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1. 发明授权

US07956339B2 Single-sided lateral-field and phototransistor-based optoelectronic tweezers 有权
标题翻译：单面横向和光电晶体管的光电镊子
公开(公告)号：US07956339B2
公开(公告)日：2011-06-07
申请号：US12565984
申请日：2009-09-24
申请人： Aaron Ohta , Pei-Yu Chiou , Hsan-Yin Hsu , Arash Jamshidi , Ming-Chiang Wu , Steven L. Neale
发明人： Aaron Ohta , Pei-Yu Chiou , Hsan-Yin Hsu , Arash Jamshidi , Ming-Chiang Wu , Steven L. Neale
IPC分类号： G01N27/447
CPC分类号： B82Y20/00 , B82Y15/00
摘要： Described herein are single-sided lateral-field optoelectronic tweezers (LOET) devices which use photosensitive electrode arrays to create optically-induced dielectrophoretic forces in an electric field that is parallel to the plane of the device. In addition, phototransistor-based optoelectronic tweezers (PhOET) devices are described that allow for optoelectronic tweezers (OET) operation in high-conductivity physiological buffer and cell culture media.
摘要翻译：这里描述的是使用光敏电极阵列在平行于器件平面的电场中产生光学诱导的介电电泳力的单面侧视场光电镊子（LOET）装置。此外，描述了基于光电晶体管的光电镊子（PhOET）装置，其允许在高电导率生理缓冲液和细胞培养基中的光电镊子（OET）操作。

2. 发明申请

US20100101960A1 SINGLE-SIDED LATERAL-FIELD AND PHOTOTRANSISTOR-BASED OPTOELECTRONIC TWEEZERS 有权
标题翻译：单面横向和基于光电子的光电二极管
公开(公告)号：US20100101960A1
公开(公告)日：2010-04-29
申请号：US12565984
申请日：2009-09-24
申请人： Aaron Ohta , Pei-Yu Chiou , Hsan-Yin Hsu , Arash Jamshidi , Ming-Chiang Wu , Steven L. Neale
发明人： Aaron Ohta , Pei-Yu Chiou , Hsan-Yin Hsu , Arash Jamshidi , Ming-Chiang Wu , Steven L. Neale
IPC分类号： G01N27/447 , H01L31/11 , H01L31/18
CPC分类号： B82Y20/00 , B82Y15/00
摘要： Described herein are single-sided lateral-field optoelectronic tweezers (LOET) devices which use photosensitive electrode arrays to create optically-induced dielectrophoretic forces in an electric field that is parallel to the plane of the device. In addition, phototransistor-based optoelectronic tweezers (PhOET) devices are described that allow for optoelectronic tweezers (OET) operation in high-conductivity physiological buffer and cell culture media.
摘要翻译：这里描述的是使用光敏电极阵列在平行于器件平面的电场中产生光学诱导的介电电泳力的单面侧视场光电镊子（LOET）装置。此外，描述了基于光电晶体管的光电镊子（PhOET）装置，其允许在高电导率生理缓冲液和细胞培养基中的光电镊子（OET）操作。

3. 发明申请

US20060238414A1 Microwave self-phasing antenna arrays for secure data transmission & satellite network crosslinks 失效
标题翻译：用于安全数据传输和卫星网络交叉的微波自相位天线阵列
公开(公告)号：US20060238414A1
公开(公告)日：2006-10-26
申请号：US11296240
申请日：2005-12-06
申请人： Ryan Miyamoto , Wayne Shiroma , Grant Shiroma , Blaine Murakami , Aaron Ohta , Michael Tamamoto
发明人： Ryan Miyamoto , Wayne Shiroma , Grant Shiroma , Blaine Murakami , Aaron Ohta , Michael Tamamoto
IPC分类号： H01Q1/00 , H04K3/00 , G01S3/02 , G01S7/36
CPC分类号： H04K3/825 , H01Q1/22 , H01Q1/288 , H01Q3/2652 , H04K3/226 , H04K3/28 , H04K3/43 , H04K3/92 , H04K2203/14 , H04K2203/18 , H04K2203/20 , H04K2203/32 , Y02A40/298
摘要： A high-directivity transponder system uses a dual system of a retrodirective array transmitting a data signal peak toward an interrogator source, and a self-null-steering array transmitting a null toward the interrogator source and a jamming signal elsewhere, resulting in high S/N reception at the interrogator source and avoidance of interception. Integrating modulators would allow each array to transmit different data while the spectra of the transmitted signals are identical, thus disabling interception. The system enables secure point-to-point communications and can be used for short-distance wireless data transmission systems such as wireless LAN and RFID servers. As another aspect, self-steering signal transmission is employed for randomly oriented satellites using circularly polarized, two-dimensional retrodirective arrays. Quadruple subharmonic mixing is used as an effective means of achieving phase conjugation when a high-frequency LO is not feasible or inapplicable. These features may be used for small-satellite communications, secure tactical communications, search and rescue, enemy location fixing and tracking, UAV command and control, forest fire detection, marine-based tracking, and many other applications requiring secure communications with high signal directivity.
摘要翻译：高方向性转发器系统使用向询问器源发送数据信号峰值的逆向阵列的双重系统，以及向询问器源发送零点的自归零转向阵列和其他地方的干扰信号，导致高S / N接收询问器来源并避免拦截。集成调制器将允许每个阵列传输不同的数据，而传输的信号的频谱是相同的，因此禁用截取。该系统实现安全的点对点通信，可用于短距离无线数据传输系统，如无线局域网和RFID服务器。作为另一方面，使用圆偏振二维逆向阵列的随机取向卫星采用自我转向信号传输。当高频LO不可行或不适用时，四次次谐波混合被用作实现相位共轭的有效手段。这些功能可用于小卫星通信，安全的战术通信，搜索和救援，敌方定位和跟踪，无人机指挥和控制，森林火灾探测，海洋跟踪等许多其他需要高信号方向性安全通信的应用。

4. 发明申请

US20120118740A1 METHODS AND DEVICES FOR SORTING CELLS AND OTHER BIOLOGICAL PARTICULATES 有权
标题翻译：用于分选细胞和其他生物颗粒的方法和装置
公开(公告)号：US20120118740A1
公开(公告)日：2012-05-17
申请号：US13250618
申请日：2011-09-30
申请人： Maurice M. Garcia , Aaron Ohta , Ming Wu , Tom F. Lue , Justin Valley
发明人： Maurice M. Garcia , Aaron Ohta , Ming Wu , Tom F. Lue , Justin Valley
IPC分类号： G01N27/447 , G01N27/453 , B01D43/00
CPC分类号： B03C5/005 , B01L3/502715 , B01L3/502761 , B01L2200/027 , B01L2200/0652 , B01L2300/0864 , B01L2400/0424 , B01L2400/0454 , B03C5/026 , G01N15/00 , G01N15/1031 , G01N27/447 , G01N2015/0003 , G01N2015/0065 , G01N2015/1081
摘要： An optical pattern-driven light induced dielectrophoresis (DEP) apparatus and separation methods are described which provide for the manipulation of particles or cells and selection based on traits correlated with the DEP response. Embodiments of the apparatus use DEP electric field patterns in combination with microfluidic laminar flows to measure response, separate, segregate and extract particles from heterogeneous mixtures according to the relative response of the particles to one or more DEP fields without damaging living cells. The methods are particularly suited for selecting and extracting the best sperm and embryo candidates based on fitness for use with existing artificial reproduction procedures and excluding defective or non-viable gametes.
摘要翻译：描述了光学图案驱动的光诱导介电电泳（DEP）装置和分离方法，其提供了基于与DEP响应相关的性状的颗粒或细胞的操作和选择。该装置的实施例使用DEP电场图案与微流体层流结合，以根据颗粒对一个或多个DEP场的相对响应而测量响应，分离和分离并从异质混合物中提取颗粒，而不损坏活细胞。该方法特别适用于选择和提取最佳的精子和胚胎候选物，其基于适用于现有的人造繁殖程序，并排除有缺陷或不可行的配子。

5. 发明申请

US20110223314A1 EFFICIENT MICROENCAPSULATION 审中-公开
标题翻译：有效的微观结构
公开(公告)号：US20110223314A1
公开(公告)日：2011-09-15
申请号：US13045244
申请日：2011-03-10
申请人： Xiaoxiao ZHANG , David Garmire , Aaron Ohta
发明人： Xiaoxiao ZHANG , David Garmire , Aaron Ohta
IPC分类号： B05D7/00 , B05C3/02 , B05C11/00 , B05D1/18 , B05D3/02 , B05D3/06 , B82Y5/00
CPC分类号： B01J13/14 , A61K9/5089 , B01F3/0807 , B01F13/0062
摘要： A device and method for generating microcapsules employs an inertial-focusing channel for introducing particles dispersed in a prepolymer suspension fluid, a droplet-generating junction for introducing oil evenly onto the flow of particles to create separated droplets of prepolymer suspension fluid encapsulating respective particles in a streamline flow, and a polymerization section for exposing the droplets to UV light or heat to cause polymerization of a polymer coating on separate microcapsules each containing a respective particle. Preferred suspension fluids may be aqueous solution of poly(ethylene-glycol)-diacrylate (PEGDA), or poly(N-isopropyl-acryalmide) (PNIPAAM). The preferred device may employ a curved or linear inertial-focusing microchannel. Functional tags and/or handles may be added to the microcapsules allowing easy detection, measurement and handling of the microcapsules.
摘要翻译：用于产生微胶囊的装置和方法使用惯性聚焦通道，用于引入分散在预聚物悬浮液中的颗粒，用于将油引入到颗粒流中的液滴产生接头，以产生将包含相应颗粒的预聚物悬浮液的分离液滴流线流动，以及聚合部分，用于将液滴暴露于UV光或加热，以使聚合物涂层在各自含有相应颗粒的分开的微胶囊上聚合。优选的悬浮液可以是聚（乙二醇） - 二丙烯酸酯（PEGDA）或聚（N-异丙基丙烯酰胺）（PNIPAAM）的水溶液。优选的装置可以采用弯曲或线性惯性聚焦微通道。功能性标签和/或手柄可以添加到微胶囊中，从而容易地检测，测量和处理微胶囊。

6. 发明授权

US07304607B2 Microwave self-phasing antenna arrays for secure data transmission and satellite network crosslinks 失效
标题翻译：用于安全数据传输和卫星网络交叉的微波自相位天线阵列
公开(公告)号：US07304607B2
公开(公告)日：2007-12-04
申请号：US11296240
申请日：2005-12-06
申请人： Ryan Y. Miyamoto , Wayne A. Shiroma , Grant S. Shiroma , Blaine T. Murakami , Aaron Ohta , Michael Tamamoto
发明人： Ryan Y. Miyamoto , Wayne A. Shiroma , Grant S. Shiroma , Blaine T. Murakami , Aaron Ohta , Michael Tamamoto
IPC分类号： H01Q1/00 , H04K3/00 , G01S3/02 , G01S7/36
CPC分类号： H04K3/825 , H01Q1/22 , H01Q1/288 , H01Q3/2652 , H04K3/226 , H04K3/28 , H04K3/43 , H04K3/92 , H04K2203/14 , H04K2203/18 , H04K2203/20 , H04K2203/32 , Y02A40/298
摘要： A high-directivity transponder system uses a dual system of a retrodirective array transmitting a data signal peak toward an interrogator source, and a self-null-steering array transmitting a null toward the interrogator source and a jamming signal elsewhere, resulting in high S/N reception at the interrogator source and avoidance of interception. Integrating modulators would allow each array to transmit different data while the spectra of the transmitted signals are identical, thus disabling interception. The system enables secure point-to-point communications and can be used for short-distance wireless data transmission systems such as wireless LAN and RFID servers. One mobile may send a broadcast interrogator signal, causing the other mobile devices to send a reply signal back to the interrogating mobile device only in the direction of the interrogating mobile device, such that each of the other mobile devices identifies its position to only the interrogating mobile device in response to its broadcast interrogator signal. As another aspect, self-steering signal transmission is employed for randomly oriented satellites using circularly polarized, two-dimensional retrodirective arrays. Quadruple subharmonic mixing is used as an effective means of achieving phase conjugation when a high-frequency LO is not feasible or inapplicable. These features may be used for small-satellite communications, secure tactical communications, search and rescue, enemy location fixing and tracking, UAV command and control, forest fire detection, marine-based tracking, and many other applications requiring secure communications with high signal directivity.
摘要翻译：高方向性转发器系统使用向询问器源发送数据信号峰值的逆向阵列的双重系统，以及向询问器源发送零点的自归零转向阵列和其他地方的干扰信号，导致高S / N接收询问器来源并避免拦截。集成调制器将允许每个阵列传输不同的数据，而传输的信号的频谱是相同的，因此禁用截取。该系统实现安全的点对点通信，可用于短距离无线数据传输系统，如无线局域网和RFID服务器。一个移动台可以发送广播询问器信号，导致其他移动设备仅在询问移动设备的方向上将回复信号发送回询问移动设备，使得每个其他移动设备将其位置识别为只有询问移动设备响应其广播询问器信号。作为另一方面，使用圆偏振二维逆向阵列的随机取向卫星采用自我转向信号传输。当高频LO不可行或不适用时，四次次谐波混合被用作实现相位共轭的有效手段。这些功能可用于小卫星通信，安全的战术通信，搜索和救援，敌方定位和跟踪，无人机指挥和控制，森林火灾探测，海洋跟踪等许多其他需要高信号方向性安全通信的应用。

7. 发明授权

US07006039B2 Microwave self-phasing antenna arrays for secure data transmission & satellite network crosslinks 失效
公开(公告)号：US07006039B2
公开(公告)日：2006-02-28
申请号：US10911928
申请日：2004-08-04
申请人： Ryan Y. Miyamoto , Wayne A. Shiroma , Grant S. Shiroma , Blaine T. Murakami , Aaron Ohta , Michael Tamamoto
发明人： Ryan Y. Miyamoto , Wayne A. Shiroma , Grant S. Shiroma , Blaine T. Murakami , Aaron Ohta , Michael Tamamoto
IPC分类号： G01S3/16 , H01Q1/00
CPC分类号： H04K3/825 , H01Q1/22 , H01Q1/288 , H01Q3/2652 , H04K3/226 , H04K3/28 , H04K3/43 , H04K3/92 , H04K2203/14 , H04K2203/18 , H04K2203/20 , H04K2203/32 , Y02A40/298
摘要： A high-directivity transponder system uses a dual system of a retrodirective array transmitting a data signal peak toward an interrogator source, and a self-null-steering array transmitting a null toward the interrogator source and a jamming signal elsewhere, resulting in high S/N reception at the interrogator source and avoidance of interception. Integrating modulators would allow each array to transmit different data while the spectra of the transmitted signals are identical, thus disabling interception. The system enables secure point-to-point communications and can be used for short-distance wireless data transmission systems such as wireless LAN and RFID servers. As another aspect, self-steering signal transmission is employed for randomly oriented satellites using circularly polarized, two-dimensional retrodirective arrays. Quadruple subharmonic mixing is used as an effective means of achieving phase conjugation when a high-frequency LO is not feasible or inapplicable. These features may be used for small-satellite communications, secure tactical communications, search and rescue, enemy location fixing and tracking, UAV command and control, forest fire detection, marine-based tracking, and many other applications requiring secure communications with high signal directivity.

8. 发明申请

US20050030226A1 Microwave self-phasing antenna arrays for secure data transmission & satellite network crosslinks 失效
标题翻译：用于安全数据传输和卫星网络交叉的微波自相位天线阵列
公开(公告)号：US20050030226A1
公开(公告)日：2005-02-10
申请号：US10911928
申请日：2004-08-04
申请人： Ryan Miyamoto , Wayne Shiroma , Grant Shiroma , Blaine Murakami , Aaron Ohta , Michael Tamamoto
发明人： Ryan Miyamoto , Wayne Shiroma , Grant Shiroma , Blaine Murakami , Aaron Ohta , Michael Tamamoto
IPC分类号： H01Q1/22 , H01Q1/28 , H01Q3/26 , G01S3/16 , H01Q1/00
CPC分类号： H04K3/825 , H01Q1/22 , H01Q1/288 , H01Q3/2652 , H04K3/226 , H04K3/28 , H04K3/43 , H04K3/92 , H04K2203/14 , H04K2203/18 , H04K2203/20 , H04K2203/32 , Y02A40/298
摘要： A high-directivity transponder system uses a dual system of a retrodirective array transmitting a data signal peak toward an interrogator source, and a self-null-steering array transmitting a null toward the interrogator source and a jamming signal elsewhere, resulting in high S/N reception at the interrogator source and avoidance of interception. Integrating modulators would allow each array to transmit different data while the spectra of the transmitted signals are identical, thus disabling interception. The system enables secure point-to-point communications and can be used for short-distance wireless data transmission systems such as wireless LAN and RFID servers. As another aspect, self-steering signal transmission is employed for randomly oriented satellites using circularly polarized, two-dimensional retrodirective arrays. Quadruple subharmonic mixing is used as an effective means of achieving phase conjugation when a high-frequency LO is not feasible or inapplicable. These features may be used for small-satellite communications, secure tactical communications, search and rescue, enemy location fixing and tracking, UAV command and control, forest fire detection, marine-based tracking, and many other applications requiring secure communications with high signal directivity.
摘要翻译：高方向性转发器系统使用向询问器源发送数据信号峰值的逆向阵列的双重系统，以及向询问器源发送零点的自归零转向阵列和其他地方的干扰信号，导致高S / N接收询问器来源并避免拦截。集成调制器将允许每个阵列传输不同的数据，而传输的信号的频谱是相同的，因此禁用截取。该系统实现安全的点对点通信，可用于短距离无线数据传输系统，如无线局域网和RFID服务器。作为另一方面，使用圆偏振二维逆向阵列的随机取向卫星采用自我转向信号传输。当高频LO不可行或不适用时，四次次谐波混合被用作实现相位共轭的有效手段。这些功能可用于小卫星通信，安全的战术通信，搜索和救援，敌方定位和跟踪，无人机指挥和控制，森林火灾探测，海洋跟踪等许多其他需要高信号方向性安全通信的应用。

9. 发明授权

US09079189B2 Methods and devices for sorting cells and other biological particulates 有权
标题翻译：用于分选细胞和其他生物微粒的方法和装置
公开(公告)号：US09079189B2
公开(公告)日：2015-07-14
申请号：US13250618
申请日：2011-09-30
申请人： Maurice M. Garcia , Aaron Ohta , Ming Wu , Tom F. Lue , Justin Valley
发明人： Maurice M. Garcia , Aaron Ohta , Ming Wu , Tom F. Lue , Justin Valley
IPC分类号： G01N27/447 , B03C5/00 , B03C5/02
CPC分类号： B03C5/005 , B01L3/502715 , B01L3/502761 , B01L2200/027 , B01L2200/0652 , B01L2300/0864 , B01L2400/0424 , B01L2400/0454 , B03C5/026 , G01N15/00 , G01N15/1031 , G01N27/447 , G01N2015/0003 , G01N2015/0065 , G01N2015/1081
摘要： An optical pattern-driven light induced dielectrophoresis (DEP) apparatus and separation methods are described which provide for the manipulation of particles or cells and selection based on traits correlated with the DEP response. Embodiments of the apparatus use DEP electric field patterns in combination with microfluidic laminar flows to measure response, separate, segregate and extract particles from heterogeneous mixtures according to the relative response of the particles to one or more DEP fields without damaging living cells. The methods are particularly suited for selecting and extracting the best sperm and embryo candidates based on fitness for use with existing artificial reproduction procedures and excluding defective or non-viable gametes.
摘要翻译：描述了光学图案驱动的光诱导介电电泳（DEP）装置和分离方法，其提供了基于与DEP响应相关的性状的颗粒或细胞的操作和选择。该装置的实施例使用DEP电场图案与微流体层流结合，以根据颗粒对一个或多个DEP场的相对响应而测量响应，分离和分离并从异质混合物中提取颗粒，而不损坏活细胞。该方法特别适用于选择和提取最佳的精子和胚胎候选物，其基于适用于现有的人造繁殖程序，并排除有缺陷或不可行的配子。

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