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1. 发明授权

US10933166B2 Bottlebrush polymer compositions, lubricating fluid, porous materials comprising said compositions, and surface bearing said compositions 有权
公开(公告)号：US10933166B2
公开(公告)日：2021-03-02
申请号：US16095051
申请日：2017-04-13
申请人： VALORISATION RECHERCHE, LIMITED PARTNERSHIP , VALORISATION HSJ, LIMITED PARTNERSHIP , CARNEGIE MELLON UNIVERSITY
发明人： Xavier Banquy , Jimmy Faivre , Buddha Ratna Shrestha , Krzysztof Matyjaszewski , Joanna Burdynska , Florina Moldovan
IPC分类号： A61L27/50 , A61L27/16 , C08F265/06 , C08B37/08 , C08L51/00 , C08L5/08 , A61L31/10 , A61L31/14 , C10M107/44 , C10M107/48 , C10M173/02 , C10N40/00 , C10N50/02
摘要： A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.

2. 发明申请

US20200024372A1 ENZYME-ASSISTED ATRP PROCEDURES 审中-公开
公开(公告)号：US20200024372A1
公开(公告)日：2020-01-23
申请号：US16520008
申请日：2019-07-23
申请人： Carnegie Mellon University
发明人： Krzysztof Matyjaszewski , Alan Enciso Barros , Liye Fu , Alan J. Russell
IPC分类号： C08F2/16 , C08K5/1545 , C08F220/28 , C08F4/26 , C12P7/00
摘要： Materials and methods for conducting an atom transfer radical polymerization in the presence of oxygen by interlocking enzymatic activities are provided herein.

3. 发明授权

US10072042B2 Atom transfer radical polymerization under biologically compatible conditions 有权
公开(公告)号：US10072042B2
公开(公告)日：2018-09-11
申请号：US15378537
申请日：2016-12-14
申请人： Carnegie Mellon University
发明人： Krzysztof Matyjaszewski , Saadyah E. Averick , Antonina Simakova
IPC分类号： C07K1/107 , C08G81/02 , C08F283/06 , C07K14/435 , C07K14/765
CPC分类号： C07K1/1077 , A61K47/60 , C07K14/43595 , C07K14/765 , C08F283/06 , C08F289/00 , C08G81/025
摘要： Methods for conducting controlled grafting-from radical polymerizations from biomolecules under conditions that are biologically compatible are described. The methods provide biomolecule-polymer conjugates with highly controlled structures and narrow polydispersities under aqueous reaction conditions and biological temperatures. Biomolecules, such as proteins and nucleotides can be conjugated to polymers with high levels of control.

4. 发明申请

US20180142288A1 NUCLEIC ACID-POLYMER CONJUGATES FOR BRIGHT FLUORESCENT TAGS 审中-公开
公开(公告)号：US20180142288A1
公开(公告)日：2018-05-24
申请号：US15802066
申请日：2017-11-02
申请人： CARNEGIE MELLON UNIVERSITY
发明人： Munira F. Fouz , Krzysztof Matyjaszewski , Bruce A. Armitage , Subha Ranjan Das , Saadyah Averick
IPC分类号： C12Q1/6834 , C07H21/04 , C08L57/00
CPC分类号： C12Q1/6834 , A61K47/6883 , C07H21/04 , C08F2438/01 , C08L57/00 , C08L57/12 , C08L2203/02 , C08L2205/14 , G01N33/582
摘要： A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.

5. 发明申请

US20170113934A1 HETEROATOM-ENRICHED PARTIALLY-GRAPHITIC NANO-CARBONS 审中-公开
公开(公告)号：US20170113934A1
公开(公告)日：2017-04-27
申请号：US15191918
申请日：2016-06-24
申请人： CARNEGIE MELLON UNIVERSITY
发明人： Tomasz Kowalewski , Mingjiang Zhong , Eric Gottlieb , Maciej Kopec , Jacob Mohin , Krzysztof Matyjaszewski
IPC分类号： C01B31/00 , H01L51/00 , H01G9/20 , H01L51/44
CPC分类号： H01G9/2022 , B82Y30/00 , B82Y40/00 , C01B32/184 , Y02E10/542 , Y02E60/13 , Y02P70/521 , Y10S977/734 , Y10S977/842
摘要： Carbon-based nanomaterials comprising graphitic domains that are doped with heteroatoms are disclosed. Processes for the production the nanomaterials, methods of using the nanomaterials, and articles or devices comprising the nanomaterials are also disclosed.

6. 发明申请

US20160200840A1 AQUEOUS ATRP IN THE PRESENCE OF AN ACTIVATOR REGENERATOR 有权
标题翻译：活塞式再生器存在的AQUEOUS ATRP
公开(公告)号：US20160200840A1
公开(公告)日：2016-07-14
申请号：US14993632
申请日：2016-01-12
申请人： Carnegie Mellon University
发明人： Krzysztof Matyjaszewski , Pawel Chmielarz , Dominik Konkolewicz , Pawel Krys , Xiangcheng Pan , Valerie Williams
IPC分类号： C08F120/28
CPC分类号： C08F120/28 , C08F4/40 , C08F4/50 , C08F220/54 , C08F2438/01
摘要： A process for polymerizing radically (co)polymerizable monomers at a temperature between −10° C. and 110° C. in an aqueous system comprising one or more radically (co)polymerizable monomer(s) is disclosed, and includes a molar excess of a ligand forming a soluble transition metal complex with an added transition metal salt that participates in a reversible reduction-oxidation cycle with one of an added site specific functional initiator and a dormant polymer chain having a radically transferable atom or group. The initial soluble catalyst complex concentration in the higher oxidation state is less than or equal to 2500 ppm. The reaction is conducted in the presence of an activator regenerator. The mole fraction of the soluble lower activator oxidation state transition metal formed by action of the activator regenerator, to transition metal in a higher deactivator oxidation state is less than 10%. The formed polymer chains have a dispersity of less than 1.5.
摘要翻译：公开了在包含一种或多种自由基（共）可聚合单体的水性体系中，在-10℃至110℃之间的温度下聚合自由基（共）可聚合单体的方法，并且包括摩尔过量的与添加的过渡金属盐形成可溶性过渡金属络合物的配体，其与加入的位点特异性官能引发剂和具有可自由基转移的原子或基团的休眠聚合物链之一参与可逆还原 - 氧化循环。较高氧化态的初始可溶性催化剂络合物浓度小于或等于2500ppm。反应在活化剂再生器的存在下进行。通过活化剂再生器的作用形成的可溶性低活化剂氧化态过渡金属与较高失活剂氧化态的过渡金属的摩尔分数小于10％。形成的聚合物链的分散性小于1.5。

7. 发明申请

US20150087795A1 LIGANDS DESIGNED TO PROVIDE HIGHLY ACTIVE CATALYST COMPLEXES 有权
标题翻译：设计提供高活性催化剂复合物的配体
公开(公告)号：US20150087795A1
公开(公告)日：2015-03-26
申请号：US14379418
申请日：2013-02-22
申请人： Carnegie Mellon University
发明人： Krzysztof Matyjaszewski , Yungwan Kwak , Joanna Burdynska , Andrea Elsen , Kristin Schroeder
IPC分类号： B01J31/22 , C08F120/18
CPC分类号： B01J31/2295 , B01J31/1815 , B01J31/2243 , B01J2231/10 , B01J2231/30 , B01J2231/42 , B01J2531/0247 , B01J2531/16 , B01J2531/842 , C08F2/38 , C08F4/10 , C08F4/26 , C08F4/40 , C08F120/18 , C08F2220/1825 , C08F2438/01 , Y02P20/52
摘要： A series of ligands with site specific electron donating substituents that form a catalyst complex with a transition metal and are suitable for catalysis of atom transfer radical reactions, including ATRP are described. Faster catalysis rates were observed allowing for low catalyst concentrations and linear increases in molecular weight with monomer conversion, and narrow molecular weight distributions. Cyclic voltammetry revealed that increasing the strength and number of conjugated electron donating groups resulted in more stable complexes and larger ATRP equilibrium constants.
摘要翻译：描述了一系列具有与过渡金属形成催化剂络合物并且适于催化原子转移自由基反应（包括ATRP）的位置特异性给电子取代基的配位体。观察到更快的催化速率，使得催化剂浓度低，分子量随单体转化率的线性增加，分子量分布窄。循环伏安法显示，增加共轭给电子基团的强度和数量导致更稳定的络合物和较大的ATRP平衡常数。

8. 发明授权

US11472894B2 Enzyme-assisted ATRP procedures 有权
公开(公告)号：US11472894B2
公开(公告)日：2022-10-18
申请号：US16520008
申请日：2019-07-23
申请人： Carnegie Mellon University
发明人： Krzysztof Matyjaszewski , Alan Enciso Barros , Liye Fu , Alan J. Russell
IPC分类号： C08F4/10 , C08F2/16 , C08K5/1545 , C08F4/26 , C12P7/00 , C08F220/28
摘要： Materials and methods for conducting an atom transfer radical polymerization in the presence of oxygen by interlocking enzymatic activities are provided herein.

9. 发明授权

US09765169B2 Functionalized polymer hybrids 有权
公开(公告)号：US09765169B2
公开(公告)日：2017-09-19
申请号：US14785334
申请日：2014-04-17
申请人： CARNEGIE MELLON UNIVERSITY
发明人： Subha Ranjan Das , Saadyah Averick , Sourav K. Dey , Krzysztof Matyjaszewski
IPC分类号： C12Q1/68 , C08F251/00 , C07H21/00 , C07H1/00
CPC分类号： C08F251/00 , C07H1/00 , C07H21/00
摘要： A method of synthesizing a polynucleotide composition includes attaching a compound including at least one initiator or at least one transfer agent for a reversible deactivation radical polymerization to an end of a nucleotide chain assembly immobilized upon a solid phase support during a solid phase synthesis of a polynucleotide so that the initiator or the transfer agent is attacked to the end of a nucleotide chain assembly in a manner which is stable under conditions of deprotection of the polynucleotide, and growing a polymer from the initiator of from a site of the chain transfer agent via the reversible deactivation radical polymerization to form the polynucleotide composition.

10. 发明申请

US20170158836A1 ORDERED MACROPOROUS HYDROGELS FOR BIORESPONSIVE PROCESSES 审中-公开
公开(公告)号：US20170158836A1
公开(公告)日：2017-06-08
申请号：US15039219
申请日：2014-11-25
申请人： Carnegie Mellon University
发明人： Krzysztof Matyjaszewski , Saadyah Averick , Hongkun He
IPC分类号： C08J9/26 , C02F3/34 , C12N9/96 , C08J9/00 , C08J9/36
CPC分类号： C08J9/26 , B01D71/40 , B01D71/44 , B01D71/52 , B01D71/82 , B01D2323/30 , C02F3/342 , C08J9/0061 , C08J9/36 , C08J2201/0462 , C08J2205/022 , C08J2205/05 , C08J2333/06 , C08J2333/12 , C08J2335/02 , C08J2489/00 , C12N9/96 , C12Y304/21004
摘要： A three-dimensionally ordered macroporous hydrogel for immobilizing a selected bioresponsive molecule and method of making are disclosed. The three-dimensionally ordered macroporous hydrogel comprises a crosslinked polymer that has a system of interconnected pores. The interconnected pores have a uniform pore size in the range of 50 to 5000 nm, and a plurality of first pore functional groups. The plurality of first pore functional groups is selected to immobilize a selected bioresponsive molecule. Examples of bioresponsive molecules include an enzyme; a molecule for: a protein scaffold, solid phase synthesis, nucleic acid synthesis, polypeptide synthesis, analyte detection, adsorption of analytes and measuring analyte concentrations, organic synthesis, and degradation of biologically active agents in wastewater. A method includes forming a colloidal crystal template, polymerizing a hydrogel within the pores of the colloidal crystal template, and selectively removing the colloidal crystal template. The hydrogel can be polymerized using CRP, ATRP and FRP polymerization processes.

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