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1. 发明申请

US20140018818A1 SYSTEM AND METHOD OF IMPLANTING A MEDICAL DEVICE 审中-公开
标题翻译：植入医疗装置的系统和方法
公开(公告)号：US20140018818A1
公开(公告)日：2014-01-16
申请号：US13547791
申请日：2012-07-12
申请人： Zoltan Somogyi , Edward Karst , Gene A. Bornzin , John W. Poore , Richard Samade , Didier Theret
发明人： Zoltan Somogyi , Edward Karst , Gene A. Bornzin , John W. Poore , Richard Samade , Didier Theret
IPC分类号： A61N1/05
CPC分类号： A61N1/372 , A61B17/3468 , A61N1/37205
摘要： A system for implanting an implantable medical device (IMD) within a patient may include a main handle assembly having proximal and distal ends, a device-connection control handle connected to the proximal end of the main handle assembly, an introducer connected to the distal end of the main handle assembly, and a connection tool extending from the introducer. The connection tool may include a device-engaging member configured to change at least one of shape or orientation to selectively connect to and disconnect from the IMD. The device-connection control handle may be operatively connected to the device-engaging member and the device-connection control handle may be configured to manipulate the device-engaging member between connected and disconnected states by changing the at least one of the shape or orientation.
摘要翻译：用于在患者体内植入可植入医疗装置（IMD）的系统可以包括具有近端和远端的主手柄组件，连接到主手柄组件的近端的装置连接控制手柄，连接到远端的导引器的主把手组件，以及从导引器延伸的连接工具。连接工具可以包括被配置为改变形状或取向中的至少一个以选择性地连接到IMD并与IMD断开连接的装置接合构件。设备连接控制手柄可以可操作地连接到装置接合构件，并且装置连接控制手柄可以被配置成通过改变形状或取向中的至少一个来在连接状态和断开状态之间操纵装置接合构件。

2. 发明申请

US20130116740A1 SINGLE-CHAMBER LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH DUAL-CHAMBER FUNCTIONALITY AND SHAPED STABILIZATION INTRA-CARDIAC EXTENSION 有权
标题翻译：具有双室功能和形状稳定的单室无胸腔内科医疗设备心脏扩张
公开(公告)号：US20130116740A1
公开(公告)日：2013-05-09
申请号：US13352101
申请日：2012-01-17
申请人： Gene A. Bornzin , Xiaoyi Min , John W. Poore , Zoltan Somogyi , Didier Theret
发明人： Gene A. Bornzin , Xiaoyi Min , John W. Poore , Zoltan Somogyi , Didier Theret
IPC分类号： A61N1/05 , A61N1/362
CPC分类号： A61N1/059 , A61N1/0573 , A61N1/3684 , A61N1/3756
摘要： A leadless intra-cardiac medical device (LIMD) configured to be implanted entirely within a heart of a patient includes a housing configured to be securely attached to an interior wall portion of a chamber of the heart, and a stabilizing intra-cardiac (IC) device extension connected to the housing. The stabilizing IC device extension may include a stabilizer arm, and/or an appendage arm, or an elongated body or a loop member configured to be passively secured within the heart.
摘要翻译：被配置为完全植入患者心脏的无引线心脏内心脏医疗装置（LIMD）包括被构造成可靠地附接到心脏室的内壁部分的壳体，以及稳定心脏内（IC）设备扩展连接到外壳。稳定IC装置延伸部可以包括稳定器臂和/或附肢臂，或者被配置为被动地固定在心脏内的细长主体或环形构件。

3. 发明申请

US20130116529A1 LEADLESS INTRA-CARDIAC MEDICAL DEVICE WITH BUILT-IN TELEMETRY SYSTEM 有权
标题翻译：无内置医疗设备与内置远程系统
公开(公告)号：US20130116529A1
公开(公告)日：2013-05-09
申请号：US13352147
申请日：2012-01-17
申请人： Xiaoyi Min , John W. Poore , Gene A. Bornzin
发明人： Xiaoyi Min , John W. Poore , Gene A. Bornzin
IPC分类号： A61B5/042 , A61N1/372
CPC分类号： A61N1/37229 , A61B5/0006 , A61B5/042 , A61B5/686 , A61N1/362 , A61N1/368 , A61N1/3756 , A61N1/3787 , A61N1/3956 , A61N1/3968
摘要： A leadless intra-cardiac medical device is configured to be implanted entirely within a heart of a patient. The device includes an intra-cardiac extension and a housing. The intra-cardiac extension includes a loop body having at least one loop segment retaining at least one coil group that is configured to one or both of receive and transmit radio frequency (RF) energy, wherein the loop body is configured to extend into a first chamber of the heart. The housing is in electrical communication within the loop body, and includes a transceiver, control logic and an energy source. The housing is configured to be securely attached to an interior wall portion of a second chamber of the heart, wherein the transceiver is configured to communicate with an external device through the RF energy.
摘要翻译：无引线心脏内心脏医疗设备被配置为完全植入患者的心脏内。该装置包括心脏内延伸部和壳体。心脏内延伸包括环体，其具有至少一个环段，保留至少一个线圈组，该线圈组配置为接收和发射射频（RF）能量中的一个或两个，其中该环体被配置为延伸到第一心脏室。壳体在环体内部电气通信，并且包括收发器，控制逻辑和能量源。壳体构造成牢固地附接到心脏的第二腔室的内壁部分，其中收发器被配置为通过RF能量与外部设备通信。

4. 发明申请

US20110060394A1 MRI RF REJECTION MODULE FOR IMPLANTABLE LEAD 有权
标题翻译：用于可植入引线的MRI RF抑制模块
公开(公告)号：US20110060394A1
公开(公告)日：2011-03-10
申请号：US12557408
申请日：2009-09-10
申请人： John W. Poore
发明人： John W. Poore
IPC分类号： A61N1/05 , B05D5/12
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3704 , H03H3/00 , H03H5/02
摘要： A high Q self-resonant inductor and method for manufacturing the same is disclosed herein for use in an implantable medical lead. The method of manufacture includes depositing a first conductive material over an elongated ceramic member and removing portions of the conductive material to leave a continuous helical metallic pattern on an elongated ceramic structure. The helical metallic pattern has a first terminal end located at a proximal end of the elongated ceramic member and a second terminal end located at a distal end of the ceramic member. The method also includes covering the helical metallic pattern with a ceramic material to form a first ceramic layer and forming vias in the ceramic material. At least one electrode is coupled to the helical metallic pattern through the vias in the ceramic material.
摘要翻译：本文公开了用于可植入医疗引线的高Q自谐振电感器及其制造方法。制造方法包括在细长陶瓷构件上沉积第一导电材料并去除导电材料的部分以在细长陶瓷结构上留下连续的螺旋金属图案。螺旋金属图案具有位于细长陶瓷构件的近端处的第一末端和位于陶瓷构件的远端的第二终端。该方法还包括用陶瓷材料覆盖螺旋状金属图案以形成第一陶瓷层并在陶瓷材料中形成通路。至少一个电极通过陶瓷材料中的通孔耦合到螺旋金属图案。

5. 发明申请

US20100331921A1 NEUROSTIMULATION DEVICE AND METHODS FOR CONTROLLING SAME 审中-公开
标题翻译：神经病学装置及其控制方法
公开(公告)号：US20100331921A1
公开(公告)日：2010-12-30
申请号：US12491101
申请日：2009-06-24
申请人： Gene A. Bornzin , John W. Poore , Rupinder Bharmi
发明人： Gene A. Bornzin , John W. Poore , Rupinder Bharmi
IPC分类号： A61N1/08
CPC分类号： A61N1/37 , A61N1/36071 , A61N1/36082 , A61N1/362
摘要： A stimulation device that includes a housing, a neuro lead configured to be coupled to the housing and to be located proximate to a neurostimulation site of interest, a neuro pulse generator, in the housing, configured to generate multi-polar neuro modulation (NM) pulses for delivery by the lead to the neuromodulation site of interest and the neuro pulse generator generating the NM pulses utilizing a waveform, with the frequency components of the ICMD compatible waveform in a range of 0 to 225 Hz having substantially limited NM energy content to avoid interference with sensing operation of the ICMD. A method for managing a neuromodulation (NM) device to avoid interference with an implantable medical device (ICMD) providing an ICMD having electrodes configured based on ICMD sensing parameters that define an ICMD sensing frequency range, providing an NM device having NM electrodes to be located proximate a region of interest, the NM electrodes delivering NM pulses based on NM pulse parameters, setting at least one NM pulse parameter in a manner that limits an amount of NM energy content that propagates beyond an active area surrounding the site of interest within the ICMD sensing frequency range.
摘要翻译：一种刺激装置，其包括壳体，神经导线，被配置为耦合到所述壳体并且位于靠近感兴趣的神经刺激部位的神经脉冲发生器，被配置为产生多极神经调制（NM）用于通过引线输送到感兴趣的神经调节部位的脉冲，以及使用波形产生NM脉冲的神经脉冲发生器，其中ICMD兼容波形的频率分量在0至225Hz的范围内具有基本上有限的NM能量含量以避免干扰ICMD的感测操作。一种用于管理神经调节（NM）装置以避免与可植入医疗装置（ICMD）的干涉的方法，所述可植入医疗装置（ICMD）提供具有基于定义ICMD感测频率范围的ICMD感测参数配置的电极的ICMD，提供具有待定位的NM电极的NM装置靠近感兴趣的区域，NM电极基于NM脉冲参数传送NM脉冲，以限制NM能量含量的量超出ICMD内的感兴趣位置周围的有效区域的方式设置至少一个NM脉冲参数感应频率范围。

6. 发明授权

US07043302B1 Methods and apparatus for overdrive pacing heart tissue using an implantable cardiac stimulation device 有权
公开(公告)号：US07043302B1
公开(公告)日：2006-05-09
申请号：US10323380
申请日：2002-12-18
申请人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
发明人： Joseph J. Florio , Gene A. Bornzin , John W. Poore , Douglas T. Kurschinski
IPC分类号： A61N1/08
CPC分类号： A61N1/368
摘要： Techniques are described for overdrive pacing the heart using a pacemaker wherein the overdrive pacing rate only increases when at least two intrinsic beats are detected within a determined search period. In one specific technique, an increase in the pacing rate occurs only if two P-waves are detected within X cardiac cycles. In another specific technique, the overdrive pacing rate is increased only if at least two P-waves are detected within a block of N cardiac cycles. In both techniques, the overdrive pacing rate is decreased if no increase has occurred in the last Z cardiac cycles. By increasing the overdrive pacing rate only in response to detection of at least two P-waves within a determined number of cardiac cycles, an excessively high overdrive pacing rate is avoided. Other techniques are described for adaptively adjusting overdrive pacing parameters so as to achieve a determined target degree of pacing of, for example, 95% paced beats. By adaptively adjusting overdrive parameters to maintain a target degree of pacing, the average overdrive pacing rate is minimized while still maintaining a high number of paced beats, thereby reducing the risk of a tachyarrhythmia occurring within the patient.

7. 发明授权

US06625488B2 Implantable cardiac stimulation device having a programmable reconfigurable sequencer 失效
公开(公告)号：US06625488B2
公开(公告)日：2003-09-23
申请号：US09805666
申请日：2001-03-13
申请人： John W. Poore , Balakrishnan Shankar , Kenneth R. McNeil, II
发明人： John W. Poore , Balakrishnan Shankar , Kenneth R. McNeil, II
IPC分类号： A61N1362
CPC分类号： A61N1/37229 , A61N1/025 , A61N1/372
摘要： A pacemaker or implantable cardioverter defibrillator is provided with a microcontroller having a general purpose microprocessor for performing high-level device functions and a sequencer for performing routine pacing functions. The general purpose microprocessor is programmed using an instruction set capable of general programming applications. The sequencer is programmed using a very simple instruction set having instructions selected only for performing routine pacing functions. The sequencer may be, for example, a programmable state machine. By providing a programmable sequencer for controlling routine pacing operations, the microprocessor is thereby free to devote its resources to performing high-level functions. Hence, the microprocessor may be operated at a lower clock frequency than would otherwise be needed if the microprocessor were also required to perform routine pacing functions and power savings are thereby achieved. By controlling all routine pacing operations using the programmable sequencer, the routine operations are thereby more expediently and reliably performed. Also, because software for the sequencer is developed using only the simple instruction set associated therewith, pacing software is quickly and reliably developed. Additional benefits are gained by isolating the pacing software from the high-level functional software to permit, for example, the microprocessor software to be replaced without affecting the sequencer software, and vice versa. Also, a method is described for generating an integrated circuit having a configuration optimized based upon predetermined software requirements. The method may be used to design the sequencer.

8. 发明授权

US5074302A Self-adjusting rate-responsive pacemaker and method thereof 失效
标题翻译：自调速率起搏器及其方法
公开(公告)号：US5074302A
公开(公告)日：1991-12-24
申请号：US549857
申请日：1990-07-09
申请人： John W. Poore , Brian M. Mann
发明人： John W. Poore , Brian M. Mann
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： A self-adjusting rate-responsive pacemaker includes a conventional programmable pulse generator, a physiological sensor, and a processor, all packaged within an implantable case. The pulse generator generates heart stimulation pulses on demand, or as otherwise programmed, as controlled by a sensor-indicated rate signal. The sensor-indicated rate signal is derived from a raw signal obtained from the physiological sensor, and provides some indication of whether the heart rate should increase or decrease. The processor converts the raw signal to the sensor-indicated rate signal in accordance with a desired relationship (FIGS. 2, 3, 7A, 8). A minimum sensor signal value sets the minimum rate at which the pacemaker generates stimulation pulses, and a maximum sensor signal value sets the maximum rate at which the pacemaker generates stimulation pulses. Both the minimum and maximum sensor signal values may be programmed to automatically be adjusted based on the sensor signals occurring during a prior prescribed time period. In one embodiment, the sensor signals occurring during the prescribed time period are classified into three categories: low, high, and intermediate. The minimum sensor signal value is then computed as the average of the low sensor signals, while the maximum sensor signal is computed as the average of the high sensor signals.
摘要翻译：自调整速率响应起搏器包括传统的可编程脉冲发生器，生理传感器和处理器，全部封装在可植入的壳体内。脉冲发生器根据传感器指示的速率信号来控制需要产生心脏刺激脉冲，或按其他方式编程。传感器指示的速率信号是从生理传感器获得的原始信号导出的，并提供心率是否增加或减少的一些指示。处理器根据期望的关系将原始信号转换成传感器指示的速率信号（图2，图3，图7A，图8）。最小传感器信号值设置起搏器产生刺激脉冲的最小速率，最大传感器信号值设置起搏器产生刺激脉冲的最大速率。最小和最大传感器信号值都可以被编程为基于在先前规定的时间段内发生的传感器信号来自动调整。在一个实施例中，在规定时间段期间发生的传感器信号被分为三类：低，高和中等。然后将最小传感器信号值计算为低传感器信号的平均值，而最大传感器信号被计算为高传感器信号的平均值。

9. 发明授权

US5040535A Average amplitude controlled rate-responsive pacemaker having automatically adjustable control parameters 失效
标题翻译：具有自动调节控制参数的平均振幅控制速率响应起搏器
公开(公告)号：US5040535A
公开(公告)日：1991-08-20
申请号：US530369
申请日：1990-05-30
申请人： Brian M. Mann , John W. Poore
发明人： Brian M. Mann , John W. Poore
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： A device for use as a rate-responsive pacemaker is disclosed in which the pacing interval is controlled by the average amplitude of a raw signal generated by a suitable physiological sensor and processed by an average amplitude converter to generate an output average amplitude signal coupled to the pacemaker control circuits to adjust the pacing interval. The average amplitude converter may be a rectifying amplifier and an integrating circuit, a voltage controlled oscillator whose frequency is measured over a suitable time interval using a time interval generator and a counter with the output of the counter being used by the control circuits of the pacemaker to vary its pacing interval, or means for measuring average amplitude of the raw signal and storing that measurement in memory and periodically processing it to alter the transfer characteristics of the rate-responsive pacemaker.
摘要翻译：公开了一种用作速率响应起搏器的装置，其中起搏间隔由合适的生理传感器产生的并由平均幅度转换器处理的原始信号的平均幅度控制，以产生耦合到该起搏器的输出平均振幅信号起搏器控制电路调节起搏间隔。平均幅度转换器可以是整流放大器和积分电路，压控振荡器，其频率在适当的时间间隔内使用时间间隔发生器和计数器的计数器由计时器的输出由起搏器的控制电路使用改变其起搏间隔或用于测量原始信号的平均幅度并将该测量存储在存储器中并定期处理它以改变速率响应起搏器的传输特性的装置。

10. 发明授权

US5040534A Microprocessor controlled rate-responsive pacemaker having automatic rate response threshold adjustment 失效
标题翻译：具有自动速率响应阈值调整的微处理器控制速率响应起搏器
公开(公告)号：US5040534A
公开(公告)日：1991-08-20
申请号：US530368
申请日：1990-05-30
申请人： Brian M. Mann , John W. Poore
发明人： Brian M. Mann , John W. Poore
IPC分类号： A61N1/365
CPC分类号： A61N1/36542
摘要： A rate-responsive pacemaker which includes a conventional programmable pulse generator, a physiological sensor, and a processor is disclosed which generates heart stimulation pulses on demand, or as otherwise programmed, as controlled by a rate control signal which is derived from the physiological sensor. The physiological sensor generates a raw signal which varies as a function of some physiological parameter, such as activity level to provide some indication of whether the heart rate should increase or decrease, and hence whether the pacemaker should change the rate at which pacing pulses are provided. The processor converts the raw signal to the sensor-indicated rate signal in accordance with a selectable transfer relationship which defines the sensor-indicated rate signal as a function of a set of discrete sensor level index signals. The sensor-indicated rate signal remains at a minimum value or base rate for all sensor level index signals below a prescribed rate response threshold, with this rate response threshold being set automatically by the processor as a function of a running average of the sensor level index signals monitored over a prescribed time period.
摘要翻译：公开了一种包括常规可编程脉冲发生器，生理传感器和处理器的速率响应起搏器，其根据从生理传感器导出的速率控制信号的需要或按其它方式产生心脏刺激脉冲。生理传感器产生作为一些生理参数（诸如活动水平的函数）变化的原始信号，以提供心率是否增加或减少的一些指示，以及因此起搏器是否应该改变起搏脉冲提供的速率。处理器根据可选择的传送关系将原始信号转换为传感器指示的速率信号，该可选传输关系将传感器指示的速率信号定义为一组离散传感器级索引信号的函数。对于低于规定速率响应阈值的所有传感器级索引信号，传感器指示的速率信号保持在最小值或基本速率，该速率响应阈值由处理器自动设置为传感器级索引的运行平均值的函数在规定的时间内监控信号。

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