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1. 发明申请

US20100049023A1 Non-invasive method and system for determining physiological characteristics 审中-公开
标题翻译：用于确定生理特征的非侵入性方法和系统
公开(公告)号：US20100049023A1
公开(公告)日：2010-02-25
申请号：US12229158
申请日：2008-08-20
申请人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
发明人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
IPC分类号： A61B5/1491
CPC分类号： A61B5/6816 , A61B5/14551 , A61B5/6826 , A61B5/6838
摘要： A non-invasive method of determining a physiological characteristic, comprising providing at least one physiological sensor that is adapted to measure at least one physiological characteristic at a target measurement site on a subject's body, heating an extended tissue region on the subject's body, whereby blood perfusion of the tissue region is enhanced, and measuring at least one physiological characteristic with the physiological sensor during or within a predetermined period after heating the extended tissue region.
摘要翻译：一种确定生理特征的非侵入性方法，包括提供至少一个生理传感器，其适于测量受试者身体上的目标测量部位上的至少一种生理特征，加热受试者身体上延伸的组织区域，由此血液增强组织区域的灌注，并且在加热延伸的组织区域之后或期间的预定时间段内测量与生理传感器的至少一个生理特征。

2. 发明申请

US20100152547A1 Method and system for determining cardiac performance 审中-公开
标题翻译：用于确定心脏性能的方法和系统
公开(公告)号：US20100152547A1
公开(公告)日：2010-06-17
申请号：US12459570
申请日：2009-07-02
申请人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
发明人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
IPC分类号： A61B5/02
CPC分类号： A61B5/029
摘要： Methods and associated algorithms for determining cardiac and/or cardiovascular performance that are based on at least one cardiac function determinant associated with or at least in part, reflective of preload, contractility and afterload.
摘要翻译：基于与预负荷，收缩性和后负荷相关联或至少部分地反映预负荷，收缩性和后负荷的至少一个心脏功能决定因素来确定心脏和/或心血管性能的方法和相关算法。

3. 发明申请

US20100049007A1 Integrated physiological sensor apparatus and system 审中-公开
标题翻译：综合生理传感器设备和系统
公开(公告)号：US20100049007A1
公开(公告)日：2010-02-25
申请号：US12229080
申请日：2008-08-20
申请人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
发明人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0261 , A61B5/14551 , A61B5/1491 , A61B5/6806 , A61B5/6816 , A61B5/6843
摘要： A physiological sensor apparatus, system and method for determining a physiological characteristic, comprising providing at least one physiological sensor that is adapted to measure at least one physiological characteristic at a target measurement site on a subject's body, heating an extended tissue region on the subject's body, whereby blood perfusion of the tissue region is enhanced, and measuring at least one physiological characteristic at the target measurement site with the physiological sensor during or within a predetermined period after heating the extended tissue region. In one embodiment, the sensor system includes at least one temperature algorithm that is adapted to adjust the heat applied to the extended tissue region based on the body's response to the heat stimuli.
摘要翻译：一种用于确定生理特征的生理传感器装置，系统和方法，包括提供至少一个生理传感器，所述生理传感器适于测量被检体的目标测量部位上的至少一个生理特征，加热被检体的延伸的组织区域从而增强组织区域的血液灌注，并且在加热延伸的组织区域之后或期间的预定时间段内，用生理传感器测量目标测量部位的至少一个生理特征。在一个实施例中，传感器系统包括至少一个温度算法，其适于基于身体对热刺激的响应来调节施加到延伸的组织区域的热量。

4. 发明授权

US08834382B2 Method for determining a cardiac function 有权
标题翻译：确定心脏功能的方法
公开(公告)号：US08834382B2
公开(公告)日：2014-09-16
申请号：US12011122
申请日：2008-01-23
申请人： Gregory I. Voss , James M. Perry , Rankin A. Clinton, III , Bernhard B. Sterling , Andrew R Lawrence
发明人： Gregory I. Voss , James M. Perry , Rankin A. Clinton, III , Bernhard B. Sterling , Andrew R Lawrence
IPC分类号： A61B5/02
CPC分类号： A61B5/026 , A61B5/02125
摘要： A method for determining a cardiac function, comprising (i) determining base anatomical characteristics associated with the subject, (ii) determining pulse delay to a first body site (PD01) and a second body site (PD02) as a function of the anatomical characteristics, wherein the distance via the arterial tree from the aortic valve to the first body site (PD01) is different than the arterial tree distance from the aortic valve to the second body site (PD02), (iii) determining pulse wave velocity between the first body site and the second body site (PWV12), (iv) determining pulse wave velocity between the aortic valve and the first body site (PWV01) as a function of PWV12, and the anatomical characteristics; and (v) determining the pre-ejection period (PEP) as a function of PD01 and PWV01.
摘要翻译：一种用于确定心脏功能的方法，包括（i）确定与受试者相关联的基础解剖特征，（ii）根据解剖特征确定到第一身体部位（PD01）和第二身体部位（PD02）的脉冲延迟，其中经由动脉树从主动脉瓣到第一身体部位（PD01）的距离不同于从主动脉瓣到第二身体部位（PD02）的动脉树距离，（iii）确定第一（PWV12），（iv）确定作为PWV12的函数的主动脉瓣与第一个体部位（PWV01）之间的脉搏波速度及其解剖特征; 和（v）确定作为PD01和PWV01的函数的预喷射周期（PEP）。

5. 发明申请

US20090187110A1 Method for determining a cardiac function 有权
标题翻译：确定心脏功能的方法
公开(公告)号：US20090187110A1
公开(公告)日：2009-07-23
申请号：US12011122
申请日：2008-01-23
申请人： Gregory I. Voss , James M. Perry , Rankin A. Clinton, III , Bernhard B. Sterling , Andrew R. Lawrence
发明人： Gregory I. Voss , James M. Perry , Rankin A. Clinton, III , Bernhard B. Sterling , Andrew R. Lawrence
IPC分类号： A61B5/024
CPC分类号： A61B5/026 , A61B5/02125
摘要： A method for determining a cardiac function, comprising (i) determining base anatomical characteristics associated with the subject, (ii) determining pulse delay to a first body site (PD01) and a second body site (PD02) as a function of the anatomical characteristics, wherein the distance via the arterial tree from the aortic valve to the first body site (PD01) is different than the arterial tree distance from the aortic valve to the second body site (PD02), (iii) determining pulse wave velocity between the first body site and the second body site (PWV12), (iv) determining pulse wave velocity between the aortic valve and the first body site (PWV01) as a function of PWV12, and the anatomical characteristics; and (v) determining the pre-ejection period (PEP) as a function of PD01 and PWV01.
摘要翻译：一种用于确定心脏功能的方法，包括（i）确定与受试者相关联的基础解剖特征，（ii）根据解剖特征确定到第一身体部位（PD01）和第二身体部位（PD02）的脉冲延迟，其中经由动脉树从主动脉瓣到第一身体部位（PD01）的距离不同于从主动脉瓣到第二身体部位（PD02）的动脉树距离，（iii）确定第一（PWV12），（iv）确定作为PWV12的函数的主动脉瓣与第一个体部位（PWV01）之间的脉搏波速度及其解剖特征; 和（v）确定作为PD01和PWV01的函数的预喷射周期（PEP）。

6. 发明申请

US20080183232A1 Method and system for determining cardiac function 审中-公开
标题翻译：确定心脏功能的方法和系统
公开(公告)号：US20080183232A1
公开(公告)日：2008-07-31
申请号：US11700328
申请日：2007-01-30
申请人： Gregory I. Voss , Bernhard B. Sterling , Anthony J. Bergman , Alexander K. Mills , Donna Wall
发明人： Gregory I. Voss , Bernhard B. Sterling , Anthony J. Bergman , Alexander K. Mills , Donna Wall
IPC分类号： A61N1/00
CPC分类号： A61B5/02255 , A61B5/02028 , A61B5/02125 , A61B5/024 , A61B5/029 , A61B5/0295 , A61B5/1455
摘要： A method for determining a physiologic characteristic associated with cardiac function in a subject comprising the steps of providing at least one electromagnetic radiation absorption measurement, providing demographic information reflecting the subject's physical condition, determining a temporal plethysmographic value from the electromagnetic radiation absorption measurement, and determining at least one physiologic characteristic from the temporal plethysmographic value and demographic information by using a predetermined phenomenological model that is adapted to provide an estimate of a blood volume-time relationship proximate the heart and compute at least one physiologic characteristic associated with cardiac function based on the estimated blood volume-time relationship.
摘要翻译：一种用于确定与受试者的心脏功能相关的生理特征的方法，包括以下步骤：提供至少一个电磁辐射吸收测量，提供反映受试者的身体状况的人口统计信息，从电磁辐射吸收测量确定时间体积描记值，以及确定通过使用适于提供邻近心脏的血液体积 - 时间关系的估计并计算与心脏功能相关联的至少一个生理特征的预定的现象学模型，来自时间体积描记值和人口统计信息的至少一个生理特征，基于估计血容量 - 时间关系。

7. 发明授权

US07955267B2 Apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的装置
公开(公告)号：US07955267B2
公开(公告)日：2011-06-07
申请号：US11300019
申请日：2005-12-13
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

8. 发明授权

US08597195B2 Method and apparatus for non-invasively measuring hemodynamic parameters using parametrics 失效
公开(公告)号：US08597195B2
公开(公告)日：2013-12-03
申请号：US12987928
申请日：2011-01-10
申请人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
发明人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/6843 , A61B2562/02 , A61B2562/0247 , G06F19/00
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.

9. 发明授权

US08945016B2 Methods and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US08945016B2
公开(公告)日：2015-02-03
申请号：US13154315
申请日：2011-06-06
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/02 , A61B5/022 , A61B5/00
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

10. 发明申请

US20110166458A1 METHOD AND APPARATUS FOR NON-INVASIVELY MEASURING HEMODYNAMIC PARAMETERS USING PARAMETRICS 失效
标题翻译：使用参数非自主测量血液动力学参数的方法和装置
公开(公告)号：US20110166458A1
公开(公告)日：2011-07-07
申请号：US12987928
申请日：2011-01-10
申请人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
发明人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
IPC分类号： A61B5/021
CPC分类号： A61B5/021 , A61B5/6843 , A61B2562/02 , A61B2562/0247 , G06F19/00
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.
摘要翻译：一种用于非侵入性评估与生物体的循环系统相关联的一个或多个血液动力学参数的改进的方法和装置。在一个方面，本发明包括通过压缩或压缩靠近所关注的血管的组织的部分直到达到所需条件，然后测量血液动力学参数来测量血液动力学参数（例如，动脉血压）的方法。这种扁平化有效地减轻了靠近血管的组织产生的转移和其它损失，从而有助于准确和稳健的测量计量。还描述了适于维持最佳压平水平的算法。还公开了基于受试者生理学来缩放这种血液动力学参数测量以及基于测量参数向对象提供治疗的方法和装置。

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