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    • 8. 发明申请
    • Compositions and Methods APC, CREB, and BAD Pathways to Assess and Affect Cancer
    • 组成和方法APC,CREB和BAD评估和影响癌症的途径
    • US20130344168A1
    • 2013-12-26
    • US14003147
    • 2012-03-05
    • Johnathan M. LancasterYin Xiong
    • Johnathan M. LancasterYin Xiong
    • C12Q1/68
    • C12Q1/6886A61K31/00G01N33/5023G01N33/57449
    • Disclosed are compositions and methods for assessing the apoptosis and survival BAD phosphorylation pathway (BAD pathway); and/or (2) the cell cycle role of APC in cell cycle regulation pathway (APC pathway); and/or (3) the transcription CREB pathway (CREB pathway) and for using these pathways to assess, treat, monitor, prognose, diagnose, etc. subjects with cancer. Also disclosed are compositions and methods for identifying molecular pathways that are common to one or more chemotherapeutic agents for the treatment of an oncological disorder, for screening for compounds or agents that can be used to treat ovarian cancer, and for selecting for compounds or agents that can enhance the cytotoxic response of cisplatin, carboplatin, and/or paclitaxel against a cancer cell, such as an ovarian cancer cell or cell line.
    • 公开了用于评估凋亡和存活BAD磷酸化途径(BAD途径)的组合物和方法; 和/或(2)APC在细胞周期调节途径(APC途径)中的细胞周期作用; 和/或(3)转录CREB途径(CREB途径),并使用这些途径来评估,治疗,监测,预后,诊断等。 还公开了用于鉴定一种或多种用于治疗肿瘤病症的化学治疗剂共有的分子途径的组合物和方法,用于筛选可用于治疗卵巢癌的化合物或药剂,以及用于选择化合物或药剂 可以增强顺铂,卡铂和/或紫杉醇对癌细胞如卵巢癌细胞或细胞系的细胞毒性反应。