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    • 2. 发明申请
    • System and Method for Dynamic Query Processing Based on Financial Information and Query Responses
    • 基于财务信息和查询响应的动态查询处理系统与方法
    • US20130054435A1
    • 2013-02-28
    • US13217832
    • 2011-08-25
    • Ye ZhangVytas KisieliusGarrett Baird
    • Ye ZhangVytas KisieliusGarrett Baird
    • G06Q40/00
    • G06Q40/02
    • Various systems, computer program products, and methods for resolving financial issues using dynamic query processing is described. For example, a method may include obtaining an attribute of a debtor having a financial issue. The attribute describes a prior history or action of the debtor. The method may include communicating a question to be posed to the debtor. The method may include receiving a response to the question such as via a web page. The method may include determining and communicating a follow-up question to be posed to the debtor based on the attribute of the debtor and the response to the question. The method may include receiving a follow-up response to the follow-up question. The method may include determining a proposal to resolve the financial issue based on the response and the follow-up response.
    • 描述了使用动态查询处理解决财务问题的各种系统,计算机程序产品和方法。 例如,一种方法可以包括获得具有财务问题的债务人的属性。 该属性描述了债务人以前的历史或行动。 该方法可能包括将要提出的问题传达给债务人。 该方法可以包括例如经由网页接收对该问题的响应。 该方法可以包括根据债务人的属性和对问题的回应来确定和传达对债务人提出的后续问题。 该方法可以包括接收对后续问题的后续响应。 该方法可以包括基于响应和后续响应来确定解决财务问题的提案。
    • 3. 发明申请
    • Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules
    • 基于脂质纳米颗粒的组合物和递送生物活性分子的方法
    • US20100048888A1
    • 2010-02-25
    • US12446882
    • 2007-10-17
    • Tongqian ChenKurt VagleChandra VargeeseWeimin WangYe Zhang
    • Tongqian ChenKurt VagleChandra VargeeseWeimin WangYe Zhang
    • C07J43/00
    • C12N15/88A61K9/1271A61K47/6911C07C217/28Y10S977/797
    • The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), short hairpin RNA (shRNA), and RNAi inhibitor molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).
    • 本发明涉及新型阳离子脂质,转染剂,微粒,纳米颗粒和短干扰核酸(siNA)分子。 本发明还涉及用于研究,诊断和治疗对受试者或生物体中基因表达和/或活性的调节作用的性状,疾病和病状的组合物和方法。 具体地说,本发明涉及有效转染或递送生物活性分子的新型阳离子脂质,微粒,纳米颗粒和转染剂,例如抗体(例如单克隆抗体,嵌合型,人源化等),胆固醇,激素,抗病毒剂,肽,蛋白质, 化学治疗剂,小分子,维生素,辅因子,核苷,核苷酸,寡核苷酸,酶核酸,反义核酸,形成三链体的寡核苷酸,2,5-A嵌合体,dsRNA,同源酶,适体,诱饵及其类似物和小核酸 相关细胞的酸分子,如短干扰核酸(siNA),短干扰RNA(siRNA),双链RNA(dsRNA),微RNA(miRNA),短发夹RNA(shRNA)和RNAi抑制剂分子 和/或组织,例如受试者或生物体。 这样的新型阳离子脂质,微粒,纳米颗粒和转染剂可用于例如提供预防,抑制或治疗细胞,受试者或生物体中的疾病,病症或性状的组合物。 本文所述的组合物通常被称为配制的分子组合物(FMC)或脂质纳米颗粒(LNP)。
    • 4. 发明授权
    • Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
    • 基于脂质纳米颗粒的组合物和递送生物活性分子的方法
    • US07514099B2
    • 2009-04-07
    • US11353630
    • 2006-02-14
    • Tongqian ChenChandra VargeeseKurt VagleWeimin WangYe Zhang
    • Tongqian ChenChandra VargeeseKurt VagleWeimin WangYe Zhang
    • A61K9/127A61K31/56
    • C07C217/28A61K9/0073A61K9/1271A61K9/1272A61K47/543A61K47/6911C07C217/42C07C217/58C07C239/20C07J41/00C12N15/88
    • The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in a subject or organism. Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles and transfection agents that effectively transfect or deliver biologically active molecules, such as antibodies (e.g., monoclonal, chimeric, humanized etc.), cholesterol, hormones, antivirals, peptides, proteins, chemotherapeutics, small molecules, vitamins, co-factors, nucleosides, nucleotides, oligonucleotides, enzymatic nucleic acids, antisense nucleic acids, triplex forming oligonucleotides, 2,5-A chimeras, dsRNA, allozymes, aptamers, decoys and analogs thereof, and small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, to relevant cells and/or tissues, such as in a subject or organism. Such novel cationic lipids, microparticles, nanoparticles and transfection agents are useful, for example, in providing compositions to prevent, inhibit, or treat diseases, conditions, or traits in a cell, subject or organism. The compositions described herein are generally referred to as formulated molecular compositions (FMC) or lipid nanoparticles (LNP).
    • 本发明涉及新型阳离子脂质,转染剂,微粒,纳米颗粒和短干扰核酸(siNA)分子。 本发明还涉及用于研究,诊断和治疗对受试者或生物体中基因表达和/或活性的调节作用的性状,疾病和病状的组合物和方法。 具体地说,本发明涉及有效转染或递送生物活性分子的新型阳离子脂质,微粒,纳米颗粒和转染剂,例如抗体(例如单克隆抗体,嵌合型,人源化等),胆固醇,激素,抗病毒剂,肽,蛋白质, 化学治疗剂,小分子,维生素,辅因子,核苷,核苷酸,寡核苷酸,酶核酸,反义核酸,形成三链体的寡核苷酸,2,5-A嵌合体,dsRNA,同源酶,适体,诱饵及其类似物和小核酸 酸分子,如短干扰核酸(siNA),短干扰RNA(siRNA),双链RNA(dsRNA),微RNA(miRNA)和短发夹RNA(shRNA)分子)相关细胞和/或 组织,例如受试者或生物体。 这样的新型阳离子脂质,微粒,纳米颗粒和转染剂可用于例如提供预防,抑制或治疗细胞,受试者或生物体中的疾病,病症或性状的组合物。 本文所述的组合物通常被称为配制的分子组合物(FMC)或脂质纳米颗粒(LNP)。
    • 5. 发明申请
    • Domain name system resolution
    • 域名系统解析
    • US20060271707A1
    • 2006-11-30
    • US11474573
    • 2006-06-26
    • Douglas ChelineMichael MaYe ZhangLester Chong
    • Douglas ChelineMichael MaYe ZhangLester Chong
    • G06F15/16
    • H04L63/0272H04L29/12066H04L61/1511H04L63/0823H04L63/0838
    • A host name query is received by a modem from a client computer. The host name query is simultaneously transmitted from the modem to a plurality of Domain Name System (DNS) servers. A response is returned to the client computer from the modem, where the response is based on the host name query and any responses received from the DNS servers. In a preferred embodiment at least one address associated with the host name query is acquired from the DNS servers. The client computer then sends a request for content to the address. If more than one address is returned, all but one of the addresses is eliminated. This can be done by rejecting all but the most recent address, or rejecting all addresses not provided by a service provider DSN server.
    • 调制解调器从客户端计算机接收主机名查询。 主机名查询同时从调制解调器发送到多个域名系统(DNS)服务器。 响应将从调制解调器返回给客户端计算机,其中响应基于主机名查询和从DNS服务器接收到的任何响应。 在优选实施例中,从DNS服务器获取与主机名查询相关联的至少一个地址。 然后,客户端计算机向地址发送内容请求。 如果返回多个地址,则除去其中一个地址。 这可以通过拒绝除最新地址之外的所有地址或拒绝服务提供商DSN服务器未提供的所有地址来完成。
    • 6. 发明申请
    • Calculating tax amount where multiple tax types may apply
    • 计算可应用多种税种的税额
    • US20060242042A1
    • 2006-10-26
    • US11113832
    • 2005-04-25
    • Richard QinAri SchapiraYe ZhangMichael SunDiamond SongChen WuJeff ZengHua Wang
    • Richard QinAri SchapiraYe ZhangMichael SunDiamond SongChen WuJeff ZengHua Wang
    • G06Q20/00G06Q40/00
    • G06Q40/02G06Q20/207G06Q40/00
    • A computer program product for calculating a tax amount where multiple types of taxes may apply to a transaction is tangibly embodied in an information carrier and includes first data structures comprising tax formulas. Each of the tax formulas is associated with one of several tax types. The computer program product includes second data structures comprising tax combinations of the several tax types, each tax combination having associated therewith at least one of the several tax types, one of the tax combinations to be selected for use with a specific transaction. The computer program product includes executable instructions that when executed determine, from information associated with the specific transaction, which one of the tax combinations to use in calculating a tax amount for the specific transaction, the tax amount to be calculated using the formula associated with any of the tax types included in the selected tax combination.
    • 用于计算可以应用于交易的多种类型的税收的税额的计算机程序产品有形地体现在信息载体中,并且包括包括税公式的第一数据结构。 每种税收公式都与几种税种之一相关联。 计算机程序产品包括包括几种税种类型的税组合的第二数据结构,每个税组合与其相关联的几种税种类型中的至少一种,要选择用于特定交易的税收组合之一。 计算机程序产品包括可执行指令,当执行确定时,从与特定交易相关联的信息确定在计算特定交易的税额时使用哪一种税收组合,使用与任何相关联的公式计算的税额 所选税种组合中纳入的税种。
    • 7. 发明授权
    • Domain name system resolution
    • 域名系统解析
    • US07099957B2
    • 2006-08-29
    • US09938430
    • 2001-08-23
    • Douglas A. ChelineMichael MaYe ZhangLester J. Chong
    • Douglas A. ChelineMichael MaYe ZhangLester J. Chong
    • G06F15/16
    • H04L63/0272H04L29/12066H04L61/1511H04L63/0823H04L63/0838
    • A host name query is received by a modem from a client computer. The host name query is simultaneously transmitted from the modem to a plurality of Domain Name System (DNS) servers. A response is returned to the client computer from the modem, where the response is based on the host name query and any responses received from the DNS servers. In a preferred embodiment at least one address associated with the host name query is acquired from the DNS servers. The client computer then sends a request for content to the address. If more than one address is returned, all but one of the addresses is eliminated. This can be done by rejecting all but the most recent address, or rejecting all addresses not provided by a service provider DNS server.
    • 调制解调器从客户端计算机接收主机名查询。 主机名查询同时从调制解调器发送到多个域名系统(DNS)服务器。 响应将从调制解调器返回给客户端计算机,其中响应基于主机名查询和从DNS服务器接收到的任何响应。 在优选实施例中,从DNS服务器获取与主机名查询相关联的至少一个地址。 然后,客户端计算机向地址发送内容请求。 如果返回多个地址,则除去其中一个地址。 这可以通过拒绝除最新地址之外的所有地址或拒绝服务提供商DNS服务器未提供的所有地址来完成。
    • 9. 发明授权
    • Establishing access to a secure network based on user-created credential indicia
    • 根据用户创建的凭据标记建立对安全网络的访问
    • US09280643B2
    • 2016-03-08
    • US13470027
    • 2012-05-11
    • Ye Zhang
    • Ye Zhang
    • G06F21/00
    • H04L63/083G06F21/00G06F21/42G06F21/45G06K7/10544G06K19/06028G06K19/06037H04L63/0428H04L63/08H04L63/102
    • In various aspects, code-based indicia contain secured network access credentials. In some aspects, a computer processor receives user input that specifies secured network access credentials, and the computer processor creates or modifies credentials for establishing a secured network connection. In these aspects, the computer processor generates code-based indicia that contain at least part of the secured network access credentials. In other aspects, a computer processor scans the code-based indicia and extracts the network access credentials. In these aspects, the computer processor employs the network access credentials to establish the secured network connection. In additional aspects, a network router apparatus renders the code-based indicia to an active display. In further aspects, a network router apparatus conditions grant of network access to a device on receipt from the device of an answer to a security question included in the secured network access credentials.
    • 在各个方面,基于代码的标记包含安全的网络访问凭证。 在一些方面,计算机处理器接收指定安全网络访问凭证的用户输入,并且计算机处理器创建或修改用于建立安全网络连接的凭证。 在这些方面,计算机处理器生成包含至少部分安全网络访问凭证的基于代码的标记。 在其他方面,计算机处理器扫描基于代码的标记并提取网络访问凭证。 在这些方面,计算机处理器采用网络访问凭证来建立安全的网络连接。 在另外的方面,网络路由器设备将基于代码的标记呈现为活动显示。 在另外的方面,网络路由器装置在从设备接收到对包括在安全网络访问凭证中的安全问题的答案的情况下,对设备进行网络访问许可。
    • 10. 发明授权
    • Minimum energy point tracking buck converter
    • 最小能量点跟踪降压转换器
    • US08866462B2
    • 2014-10-21
    • US13637230
    • 2011-02-28
    • Ping LuoShaowei ZhenXiang GengYe ZhangYajuan HeBo Zhang
    • Ping LuoShaowei ZhenXiang GengYe ZhangYajuan HeBo Zhang
    • H02M3/157H02M3/158H02M1/00
    • H02M3/157H02M3/158H02M2001/0025
    • This invention involves with a low power IC (Integrated Circuit) with high energy efficiency. This invention describes a Buck converter that can track the minimum energy point of the load. It works by estimating input energy of every sensing period, taking advantage of energy consumption curve of IC in sub-threshold. Energy estimation is implemented with counting conducted pulses, while maintaining constant input energy of each pulse by regulating output voltage and ON time with digital control circuit. With digital control circuit, minimum energy point can be tracked with a lookup table stored inside. Most of this invention's control circuit is digital, with benefits of low power consumption and small chip area.
    • 本发明涉及具有高能量效率的低功率IC(集成电路)。 本发明描述了可以跟踪负载的最小能量点的降压转换器。 通过估计每个感测周期的输入能量,利用IC的能量消耗曲线在次阈值中起作用。 通过计数传导脉冲实现能量估计,同时通过使用数字控制电路调节输出电压和导通时间来保持每个脉冲的恒定输入能量。 使用数字控制电路,可以使用存储在其中的查找表来跟踪最小能量点。 本发明的大多数控制电路是数字式的,具有低功耗和小芯片面积的优点。