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1. 发明授权

US08996109B2 Leadless intra-cardiac medical device with dual chamber sensing through electrical and/or mechanical sensing 有权
标题翻译：无铅心脏内心脏医疗器械，通过电气和/或机械感测实现双室感应
公开(公告)号：US08996109B2
公开(公告)日：2015-03-31
申请号：US13485513
申请日：2012-05-31
申请人： Edward Karst , Richard Samade , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret
发明人： Edward Karst , Richard Samade , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/00 , A61N1/365 , A61N1/375 , A61N1/372 , A61B5/00 , A61B5/042 , A61B5/11 , A61B5/0452 , A61N1/368 , A61B5/0464
CPC分类号： A61N1/368 , A61B5/0422 , A61B5/0452 , A61B5/0464 , A61B5/1107 , A61B5/6869 , A61B5/6882 , A61B2560/0468 , A61N1/36507 , A61N1/36514 , A61N1/36578 , A61N1/36592 , A61N1/37205 , A61N1/3756
摘要： A leadless intra-cardiac medical device senses cardiac activity from multiple chambers and applies cardiac stimulation to at least one cardiac chamber and/or generates a cardiac diagnostic indication. The leadless device may be implanted in a local cardiac chamber (e.g., the right ventricle) and detect near-field signals from that chamber as well as far-field signals from an adjacent chamber (e.g., the right atrium).
摘要翻译：无引导心脏内心脏医疗装置感测来自多个腔室的心脏活动，并将心脏刺激应用于至少一个心室，和/或产生心脏诊断指示。无引线装置可以植入局部心室（例如右心室）并检测来自该腔室的近场信号以及来自相邻腔室（例如，右心房）的远场信号。

2. 发明授权

US08798740B2 Single chamber leadless intra-cardiac medical device with dual-chamber functionality 有权
标题翻译：具有双室功能的单室无引线心脏内心脏医疗设备
公开(公告)号：US08798740B2
公开(公告)日：2014-08-05
申请号：US13352048
申请日：2012-01-17
申请人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
发明人： Richard Samade , Edward Karst , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret , Nirav Dalal
IPC分类号： A61N1/00
CPC分类号： A61N1/3684 , A61N1/0573 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes a housing configured to be implanted entirely within a single local chamber of the heart.
摘要翻译：无引线心脏内心脏医疗装置（LIMD）包括被配置为完全植入心脏的单个局部室内的壳体。

3. 发明申请

US20130110127A1 MULTI-PIECE DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE AND METHOD OF IMPLANTING SAME 有权
公开(公告)号：US20130110127A1
公开(公告)日：2013-05-02
申请号：US13352005
申请日：2012-01-17
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Xiaoyi Min
IPC分类号： A61N1/05 , A61B19/00
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/36521 , A61N1/37288 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) includes an electrode assembly configured to be anchored within a first wall portion of a first chamber of a heart. The electrode assembly includes an electrode main body having a first securing helix, an electrode wire segment extending from the body, and a first segment-terminating contact positioned on the electrode wire segment. The device further includes a housing assembly configured to be anchored within a second wall portion of a second chamber of the heart. The housing assembly includes a body having a second securing helix, a housing wire segment extending from the body, and a second segment-terminating contact positioned on the housing wire segment. The device also includes a connector block that electrically connects the electrode wire segment to the housing wire segment by retaining the first and second segment-terminating contacts.

4. 发明申请

US20130345770A1 LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH REDUCED NUMBER OF FEED-THRUS 有权
公开(公告)号：US20130345770A1
公开(公告)日：2013-12-26
申请号：US13529226
申请日：2012-06-21
申请人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
发明人： Ali Dianaty , Gabriel A. Mouchawar , Gene A. Bornzin , John W. Poore , Xiaoyi Min , Zoltan Somogyi , Richard Williamson
IPC分类号： A61N1/375
CPC分类号： A61N1/3756 , A61B5/042 , A61N1/362 , A61N1/368 , Y10T29/49002
摘要： A leadless implantable medical device (LIMD) includes a housing formed from a battery and an end cap. A proximal end of the end cap forms an LIMD proximal end and a distal end of the battery case forms an LIMD distal end. A non-conductive coupler mechanically secures a terminal end of the battery case to a mating end of the end cap, while maintaining the battery case and end cap electrically separated. A first electrode projects from the proximal end of the end cap. An intra-cardiac (IC) device extension projects from the distal end of the battery case. The extension includes a second electrode that is electrically connected to the battery case. The second electrode is located remote from the LIMD distal end. An electronics module is located within an internal cavity of the end cap and communicates with the first and second electrodes.

5. 发明申请

US20130325081A1 LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH DUAL CHAMBER SENSING THROUGH ELECTRICAL AND/OR MECHANICAL SENSING 有权
公开(公告)号：US20130325081A1
公开(公告)日：2013-12-05
申请号：US13485513
申请日：2012-05-31
申请人： Edward Karst , Richard Samade , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret
发明人： Edward Karst , Richard Samade , Gene A. Bornzin , John W. Poore , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61B5/0422 , A61B5/0452 , A61B5/0464 , A61B5/1107 , A61B5/6869 , A61B5/6882 , A61B2560/0468 , A61N1/36507 , A61N1/36514 , A61N1/36578 , A61N1/36592 , A61N1/37205 , A61N1/3756
摘要： A leadless intra-cardiac medical device senses cardiac activity from multiple chambers and applies cardiac stimulation to at least one cardiac chamber and/or generates a cardiac diagnostic indication. The leadless device may be implanted in a local cardiac chamber (e.g., the right ventricle) and detect near-field signals from that chamber as well as far-field signals from an adjacent chamber (e.g., the right atrium).

6. 发明申请

US20100082087A1 IMPLANTABLE LEAD/ELECTRODE DELIVERY MEASUREMENT AND FEEDBACK SYSTEM 有权
标题翻译：可伸缩导线/电极传送测量和反馈系统
公开(公告)号：US20100082087A1
公开(公告)日：2010-04-01
申请号：US12243674
申请日：2008-10-01
申请人： Enzo Silipo , Kyungmoo Ryu , Gene A. Bornzin , John W. Poore , Keith Victorine , Zoltan Somogyi , Nalin Perera
发明人： Enzo Silipo , Kyungmoo Ryu , Gene A. Bornzin , John W. Poore , Keith Victorine , Zoltan Somogyi , Nalin Perera
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/08
摘要： A lead implantation system with an introducer, a lead configured to engage with the introducer such that the introducer can convey the lead to a desired internal target location, and at least one sensor. The sensor is adapted to generate an indicator of desired engagement of the system with the desired target tissue location prior to engagement of the lead with the target tissue. Also a method of implanting an implantable patient lead including advancing a lead implantation assembly towards a desired target location along an introduction axis and monitoring at least one indicator of lead implantation assembly position along the lead introduction axis. At least one indicator can be generated by the lead implantation assembly. Advancing of the lead introduction assembly can be halted when the monitoring indicates contact with the desired target tissue. The patient lead can then be advanced towards the target tissue and fixed to the target tissue.
摘要翻译：一种具有引导器的引线植入系统，引线被构造成与导引器接合，使得导引器可将引线传送到期望的内部目标位置，以及至少一个传感器。所述传感器适于在所述引线与所述目标组织接合之前产生具有期望的目标组织位置的所述系统期望接合的指示器。还有一种植入可植入患者导线的方法，包括沿着引入轴线将引线植入组件推向所需目标位置，并且沿导线引入轴监测铅植入组件位置的至少一个指示器。至少一个指示器可以由引线注入组件产生。当监测指示与所需目标组织接触时，引导组件的推进可以停止。然后可以将患者导线朝向目标组织推进并固定到靶组织。

7. 发明授权

US09241638B2 System and method for implanting a physiologic sensor assembly 有权
标题翻译：用于植入生理传感器组件的系统和方法
公开(公告)号：US09241638B2
公开(公告)日：2016-01-26
申请号：US13464590
申请日：2012-05-04
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/11 , A61B5/145
CPC分类号： A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14532
摘要： An implantable physiologic sensor assembly is configured to be implanted within a patient. The assembly includes a module that houses an internal operative chamber, and a flexible pressure-detecting member connected to the module. The module and the pressure-detecting member are separated before implantation into the patient. At least a first end of the pressure-detecting member is configured to be inserted into an artery of the patient and a second end of the pressure-detecting member is connected to the module. The module is configured to be subcutaneously positioned within the patient.
摘要翻译：可植入生理传感器组件被配置为植入患者体内。组件包括容纳内部操作室的模块和连接到模块的柔性压力检测构件。模块和压力检测构件在植入之前被分离到患者体内。压力检测构件的至少第一端构造成插入到患者的动脉中，并且压力检测构件的第二端连接到模块。该模块被配置为皮下置于患者体内。

8. 发明授权

US08781605B2 Unitary dual-chamber leadless intra-cardiac medical device and method of implanting same 有权
标题翻译：单腔双腔无引线心脏内医疗器械及其植入方法
公开(公告)号：US08781605B2
公开(公告)日：2014-07-15
申请号：US13352167
申请日：2012-01-17
申请人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi
发明人： Gene A. Bornzin , John W. Poore , Zoltan Somogyi
IPC分类号： A61N1/372 , A61N1/362 , A61B17/34 , A61N1/375 , A61N1/05 , A61N1/39
CPC分类号： A61N1/059 , A61B17/3468 , A61N1/0573 , A61N1/37205 , A61N1/3756 , A61N1/3962
摘要： An assembly for introducing a leadless intra-cardiac medical device includes a sheath having an internal passage, wherein the sheath is configured to be maneuvered into the heart of the patient. A housing may be retained within the internal passage, wherein the housing is configured to be pushed out of the sheath, the housing having a first anchoring member configured to anchor the housing to a first implant location within the heart. The assembly may also include an electrode trailing the housing within the internal passage, wherein the electrode is also configured to be pushed out of the sheath. The electrode has a second anchoring member configured to anchor the electrode to a second implant location within the heart. A conductive wire connects the housing to the electrode, wherein movement of the housing out of the sheath causes the electrode to follow the movement to a distal end of the sheath.
摘要翻译：用于引入无引线心脏内心脏医疗装置的组件包括具有内部通道的护套，其中护套构造成被操纵到患者的心脏中。壳体可以被保持在内部通道内，其中壳体构造成被推出护套，壳体具有构造成将壳体锚定到心脏内的第一植入位置的第一锚定构件。该组件还可以包括在内部通道内拖曳壳体的电极，其中电极还构造成被推出护套。电极具有被配置为将电极锚定到心脏内的第二植入位置的第二锚定构件。导电线将壳体连接到电极，其中壳体从鞘的移动导致电极跟随到鞘的远端的运动。

9. 发明授权

US08442620B2 Implantable lead/electrode delivery measurement and feedback system 有权
标题翻译：可植入铅/电极传输测量和反馈系统
公开(公告)号：US08442620B2
公开(公告)日：2013-05-14
申请号：US12243674
申请日：2008-10-01
申请人： Enzo Silipo , Kyungmoo Ryu , Gene A. Bornzin , John W. Poore , Keith Victorine , Zoltan Somogyi , Nalin Perera
发明人： Enzo Silipo , Kyungmoo Ryu , Gene A. Bornzin , John W. Poore , Keith Victorine , Zoltan Somogyi , Nalin Perera
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61N1/05 , A61N1/08
摘要： A lead implantation system with an introducer, a lead configured to engage with the introducer such that the introducer can convey the lead to a desired internal target location, and at least one sensor. The sensor is adapted to generate an indicator of desired engagement of the system with the desired target tissue location prior to engagement of the lead with the target tissue. Also a method of implanting an implantable patient lead including advancing a lead implantation assembly towards a desired target location along an introduction axis and monitoring at least one indicator of lead implantation assembly position along the lead introduction axis. At least one indicator can be generated by the lead implantation assembly. Advancing of the lead introduction assembly can be halted when the monitoring indicates contact with the desired target tissue. The patient lead can then be advanced towards the target tissue and fixed to the target tissue.
摘要翻译：一种具有引导器的引线植入系统，引线被构造成与导引器接合，使得导引器可将引线传送到期望的内部目标位置，以及至少一个传感器。所述传感器适于在所述引线与所述目标组织接合之前产生具有期望的目标组织位置的所述系统期望接合的指示器。还有一种植入可植入患者导线的方法，包括沿着引入轴线将引线植入组件推向所需目标位置，并且沿导线引入轴监测铅植入组件位置的至少一个指示器。至少一个指示器可以由引线注入组件产生。当监测指示与所需目标组织接触时，引导组件的推进可以停止。然后可以将患者导线朝向目标组织推进并固定到靶组织。

10. 发明申请

US20130116741A1 DUAL-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH INTRA-CARDIAC EXTENSION 有权
标题翻译：双室无胸腔内科医疗器械与心脏扩张
公开(公告)号：US20130116741A1
公开(公告)日：2013-05-09
申请号：US13352136
申请日：2012-01-17
申请人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
发明人： Gene A. Bornzin , Gabriel A. Mouchawar , Xiaoyi Min , John W. Poore , Edward Karst , Richard Samade , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/057 , A61N1/0573 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3688 , A61N1/3756
摘要： A leadless intra-cardiac medical device includes a housing that is configured to be implanted entirely within a single local chamber of the heart. A first electrode is provided on the housing at a first position such that when the housing is implanted in the local chamber, the first electrode engages the local wall tissue at a local activation site within the conduction network of the local chamber. An intra-cardiac extension is coupled to the housing and configured to extend from the local chamber into an adjacent chamber of the heart. A stabilization arm of the intra-cardiac extension engages the adjacent chamber. A second electrode on the intra-cardiac extension engages distal wall tissue at a distal activation site within the conduction network of the adjacent chamber.
摘要翻译：无引线心脏内心脏医疗设备包括被配置为完全植入心脏的单个局部腔室内的壳体。第一电极在第一位置处设置在壳体上，使得当壳体被植入局部腔室时，第一电极在局部腔室的传导网络内的局部激活位置接合局部壁组织。心脏内延伸部分耦合到壳体并且构造成从局部腔室延伸到心脏的相邻室中。心脏内延伸部的稳定臂与相邻的腔室相接合。心脏延伸部分上的第二个电极与相邻腔室的传导网络内的远端活化位点处的远端壁组织接合。

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