专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20230129228A1 RESTORING PHASE IN MASSIVELY PARALLEL SEQUENCING 有权
公开(公告)号：US20230129228A1
公开(公告)日：2023-04-27
申请号：US17912008
申请日：2021-03-18
申请人： MGI Tech Co. Ltd.
发明人： Matthew J. Callow , Radoje Drmanac , Snezana Drmanac
IPC分类号： C12Q1/6874
摘要： Determining the sequence of a nucleic acid typically entails performing multiple cycles of a reaction that generates a signal, depending on the identity of one or more nucleotides in the sequence. Sequencing typically is done on a plurality of copies of a template to fortify the signal and to increase accuracy. However, as the number of cycles increases, some of the copies go out of phase, increasing signal-to-noise ratio and compromising accuracy. Provided is a strategy using blocking groups and dinucleotide recognition to bring each of the copies back into phase. This improves accuracy and enables the user to increase the length of sequence reads.

2. 发明授权

US11635427B2 Sandwich assays in droplets 有权
公开(公告)号：US11635427B2
公开(公告)日：2023-04-25
申请号：US16937908
申请日：2020-07-24
申请人： Bio-Rad Laboratories, Inc.
发明人： Michael L. Samuels , Darren Roy Link
IPC分类号： G01N33/543 , C40B40/04 , G01N33/532 , C40B40/00 , C12Q1/6874 , B01F33/3011 , B01F33/302 , C40B70/00
摘要： The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.

3. 发明授权

US11634779B2 Methods and systems for analyzing nucleic acid molecules 有权
公开(公告)号：US11634779B2
公开(公告)日：2023-04-25
申请号：US17661730
申请日：2022-05-02
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： David M. Kurtz , Maximilian Diehn , Arash Ash Alizadeh
IPC分类号： C12Q1/6886 , G16B30/10 , G16B20/20 , G16B35/20 , G16B30/00 , C12Q1/6874 , G16H70/60 , G16H10/40 , G16H50/30 , G16H50/70 , G16H20/10 , G16B40/00 , G16B20/10 , C12N15/10 , G16H50/20 , C12Q1/6869 , G16H10/60
摘要： Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.

4. 发明授权

US11634768B2 Methods for indexing samples and sequencing multiple polynucleotide templates 有权
公开(公告)号：US11634768B2
公开(公告)日：2023-04-25
申请号：US17186571
申请日：2021-02-26
申请人： Illumina Cambridge Limited
发明人： Helen Bignell , Louise Fraser , Niall Anthony Gormley
IPC分类号： C12Q1/6874 , C12Q1/6837 , C12Q1/6855 , C12Q1/6869
摘要： The invention relates to methods for indexing samples during the sequencing of polynucleotide templates, resulting in the attachment of tags specific to the source of each nucleic acid sample such that after a sequencing run, both the source and sequence of each polynucleotide can be determined. Thus, the present invention pertains to analysis of complex genomes (e.g., human genomes), as well as multiplexing less complex genomes, such as those of bacteria, viruses, mitochondria, and the like.

5. 再颁专利

USRE49495E1 Binding polypeptides having a mutated scaffold 有权
公开(公告)号：USRE49495E1
公开(公告)日：2023-04-18
申请号：US16840882
申请日：2020-04-06
申请人： Affibody AB
发明人： Erik Nordling , Joakim Nilsson , Patrik Strömberg
IPC分类号： C07K14/00 , C07K1/04 , C07K14/31 , C12Q1/6874 , G01N33/68
摘要： The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55). The present disclosure also relates to populations of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the amino acid sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QX20 X21AFIX25X26LX28X29X30 PX32QSX35X36LLX39E AKKLX45X46X47Q (SEQ ID NO: 55), and methods for selecting a desired polypeptide having an affinity for a predetermined target from said population.

6. 发明授权

US11629380B2 Nanoarrays and methods of use thereof 有权
公开(公告)号：US11629380B2
公开(公告)日：2023-04-18
申请号：US17817960
申请日：2022-08-05
申请人： Singular Genomics Systems, Inc.
发明人： Eli N. Glezer , Vahid Karimkhani , Shahed Kay , Mohammad Vatankhah Varnosfaderani , Daan Witters
IPC分类号： C12Q1/6874 , C12Q1/6876 , C40B40/06
摘要： Disclosed herein, inter alia, are nanoarrays and methods of use thereof.

7. 发明授权

US11629344B2 Methods and systems for processing polynucleotides 有权
公开(公告)号：US11629344B2
公开(公告)日：2023-04-18
申请号：US17860880
申请日：2022-07-08
申请人： 10x Genomics, Inc.
发明人： Benjamin Hindson , Christopher Hindson , Michael Schnall-Levin , Kevin Ness , Mirna Jarosz , Serge Saxonov
IPC分类号： C12Q1/6874 , C12Q1/6804 , C12Q1/6806 , C12Q1/683 , C12N15/10 , C40B50/16 , C40B20/04
摘要： The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.

8. 发明授权

US11613787B2 Methods and systems for analyzing nucleic acid molecules 有权
公开(公告)号：US11613787B2
公开(公告)日：2023-03-28
申请号：US17646473
申请日：2021-12-29
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： David M. Kurtz , Maximilian Diehn , Arash Ash Alizadeh
IPC分类号： C12Q1/6886 , G16B30/10 , G16B20/20 , G16B35/20 , G16B30/00 , C12Q1/6874 , G16B20/10 , C12Q1/6869 , G16H70/60 , G16H10/40 , G16H50/30 , G16H50/70 , G16H20/10 , C12N15/10 , G16H50/20 , G16B40/00 , G16H10/60
摘要： Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic variants occurring in phase can indicate the presence of cancer in a diagnostic scan and a clinical intervention can be performed.

9. 发明申请

US20230087757A1 SYSTEMS AND METHODS FOR USING TRAPPED CHARGE FOR BILAYER FORMATION AND PORE INSERTION IN A NANOPORE ARRAY 有权
公开(公告)号：US20230087757A1
公开(公告)日：2023-03-23
申请号：US18051619
申请日：2022-11-01
申请人： Roche Sequencing Solutions, Inc.
发明人： Geoffrey BARRALL , George John CARMAN , Harikrishnan JAYAMOHAN , Jason KOMADINA , J. William MANEY, JR.
IPC分类号： C12Q1/6874 , B01L3/00 , G01N33/487
摘要： A nanopore-based sequencing chip can have a surface with an array of wells, with each well having a working electrode. Charge can be established within the wells by applying a voltage between the working electrodes and a counter electrode. The charge can then be trapped within the wells by sealing the wells with a membrane. The trapped charge can be used to facilitate pore insertion into the membranes.

10. 发明授权

US11609184B2 Apparatus for characterizing luminescent entities 有权
公开(公告)号：US11609184B2
公开(公告)日：2023-03-21
申请号：US16466372
申请日：2017-12-05
申请人： Gnothis AB
发明人： Rudolf Rigler , Lars Edman , Daniel Rönnlund , Margo Tiiman
IPC分类号： G01N21/64 , C12Q1/6874 , G02B27/56 , G02B21/00 , G02B21/16
摘要： An apparatus for characterizing luminescent entities by excitation comprising: • a substrate (6) being in contact with a solution comprising luminescent entities; • a source of electromagnetic radiation (4) providing at least a primary beam of radiation (8); an objective (5); a first optical element (1) capable of transforming the intensity profile of the primary beam (8) into an arbitrary secondary intensity profile (distribution) (9); a second optical element (2) capable of separating (discriminating) radiation by wavelength; and a detector (7), where the arbitrary secondary intensity profile has at least an off-center circular continuous intensity distribution (33) focused on the back focal plane (12) of the objective forming a collimated beam (10) capable of creating an evanescent field on the side of the substrate where the solution comprising luminescent entities are located, where the evanescent field excites the luminescent entities thereby creating emission radiation separated by the second optical element (2) and captioned by the detector (7). The invention also relates to an apparatus comprising two optical elements providing a final third intensity profile (distribution) which is the convolution of two mathematical transformations corresponding to each of optical element one and four, respectively.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式