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1. 发明授权

US10316361B2 Genome-wide methylation analysis and use to identify genes specific to breast cancer hormone receptor status and risk of recurrence 有权
公开(公告)号：US10316361B2
公开(公告)日：2019-06-11
申请号：US14232981
申请日：2012-07-16
申请人： Saraswati V. Sukumar , Christopher Benedict Umbricht , Antonio C. Wolff , Mary Jo Steele Fackler , Zhe Zhang , Leslie M. Cope , Kala Visvanathan , Peng Huang
发明人： Saraswati V. Sukumar , Christopher Benedict Umbricht , Antonio C. Wolff , Mary Jo Steele Fackler , Zhe Zhang , Leslie M. Cope , Kala Visvanathan , Peng Huang
IPC分类号： C12P19/34 , C12Q1/68 , C12Q1/6874 , C12Q1/6886
摘要： To better understand the biology of hormone receptor-positive and negative breast cancer and to identify methylated gene markers of disease progression, a genome-wide methylation array analysis was performed on 103 primary invasive breast cancers and 21 normal breast samples using the Illumina Infinium HumanMethylation27 array that queried 27,578 CpG loci. Forty CpG loci showed differential methylation specific to either ER-positive or ER-negative tumors. Each of the 40 ER-subtype-specific loci was validated in silico using an independent, publicly available methylome dataset from The Cancer Genome Atlas (TCGA). In addition, 100 methylated CpG loci were identified that were significantly associated with disease progression. Arrays containing the ER-subtype-specific loci and their use in methods of diagnosis and treatment of breast cancer are provided.

2. 发明授权

US09292317B2 Cloud of virtual clouds for increasing isolation among execution domains 有权
标题翻译：云虚拟云，以增加执行域之间的隔离
公开(公告)号：US09292317B2
公开(公告)日：2016-03-22
申请号：US13613510
申请日：2012-09-13
申请人： Han Chen , Hui Lei , Zhe Zhang
发明人： Han Chen , Hui Lei , Zhe Zhang
IPC分类号： G06F9/46 , G06F9/455
CPC分类号： G06F9/455 , G06F9/45558 , G06F2009/45566
摘要： A method for providing a cloud environment for provisioning a guest virtual machine instance. The method includes selecting at least one machine from a collection of machines as a management node, wherein the at least one machine includes a hypervisor enabled with nested virtualization capability, deploying a plurality of cloud managers on each management node, selecting at least one machine from the collection of machines as a host node, deploying a plurality of level two hypervisors on each host node, forming a plurality of virtual clouds, wherein each virtual cloud contains at least one of the plurality of cloud managers and one of the plurality of level two hypervisors, and provisioning, via the at least one cloud manager, at least one guest virtual machine instance on top of the at least one level two hypervisors.
摘要翻译：一种用于提供用于配置来宾虚拟机实例的云环境的方法。该方法包括从作为管理节点的机器集合中选择至少一个机器，其中所述至少一个机器包括启用嵌套虚拟化能力的管理程序，在每个管理节点上部署多个云管理器，从至少一个机器作为主机节点的机器的集合，在每个主机节点上部署多个二级管理程序，形成多个虚拟云，其中每个虚拟云包含多个云管理器中的至少一个和多个二级中的一个管理程序和经由所述至少一个云管理器供应至少一个级别的两个虚拟机管理程序之上的至少一个来宾虚拟机实例。

3. 发明申请

US20140221242A1 GENOME-WIDE METHYLATION ANALYSIS AND USE TO IDENTIFY GENES SPECIFIC TO BREAST CANCER HORMONE RECEPTOR STATUS AND RISK OF RECURRANCE 审中-公开
标题翻译：基因型甲基化分析和鉴定特异性乳腺癌HORMONE受体基因和转录风险
公开(公告)号：US20140221242A1
公开(公告)日：2014-08-07
申请号：US14232981
申请日：2012-07-16
申请人： Saraswati V. Sukumar , Christopher Benedict Umbricht , Antonio C. Wolff , Mary Jo Steele Fackler , Zhe Zhang , Leslie M. Cope , Kala Visvanathan , Peng Huang
发明人： Saraswati V. Sukumar , Christopher Benedict Umbricht , Antonio C. Wolff , Mary Jo Steele Fackler , Zhe Zhang , Leslie M. Cope , Kala Visvanathan , Peng Huang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/154
摘要： To better understand the biology of hormone receptor-positive and negative breast cancer and to identify methylated gene markers of disease progression, a genome-wide methylation array analysis was performed on 103 primary invasive breast cancers and 21 normal breast samples using the Illumina Infinium HumanMethylation27 array that queried 27,578 CpG loci. Forty CpG loci showed differential methylation specific to either ER-positive or ER-negative tumors. Each of the 40 ER-subtype-specific loci was validated in silico using an independent, publicly available methylome dataset from The Cancer Genome Atlas (TCGA). In addition, 100 methylated CpG loci were identified that were significantly associated with disease progression. Arrays containing the ER-subtype-specific loci and their use in methods of diagnosis and treatment of breast cancer are provided.
摘要翻译：为了更好地了解激素受体阳性和阴性乳腺癌的生物学，并确定疾病进展的甲基化基因标记，使用Illumina Infinium HumanMethylation27阵列对103例原发性浸润性乳腺癌和21例正常乳腺样品进行全基因组甲基化阵列分析查询了27,578个CpG位点。 40个CpG基因座显示ER-阳性或ER阴性肿瘤特异性差异甲基化。 40个ER亚型特异性基因座中的每一个都使用“癌症基因组图谱”（TCGA）中独立的，公开的甲基化数据集进行了计算机验证。此外，确定了与疾病进展显着相关的100个甲基化CpG基因座。提供了含有ER亚型特异性基因座的阵列及其在乳腺癌诊断和治疗方法中的应用。

4. 发明授权

US08737077B2 Linkage device 有权
标题翻译：联动装置
公开(公告)号：US08737077B2
公开(公告)日：2014-05-27
申请号：US13284959
申请日：2011-10-30
申请人： Guang-Yi Zhang , Zhe Zhang , Bing-Bao Guo
发明人： Guang-Yi Zhang , Zhe Zhang , Bing-Bao Guo
IPC分类号： H02B1/01 , F16M13/00
CPC分类号： G06F1/187
摘要： A linkage device includes a shell, an active arm, a linkage lever, a random arm and at least two fixed poles. The shell includes two side plates and an upper plate interconnecting the two side plates. The active arm and random arm are both arranged horizontally under the upper plate and between the two side plates. The active arm and random arm each comprise a slide rail inclined to a horizontal surface. The slide rail of the random arm has an inclined direction opposite to that of the slide rail of the active arm. The linkage lever is arranged outside the shell. The linkage lever comprises a central portion pivoted to one of the side plates and two ends respectively pivoted to the active arm and random arm. Two of the at least two fixed poles respectively slide into the slide rails of the active arm and random arm.
摘要翻译：联动装置包括外壳，主动臂，连杆，随机臂和至少两个固定杆。壳体包括两个侧板和互连两个侧板的上板。主动臂和随机臂均布置在上板下方和两个侧板之间。主动臂和随机臂各自包括倾斜于水平表面的滑轨。随机臂的滑轨具有与主动臂的滑轨相反的倾斜方向。联动杆布置在外壳外。联动杆包括枢转到一个侧板的中心部分，并且两个端部分别枢转到主动臂和随机臂。至少两个固定杆中的两个分别滑入主动臂和随机臂的滑轨。

5. 发明申请

US20140052698A1 Virtual Machine Image Access De-Duplication 审中-公开
标题翻译：虚拟机映像访问重复
公开(公告)号：US20140052698A1
公开(公告)日：2014-02-20
申请号：US13588173
申请日：2012-08-17
申请人： Han Chen , Alexei A. Karve , Minkyong Kim , Andrzej P. Kochut , Hui Lei , Jayaram Kallapalayam Radhakrishnan , Zhiming Shen , Zhe Zhang
发明人： Han Chen , Alexei A. Karve , Minkyong Kim , Andrzej P. Kochut , Hui Lei , Jayaram Kallapalayam Radhakrishnan , Zhiming Shen , Zhe Zhang
IPC分类号： G06F17/30
CPC分类号： G06F9/45558 , G06F2009/45562
摘要： A system and an article of manufacture for de-duplicating virtual machine image accesses include identifying one or more identical blocks in two or more images in a virtual machine image repository, generating a block map for mapping different blocks with identical content into a same block, deploying a virtual machine image by reconstituting an image from the block map and fetching any unique blocks remotely on-demand, and de-duplicating virtual machine image accesses by storing the deployed virtual machine image in a local disk cache.
摘要翻译：用于去复制虚拟机图像访问的系统和制品包括识别虚拟机图像库中的两个或更多个图像中的一个或多个相同块，生成用于将具有相同内容的不同块映射到相同块中的块映射，通过从块映射重构图像并根据需要远程获取任何唯一的块来部署虚拟机映像，以及通过将部署的虚拟机映像存储在本地磁盘缓存中来解除虚拟机映像访问。

6. 发明授权

US08547691B2 Mounting clamp for USB device and motherboard assembly incorporating the same 失效
标题翻译： USB设备和包含其的主板组件的安装夹
公开(公告)号：US08547691B2
公开(公告)日：2013-10-01
申请号：US12979311
申请日：2010-12-27
申请人： Wen-Tang Peng , Zhe Zhang , Bing-Bao Guo
发明人： Wen-Tang Peng , Zhe Zhang , Bing-Bao Guo
IPC分类号： G06F1/16
CPC分类号： H01R13/6395
摘要： A motherboard assembly includes a motherboard, a universal serial bus (USB) interface arranged on the motherboard. Also included is a USB device, a mounting seat and a cover. The USB device engages with the USB interface. The mounting seat is attached to the motherboard and enclosing the USB interface, and the cover is mounted to the mounting seat and resists against a top of the USB device to fasten the USB device to the USB interface.
摘要翻译：主板组件包括主板，布置在主板上的通用串行总线（USB）接口。还包括USB设备，安装座和盖。 USB设备与USB接口配合使用。安装座安装在主板上并封装USB接口，盖子安装在安装座上，抵抗USB设备顶部，将USB设备固定在USB接口上。

7. 发明授权

US08482933B2 Holding apparatus for upright plug-in element 失效
标题翻译：用于直立插入元件的保持装置
公开(公告)号：US08482933B2
公开(公告)日：2013-07-09
申请号：US12954553
申请日：2010-11-24
申请人： Wen-Tang Peng , Zhe Zhang , Tie-Shan Jiang
发明人： Wen-Tang Peng , Zhe Zhang , Tie-Shan Jiang
IPC分类号： H05K7/02
CPC分类号： H05K5/0286
摘要： A holding apparatus includes a receiving element and an elastic element. The receiving element is fixed on a circuit board and receives an upright plug-in element. The receiving element defines two through holes in two sides of the receiving element. The through holes have different axial lines. The elastic element includes a main pole and two branch poles respectively perpendicularly extending down from two ends of the main pole. Two opposite pins respectively extend from distal ends of the branch poles. The pins of the elastic element are respectively inserted in the through holes of the receiving element, to locate the upright plug-in element between the elastic element and the receiving element.
摘要翻译：保持装置包括接收元件和弹性元件。接收元件固定在电路板上并接收直立插入元件。接收元件在接收元件的两侧限定两个通孔。通孔具有不同的轴线。弹性元件包括主极和从主极的两端垂直向下延伸的两个分支极。两个相对的销分别从分支极的远端延伸。弹性元件的销分别插入接收元件的通孔中，以将直立插入元件定位在弹性元件和接收元件之间。

8. 发明授权

US08356976B2 Mounting apparatus for fan 失效
标题翻译：风扇安装装置
公开(公告)号：US08356976B2
公开(公告)日：2013-01-22
申请号：US12475583
申请日：2009-05-31
申请人： Guang-Yi Zhang , Zhe Zhang , Jian Fu
发明人： Guang-Yi Zhang , Zhe Zhang , Jian Fu
IPC分类号： F04D29/64
CPC分类号： H05K7/20172 , G06F1/181 , G06F1/20 , H05K7/20181
摘要： A mounting apparatus for a fan includes a plate and a frame. The plate includes a venting portion. A number of locking holes and an engaging hole are defined in the plate, surrounding the venting portion. The frame includes a main body and a resilient portion extending from a side of the main body. An airflow opening is defined in the main body aligned with the venting portion of the plate. A number of hooks extend from the main body, around the airflow opening, to be engaged in the corresponding locking holes of the plate. A bulge protrudes out from the resilient portion to be engaged in the engaging hole.
摘要翻译：用于风扇的安装装置包括板和框架。该板包括通气部分。在板中限定了许多锁定孔和接合孔，围绕着通气部分。框架包括主体和从主体的一侧延伸的弹性部分。在主体中限定了与该板的排气部对准的气流开口。许多钩子从主体，围绕气流开口延伸，以接合在板的相应的锁定孔中。凸出部从弹性部突出而与接合孔接合。

9. 发明申请

US20120284652A1 HUMAN-ENVIRONMENT INTERACTIVE SYSTEM AND PORTABLE DEVICE USING THE SAME 审中-公开
标题翻译：人与环境互动系统及其使用的便携式设备
公开(公告)号：US20120284652A1
公开(公告)日：2012-11-08
申请号：US13165815
申请日：2011-06-22
申请人： Chung-Hsien Kuo , Jiann-Jone Chen , Han-Yen Yu , Chen-Han Lee , Rui-Zhe Zhang
发明人： Chung-Hsien Kuo , Jiann-Jone Chen , Han-Yen Yu , Chen-Han Lee , Rui-Zhe Zhang
IPC分类号： G06F3/048
CPC分类号： H04L12/2827
摘要： A human-environment interactive system and a portable device using the same are provided. The human-environment interactive system includes a ubiquitous computing system, at least one home-equipment, and the portable device. The portable device is suitable for two-way communicating with the portable device, and includes a RF transceiver, a browser, and a controller. When the portable device is taken into an environmental space, the controller actively receives a set of situational information from the ubiquitous computing system through the RF transceiver. The situational information includes a status information of at least one home-equipment, and a real time position information of the portable device. The controller displays this set of situational information in the browser for a user to perceive variations of the surrounding environment, so as to operate the at least one home-equipment through the browser.
摘要翻译：提供了人与环境交互系统和使用它的便携式设备。人类环境交互系统包括无处不在的计算系统，至少一个家庭设备和便携式设备。便携式设备适用于与便携式设备的双向通信，并且包括RF收发器，浏览器和控制器。当便携式设备进入环境空间时，控制器通过RF收发器主动从无所不在的计算系统接收一组情景信息。情境信息包括至少一个家庭设备的状态信息和便携式设备的实时位置信息。控制器在浏览器中显示这组情景信息，供用户感知周围环境的变化，以便通过浏览器操作至少一个家庭设备。

10. 发明申请

US20120113612A1 HOLDING APPARATUS FOR UPRIGHT PLUG-IN ELEMENT 失效
标题翻译：用于直升机元件的保持装置
公开(公告)号：US20120113612A1
公开(公告)日：2012-05-10
申请号：US12954553
申请日：2010-11-24
申请人： WEN-TANG PENG , ZHE ZHANG , TIE-SHAN JIANG
发明人： WEN-TANG PENG , ZHE ZHANG , TIE-SHAN JIANG
IPC分类号： H05K7/06
CPC分类号： H05K5/0286
摘要： A holding apparatus includes a receiving element and an elastic element. The receiving element is fixed on a circuit board and receives an upright plug-in element. The receiving element defines two through holes in two sides of the receiving element. The through holes have different axial lines. The elastic element includes a main pole and two branch poles respectively perpendicularly extending down from two ends of the main pole. Two opposite pins respectively extend from distal ends of the branch poles. The pins of the elastic element are respectively inserted in the through holes of the receiving element, to locate the upright plug-in element between the elastic element and the receiving element.
摘要翻译：保持装置包括接收元件和弹性元件。接收元件固定在电路板上并接收直立插入元件。接收元件在接收元件的两侧限定两个通孔。通孔具有不同的轴线。弹性元件包括主极和从主极的两端垂直向下延伸的两个分支极。两个相对的销分别从分支极的远端延伸。弹性元件的销分别插入接收元件的通孔中，以将直立插入元件定位在弹性元件和接收元件之间。

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