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1. 发明授权

US08822482B2 Icotinib hydrochloride, synthesis, crystalline forms, pharmaceutical compositions, and uses thereof 有权
标题翻译：盐酸伊替替，合成，结晶形式，药物组合物及其用途
公开(公告)号：US08822482B2
公开(公告)日：2014-09-02
申请号：US13003216
申请日：2009-07-07
申请人： Yinxiang Wang , Guojian Xie , Lieming Ding , Fenlai Tan , Yunyan Hu , Wei He , Bin Han , Wei Long , Yong Liu , Haima Ai , Charles Davis , Don Zhang
发明人： Yinxiang Wang , Guojian Xie , Lieming Ding , Fenlai Tan , Yunyan Hu , Wei He , Bin Han , Wei Long , Yong Liu , Haima Ai , Charles Davis , Don Zhang
IPC分类号： A61K31/519 , C07D491/056
CPC分类号： C07D491/056 , A61K31/519 , C07B2200/13
摘要： The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.
摘要翻译：本发明涉及4 - [（3-乙炔基苯基）氨基] -6,7-苯并-12-冠 - 喹唑啉盐酸盐，其新结晶形式，其用于治疗由EGFR激酶介导的疾病及其组合治疗用途的治疗用途与其他治疗剂。本发明还提供用于制备4 - [（3-乙炔基苯基）氨基] -6,7-苯并-12-冠 - 喹唑啉盐酸盐的合成方法，其新结晶形式和用于合成4 - [（ -3-乙炔基苯基）氨基] -6,7-苯并-12-冠 - 喹唑啉盐酸盐。

2. 发明申请

US20130053304A1 GLUCAGON-LIKE PEPTIDE-1 ANALOGUES AND USES THEREOF 有权
标题翻译： GLUCAGON-like肽类肽类及其用途
公开(公告)号：US20130053304A1
公开(公告)日：2013-02-28
申请号：US13643840
申请日：2011-04-29
申请人： Yinxiang Wang , Fenlai Tan , Shaojing Hu , Xiangdong Zhao , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Lieming Ding , Yunyan Hu , Hong Cao , Wei Long
发明人： Yinxiang Wang , Fenlai Tan , Shaojing Hu , Xiangdong Zhao , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Lieming Ding , Yunyan Hu , Hong Cao , Wei Long
IPC分类号： A61K38/26 , A61P3/10 , A61P3/08 , A61P3/04 , A61P9/12 , A61P1/04 , A61P25/00 , A61P9/10 , A61P9/00 , A61P7/02 , A61P1/00 , C07K14/605 , A61P3/06
CPC分类号： C07K14/605 , A61K38/00
摘要： Provided is a glucagon-like peptide-1 (GLP-1) analogue shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analogue has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analogue is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analogue in conquering blood sugar.
摘要翻译：本发明提供如下式所示的胰高血糖素样肽-1（GLP-1）类似物，其中X选自甘氨酸和甘氨酰胺。 GLP-1类似物相对于序列GLP-1具有位置8的非蛋白原性氨基酸残基，并且用包含两个酸性基团的部分酰化至位置26的赖氨酸残基。GLP-1类似物对二肽基肽酶IV，以使体内延长半衰期。还提供了GLP-1类似物在征服血糖中的用途。

3. 发明申请

US20110182882A1 Icotinib Hydrochloride, Synthesis, Crystalline Forms, Pharmaceutical Compositions, and Uses Thereof 有权
标题翻译：盐酸伊可啶，合成，结晶形式，药物组合物及其用途
公开(公告)号：US20110182882A1
公开(公告)日：2011-07-28
申请号：US13003216
申请日：2009-07-07
申请人： Yinxiang Wang , Guojian Xie , Lieming Ding , Fenlai Tan , Yunyan Hu , Wei He , Bin Han , Wei Long , Yong Liu , Haima Ai , Charles Davis , Don Zhang
发明人： Yinxiang Wang , Guojian Xie , Lieming Ding , Fenlai Tan , Yunyan Hu , Wei He , Bin Han , Wei Long , Yong Liu , Haima Ai , Charles Davis , Don Zhang
IPC分类号： A61K39/395 , C07D491/056 , A61K31/519 , A61K38/43 , A61P35/00
CPC分类号： C07D491/056 , A61K31/519 , C07B2200/13
摘要： The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.
摘要翻译：本发明涉及4 - [（3-乙炔基苯基）氨基] -6,7-苯并-12-冠 - 喹唑啉盐酸盐，其新结晶形式，其用于治疗由EGFR激酶介导的疾病及其组合治疗用途的治疗用途与其他治疗剂。本发明还提供用于制备4 - [（3-乙炔基苯基）氨基] -6,7-苯并-12-冠 - 喹唑啉盐酸盐的合成方法，其新结晶形式和用于合成4 - [（ 3-乙炔基苯基）氨基] -6,7-苯并-12-冠 - 喹唑啉盐酸盐。

4. 发明申请

US20060055492A1 HIGH-TEMPERATURE SHUTDOWN PROTECTING RELAY 失效
标题翻译：高温切断保护继电器
公开(公告)号：US20060055492A1
公开(公告)日：2006-03-16
申请号：US11199288
申请日：2005-08-08
申请人： Fang Yu , Jianhua Han , Yinxiang Wang
发明人： Fang Yu , Jianhua Han , Yinxiang Wang
IPC分类号： H01H67/02
CPC分类号： H01H3/32 , H01H3/503
摘要： A high-temperature shutdown protecting relay comprises a base; a L copper pin and a N copper pin are provided on the base with resting contacts provided at their bottoms respectively; stretchy copper blades are provided on the base, which are fit to the L copper pin and the N copper pin respectively, with movable contacts provided thereon, which are fit to said resting contacts; a stand is provided on the base and above the stretchy copper blades; grooves are provided on the lower side of the stand with ceramic rods for insulating the stand from the stretchy copper blades embedded therein. The high-temperature shutdown protecting relay provided by the present utility model can keep normal operating property under high temperature. When the movable contacts and the resting contacts are engaged with each other, a larger locking force can be kept therebetween; when the movable contacts and the resting contacts are disengaged, there is a larger disengaging force to ensure these two kinds of contacts disengaged, and to ensure a certain disengaging interval therebetween and very quick disengaging time.
摘要翻译：高温关断保护继电器包括基座; 底座上设有一个L铜针和一个N铜针，底座上分别设有静电触点，在基座上设置有伸缩的铜叶片，它们分别与L铜销和N铜销配合，其上设置有可移动触点，其上配置有所述静止触点; 在基部和伸缩铜叶片上方设置支架; 在支架的下侧设置有陶瓷棒的槽，用于使支架与嵌入其中的伸缩铜叶片绝缘。本实用新型提供的高温关断保护继电器可保持高温下的正常工作性能。当可动触点和静止触点彼此接合时，可以保持较大的锁定力; 当可动触点和静止触点脱离时，存在较大的分离力，以确保这两种触头脱离，并确保其间具有一定的脱离间隔并且非常快速的分离时间。

5. 发明授权

US09409900B2 Compound for increasing kinase active and application thereof 有权
标题翻译：增加激酶活性的化合物及其应用
公开(公告)号：US09409900B2
公开(公告)日：2016-08-09
申请号：US13884470
申请日：2011-11-09
申请人： Xinshan Kang , Wei Long , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Yunyan Hu , Fenlai Tan , Yinxiang Wang
发明人： Xinshan Kang , Wei Long , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Yunyan Hu , Fenlai Tan , Yinxiang Wang
IPC分类号： C07D417/12 , C07D233/88 , C07D405/14 , C07D417/14 , C07D213/74 , C07D213/80 , C07D213/803 , C07D241/20 , C07D277/42 , C07D285/08 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D401/14
CPC分类号： C07D417/14 , C07D213/74 , C07D213/80 , C07D213/803 , C07D233/88 , C07D241/20 , C07D277/42 , C07D285/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/12
摘要： The compound of Formula (I), pharmaceutically acceptable salts thereof, solvates thereof, chelates thereof, non-covalent complexes thereof or produgs of compounds mentioned above or the mixture of any form above mentioned are provided. The use of the compounds in manufacturing a medicament for the treatment and/or prevention of diabetes, obesity and related disorders.
摘要翻译：提供式（I）的化合物，其药学上可接受的盐，其溶剂化物，其螯合物，其非共价络合物或上述化合物的产物或上述任何形式的混合物。化合物在制备用于治疗和/或预防糖尿病，肥胖症和相关疾病的药物中的用途。

6. 发明授权

US09242991B2 Substituted fused heterocycles as c-Met tyrosine kinase inhibitors 有权
标题翻译：取代的稠合杂环作为c-Met酪氨酸激酶抑制剂
公开(公告)号：US09242991B2
公开(公告)日：2016-01-26
申请号：US13809836
申请日：2011-07-14
申请人： Shaojing Hu , Fei Wang , Wei Long , Xiaoyan Shen , Fenlai Tan , Yinxiang Wang
发明人： Shaojing Hu , Fei Wang , Wei Long , Xiaoyan Shen , Fenlai Tan , Yinxiang Wang
IPC分类号： A61K31/519 , A61K31/4353 , C07D491/14 , C07D491/04 , C07D498/04
CPC分类号： C07D491/04 , C07D498/04
摘要： This invention relates to certain novel fused quinazoline derivatives (Formula I) as c-Met inhibitors which is shown as formula I, their synthesis and their use for treating a c-Met mediated disorder. More particularly, this invention is directed to fused heterocyclic derivatives useful inhibitors of c-Met, methods for producing such compounds and methods for treating as c-Met mediated disorder
摘要翻译：本发明涉及某些新的稠合喹唑啉衍生物（式I）作为c-Met抑制剂，其如式I所示，其合成及其用于治疗c-Met介导的病症的用途。更具体地，本发明涉及用于c-Met的有用的抑制剂的稠合杂环衍生物，这种化合物的制备方法和作为c-Met介导的病症治疗的方法

7. 发明授权

US08951959B2 Glucagon-like peptide-1 analogues and uses thereof 有权
标题翻译：胰高血糖素样肽-1类似物及其用途
公开(公告)号：US08951959B2
公开(公告)日：2015-02-10
申请号：US13643840
申请日：2011-04-29
申请人： Yinxiang Wang , Fenlai Tan , Shaojing Hu , Xiangdong Zhao , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Lieming Ding , Yunyan Hu , Hong Cao , Wei Long
发明人： Yinxiang Wang , Fenlai Tan , Shaojing Hu , Xiangdong Zhao , Cunbo Ma , Yanping Wang , Xiaoyan Shen , Lieming Ding , Yunyan Hu , Hong Cao , Wei Long
IPC分类号： A61K38/00 , A61P9/10 , C07K14/47 , A61P3/04 , A61K38/22 , A61P3/08 , A61P3/10 , A61K38/26 , A61P7/12 , C07K14/605 , A61K38/28 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/605 , A61K38/00
摘要： Provided is a glucagon-like peptide-1 (GLP-1) analog shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analog has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analog is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analog in conquering blood sugar.
摘要翻译：本发明提供如下式所示的胰高血糖素样肽-1（GLP-1）类似物，其中X选自甘氨酸和甘氨酰胺。 GLP-1类似物相对于序列GLP-1具有位置8的非蛋白原性氨基酸残基，并且用包含两个酸性基团的部分酰化至位置26的赖氨酸残基。GLP-1类似物对二肽基肽酶IV，以使体内延长半衰期。还提供了GLP-1类似物在征服血糖中的用途。

8. 发明申请

US20140343137A1 Stable Polymorphic Forms of Compound as Hypoxia Mimetics, and Uses Thereof 有权
标题翻译：作为缺氧模拟物的化合物的稳定多晶型及其用途
公开(公告)号：US20140343137A1
公开(公告)日：2014-11-20
申请号：US14166203
申请日：2012-07-30
申请人： Xinshan Kang , Wei Long , Fei Wang , Cunbo Ma , Liufeng Zhou , Yunyan Hu , Yanping Wang , Hong Cao , Yinxiang Wang , Fenlai Tan
发明人： Xinshan Kang , Wei Long , Fei Wang , Cunbo Ma , Liufeng Zhou , Yunyan Hu , Yanping Wang , Hong Cao , Yinxiang Wang , Fenlai Tan
IPC分类号： C07D311/56
CPC分类号： C07D311/56
摘要： The polymorphic forms of the compound of Formula I, the preparation thereof including the preparation of the intermediates, the pharmaceutical compositions thereof and the uses of a polymorph above in the manufacture of medicaments for treating a disease, a disorder or a condition are disclosed.
摘要翻译：公开了式I化合物的多晶型物，其制备方法，包括制备中间体，其药物组合物，以及上述多晶型物在制备用于治疗疾病，病症或病症的药物中的用途。

9. 发明授权

US07030722B2 High-temperature shutdown protecting relay 失效
标题翻译：高温关断保护继电器
公开(公告)号：US07030722B2
公开(公告)日：2006-04-18
申请号：US11199288
申请日：2005-08-08
申请人： Fang Yu , Jianhua Han , Yinxiang Wang
发明人： Fang Yu , Jianhua Han , Yinxiang Wang
IPC分类号： H01H75/00
CPC分类号： H01H3/32 , H01H3/503
摘要： A high-temperature shutdown protecting relay comprises a base; a L copper pin and a N copper pin are provided on the base with resting contacts provided at their bottoms respectively; stretchy copper blades are provided on the base, which are fit to the L copper pin and the N copper pin respectively, with movable contacts provided thereon, which are fit to said resting contacts; a stand is provided on the base and above the stretchy copper blades; grooves are provided on the lower side of the stand with ceramic rods for insulating the stand from the stretchy copper blades embedded therein. The high-temperature shutdown protecting relay provided by the present utility model can keep normal operating property under high temperature. When the movable contacts and the resting contacts are engaged with each other, a larger locking force can be kept therebetween; when the movable contacts and the resting contacts are disengaged, there is a larger disengaging force to ensure these two kinds of contacts disengaged, and to ensure a certain disengaging interval therebetween and very quick disengaging time.
摘要翻译：高温关断保护继电器包括基座; 底座上设有一个L铜针和一个N铜针，底座上分别设有静电触点，在基座上设置有伸缩的铜叶片，它们分别与L铜销和N铜销配合，其上设置有可移动触点，其上配置有所述静止触点; 在基部和伸缩铜叶片上方设置支架; 在支架的下侧设置有陶瓷棒的槽，用于使支架与嵌入其中的伸缩铜叶片绝缘。本实用新型提供的高温关断保护继电器可保持高温下的正常工作性能。当可动触点和静止触点彼此接合时，可以保持较大的锁定力; 当可动触点和静止触点脱离时，存在较大的分离力，以确保这两种触头脱离，并确保其间具有一定的脱离间隔并且非常快速的分离时间。

10. 发明授权

US09487570B2 Glucagon like peptide analogs, composition, and method of use 有权
标题翻译：胰高血糖素样肽类似物，组合物和使用方法
公开(公告)号：US09487570B2
公开(公告)日：2016-11-08
申请号：US13698819
申请日：2010-05-17
申请人： Shaojing Hu , Fenlai Tan , Yanping Wang , Cunbo Ma , Yunyan Hu , Hong Cao , Xiangdong Zhao , Wei Long , Yinxiang Wang , Lieming Ding
发明人： Shaojing Hu , Fenlai Tan , Yanping Wang , Cunbo Ma , Yunyan Hu , Hong Cao , Xiangdong Zhao , Wei Long , Yinxiang Wang , Lieming Ding
IPC分类号： A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605 , A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K9/00
CPC分类号： C07K14/605 , A61K9/0019 , A61K38/00
摘要： The present invention relates to novel analogs of glucagon like peptide and compositions that are useful for up-regulating insulin expression in mammals and for treating diabetes. In particular, these peptide derivatives have a peptide mimic linker and provides long duration of action for the treatment of diabetes and other insulinotropic peptide related diseases, gastrointestinal function and activities associated with glucagon levels.
摘要翻译：本发明涉及胰高血糖素样肽的新型类似物和可用于上调哺乳动物胰岛素表达和治疗糖尿病的组合物。特别地，这些肽衍生物具有肽模拟接头并且提供用于治疗糖尿病和其它促胰岛素肽相关疾病，胃肠功能和与胰高血糖素水平相关的活性的长期作用。

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