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1. 发明授权

US08792095B2 Methods and apparatus for transport of airborne molecules using an active cyclical vapor/liquid exchange 有权
标题翻译：使用活性循环蒸汽/液体交换运输空气传播分子的方法和装置
公开(公告)号：US08792095B2
公开(公告)日：2014-07-29
申请号：US13318983
申请日：2010-05-07
申请人： Brian D. Piorek , Carl D. Meinhart , Seung Joon Lee
发明人： Brian D. Piorek , Carl D. Meinhart , Seung Joon Lee
IPC分类号： G01J3/44 , G01N33/00
CPC分类号： G01N33/0057 , C02F2209/00
摘要： Methods and apparatus for detection and/or analysis of gas phase analytes and chemical compounds. The apparatus can be formed with microfluidic cells containing a selected fluid that interacts with the analyte(s), wherein the fluid can selectively transition between a vapor phase and a liquid phase. During condensation of the fluid, the population of analytes present within the vapor phase region of the fluid can be transported into the liquid phase region of the fluid within the microfluidic cells. During evaporation of the fluid, the analytes can be substantially retained within liquid phase region of the fluid and within the cells. Repetitive cycling of this vapor/liquid exchange can provide a build-up of the analytes within the microfluidic cells where they can be detected/analyzed.
摘要翻译：用于气相分析物和化合物的检测和/或分析的方法和装置。该装置可以由含有与分析物相互作用的选定流体的微流体细胞形成，其中流体可以选择性地在气相和液相之间转变。在流体冷凝期间，存在于流体的气相区域内的分析物群可以被输送到微流体细胞内的流体的液相区域。在流体蒸发期间，分析物可以基本上保留在流体的液相区域内和细胞内。这种蒸汽/液体交换的重复循环可以提供在微流体细胞内的分析物的积累，其中它们可被检测/分析。

2. 发明申请

US20120236304A1 SERS-ACTIVE ABSORBERS FOR THE ANALYSIS OF ANALYTES 有权
标题翻译：用于分析分析的SERS主动吸收器
公开(公告)号：US20120236304A1
公开(公告)日：2012-09-20
申请号：US13501716
申请日：2010-10-14
申请人： Seung Joon Lee , Brian D. Piorek , Carl D. Meinhart , Casey Hare , Norman Douglas Bradley
发明人： Seung Joon Lee , Brian D. Piorek , Carl D. Meinhart , Casey Hare , Norman Douglas Bradley
IPC分类号： G01N21/65
CPC分类号： G01N21/658
摘要： Solid-type SERS-active substrates (e.g., noble metallic nanostructured powders or noble metallic nanoparticle-coatings on beads, microbeads, particles, etc.) are contained within optically-transparent modules. The modules allow for the controlled introduction of analyte-bearing fluid(s) into SERS-active substrates. The modules also allow for the monitoring of SERS signals emanating from analyte(s) which have accumulated on the confined SERS-active substrates. These SERS signals may be monitored over time by direct readout of the SERS substrates through the optically transparent module for chemical analysis and chemical detection applications.
摘要翻译：固体型SERS活性基底（例如，贵金属纳米结构粉末或珠，微珠，颗粒等上的贵金属纳米颗粒涂层）包含在光学透明模块内。这些模块允许将有分析物的流体控制引入SERS活性底物。这些模块还允许对已经积聚在受限制的SERS活性基底上的分析物发出的SERS信号进行监测。可以通过用于化学分析和化学检测应用的光学透明模块直接读出SERS衬底来监测这些SERS信号。

3. 发明授权

US09091656B2 SERS-active absorbers for the analysis of analytes 有权
标题翻译：用于分析分析物的SERS活性吸收剂
公开(公告)号：US09091656B2
公开(公告)日：2015-07-28
申请号：US13501716
申请日：2010-10-14
申请人： Seung Joon Lee , Brian D. Piorek , Carl D. Meinhart , Casey Hare , Norman Douglas Bradley
发明人： Seung Joon Lee , Brian D. Piorek , Carl D. Meinhart , Casey Hare , Norman Douglas Bradley
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/658
摘要： Solid-type SERS-active substrates (e.g., noble metallic nanostructured powders or noble metallic nanoparticle-coatings on beads, microbeads, particles, etc.) are contained within optically-transparent modules. The modules allow for the controlled introduction of analyte-bearing fluid(s) into SERS-active substrates. The modules also allow for the monitoring of SERS signals emanating from analyte(s) which have accumulated on the confined SERS-active substrates. These SERS signals may be monitored over time by direct readout of the SERS substrates through the optically transparent module for chemical analysis and chemical detection applications.
摘要翻译：固体型SERS活性基底（例如，贵金属纳米结构粉末或珠，微珠，颗粒等上的贵金属纳米颗粒涂层）包含在光学透明模块内。这些模块允许将有分析物的流体控制引入SERS活性底物。这些模块还允许对已经积聚在受限制的SERS活性基底上的分析物发出的SERS信号进行监测。可以通过用于化学分析和化学检测应用的光学透明模块直接读出SERS衬底来监测这些SERS信号。

4. 发明授权

US08917389B2 SERS devices for the remote analysis of analytes 有权
标题翻译：用于远程分析分析物的SERS设备
公开(公告)号：US08917389B2
公开(公告)日：2014-12-23
申请号：US13511960
申请日：2010-11-29
申请人： Brian D. Piorek , Carl D. Meinhart , Seung Joon Lee
发明人： Brian D. Piorek , Carl D. Meinhart , Seung Joon Lee
IPC分类号： G01J3/44 , G01N21/65 , G01N21/17
CPC分类号： G01N21/658 , G01N2021/1793 , G01N2201/0221
摘要： SERS-active materials are delivered to a remote zone, then optically interrogated to detect and analyze from a safe distance the presence of explosives or other materials which may or may not be hazardous. Delivery methods include deploying projectiles comprising SERS-active material(s) which distribute their contents upon deployment to a target zone.
摘要翻译： SERS活性物质被运送到远程区域，然后进行光学询问，从安全的距离探测和分析爆炸物或其他可能危险的材料。交付方式包括部署包含SERS活动材料的弹丸，将其内容部署到目标区域后将其分发。

5. 发明申请

US20120281210A1 Nano-/Micro-Droplets for the Detection of Analytes 有权
标题翻译：用于检测分析物的纳米/微滴
公开(公告)号：US20120281210A1
公开(公告)日：2012-11-08
申请号：US13289679
申请日：2011-11-04
申请人： Seung Joon Lee , Brian D. Piorek , Carl D. Meinhart
发明人： Seung Joon Lee , Brian D. Piorek , Carl D. Meinhart
IPC分类号： G01J3/44 , B82Y15/00
CPC分类号： G01N21/658
摘要： For a rapid and real-time SERS detection of organic chemicals in the air and the interfaces of air/solids, colloidal silver and/or gold nanoparticles solution is sprayed, in the form of nano-/micro-sized droplets, at the desired target area where the analytes of interest are present, e.g., in the air or onto certain organic/inorganic interfaces.
摘要翻译：为了快速和实时的SERS检测空气中的有机化学物质和空气/固体的界面，将胶体银和/或金纳米颗粒溶液以纳米/微米级的液滴的形式喷射到所需目标存在感兴趣分析物的区域，例如在空气中或某些有机/无机界面上。

6. 发明授权

US09036144B2 Nano-/micro-droplets for the detection of analytes 有权
标题翻译：用于检测分析物的纳米/微滴
公开(公告)号：US09036144B2
公开(公告)日：2015-05-19
申请号：US13289679
申请日：2011-11-04
申请人： Seung Joon Lee , Brian D. Piorek , Carl D. Meinhart
发明人： Seung Joon Lee , Brian D. Piorek , Carl D. Meinhart
IPC分类号： G01N21/65
CPC分类号： G01N21/658
摘要： For a rapid and real-time SERS detection of organic chemicals in the air and the interfaces of air/solids, colloidal silver and/or gold nanoparticles solution is sprayed, in the form of nano-/micro-sized droplets, at the desired target area where the analytes of interest are present, e.g., in the air or onto certain organic/inorganic interfaces.
摘要翻译：为了快速和实时的SERS检测空气中的有机化学物质和空气/固体的界面，将胶体银和/或金纳米颗粒溶液以纳米/微米级的液滴的形式喷射到所需目标存在感兴趣分析物的区域，例如在空气中或某些有机/无机界面上。

7. 发明申请

US20120225493A1 Electronic-Chemometric Controlled System and Process for the Analysis of Analytes 审中-公开
标题翻译：电子化学计量控制系统和分析物分析方法
公开(公告)号：US20120225493A1
公开(公告)日：2012-09-06
申请号：US13390664
申请日：2010-08-17
申请人： Brian D. Piorek , Carl D. Meinhart , Seung Joon Lee , Casey Hare , Norman Douglas Bradley
发明人： Brian D. Piorek , Carl D. Meinhart , Seung Joon Lee , Casey Hare , Norman Douglas Bradley
IPC分类号： G01J3/28 , G01J3/44 , G01N33/53 , H01J49/26
CPC分类号： G01N1/2273 , G01N15/0612 , G01N2015/0038 , G01N2015/0687
摘要： A series of electronic-chemometric control processes to enhance the selectivity, concentration, analysis, and detec tion of chemical species (analytes) in the gas phase, such as when using SERS-based techniques. Controls consist variously of: 1) feedback of electronic signals corresponding to changes of static and variable parameters in targeted chemical species that vary according to a reduction, increase, maximization, linearization, or improved confidence in one or more chemometric output parameters; 2) methods for spatially locating the source of an analyte species; and, 3) variable duty cycling to save power and materials according to altered physical and environmental conditions within a monitored zone.
摘要翻译：一系列电子化学计量控制过程，以提高气相中化学物质（分析物）的选择性，浓度，分析和检测，例如使用基于SERS的技术时。控制包括以下各项：1）对应于目标化学物种中的静态和可变参数的变化的电子信号的反馈，其根据减少，增加，最大化，线性化或改善一个或多个化学计量输出参数的置信度而变化; 2）用于空间定位分析物种源的方法; 以及3）根据被监测区域内物理和环境条件的改变来节省电力和材料的可变负荷循环。

8. 发明申请

US20120127465A1 Methods and Apparatus for Transport of Airborne Molecules Using an Active Cyclical Vapor/Liquid Exchange 有权
标题翻译：使用活性循环蒸汽/液体交换运输空气分子的方法和装置
公开(公告)号：US20120127465A1
公开(公告)日：2012-05-24
申请号：US13318983
申请日：2010-05-07
申请人： Brian D. Piorek , Carl D. Meinhart , Seung Joon Lee
发明人： Brian D. Piorek , Carl D. Meinhart , Seung Joon Lee
IPC分类号： G01J3/44
CPC分类号： G01N33/0057 , C02F2209/00
摘要： Methods and apparatus for detection and/or analysis of gas phase analytes and chemical compounds. The apparatus can be formed with microfluidic cells containing a selected fluid that interacts with the analyte(s), wherein the fluid can selectively transition between a vapor phase and a liquid phase. During condensation of the fluid, the population of analytes present within the vapor phase region of the fluid can be transported into the liquid phase region of the fluid within the microfluidic cells. During evaporation of the fluid, the analytes can be substantially retained within liquid phase region of the fluid and within the cells. Repetitive cycling of this vapor/liquid exchange can provide a build-up of the analytes within the microfluidic cells where they can be detected/analyzed.
摘要翻译：用于气相分析物和化合物的检测和/或分析的方法和装置。该装置可以由含有与分析物相互作用的选定流体的微流体细胞形成，其中流体可以选择性地在气相和液相之间转变。在流体冷凝期间，存在于流体的气相区域内的分析物群可以被输送到微流体细胞内的流体的液相区域。在流体蒸发期间，分析物可以基本上保留在流体的液相区域内和细胞内。这种蒸汽/液体交换的重复循环可以提供在微流体细胞内的分析物的积累，其中它们可被检测/分析。

9. 发明授权

US08247238B2 Device and methods of detection of airborne agents 有权
标题翻译：空气传播剂检测装置及方法
公开(公告)号：US08247238B2
公开(公告)日：2012-08-21
申请号：US13217616
申请日：2011-08-25
申请人： Carl D. Meinhart , Brian Piorek , Seung Joon Lee , Martin Moskovits , Sanjoy Banerjee , Juan Santiago
发明人： Carl D. Meinhart , Brian Piorek , Seung Joon Lee , Martin Moskovits , Sanjoy Banerjee , Juan Santiago
IPC分类号： G01N21/75
CPC分类号： G01N21/658 , G01N21/0332 , G01N21/05 , G01N33/0057 , G01N2021/0346 , G01N2201/06113 , G01N2201/1087 , Y10S977/902
摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
摘要翻译：提供了利用自由表面流体学和SERS用于具有高灵敏度和特异性的分析物检测的方法，装置和系统。分子可以是空气传播剂，包括但不限于爆炸物，麻醉剂，危险化学品或其他化学物质。自由表面流体结构使用开放的微通道产生，并且表现出大的表面与体积比。自由表面流体界面可以过滤干扰分子，同时浓缩空气中的分析物。微通道流动使SERS活性探针颗粒在流动中受控聚集，从而提高检测器的灵敏度。

10. 发明授权

US08017408B2 Device and methods of detection of airborne agents 有权
标题翻译：空气传播剂检测装置及方法
公开(公告)号：US08017408B2
公开(公告)日：2011-09-13
申请号：US12597742
申请日：2008-04-25
申请人： Carl D. Meinhart , Brian Piorek , Seung Joon Lee , Martin Moskovits , Sanjoy Banerjee , Juan G. Santiago
发明人： Carl D. Meinhart , Brian Piorek , Seung Joon Lee , Martin Moskovits , Sanjoy Banerjee , Juan G. Santiago
IPC分类号： G01N21/75
CPC分类号： G01N21/658 , G01N21/0332 , G01N21/05 , G01N33/0057 , G01N2021/0346 , G01N2201/06113 , G01N2201/1087 , Y10S977/902
摘要： Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
摘要翻译：提供了利用自由表面流体学和SERS用于具有高灵敏度和特异性的分析物检测的方法，装置和系统。分子可以是空气传播剂，包括但不限于爆炸物，麻醉剂，危险化学品或其他化学物质。自由表面流体结构使用开放的微通道产生，并且表现出大的表面与体积比。自由表面流体界面可以过滤干扰分子，同时浓缩空气中的分析物。微通道流动使SERS活性探针颗粒在流动中受控聚集，从而提高检测器的灵敏度。

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