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1. 发明授权

US07803149B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US07803149B2
公开(公告)日：2010-09-28
申请号：US10618977
申请日：2003-07-14
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

2. 发明授权

US07731685B2 Coated medical device 有权
标题翻译：涂层医疗器械
公开(公告)号：US07731685B2
公开(公告)日：2010-06-08
申请号：US11234702
申请日：2005-09-23
申请人： Anthony O. Ragheb , Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon
发明人： Anthony O. Ragheb , Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/958 , A61F2210/0014 , A61F2210/0076 , A61F2240/001 , A61F2250/0025 , A61F2250/0026 , A61F2250/0067 , A61F2250/0081 , A61F2250/0098 , A61F2310/00011 , A61L27/54 , A61L29/08 , A61L29/085 , A61L29/16 , A61L29/18 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61M25/1029 , A61M25/104 , A61M2025/1031 , A61M2025/105 , A61M2250/00
摘要： A coated medical device adapted for introduction into a passage or vessel of a patient is provided. The medical device is preferably an implantable balloon with a bioactive deposited or within the balloon. The balloon can further include a hydrophilic material positioned between the balloon and a bioactive material posited on the balloon.
摘要翻译：提供适于引入患者的通道或容器中的涂覆医疗装置。医疗装置优选地是具有生物活性沉积的或在球囊内的可植入气球。球囊可以进一步包括位于球囊和放置在球囊上的生物活性物质之间的亲水材料。

3. 发明授权

US10532190B2 Coated medical device 有权
公开(公告)号：US10532190B2
公开(公告)日：2020-01-14
申请号：US12892177
申请日：2010-09-28
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61M31/00 , A61M25/10 , A61F2/82 , A61L27/54 , A61L31/16 , A61L29/16 , A61F2/844 , A61F2/958 , A61L29/08 , A61L29/18 , A61L31/14 , A61F2/86
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.

4. 发明申请

US20110015725A1 COATED MEDICAL DEVICE 审中-公开
标题翻译：涂层医疗器械
公开(公告)号：US20110015725A1
公开(公告)日：2011-01-20
申请号：US12892177
申请日：2010-09-28
申请人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
发明人： Brian L. Bates , Scott E. Boatman , David G. Burton , Michael C. Hoffa , Darin G. Schaeffer , Jason S. Sturgeon , Anthony O. Ragheb
IPC分类号： A61F2/82
摘要： A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.
摘要翻译：一种涂覆的医疗装置（10），包括适于引入患者的通道或容器中的结构（12）。该结构优选由其上设置有生物活性材料层（18）的无孔基材（14）形成。该医疗装置优选为其上沉积有生物活性物质层的可植入支架或球囊（26）。支架可以围绕气囊定位，另一层生物活性材料放置在整个结构上并延伸超过定位的支架的端部。气囊的端部延伸超过支架的端部并且包括其上的生物活性材料，用于将生物活性材料输送到与其接触的血管壁的细胞。气囊还包括位于气囊的基部和生物活性材料层之间的一层亲水材料（58）。

5. 发明申请

US20080183268A1 COATED IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：涂层可植入医疗器械
公开(公告)号：US20080183268A1
公开(公告)日：2008-07-31
申请号：US11965385
申请日：2007-12-27
申请人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma , David D. Grewe , Darin G. Schaeffer , JiChao Sun
发明人： Brian L. Bates , Anthony O. Ragheb , Neal E. Fearnot , William D. Voorhees , Thomas G. Kozma , David D. Grewe , Darin G. Schaeffer , JiChao Sun
IPC分类号： A61F2/82
CPC分类号： A61F2/885 , A61F2/0077 , A61F2250/0068
摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.
摘要翻译：涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 以及至少一层生物活性材料层18，其被定位在涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。此外，至少一个多孔层20可以位于生物活性材料层18上，其中多孔层包括聚合物，并且通过其提供生物活性材料的受控释放。优选地，结构12是冠状动脉支架。多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。

6. 发明授权

US09078780B2 Balloon flareable branch vessel prosthesis and method 有权
标题翻译：气球爆裂分支血管假体和方法
公开(公告)号：US09078780B2
公开(公告)日：2015-07-14
申请号：US10984417
申请日：2004-11-08
申请人： Darin G. Schaeffer , Michael C. Hoffa , Scott E. Boatman , Kimberly D. Roberts
发明人： Darin G. Schaeffer , Michael C. Hoffa , Scott E. Boatman , Kimberly D. Roberts
IPC分类号： A61F2/06 , A61F2/954 , A61F2/07 , A61F2/856 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2/958 , A61B17/11 , A61F2/82 , A61F2/848 , A61F2/95 , A61F2/89
CPC分类号： A61F2/954 , A61B2017/1107 , A61B2017/1139 , A61F2/064 , A61F2/07 , A61F2/856 , A61F2/88 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/065 , A61F2002/067 , A61F2002/075 , A61F2002/821 , A61F2002/8483 , A61F2002/8486 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/9511 , A61F2210/0076 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2250/0018 , A61F2250/0039 , A61F2250/0097 , A61F2250/0098
摘要： A stent graft system for intraluminal deployment in an aorta and a branch vessel that includes an aorta stent graft for deployment within the aorta and defining a lumen for the passage of blood therethrough, and having a fenestration positioned and sized so as to allow blood to flow to a contiguous branch vessel. The system also includes a branch vessel prosthesis, preferably a stent graft, having a tubular portion and a flaring portion, such that, when deployed, the flaring portion is located within the lumen of the aorta stent graft and the tubular portion passes through the fenestration and into the branch vessel. A balloon expansion catheter expands the tubular portion and flare the flaring portion. The expansion of the tubular portion and the flaring of the flaring portion may occur sequentially or simultaneously.
摘要翻译：一种用于腔内部署在主动脉和分支血管中的支架移植系统，其包括用于展开在主动脉内的主动脉支架移植物并且限定用于血液通过的管腔，并且具有定位和尺寸以使血液流动的开窗到连续的分支船。该系统还包括具有管状部分和扩口部分的分支容器假体，优选为支架移植物，使得当展开时，扩张部分位于主动脉支架移植物的内腔内，并且管状部分通过开窗并进入分支船。气球膨胀导管使管状部分膨胀并且扩张扩口部分。管状部分的膨胀和扩口部分的扩口可以顺序地或同时地发生。

7. 发明授权

US09358141B2 Stent deployment device 有权
标题翻译：支架部署装置
公开(公告)号：US09358141B2
公开(公告)日：2016-06-07
申请号：US11547020
申请日：2005-03-22
申请人： Scott E. Boatman , Michael C. Hoffa , Kimberly D. Roberts , Darin G. Schaeffer
发明人： Scott E. Boatman , Michael C. Hoffa , Kimberly D. Roberts , Darin G. Schaeffer
IPC分类号： A61F2/958 , A61F2/82
CPC分类号： A61F2/958 , A61F2002/821
摘要： A stent deployment device (110) is provided for deploying a stent in a lumen of a patient. The device can include a catheter (112), a first balloon (122) positioned near a distal end of the catheter and a second balloon (123) adjacent to the first balloon. Alternatively, the second balloon can be positioned over the first balloon. The device also includes an expandable stent (210) positioned over the first balloon and the second balloon. The first balloon comprises a semi-compliant material, a noncompliant material or a compliant material. Similarly, the second balloon comprises a semi-compliant material, a noncompliant material or a compliant material. The first balloon is expandable to a first diameter, while the second balloon can be expandable to a second diameter.
摘要翻译：提供支架展开装置（110）用于将支架展开在患者的内腔中。该装置可以包括导管（112），定位在导管的远端附近的第一球囊（122）和邻近第一球囊的第二球囊（123）。或者，第二气球可以位于第一气球上方。该装置还包括位于第一球囊和第二球囊之上的可扩张支架（210）。第一气囊包括半柔顺材料，不符合材料或柔顺材料。类似地，第二气囊包括半柔顺材料，不合格材料或顺应性材料。第一气囊可扩张至第一直径，而第二球囊可扩张至第二直径。

8. 发明授权

US09259336B2 Stent with a crush-resistant zone 有权
标题翻译：支架具有耐挤压区域
公开(公告)号：US09259336B2
公开(公告)日：2016-02-16
申请号：US11810533
申请日：2007-06-06
申请人： Darin G. Schaeffer , Scott E. Boatman , Jay A. Dittman , David Earnest Hartley
发明人： Darin G. Schaeffer , Scott E. Boatman , Jay A. Dittman , David Earnest Hartley
IPC分类号： A61F2/06 , A61F2/856 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2/82
CPC分类号： A61F2/86 , A61F2/07 , A61F2/856 , A61F2/91 , A61F2/915 , A61F2/92 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/072 , A61F2002/075 , A61F2002/821 , A61F2002/91525 , A61F2002/91558 , A61F2002/91566 , A61F2220/0016 , A61F2220/0025 , A61F2220/0075 , A61F2250/0018 , A61F2250/0029 , A61F2250/0039 , A61F2250/0073
摘要： An endoluminal prosthesis system for a branched body lumen comprises a branch vessel prosthesis. The branch vessel prosthesis is deployable within a branch vessel body lumen and comprises a stent having a generally tubular body portion, a flareable proximal end portion, and a coupling portion disposed intermediate the body portion and the flareable portion. The coupling portion is preferably more crush-resistant than the body portion.
摘要翻译：用于分支体腔的腔内假体系统包括分支血管假体。分支血管假体可展开在分支血管体腔内，并且包括具有大致管状的主体部分，可扩张的近端部分和设置在主体部分和可扩张部分之间的联接部分的支架。联接部分优选地比主体部分更耐压。

9. 发明授权

US07534250B2 Introducer sheath 有权
标题翻译：导引鞘
公开(公告)号：US07534250B2
公开(公告)日：2009-05-19
申请号：US10608043
申请日：2003-06-27
申请人： Darin G. Schaeffer , Bruce Gingles , Jason Urbanski , Daniel J. Sirota , Michael C. Hoffa
发明人： Darin G. Schaeffer , Bruce Gingles , Jason Urbanski , Daniel J. Sirota , Michael C. Hoffa
IPC分类号： A61M29/00
CPC分类号： A61M16/0472 , A61M25/0017
摘要： An apparatus and method for inserting an article into a body opening. A radially expandable introducer sheath is delivered in a non-expanded condition into a body opening. A release mechanism releases the introducer sheath from the non-expanded condition into a condition that permits radial expansion of the introducer sheath upon introduction of a medical device through the sheath into the body opening. An optional handle having a circumferential opening may be provided for withdrawing the sheath from the body opening, while leaving the medical device in place.
摘要翻译：一种用于将物品插入体开口中的装置和方法。径向可扩张的导引鞘被以非膨胀状态输送到体开口中。释放机构将引导器护套从非扩张状态释放到在将医疗装置通过护套引入体开口时允许导引鞘的径向膨胀的状态。可以提供具有周向开口的可选手柄，用于在离开医疗装置就位的同时从主体开口抽出护套。

10. 发明授权

US08287586B2 Flareable branch vessel prosthesis and method 有权
标题翻译：可扩张分支血管假体和方法
公开(公告)号：US08287586B2
公开(公告)日：2012-10-16
申请号：US10984520
申请日：2004-11-08
申请人： Darin G. Schaeffer , Michael C. Hoffa
发明人： Darin G. Schaeffer , Michael C. Hoffa
IPC分类号： A61F2/86
CPC分类号： A61F2/954 , A61B2017/1107 , A61B2017/1139 , A61F2/064 , A61F2/07 , A61F2/856 , A61F2/88 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/065 , A61F2002/067 , A61F2002/075 , A61F2002/821 , A61F2002/8483 , A61F2002/8486 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/9511 , A61F2210/0076 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2220/0083 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2250/0018 , A61F2250/0039 , A61F2250/0097 , A61F2250/0098
摘要： A branch vessel prosthesis for use with an aorta stent graft defining a lumen and having a fenestration aligned with a branch vessel, includes an expandable stent that has a tubular portion, a flareable portion, and at least one bending portion located between the tubular and the flareable portions. Upon deployment of the branch vessel prosthesis, the flareable portion is flared by bending of the bending portion.
摘要翻译：一种用于与限定内腔并具有与分支血管对准的开窗的主动脉支架移植物一起使用的分支血管假体，包括可扩张支架，其具有管状部分，可扩张部分和至少一个弯曲部分，位于管状部分和第可爆部分在展开分支血管假体时，通过弯曲部分的弯曲来扩张可扩张部分。

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