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1. 发明申请

US20120149129A1 LOW COST, PORTABLE SENSOR FOR MOLECULAR ASSAYS 有权
标题翻译：低成本，便携式传感器用于分子测定
公开(公告)号：US20120149129A1
公开(公告)日：2012-06-14
申请号：US13299087
申请日：2011-11-17
申请人： Alex H. Pai , Stephen A. Chapman , Seyed Ali Hajimiri
发明人： Alex H. Pai , Stephen A. Chapman , Seyed Ali Hajimiri
IPC分类号： G01N33/53 , G01N27/00 , G01N27/72
CPC分类号： G01N27/745 , C12Q1/6825 , C12Q1/6834 , C12Q2523/303 , C12Q2525/301 , C12Q2563/143 , G01N27/3278
摘要： An integrated sensor that is capable of discriminating the distance of a label from the sensor without using an optical signal. The label is attached to a single probe molecule or a group of probe molecules that interacts with a single or group of target molecules. As a consequence of this interaction, the probe molecule and/or the target molecule undergo a conformal change. This conformal change leads to perturbations in the distance of the label from the sensor. Thus, measurements and properties such as the concentration and the identity of one or more target molecules can be discerned from signals generated by the sensor (or by a plurality of sensors in a sensor array) and subjected to analysis using general purpose programmable computers programmed with suitable software that controls the analytical process, and such measurements and properties can be provided as a result of the analysis.
摘要翻译：能够在不使用光信号的情况下识别标签与传感器的距离的集成传感器。标签连接到与单个或一组靶分子相互作用的单个探针分子或一组探针分子。作为这种相互作用的结果，探针分子和/或靶分子经历保形变化。这种共形变化导致标签与传感器距离的扰动。因此，可以从由传感器（或传感器阵列中的多个传感器）产生的信号中识别出一个或多个目标分子的浓度和特性的测量和性质，并使用通过编程的通用可编程计算机进行分析作为分析过程的结果，可以提供控制分析过程的合适的软件，并且可以提供这样的测量和性质。

2. 发明授权

US09599591B2 Low cost, portable sensor for molecular assays 有权
公开(公告)号：US09599591B2
公开(公告)日：2017-03-21
申请号：US13299087
申请日：2011-11-17
申请人： Alex H. Pai , Stephen A. Chapman , Seyed Ali Hajimiri
发明人： Alex H. Pai , Stephen A. Chapman , Seyed Ali Hajimiri
IPC分类号： G01N27/00 , G01N27/74 , G01N27/327 , C12Q1/68
CPC分类号： G01N27/745 , C12Q1/6825 , C12Q1/6834 , C12Q2523/303 , C12Q2525/301 , C12Q2563/143 , G01N27/3278
摘要： An integrated sensor that is capable of discriminating the distance of a label from the sensor without using an optical signal. The label is attached to a single probe molecule or a group of probe molecules that interacts with a single or group of target molecules. As a consequence of this interaction, the probe molecule and/or the target molecule undergo a conformal change. This conformal change leads to perturbations in the distance of the label from the sensor. Thus, measurements and properties such as the concentration and the identity of one or more target molecules can be discerned from signals generated by the sensor (or by a plurality of sensors in a sensor array) and subjected to analysis using general purpose programmable computers programmed with suitable software that controls the analytical process, and such measurements and properties can be provided as a result of the analysis.

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