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1. 发明授权

US09011376B2 Drug delivery device with electrically controlled volume changing means 有权
标题翻译：具有电控体积变化装置的药物输送装置
公开(公告)号：US09011376B2
公开(公告)日：2015-04-21
申请号：US11996468
申请日：2006-07-03
申请人： Amir Genosar , Jonathan Goldstein
发明人： Amir Genosar , Jonathan Goldstein
IPC分类号： A61M1/00 , A61M37/00 , A61M5/00 , A61K9/22 , A61M5/142 , A61M5/145 , A61B5/01 , A61B5/145 , A61B5/00 , A61M5/172
CPC分类号： A61M5/14244 , A61B5/01 , A61B5/14532 , A61B5/4839 , A61M5/14526 , A61M5/1454 , A61M5/14566 , A61M5/14593 , A61M5/1723 , A61M2005/14252 , A61M2005/14513 , A61M2230/201
摘要： The present invention provides a drug delivery device comprising a drug reservoir chamber (15) containing a substance (16) to be delivered in fluid connection with a drug administration means (17) and (18), and a hydraulic control chamber (9) containing an electrically controlled, non-gassing, volume changing means (13), a coupling means (14) coupling said hydraulic control chamber (9) to said drug chamber (15), the arrangement being such that a change in the electrical control means (11) causes a change in the volume of the volume changing means (13), the volume change being conveyed by the coupling means (14) to the drug chamber (15) such that the substance (16) is expelled from the drug chamber (15) towards the drug administration means (17) and (18).
摘要翻译：本发明提供了一种药物输送装置，其包括药物储存室（15），其包含与药物施用装置（17）和（18）流体连接地输送的物质（16），以及液压控制室（9），其包含电控制的非气体体积变化装置（13），将所述液压控制室（9）联接到所述药物室（15）的联接装置（14），所述装置使得电气控制装置 11）引起体积变化装置（13）的体积变化，体积变化由联接装置（14）输送到药物室（15），使得物质（16）从药物室排出 15）朝向药物施用装置（17）和（18）。

2. 发明授权

US08834454B2 Drug delivery device 有权
标题翻译：给药装置
公开(公告)号：US08834454B2
公开(公告)日：2014-09-16
申请号：US12299602
申请日：2007-05-06
申请人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
发明人： Amir Genosar , Doron Aurbach , Elena Markevich , Grigory Salitra , Jonathan Goldstein , Mikhail Levi , Niles Fleischer , Yehuda Bachar , Yossi Aldar
IPC分类号： A61K9/22 , A61M5/20 , A61M5/145 , A61M5/142 , A61M5/172
CPC分类号： A61M5/145 , A61M5/14248 , A61M5/14276 , A61M5/1452 , A61M5/14586 , A61M5/172 , A61M5/1723 , A61M5/2046 , A61M2005/14204 , A61M2005/14252 , A61M2005/14513 , A61M2205/35 , A61M2205/8206 , A61M2230/201 , H01M2/02 , H01M10/02 , H01M10/05 , H01M10/42 , H01M2220/30
摘要： The present application provides a drug-delivery device comprising a drug reservoir chamber 16, containing a substance to be delivered, in fluid connection with a drug administration means 18, and an electrically-controlled battery unit 10 comprising at least one displacement-generating battery cell 19 coupled to the drug reservoir chamber 16 by a coupling means 14, the arrangement being such that the displacement derived from the battery unit 10 is conveyed by the coupling means 14 to the drug reservoir chamber 16 such that the substance is expelled from the drug reservoir chamber 16 towards the drug administration means 18.
摘要翻译：本申请提供了一种药物递送装置，其包括药物储存室16，其包含与药物施用装置18流体连接的待递送物质，以及电控电池单元10，其包括至少一个位移产生电池单元 19通过联接装置14耦合到药物储存室16，该布置使得从电池单元10获得的位移被耦合装置14输送到药物储存室16，使得物质从药物储存器中排出腔室16朝向药物管理装置18。

3. 发明授权

US07918843B2 Controllable drug delivery device 有权
标题翻译：可控药物输送装置
公开(公告)号：US07918843B2
公开(公告)日：2011-04-05
申请号：US12604278
申请日：2009-10-22
申请人： Amir Genosar , Jonathan Goldstein , Niles A. Fleisher , Yehuda Bachar , Yossi Aldar
发明人： Amir Genosar , Jonathan Goldstein , Niles A. Fleisher , Yehuda Bachar , Yossi Aldar
IPC分类号： A61K9/22 , A61M31/00
CPC分类号： A61M5/14248 , A61M5/14593 , A61M5/1486 , A61M2005/14252 , A61M2005/14268 , A61M2005/14506 , A61M2205/0272
摘要： A controllable drug delivery device for delivering a liquid injectable drug, the device comprising a drug reservoir (22), a drug administration device (28), a displacement-generating battery (20), and a current-depletion circuit (85), wherein displacement generated by the battery as current is depleted from the battery by the current depletion circuit displaces a wall of the drug reservoir thereby causing the reservoir to expel liquid injectable drug contained therein via the drug administration device, and wherein the drug delivery device further includes a controller (78) that is responsive to a measured parameter indicative of displacement generated by the battery for applying a variable load (80) across the battery in order to provide a substantially constant-current depletion of the battery and thereby cause the drug delivery device to deliver a substantially constant drug delivery rate.
摘要翻译：一种用于输送液体可注射药物的可控药物递送装置，所述装置包括药物储存器（22），药物施用装置（28），置换产生电池（20）和耗尽电路（85），其中由于电流由电流消耗电路而从电池中耗尽的电池产生的位移使药物储存器的壁移位，从而使储存器经由药物给药装置排出其中所含的可注射液体，并且其中药物输送装置还包括：控制器（78），其响应于指示由电池产生的位移的测量参数，用于施加跨越电池的可变负载（80），以便提供电池的基本上恒定的电流消耗，从而使药物输送装置提供基本上恒定的药物递送率。

4. 发明申请

US20100087778A1 CONTROLLABLE DRUG DELIVERY DEVICE 有权
标题翻译：可控制药物递送装置
公开(公告)号：US20100087778A1
公开(公告)日：2010-04-08
申请号：US12604278
申请日：2009-10-22
申请人： Amir Genosar , Jonathan Goldstein , Niles A. Fleisher , Yehuda Bachar , Yossi Aldar
发明人： Amir Genosar , Jonathan Goldstein , Niles A. Fleisher , Yehuda Bachar , Yossi Aldar
IPC分类号： A61M5/168
CPC分类号： A61M5/14248 , A61M5/14593 , A61M5/1486 , A61M2005/14252 , A61M2005/14268 , A61M2005/14506 , A61M2205/0272
摘要： A controllable drug delivery device for delivering a liquid injectable drug, said device comprising a drug reservoir (22), a drug administration device (28), a displacement-generating battery (20), and a current-depletion circuit (85), wherein displacement generated by said battery as current is depleted from the battery by the current depletion circuit displaces a wall of the drug reservoir thereby causing the reservoir to expel liquid injectable drug contained therein via said drug administration device, and wherein the drug delivery device further includes a controller (78) that is responsive to a measured parameter indicative of displacement generated by the battery for applying a variable load (80) across the battery in order to provide a substantially constant-current depletion of said battery and thereby cause said drug delivery device to deliver a substantially constant drug delivery rate.
摘要翻译：一种用于输送液体可注射药物的可控药物递送装置，所述装置包括药物储存器（22），药物施用装置（28），排量产生电池（20）和耗尽电路（85），其中所述电池产生的位移由电流耗尽电路从电池中耗尽，使药剂贮存器的壁移位，从而使储存器经由所述药物给药装置排出其中所含的液体可注射药物，并且其中所述药物输送装置还包括控制器（78），其响应于指示由所述电池产生的位移的测量参数，以在所述电池上施加可变负载（80），以便提供所述电池的基本上恒定的电流消耗，从而使所述药物递送装置提供基本上恒定的药物递送率。

5. 发明申请

US20090093772A1 Drug Delivery Device with Electrically Controlled Volume Changing Means 有权
标题翻译：具有电控体积变化手段的药物输送装置
公开(公告)号：US20090093772A1
公开(公告)日：2009-04-09
申请号：US11996468
申请日：2006-07-03
申请人： Amir Genosar , Jonathan Goldstein
发明人： Amir Genosar , Jonathan Goldstein
IPC分类号： A61M5/142
CPC分类号： A61M5/14244 , A61B5/01 , A61B5/14532 , A61B5/4839 , A61M5/14526 , A61M5/1454 , A61M5/14566 , A61M5/14593 , A61M5/1723 , A61M2005/14252 , A61M2005/14513 , A61M2230/201
摘要： The present invention provides a drug delivery device comprising a drug reservoir chamber (15) containing a substance (16) to be delivered in fluid connection with a drug administration means (17) and (18), and a hydraulic control chamber (9) containing an electrically controlled, non-gassing, volume changing means (13), a coupling means (14) coupling said hydraulic control chamber (9) to said drug chamber (15), the arrangement being such that a change in the electrical control means (11) causes a change in the volume of the volume changing means (13), the volume change being conveyed by the coupling means (14) to the drug chamber (15) such that the substance (16) is expelled from the drug chamber (15) towards the drug administration means (17) and (18).
摘要翻译：本发明提供了一种药物输送装置，其包括药物储存室（15），其包含与药物施用装置（17）和（18）流体连接地输送的物质（16），以及液压控制室（9），其包含电控制的非气体体积变化装置（13），将所述液压控制室（9）联接到所述药物室（15）的联接装置（14），所述装置使得电气控制装置 11）引起体积变化装置（13）的体积变化，体积变化由联接装置（14）输送到药物室（15），使得物质（16）从药物室排出 15）朝向药物施用装置（17）和（18）。

6. 发明申请

US20110093866A1 TIME-BASED EVENT PROCESSING USING PUNCTUATION EVENTS 有权
标题翻译：基于时间的事件处理使用打孔事件
公开(公告)号：US20110093866A1
公开(公告)日：2011-04-21
申请号：US12603445
申请日：2009-10-21
申请人： Torsten W. Grabs , Jonathan Goldstein , Beysim Sezgin
发明人： Torsten W. Grabs , Jonathan Goldstein , Beysim Sezgin
IPC分类号： G06F9/44
CPC分类号： G06F9/542 , G06F11/3065 , G06F11/3075
摘要： Methods, systems, and computer-readable media are disclosed for time-based event processing using punctuation events. A particular method includes receiving a first event object comprising a first validity start time and a first validity end time, where the first validity end time is initially undefined. A punctuation object is received after the first event object. The punctuation event object has a punctuation timestamp indicating a time subsequent to the first validity start time. The punctuation event object indicates that event objects to be received at the computer system after the punctuation event object have validity start times later than the time indicated by the punctuation timestamp. The method includes setting the first validity end time to a value later than or equal to the time indicated by the punctuation timestamp.
摘要翻译：公开了使用标点符号事件的基于时间的事件处理的方法，系统和计算机可读介质。一种特定的方法包括：接收包括第一有效性开始时间和第一有效期结束时间的第一事件对象，其中第一有效结束时间最初未定义。在第一个事件对象之后接收标点符号对象。标点符号事件对象具有指示第一有效性开始时间之后的时间的标点符号时间戳。标点符号事件对象指示在标点符号事件对象之后在计算机系统处接收到的事件对象比标点符号时间戳所指示的时间晚的有效性开始时间。该方法包括将第一有效结束时间设置为晚于或等于标点符号时间戳指示的时间的值。

7. 发明申请

US20100030896A1 ESTIMATING LATENCIES FOR QUERY OPTIMIZATION IN DISTRIBUTED STREAM PROCESSING 审中-公开
标题翻译：估计分布式流程中查询优化的延迟
公开(公告)号：US20100030896A1
公开(公告)日：2010-02-04
申请号：US12573108
申请日：2009-10-03
申请人： Badrish Chandramouli , Jonathan Goldstein
发明人： Badrish Chandramouli , Jonathan Goldstein
IPC分类号： G06F15/173
CPC分类号： G06F16/24568
摘要： A “Query Optimizer” provides a cost estimation metric referred to as “Maximum Accumulated Overload” (MAO). MAO is approximately equivalent to maximum system latency in a data stream management system (DSMS). Consequently, MAO is directly relevant for use in optimizing latencies in real-time streaming applications running multiple continuous queries (CQs) over high data-rate event sources. In various embodiments, the Query Optimizer computes MAO given knowledge of original operator statistics, including “operator selectivity” and “cycles/event” in combination with an expected event arrival workload. Beyond use in query optimization to minimize worst-case latency, MAO is useful for addressing problems including admission control, system provisioning, user latency reporting, operator placements (in a multi-node environment), etc. In addition, MAO, as a surrogate for worst-case latency, is generally applicable beyond streaming systems, to any queue-based workflow system with control over the scheduling strategy.
摘要翻译： “查询优化器”提供了称为“最大累积过载”（MAO）的成本估算度量。 MAO大致相当于数据流管理系统（DSMS）中的最大系统延迟。因此，MAO与通过高数据速率事件源运行多个连续查询（CQ）的实时流应用的优化延迟有直接关系。在各种实施例中，查询优化器结合预期的事件到达工作负载来计算给定原始运营商统计信息的MAO，包括“运营商选择性”和“周期/事件”。除了在查询优化中使用以最小化最坏情况的延迟之外，MAO可用于解决问题，包括准入控制，系统配置，用户延迟报告，运营商布置（在多节点环境中）等。此外，MAO作为替代对于最差情况下的延迟，通常适用于流式传输系统以及具有对调度策略的控制的任何基于队列的工作流系统。

8. 发明授权

US07594939B2 System for hydrogen storage and generation 失效
标题翻译：氢储存和生成系统
公开(公告)号：US07594939B2
公开(公告)日：2009-09-29
申请号：US11210086
申请日：2005-08-23
申请人： Jonathan Goldstein , Menachem Givon
发明人： Jonathan Goldstein , Menachem Givon
IPC分类号： B01J7/00 , B01J19/00 , A62D3/00 , B01J19/18 , C01B3/08 , C01B3/00
CPC分类号： C01B3/065 , C01B2203/066 , H01M8/04097 , H01M8/04156 , H01M8/065 , Y02E60/362 , Y02P20/129
摘要： The invention provides a solid phase hydrogen-generating system utilizing a solid chemical hydride fuel selected from the group consisting of sodium borohydride, lithium borohydride, magnesium hydride and calcium hydride, wherein the fuel is encapsulated in a plurality of removable capsules, the capsules being pumpable and having a major axis of up to 40 mm.
摘要翻译：本发明提供了一种使用选自硼氢化钠，硼氢化锂，氢化镁和氢化钙的固体化学氢化物燃料的固相氢气发生系统，其中燃料被包封在多个可移除的胶囊中，胶囊可泵送并且具有高达40mm的长轴。

9. 发明授权

US07383256B2 System and method for optimizing queries using materialized views and fast view matching 失效
标题翻译：使用物化视图和快速视图匹配优化查询的系统和方法
公开(公告)号：US07383256B2
公开(公告)日：2008-06-03
申请号：US10977707
申请日：2004-10-29
申请人： Per-Ake Larson , Jonathan Goldstein
发明人： Per-Ake Larson , Jonathan Goldstein
IPC分类号： G06F17/30
CPC分类号： G06F17/30457 , G06F17/30451 , Y10S707/99932 , Y10S707/99934 , Y10S707/99943
摘要： A transformation-based optimizer generates rewritings by applying local algebraic transformation rules on subexpressions of a query. Application of a transformation rule produces substitute expressions, logically equivalent to the original expression. View matching, that is, computing a subexpression from materialized views, is one such transformation rule. The view matching rule applies a view matching technique that determines whether the original query can be computed from one or more of the existing materialized views and, if so, generates substitute expressions. An index structure of materialized views is provided that quickly narrows the search to a set of candidate views on which the view matching techniques can be applied. The index structure, also called a filter tree, speeds up the search for applicable materialized views.
摘要翻译：基于变换的优化器通过在查询的子表达式上应用本地代数变换规则来生成重写。转换规则的应用产生替代表达式，逻辑上等同于原始表达式。查看匹配，即从物化视图计算子表达式，是一个这样的转换规则。视图匹配规则应用视图匹配技术，其确定是否可以从一个或多个现有物化视图计算原始查询，如果是，则生成替代表达式。提供了物化视图的索引结构，其快速地将搜索缩小到可应用视图匹配技术的一组候选视图。索引结构（也称为过滤器树）可加速搜索适用的实例化视图。

10. 发明申请

US20070088749A1 Registration based mail-addressing system 审中-公开
标题翻译：基于注册的邮件寻址系统
公开(公告)号：US20070088749A1
公开(公告)日：2007-04-19
申请号：US11501915
申请日：2006-08-10
申请人： Yoav Lorch , Gila Oren , Brandon Bezzant , Jonathan Goldstein , Steven Fox
发明人： Yoav Lorch , Gila Oren , Brandon Bezzant , Jonathan Goldstein , Steven Fox
IPC分类号： G06F17/00
CPC分类号： G07B17/00508 , G07B17/00435 , G07B2017/00596 , H04L63/0281 , H04L63/029 , H04L63/083
摘要： A method, system and product for delivering a postal mailpiece to a recipient address. A registration based mail-addressing protocol is utilized that allows a postal recipient to create and maintain a proxy address, which is dynamically associated with the recipient's postal address and is more simple than the postal address. The sender of a postal mailpiece addresses the mailpiece with the simplified proxy address instead of the burdensome recipient postal address. The method, system and product allows recipients to create and manage proxy addresses, detects a proxy address on a mailpiece and takes the appropriate measures to deliver the postal mailpiece to a physical address corresponding recipient postal address.
摘要翻译：用于将邮政邮件递送到收件人地址的方法，系统和产品。使用基于注册的邮件寻址协议，其允许邮政接收者创建和维护与接收者的邮政地址动态相关联的代理地址，并且比邮政地址更简单。邮政邮件的发件人用简化的代理地址代替邮件，而不是繁重的收件人邮政地址。方法，系统和产品允许收件人创建和管理代理地址，检测邮件上的代理地址，并采取适当措施将邮政邮件传递到相应的收件人邮政地址的物理地址。

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