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1. 发明授权

US08946386B2 Proteins expressed in NK cells 有权
标题翻译：在NK细胞中表达的蛋白质
公开(公告)号：US08946386B2
公开(公告)日：2015-02-03
申请号：US10574045
申请日：2004-09-29
申请人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
发明人： Kouji Matsushima , Shinichi Hashimoto , Masayuki Tsuchiya , Yuichi Hirata , Kenji Yoshida , Kazuyuki Ojima
IPC分类号： A61K38/17 , C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566
CPC分类号： C07K14/705 , A61K31/00 , G01N33/564 , G01N33/566 , G01N2500/00
摘要： Purified immunocytes were analyzed for expression frequencies, and the NKIR gene expressed specifically in natural killer (NK) cells was successfully identified. The NKIR gene encodes a receptor. Agonists and antagonists for the receptor can be identified by using the receptor.
摘要翻译：分析纯化的免疫细胞的表达频率，并且成功鉴定了在自然杀伤（NK）细胞中特异表达的NKIR基因。 NKIR基因编码受体。用于受体的激动剂和拮抗剂可以通过使用受体来鉴定。

2. 发明申请

US20130092675A1 METHOD AND APPARATUS FOR ELECTRICALLY HEATING SPRING 审中-公开
标题翻译：电加热弹簧的方法和装置
公开(公告)号：US20130092675A1
公开(公告)日：2013-04-18
申请号：US13636259
申请日：2011-03-15
申请人： Yuichi Hirata , Hiroyuki Ogiso , Atsushi Fukatsu
发明人： Yuichi Hirata , Hiroyuki Ogiso , Atsushi Fukatsu
IPC分类号： C21D9/02 , H05B3/03
CPC分类号： C21D9/02 , C21D1/40 , H05B3/023 , H05B3/03
摘要： A method for heating an entire spring, including regions adjacent to electrodes attached thereto, in a single electrical heating process includes (i) causing at least a pair of electrodes to make contact with the spring, and then (ii) electrically heating the spring by applying a voltage across the pair of electrodes. Each of the electrodes includes a first part having a first electric resistance value and a second part having a second electric resistance value that is higher than the first electric resistance value.
摘要翻译：一种用于加热整个弹簧的方法，包括：（i）使至少一对电极与弹簧接触，然后（ii）通过在一对电极上施加电压。每个电极包括具有第一电阻值的第一部分和具有高于第一电阻值的第二电阻值的第二部分。

3. 发明申请

US20110293602A1 VEGF-LIKE FACTOR ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译： VEGF-样因子抗体及其使用方法
公开(公告)号：US20110293602A1
公开(公告)日：2011-12-01
申请号：US12729708
申请日：2010-03-23
申请人： Yuichi Hirata , Junichi Nezu
发明人： Yuichi Hirata , Junichi Nezu
IPC分类号： A61K39/395 , A61P7/00 , C07K16/18
CPC分类号： C07K14/52 , A61K38/00 , A61K48/00
摘要： A novel human gene having a significant homology with a VEGF-C gene, a member of the VEGF family, has been isolated by the PCR method using primers designed based on the sequence of EST that is assumed to be homologous with the C-terminal region of the VEGF-C gene. Mouse and rat genes have been isolated based on the human gene isolated as above. A protein encoded by the above human gene has been isolated by introducing the gene into Escherichia coli and expressing it. The isolated protein and genes can be applied to, for example, gene therapy for the VEGF-D deficiency, wound healing, and promotion of collateral vessel formation. Furthermore, VEGF-D protein inhibitors can be used as a novel anticancer drug, etc.
摘要翻译：已经通过PCR方法分离了与VEGF-C基因具有显着同源性的新型人基因，该方法使用基于EST序列设计的引物，其被假设与C-末端区域同源的VEGF-C基因。已经基于如上分离的人基因分离了小鼠和大鼠基因。通过将该基因导入大肠杆菌并表达上述人基因编码的蛋白质已被分离。分离的蛋白质和基因可以应用于例如VEGF-D缺陷的基因治疗，伤口愈合和促进旁路血管形成。此外，VEGF-D蛋白抑制剂可用作新型抗癌药物等。

4. 发明授权

US08008073B2 Anti-Mpl antibodies 失效
标题翻译：抗Mpl抗体
公开(公告)号：US08008073B2
公开(公告)日：2011-08-30
申请号：US12874872
申请日：2010-09-02
申请人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
发明人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
IPC分类号： C12N5/07 , C12N5/00 , C12N15/00 , C12P21/06 , C07H21/04
CPC分类号： C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/75
摘要： Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also humanized. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
摘要翻译：分离纯化抗人Mpl抗体。使用遗传工程技术制备抗人Mpl双抗体和抗人Mpl sc（Fv）2，抗人Mpl sc（Fv）2也被人源化。测定双抗体和sc（Fv）2的TPO样激动活性，发现其活性高于抗人Mpl抗体的活性，或与天然存在的人TPO配体相当或更高的活性。

5. 发明授权

US07750126B2 Antibodies that bind to a member of the IL-6/G-CSF/MGF family 失效
标题翻译：结合IL-6 / G-CSF / MGF家族成员的抗体
公开(公告)号：US07750126B2
公开(公告)日：2010-07-06
申请号：US11716808
申请日：2007-03-12
申请人： Yuichi Hirata
发明人： Yuichi Hirata
IPC分类号： C07K16/24
CPC分类号： C07K14/54 , A01K2217/05 , A61K38/00 , C07K14/52
摘要： A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by synthesizing primers based on the EST sequence, and effecting PCR-cloning from a human fetal spleen library. Sequencing of the thus-isolated cDNA and analysis of its structure revealed that the cDNA has typical characteristics of a factor belonging to the IL-6/G-CSF/MGF family. It is also found out that the culture supernatant of said sequence-transfected CHO cells shows a proliferation supporting activity towards bone marrow cells in the coexistence of kit ligand.
摘要翻译：已经通过基于EST序列的合成引物成功地分离了对应于EST（AA418955）的全长cDNA，其不与数据库中的其它蛋白质显示任何同源性，但与G-CSF具有弱同源性，并且通过来自人胎儿脾脏文库的PCR克隆。这样分离的cDNA的测序及其结构的分析显示cDNA具有属于IL-6 / G-CSF / MGF家族的因子的典型特征。还发现所述序列转染的CHO细胞的培养上清液在试剂盒配体的共存下显示对骨髓细胞的增殖支持活性。

6. 发明申请

US20090288177A1 SGRF GENE-MODIFIED MOUSE 有权
标题翻译： SGRF基因修饰鼠
公开(公告)号：US20090288177A1
公开(公告)日：2009-11-19
申请号：US12499694
申请日：2009-07-08
申请人： Kiyoshi Habu , Yuichi Hirata
发明人： Kiyoshi Habu , Yuichi Hirata
IPC分类号： A01K67/027
CPC分类号： A01K67/0276 , A01K67/0271 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0368 , C12N15/8509 , C12N2800/30
摘要： A targeting vector was constructed by replacing exon regions in the SGRF gene with appropriate drug marker genes. This vector was transfected into mouse ES cell lines to obtain chimeric mice, which were then crossed with C57BL/6J mice to obtain mice comprising cells in which one SGRF gene alleles was inactivated. By crossing these mice with each other, the present inventors succeeded in producing mice in which both SGRF gene alleles were inactivated. These genetically modified animals can be used to predict the side effects of drugs such as SGRF antagonists.
摘要翻译：通过用适当的药物标记基因取代SGRF基因中的外显子区域构建靶向载体。将该载体转染入小鼠ES细胞系以获得嵌合小鼠，然后将其与C57BL / 6J小鼠杂交，以获得包含其中一个SGRF基因等位基因被灭活的细胞的小鼠。通过使这些小鼠相互交叉，本发明人成功地生产了两种SGRF基因等位基因都被灭活的小鼠。这些转基因动物可用于预测药物如SGRF拮抗剂的副作用。

7. 发明申请

US20070193235A1 Filtration member for inflator and method of manufacturing the same 有权
标题翻译：充气机的过滤构件及其制造方法
公开(公告)号：US20070193235A1
公开(公告)日：2007-08-23
申请号：US10596524
申请日：2005-01-27
申请人： Yuichi Hirata
发明人： Yuichi Hirata
IPC分类号： B01D50/00 , B60R21/26 , B23P15/16
CPC分类号： B01D39/12 , B60R21/2644 , Y10S55/05 , Y10T29/49604
摘要： An inflator filter (15) includes a cylindrical body (15a) that is formed by winding a wire (16). The cylindrical body (15a) includes an inner circumferential portion (21) and an outer circumferential portion (22) covering an outer circumferential surface of the inner circumferential portion (21). The inner circumferential portion (21) is formed by superimposing a plurality of first pattern layers (18a) in a radial direction. The outer circumferential portion (22) is formed by superimposing one or more second pattern layers (18b) on an outer circumferential surface of the inner circumferential portion (21) in the radial direction. Each of the first and second pattern layers (18a and 18b) is formed from the wire (16) so as to have meshes. The meshes of each second pattern layer (18b) are smaller than the meshes of the first pattern layers (18a).
摘要翻译：充气机过滤器（15）包括通过缠绕线（16）而形成的圆筒体（15a）。圆筒体（15a）包括内周部（21）和覆盖内周部（21）的外周面的外周部（22）。内圆周部分（21）通过在径向上叠加多个第一图案层（18a）而形成。外周部（22）通过在径向上在内周部（21）的外周面上重叠一个以上的第二图案层（18b）而形成。第一和第二图案层（18a和18b）中的每一个由线（16）形成以具有网格。每个第二图案层（18b）的网格小于第一图案层（18a）的网格。

8. 发明授权

US07252967B2 Nucleic acids encoding cytokine-like proteins that promote cell proliferation 有权
标题翻译：编码促进细胞增殖的细胞因子样蛋白的核酸
公开(公告)号：US07252967B2
公开(公告)日：2007-08-07
申请号：US10440066
申请日：2003-05-15
申请人： Yuichi Hirata
发明人： Yuichi Hirata
IPC分类号： C12P21/02 , C07H21/04 , A61K38/18
CPC分类号： C07K14/54 , A01K2217/05 , A61K38/00 , C07K14/52
摘要： A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by synthesizing printers based on the EST sequence, and effecting PCR-cloning from a human fetal spleen library. Sequencing of the thus-isolated cDNA and analysis of its structure revealed that the cDNA has typical characteristics of a factor belonging to the IL-6/G-CSF/MGF family. It is also found out that the culture supernatant of said sequence-transfected CHO cells shows a proliferation supporting activity towards bone marrow cells in the coexistence of kit ligand.
摘要翻译：已经通过基于EST序列的合成引物成功地分离了对应于EST（AA418955）的全长cDNA，其不与数据库中的其它蛋白质显示任何同源性，但与G-CSF具有弱同源性。来自人胎儿脾脏文库的PCR克隆。这样分离的cDNA的测序及其结构的分析显示cDNA具有属于IL-6 / G-CSF / MGF家族的因子的典型特征。还发现所述序列转染的CHO细胞的培养上清液在试剂盒配体的共存下显示对骨髓细胞的增殖支持活性。

9. 发明申请

US20060222643A1 Anti-mpl antibody 失效
标题翻译：抗mpl抗体
公开(公告)号：US20060222643A1
公开(公告)日：2006-10-05
申请号：US10551504
申请日：2004-12-10
申请人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
发明人： Hiroyuki Tsunoda , Kiyotaka Nakano , Tetsuro Orita , Masayuki Tsuchiya , Yuichi Hirata
IPC分类号： A61K39/395 , C07K16/44 , C07K16/28
CPC分类号： C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/75
摘要： Anti-human Mpl antibodies were isolated and purified, and then anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were purified using genetic engineering techniques. Furthermore, the present inventors succeeded in humanizing anti-human Mpl sc(Fv)2. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
摘要翻译：分离和纯化抗人Mpl抗体，然后使用遗传工程技术纯化抗人Mpl双抗体和抗人Mpl sc（Fv）2。此外，本发明人成功地将抗人Mpl sc（Fv）2人源化。测定双抗体和sc（Fv）2的TPO样激动活性，发现其活性高于抗人Mpl抗体的活性，或与天然存在的人TPO配体相当或更高的活性。

10. 发明申请

US20060172343A1 Novel VEGF-like factors 有权
标题翻译：新型VEGF样因子
公开(公告)号：US20060172343A1
公开(公告)日：2006-08-03
申请号：US11397289
申请日：2006-04-04
申请人： Yuichi Hirata , Junichi Nezu
发明人： Yuichi Hirata , Junichi Nezu
IPC分类号： C07K14/475 , C07K16/22 , G01N33/53 , C07H21/04 , C12P21/06
CPC分类号： C07K14/52 , A61K38/00 , A61K48/00
摘要： A novel human gene having a significant homology with a VEGF-C gene, a member of the VEGF family, has been isolated by the PCR method using primers designed based on the sequence of EST that is assumed to be homologous with the C-termial region of the VEGF-C gene. Mouse and rat genes have been isolated based on the human gene isolated as above. A protein encoded by the above human gene has been isolated by introducing the gene into Escherichia coli and expressing it. The isolated protein and genes can be applied to, for example, gene therapy for the VEGF-D deficiency, wound healing, and promotion of collateral vessel formation. Furthermore,VEGF-D protein inhibitorscanbeused as a novel anticancer drug, etc.
摘要翻译：已经通过PCR方法分离了与VEGF-C基因具有显着同源性的新型人基因，所述PCR方法使用基于EST序列设计的引物，其被假设为与C末端区域同源的VEGF-C基因。已经基于如上分离的人基因分离了小鼠和大鼠基因。通过将该基因导入大肠杆菌并表达上述人基因编码的蛋白质已被分离。分离的蛋白质和基因可以应用于例如VEGF-D缺陷的基因治疗，伤口愈合和促进旁路血管形成。此外，VEGF-D蛋白抑制剂可被用作新型抗癌药物等。

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