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1. 发明授权

US09364831B2 Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting 有权
标题翻译：脉冲激光触发高速微流体开关和应用于荧光激活细胞分选
公开(公告)号：US09364831B2
公开(公告)日：2016-06-14
申请号：US12852320
申请日：2010-08-06
申请人： Pei-Yu Chiou , Ting-Hsiang Wu , Michael A. Teitell
发明人： Pei-Yu Chiou , Ting-Hsiang Wu , Michael A. Teitell
IPC分类号： G01N15/10 , B01L3/00 , F16K99/00 , G01N15/14
CPC分类号： B01L3/502761 , B01L3/502738 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/123 , B01L2400/0442 , B01L2400/0454 , B01L2400/0622 , B01L2400/0655 , F16K99/0001 , F16K99/0026 , F16K99/0028 , F16K99/004 , F16K99/0061 , F16K2099/0084 , G01N15/1459 , G01N2015/149 , Y10T137/0391 , Y10T137/2224
摘要： In certain embodiments this invention provides a pulsed-laser triggered microfluidic switching mechanism that can achieve a switching time of 70 μs. This switching speed is two orders of magnitude shorter than that of the fastest switching mechanism utilized in previous μFACS.
摘要翻译：在某些实施例中，本发明提供了可实现70μs的切换时间的脉冲激光触发微流体切换机构。该切换速度比先前μFACS中使用的最快切换机制的切换速度短两个数量级。

2. 发明授权

US09176504B2 High-speed on demand droplet generation and single cell encapsulation driven by induced cavitation 有权
标题翻译：诱导气穴驱动的高速点播液滴生成和单细胞封装
公开(公告)号：US09176504B2
公开(公告)日：2015-11-03
申请号：US13370196
申请日：2012-02-09
申请人： Pei-Yu Chiou , Ting-Hsiang S. Wu , Sung-Yong Park , Michael A. Teitell
发明人： Pei-Yu Chiou , Ting-Hsiang S. Wu , Sung-Yong Park , Michael A. Teitell
IPC分类号： B01L3/00 , G05D11/13 , B01J13/04 , G01N29/24 , G01N21/64 , G01N15/10 , G01N15/14
CPC分类号： B01L3/502715 , B01J13/04 , B01L3/502761 , B01L3/502784 , B01L2200/0636 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2400/0403 , B01L2400/0442 , G01N15/10 , G01N21/64 , G01N29/2418 , G01N2015/1481 , G01N2291/02433 , G05D11/13 , Y10T137/0318 , Y10T137/2496
摘要： Methods and devices for the formation of droplets of a first fluid in a second fluid and the encapsulation of particles or cells within such droplets are disclosed. Impetus for droplet formation is provided by the creation of a transient bubble, which may be induced using a pulsed laser. Droplet volume and the frequency at which droplets are formed can be controlled by modulation of the pulsed laser. The disclosed methods and devices are particularly suitable for use in microfluidic devices.
摘要翻译：公开了用于在第二流体中形成第一流体的液滴的方法和装置以及在这些液滴内的颗粒或细胞的包封。通过产生可以使用脉冲激光诱发的瞬态气泡来提供液滴形成的动力。可以通过调制脉冲激光来控制液滴体积和形成液滴的频率。所公开的方法和装置特别适用于微流体装置。

3. 发明申请

US20120024708A1 SINGLE-SIDED CONTINUOUS OPTOELECTROWETTING (SCEOW) DEVICE FOR DROPLET MANIPULATION WITH LIGHT PATTERNS 有权
标题翻译：单面连续光电（SCEOW）装置，用于轻型模式的抛光操作
公开(公告)号：US20120024708A1
公开(公告)日：2012-02-02
申请号：US13194966
申请日：2011-07-31
申请人： Pei-Yu Chiou , Sung-Yong Park
发明人： Pei-Yu Chiou , Sung-Yong Park
IPC分类号： C25B7/00
CPC分类号： B01L3/502792 , B01L2300/0816 , B01L2400/0427
摘要： A single-sided continuous optoelectrowetting (SCOEW) device for manipulating droplets retained in a fluid over the SCOEW device with dynamic patterns of low intensity light, such as from a display screen, is described. A single pair of lateral electrodes are utilized for providing a lateral electric field bias, with transport motion controlled in response to projecting light through a photoconductive layer and dielectric layer adjacent to which droplets are retained. The device is configured for optically manipulating droplets having volumes spanning over five orders of magnitude, and can be configured to perform droplet dispensing, transport, splitting, merging, mixing and other droplet manipulation functions involving any of the above on a single sided surface.
摘要翻译：描述了用于操纵SCOEW装置中流体中的液滴的单面连续光电投影（SCOEW）装置，其具有诸如从显示屏幕的低强度光的动态图案。一对横向电极用于提供横向电场偏置，响应于通过光电导层和靠近液滴的电介质层的投影而控制传输运动。该装置被配置为用于光学操纵具有超过五个数量级的体积的液滴，并且可以被配置为在单面表面上执行涉及上述任一项的液滴分配，传输，分离，合并，混合和其它液滴操作功能。

4. 发明授权

US07727771B2 Systems and methods for optical actuation of microfluidics based on OPTO-electrowetting 有权
标题翻译：基于OPTO电润湿的微流体光学致动系统和方法
公开(公告)号：US07727771B2
公开(公告)日：2010-06-01
申请号：US11209587
申请日：2005-08-22
申请人： Pei Yu Chiou , Ming C. Wu
发明人： Pei Yu Chiou , Ming C. Wu
IPC分类号： G01N1/10 , G01N21/01
CPC分类号： B01L3/502792 , B01L2300/089 , B01L2400/0415 , B01L2400/0427 , F04B19/006 , G01N2035/1034 , Y10T436/2575
摘要： The invention is related to methods and apparatus that manipulate droplets in a microfluidic environment. Advantageously, embodiments of the invention manipulate droplets by controlling the electro-wetting characteristics of a surface with light, thereby inducing a gradient in the surface tension of a droplet. The gradient in the surface tension propels the droplet by capillary force. A variety of operations, such as transporting, joining, cutting, and creating can be performed. Advantageously, embodiments of the invention obviate the need to create a relatively large and complex control electrode array. A plurality of photoconductive cells or a layer of a photoconductive material selectively couples an electrode carrying an electrical bias to otherwise floating conductive cells in response to a beam of light. The electrical bias applied to the conductive cell generates a localized electric field, which can change the contact angle of the droplet, thereby permitting the droplet to be propelled.
摘要翻译：本发明涉及在微流体环境中操纵液滴的方法和装置。有利地，本发明的实施例通过用光控制表面的电润湿特性来操纵液滴，由此引起液滴的表面张力的梯度。表面张力的梯度通过毛细管力推动液滴。可以进行各种操作，例如运输，连接，切割和创建。有利地，本发明的实施例消除了产生相对较大和复杂的控制电极阵列的需要。响应于光束，多个光电导电池或光电导材料层将携带电偏压的电极选择性地耦合到另外的浮动导电单元。施加到导电电池的电偏压产生局部电场，这可以改变液滴的接触角，从而允许液滴被推进。

5. 发明申请

US20090170186A1 OPTOELECTRONIC TWEEZERS FOR MICROPARTICLE AND CELL MANIPULATION 有权
标题翻译：用于微波和细胞操作的光电二极管
公开(公告)号：US20090170186A1
公开(公告)日：2009-07-02
申请号：US11105304
申请日：2005-04-12
申请人： Ming Chiang Wu , Pei Yu Chiou , Aaron T. Ohta
发明人： Ming Chiang Wu , Pei Yu Chiou , Aaron T. Ohta
IPC分类号： C12M1/36 , B01J19/08
CPC分类号： B03C5/026 , B01L3/502761 , B01L2400/0454 , G01N2035/1046
摘要： An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 μm or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical tweezers, in particular the ability to perform operations in parallel and over a large area without damage to living cells. The OET device generally comprises a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a change in the electric field pattern. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or groups of particles/cells. The OET preferably includes a microscopic imaging means to provide feedback for the optical manipulation, such as detecting position and characteristics wherein the light patterns are modulated accordingly.
摘要翻译：描述了一种光学图像驱动的光诱导介电电泳（DEP）装置和方法，其提供对具有大约100μm或更小的直径的颗粒或细胞的操纵。该设备被称为光电镊子（OET），并且提供了许多优于常规光学镊子的优点，特别是并行地和大面积地进行操作而不损坏活细胞的能力。 OET装置通常包括具有一个或多个光电导体部分的平面液体填充结构，以将入射光转换成电场图案的变化。动态地产生光图案以提供可操纵单个颗粒和细胞或颗粒/细胞组的多个操作结构。 OET优选地包括用于为光学操作提供反馈的微观成像装置，例如检测位置和特性，其中相应地调制光图案。

6. 发明授权

US09533306B2 Single sided continuous optoelectrowetting (SCEOW) device for droplet manipulation with light patterns 有权
标题翻译：单面连续光电投影（SCEOW）装置用于具有光图案的液滴操纵
公开(公告)号：US09533306B2
公开(公告)日：2017-01-03
申请号：US13194966
申请日：2011-07-31
申请人： Pei-Yu Chiou , Sung-Yong Park
发明人： Pei-Yu Chiou , Sung-Yong Park
IPC分类号： C25B7/00 , B01L3/00
CPC分类号： B01L3/502792 , B01L2300/0816 , B01L2400/0427
摘要： A single-sided continuous optoelectrowetting (SCOEW) device for manipulating droplets retained in a fluid over the SCOEW device with dynamic patterns of low intensity light, such as from a display screen, is described. A single pair of lateral electrodes are utilized for providing a lateral electric field bias, with transport motion controlled in response to projecting light through a photoconductive layer and dielectric layer adjacent to which droplets are retained. The device is configured for optically manipulating droplets having volumes spanning over five orders of magnitude, and can be configured to perform droplet dispensing, transport, splitting, merging, mixing and other droplet manipulation functions involving any of the above on a single sided surface.
摘要翻译：描述了用于操纵SCOEW装置中流体中的液滴的单面连续光电投影（SCOEW）装置，其具有诸如从显示屏幕的低强度光的动态图案。一对横向电极用于提供横向电场偏置，响应于通过光电导层和靠近液滴的电介质层的投影而控制传输运动。该装置被配置为用于光学操纵具有超过五个数量级的体积的液滴，并且可以被配置为在单面表面上执行涉及上述任一项的液滴分配，输送，分离，合并，混合和其它液滴操作功能。

7. 发明申请

US20120236299A1 HIGH-SPEED ON DEMAND DROPLET GENERATION AND SINGLE CELL ENCAPSULATION DRIVEN BY INDUCED CAVITATION 有权
标题翻译：通过诱导加速驱动的高速需求滴灌产生和单细胞封装
公开(公告)号：US20120236299A1
公开(公告)日：2012-09-20
申请号：US13370196
申请日：2012-02-09
申请人： PEI-YU CHIOU , TING-HSIANG S. WU , SUNG-YONG PARK , MICHAEL A. TEITELL
发明人： PEI-YU CHIOU , TING-HSIANG S. WU , SUNG-YONG PARK , MICHAEL A. TEITELL
IPC分类号： G05D11/00 , G01J3/44 , B05B7/00 , G01R19/00 , G01R33/10 , G01H5/00 , G01N21/64 , G01N21/49
CPC分类号： B01L3/502715 , B01J13/04 , B01L3/502761 , B01L3/502784 , B01L2200/0636 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2300/0816 , B01L2400/0403 , B01L2400/0442 , G01N15/10 , G01N21/64 , G01N29/2418 , G01N2015/1481 , G01N2291/02433 , G05D11/13 , Y10T137/0318 , Y10T137/2496
摘要： Methods and devices for the formation of droplets of a first fluid in a second fluid and the encapsulation of particles or cells within such droplets are disclosed. Impetus for droplet formation is provided by the creation of a transient bubble, which may be induced using a pulsed laser. Droplet volume and the frequency at which droplets are formed can be controlled by modulation of the pulsed laser. The disclosed methods and devices are particularly suitable for use in microfluidic devices.
摘要翻译：公开了用于在第二流体中形成第一流体的液滴的方法和装置以及在这些液滴内的颗粒或细胞的包封。通过产生可以使用脉冲激光诱发的瞬态气泡来提供液滴形成的动力。可以通过调制脉冲激光来控制液滴体积和形成液滴的频率。所公开的方法和装置特别适用于微流体装置。

8. 发明授权

US07956339B2 Single-sided lateral-field and phototransistor-based optoelectronic tweezers 有权
标题翻译：单面横向和光电晶体管的光电镊子
公开(公告)号：US07956339B2
公开(公告)日：2011-06-07
申请号：US12565984
申请日：2009-09-24
申请人： Aaron Ohta , Pei-Yu Chiou , Hsan-Yin Hsu , Arash Jamshidi , Ming-Chiang Wu , Steven L. Neale
发明人： Aaron Ohta , Pei-Yu Chiou , Hsan-Yin Hsu , Arash Jamshidi , Ming-Chiang Wu , Steven L. Neale
IPC分类号： G01N27/447
CPC分类号： B82Y20/00 , B82Y15/00
摘要： Described herein are single-sided lateral-field optoelectronic tweezers (LOET) devices which use photosensitive electrode arrays to create optically-induced dielectrophoretic forces in an electric field that is parallel to the plane of the device. In addition, phototransistor-based optoelectronic tweezers (PhOET) devices are described that allow for optoelectronic tweezers (OET) operation in high-conductivity physiological buffer and cell culture media.
摘要翻译：这里描述的是使用光敏电极阵列在平行于器件平面的电场中产生光学诱导的介电电泳力的单面侧视场光电镊子（LOET）装置。此外，描述了基于光电晶体管的光电镊子（PhOET）装置，其允许在高电导率生理缓冲液和细胞培养基中的光电镊子（OET）操作。

9. 发明申请

US20110117648A1 SINGLE CELL SURGERY TOOL AND A CELL TRANSFECTION DEVICE UTILIZING THE PHOTOTHERMAL PROPERTIES OF THIN FILMS AND/OR METAL NANOPARTICLES 审中-公开
标题翻译：单细胞手术工具和利用薄膜和/或金属纳米颗粒的光热特性的细胞转染装置
公开(公告)号：US20110117648A1
公开(公告)日：2011-05-19
申请号：US12667594
申请日：2008-07-25
申请人： Pei-Yu Chiou , Ting-Hsiang Wu , Michael A. Teitell , Sheraz Kalim Butt
发明人： Pei-Yu Chiou , Ting-Hsiang Wu , Michael A. Teitell , Sheraz Kalim Butt
IPC分类号： C12N5/071 , C12M1/02 , C12M1/26 , A61M25/00 , B82Y5/00
CPC分类号： C12M35/02 , C12M23/16
摘要： This invention provides novel tools for surgery on single cells. In certain embodiments the tools comprise a microcapillary having at and/or near the tip a metal coating or a plurality of nanoparticles that can be heated by application of electromagnetic energy. In certain embodiments substrates are provided that facilitate the introduction of agents into cells. The substrates typically comprise a surface bearing a film or particles or nanoparticles that can be heated by application of electromagnetic energy.
摘要翻译：本发明提供用于单细胞手术的新型工具。在某些实施方案中，该工具包括在尖端处和/或附近具有可通过施加电磁能量加热的金属涂层或多个纳米颗粒的微毛细管。在某些实施方案中，提供有助于将试剂引入细胞的底物。基底通常包括带有能够通过施加电磁能量加热的膜或颗粒或纳米颗粒的表面。

10. 发明申请

US20100101960A1 SINGLE-SIDED LATERAL-FIELD AND PHOTOTRANSISTOR-BASED OPTOELECTRONIC TWEEZERS 有权
标题翻译：单面横向和基于光电子的光电二极管
公开(公告)号：US20100101960A1
公开(公告)日：2010-04-29
申请号：US12565984
申请日：2009-09-24
申请人： Aaron Ohta , Pei-Yu Chiou , Hsan-Yin Hsu , Arash Jamshidi , Ming-Chiang Wu , Steven L. Neale
发明人： Aaron Ohta , Pei-Yu Chiou , Hsan-Yin Hsu , Arash Jamshidi , Ming-Chiang Wu , Steven L. Neale
IPC分类号： G01N27/447 , H01L31/11 , H01L31/18
CPC分类号： B82Y20/00 , B82Y15/00
摘要： Described herein are single-sided lateral-field optoelectronic tweezers (LOET) devices which use photosensitive electrode arrays to create optically-induced dielectrophoretic forces in an electric field that is parallel to the plane of the device. In addition, phototransistor-based optoelectronic tweezers (PhOET) devices are described that allow for optoelectronic tweezers (OET) operation in high-conductivity physiological buffer and cell culture media.
摘要翻译：这里描述的是使用光敏电极阵列在平行于器件平面的电场中产生光学诱导的介电电泳力的单面侧视场光电镊子（LOET）装置。此外，描述了基于光电晶体管的光电镊子（PhOET）装置，其允许在高电导率生理缓冲液和细胞培养基中的光电镊子（OET）操作。

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