an adapter housing configured to receive an objective lens and receive a portable electronic communication device. The slide housing positions the analytical slide between the objective lens and the dark-field condenser. The adapter housing registers the objective lens with a camera lens of the portable electronic communication device. A method for performing a biological quantitative study using the dark-field microscope apparatus is further provided.

3. 发明授权

US08685755B2 Combinatorial multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules 有权
$Combinatorial multidomain mesoporous chips and a method for fractionation, stabilization, and storage of biomolecules$
标题翻译：组合多畴介孔芯片和生物分子分级，稳定和储存的方法
公开(公告)号：US08685755B2
公开(公告)日：2014-04-01
申请号：US12839606
申请日：2010-07-20
申请人： Mauro Ferrari , Xuewu Liu , Ennio Tasciotti , Ali Bouamrani , Ye Hu
发明人： Mauro Ferrari , Xuewu Liu , Ennio Tasciotti , Ali Bouamrani , Ye Hu
IPC分类号： G01N33/552 , B32B5/16 , B23H3/00 , C03C15/00
CPC分类号： G01N1/405 , G01N33/552
摘要： A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 μl in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity, and in the rational modulation of therapy based on the changes in the protein networks associated with the prognosis and the drug resistance of the disease.
摘要翻译：新的分馏装置显示出探索性筛选和生物标志物发现的理想特征。组成的MSC可以针对所需的孔径和表面性质以及在质量/电荷谱的期望范围内极低的丰富蛋白质和肽的螯合和富集而定制。 MSCs有效地从短至30分钟的时间内将复杂的生物样品中的可重复提取物产生少至10μl。它们制造成本便宜，并且允许放大生产以获得大量样品的同时处理。 MSCs是复合的，无标记的诊断工具，具有生物识别部分修饰的潜力，以增强特异性。 MSC可以存储，保护和稳定生物液体，从而简化和成本有效地收集和运输临床样品。基于MSC的装置可以用作补充组织病理学，成像和其他常规临床技术的诊断工具。 MSCs介导的疾病特异性蛋白质特征的鉴定可能有助于个性化治疗组合的选择，治疗功效和毒性的实时评估，以及基于与蛋白质网络相关联的蛋白质网络的变化的合理调节治疗预后和耐药性的疾病。

4. 发明申请

US20200183137A1 DARK-FIELD MICROSCOPE APPARATUS UTILIZING PORTABLE ELECTRONIC COMMUNICATION DEVICE 审中-公开
公开(公告)号：US20200183137A1
公开(公告)日：2020-06-11
申请号：US16637733
申请日：2018-08-09
申请人： Ye Hu , Dali Sun
发明人： Ye Hu , Dali Sun
IPC分类号： G02B21/00 , G01N21/51 , G01N33/58 , G02B21/10 , G02B21/26 , G02B21/02
摘要： A mobile phone-based dark field microscope (MDFM) apparatus suitable for quantifying nanoparticle signals is provided. The MDFM apparatus includes an electrically operated light source, a dark-field condenser, a slide housing configured to receive an analytical slide, and an adapter housing configured to receive an objective lens and receive a portable electronic communication device. The slide housing positions the analytical slide between the objective lens and the dark-field condenser. The adapter housing registers the objective lens with a camera lens of the portable electronic communication device. A method for performing a biological quantitative study using the dark-field microscope apparatus is further provided.

5. 发明申请

US20110065207A1 COMBINATORIAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES 有权
标题翻译：组合多元醇多糖和一种分解，稳定和储存生物分子的方法
公开(公告)号：US20110065207A1
公开(公告)日：2011-03-17
申请号：US12839606
申请日：2010-07-20
申请人： Mauro Ferrari , Xuewu Liu , Ennio Tasciotti , Ali Bouamrani , Ye Hu
发明人： Mauro Ferrari , Xuewu Liu , Ennio Tasciotti , Ali Bouamrani , Ye Hu
IPC分类号： G01N33/53 , G01N33/00 , G01N33/68 , H01J49/26 , G01N30/02
CPC分类号： G01N1/405 , G01N33/552
摘要： A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 μl in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples. The MSC-based device may serve as a diagnostic tool to complement histopathology, imaging, and other conventional clinical techniques. The MSCs mediated identification of disease-specific protein signatures may help in the selection of personalized therapeutic combinations, in the real-time assessment of therapeutic efficacy and toxicity, and in the rational modulation of therapy based on the changes in the protein networks associated with the prognosis and the drug resistance of the disease.
摘要翻译：新的分馏装置显示出探索性筛选和生物标志物发现的理想特征。组成的MSC可以针对所需的孔径和表面性质以及在质量/电荷谱的期望范围内极低的丰富蛋白质和肽的螯合和富集而定制。 MSCs有效地从短至30分钟的时间内将复杂的生物样品中的可重复提取物产生少至10μl。它们制造成本便宜，并且允许放大生产以获得大量样品的同时处理。 MSCs是复合的，无标记的诊断工具，具有生物识别部分修饰的潜力，以增强特异性。 MSC可以存储，保护和稳定生物液体，从而简化和成本有效地收集和运输临床样品。基于MSC的装置可以用作补充组织病理学，成像和其他常规临床技术的诊断工具。 MSCs介导的疾病特异性蛋白质特征的鉴定可能有助于个性化治疗组合的选择，治疗功效和毒性的实时评估，以及基于与蛋白质网络相关联的蛋白质网络的变化的合理调节治疗预后和耐药性的疾病。

6. 发明申请

US20100208757A1 METHOD OF FERROELECTRONIC DOMAIN INVERSION AND ITS APPLICATIONS 审中-公开
标题翻译：电子域反演方法及其应用
公开(公告)号：US20100208757A1
公开(公告)日：2010-08-19
申请号：US12670765
申请日：2008-07-31
申请人： Ye Hu
发明人： Ye Hu
IPC分类号： H01S3/109 , H05F3/00
CPC分类号： G02F1/3558 , G02F1/3775 , G02F2001/3546 , G02F2203/15
摘要： The present invention is related to a method to control the nucleation and to achieve designed domain inversion in single-domain ferroelectric substrates (e.g. MgO doped LiNbO3 substrates). It includes the first poling of the substrate with defined electrode patterns based on the corona discharge method to form shallow domain inversion (i.e. nucleation) under the electrode patterns, and is followed by the second crystal poling based on the electrostatic method to realize deep uniform domain inversion. Another objective of the present invention is to provide methods to achieve broadband light sources using a nonlinear crystal with a periodically domain inverted structure.
摘要翻译：本发明涉及一种控制成核并在单畴铁电衬底（例如MgO掺杂的LiNbO 3衬底）中实现设计的域反转的方法。它包括基于电晕放电方法的具有限定电极图案的基板的第一极化，以在电极图案下形成浅域反转（即成核），并且随后是基于静电方法的第二晶体极化，以实现深均匀域反转。本发明的另一个目的是提供使用具有周期性域倒置结构的非线性晶体来实现宽带光源的方法。

7. 发明申请

US20120087383A1 BONDED PERIODICALLY POLED OPTICAL NONLINEAR CRYSTALS 审中-公开
标题翻译：结合周期性光学非线性晶体
公开(公告)号：US20120087383A1
公开(公告)日：2012-04-12
申请号：US13377633
申请日：2010-09-29
申请人： Ye Hu , Wanguo Liang
发明人： Ye Hu , Wanguo Liang
IPC分类号： H01S3/10 , B32B37/14
CPC分类号： H01S3/109 , H01S3/0405 , H01S3/0612 , H01S3/0627 , H01S3/09415 , H01S3/1611 , H01S3/1673 , Y10T156/10
摘要： A method for designing optimized length of a nonlinear crystal (3) with a bonded structure is provided. Also provided are a method for forming a short Quasi-Phase Matching (QPM) crystal (3) sandwiched by non-poled nonlinear crystals (2, 4), and a method for designing multiple-section periodically poled nonlinear crystal with a high temperature, while keeping sufficient long crystal length and high conversion efficiency.
摘要翻译：提供了一种用结合结构设计非线性晶体（3）优化长度的方法。还提供了用于形成被非极化非线性晶体（2,4）夹持的短准相位匹配（QPM）晶体（3）的方法，以及用于设计具有高温的多段周期性极化非线性晶体的方法，同时保持足够长的晶体长度和高转换效率。

8. 发明申请

US20120077003A1 METHOD OF NONLINEAR CRYSTAL PACKAGING AND ITS APPLICATION IN DIODE PUMPED SOLID STATE LASERS 审中-公开
标题翻译：非线性晶体包装方法及其在二极管泵浦固体激光器中的应用
公开(公告)号：US20120077003A1
公开(公告)日：2012-03-29
申请号：US13377394
申请日：2010-12-31
申请人： Ye Hu
发明人： Ye Hu
IPC分类号： B32B7/02 , B32B37/06 , B32B15/04 , B32B9/04 , B32B27/38
CPC分类号： H01S3/109 , G02F1/3558 , G02F1/37 , H01S3/025 , H01S3/0405 , H01S3/0612 , H01S3/0621 , H01S3/0625 , H01S3/0627 , H01S3/1611 , H01S3/1673 , Y10T428/2495 , Y10T428/31511 , Y10T428/31678
摘要： The present invention is related to methods of packaging optical nonlinear crystal with a periodically domain inversion structure (e.g. periodically poled MgO doped lithium niobate) which is bonded with a laser crystal (e.g. Nd doped YVO4) and to achieve efficient second harmonic generation in an intra-cavity configuration.
摘要翻译：本发明涉及包含与激光晶体（例如Nd掺杂的YVO4）结合的周期性域反转结构（例如周期性极化的MgO掺杂的铌酸锂）的光学非线性晶体的方法，并且在内部实现有效的二次谐波生成 - 腔配置。

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