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    • 5. 发明申请
    • BIOMOLECULE ANALYZER
    • 生物分析仪
    • US20050213090A1
    • 2005-09-29
    • US11017506
    • 2004-12-20
    • Akihiro NambaKiyochika IshibashiYoshiaki Horikawa
    • Akihiro NambaKiyochika IshibashiYoshiaki Horikawa
    • G01N21/64
    • G01N21/6458G01N21/6408G02B21/0076
    • A biomolecule analyzer of the present invention analyzes dynamic behaviors of biomolecules, and comprises image obtaining means for obtaining an image corresponding to at least one observation area of a biological sample containing biomolecules held in a measurable state, designation means for designating an arbitrary point on the image obtained by the image obtaining means, arrangement means for arranging a measuring point in a point position on the sample corresponding to the point designated by the designation means so that the measuring point may continuously coincide with the point position, measurement means for measuring a signal derived from dynamic information of an object to be measured from the measuring point arranged by the arrangement means, and analysis means for analyzing measuring results of the measurement means.
    • 本发明的生物分子分析仪分析生物分子的动态行为,并且包括图像获取装置,用于获得与包含保持在可测量状态的生物分子的生物样品的至少一个观察区域相对应的图像,用于指定在可测量状态下的任意点的指定装置 由图像获得装置获得的图像,用于将测量点布置在与由指定装置指定的点相对应的样本上的点位置的测量点的布置装置,使得测量点可以与点位置连续一致,用于测量信号的测量装置 从由所述布置装置布置的测量点的待测物体的动态信息导出;以及分析装置,用于分析测量装置的测量结果。
    • 8. 发明授权
    • Scanning optical microscope
    • 扫描光学显微镜
    • US4893008A
    • 1990-01-09
    • US204277
    • 1988-06-09
    • Yoshiaki Horikawa
    • Yoshiaki Horikawa
    • G01N21/88G01N21/64G02B21/00
    • G01N21/6458G02B21/0048G02B21/0076G01N2201/1087
    • A scanning optical microscope comprises a light source, an objective lens for focusing light emitted from the light source upon an object to be observed, a light deflecting optical system provided between the light source and the objective lens and including a light deflector formed by an acousto-optic light deflector (AOD), photoelectric transducing means for detecting light from the object, and light shielding means having an elongated aperture provided between the object and the photoelectric transducing means. Light from the light source is deflected by the AOD to scan the object at a high speed, and light from the object is led to the photoelectric transducing means through the aperture of the light shielding means, without passing through the AOD, to realize confocal microscopy.
    • 扫描光学显微镜包括光源,用于将从光源发射的光聚焦在待观察物体上的物镜,设置在光源和物镜之间的光偏转光学系统,并且包括由声音形成的光偏转器 - 光学偏光器(AOD),用于检测来自物体的光的光电转换装置,以及在物体和光电转换装置之间具有细长孔的遮光装置。 来自光源的光由AOD偏转以高速扫描物体,并且来自物体的光通过遮光装置的孔通过光电转换装置,而不通过AOD,以实现共聚焦显微镜 。
    • 9. 发明授权
    • Scanning type optical microscope
    • 扫描型光学显微镜
    • US4800269A
    • 1989-01-24
    • US065034
    • 1987-06-19
    • Yoshiaki Horikawa
    • Yoshiaki Horikawa
    • G02B21/00G02B26/10G01N21/00
    • G02B21/002
    • In order to make it feasible to obtain a differential phase image having a uniform brightness and good quality, a scanning type optical microscope comprises: a laser light source; an objective lens for collecting, onto an object under observation, a light beam emitting from the laser light source; a scanning light deflector disposed between the laser light source and the objective lens; a light detector comprised of a plurality of photoelectric converters receiving a light from the object and being separated into two sections; a signal processing circuit for calculating the difference between the signals coming from the two sections of the light detector to thereby obtain a differential phase signal; and adjusting means for adjusting the differential phase signal with a signal varying with an image height and being synchronous with the scanning of the light beam.
    • 为了使得获得具有均匀亮度和良好质量的差分相位图像变得可行,扫描型光学显微镜包括:激光源; 用于在观察对象上收集从激光光源发射的光束的物镜; 设置在激光光源和物镜之间的扫描光偏转器; 光检测器,由多个光电转换器构成,所述多个光电转换器从所述物体接收光并将其分成两部分; 信号处理电路,用于计算来自光检测器的两个部分的信号之间的差,从而获得差分相位信号; 以及调整装置,用于利用以图像高度变化并与光束的扫描同步的信号来调整差分相位信号。