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1. 发明授权

US10858390B2 Use of excess carbodiimide for peptide synthesis at elevated temperatures 有权
公开(公告)号：US10858390B2
公开(公告)日：2020-12-08
申请号：US15686719
申请日：2017-08-25
申请人： CEM Corporation
发明人： Jonathan M. Collins , Sandeep K. Singh
IPC分类号： C07K1/08 , C07K1/10 , C07K1/107 , C07K1/04 , C07C267/00 , C07K1/06
摘要： An improved method of coupling amino acids into peptides or peptidomimetics is disclosed in which the activation and coupling are carried out in the same vessel, in the presence of a carbodiimide in an amount greater than 1 equivalent as compared to the amino acid, in the presence of an activator additive, and at a temperature greater than 30° C.

2. 发明授权

US10308677B2 Coupling method for peptide synthesis at elevated temperatures 有权
公开(公告)号：US10308677B2
公开(公告)日：2019-06-04
申请号：US14969004
申请日：2015-12-15
申请人： CEM CORPORATION
发明人： Jonathan M. Collins , Sandeep Kumar Singh
IPC分类号： C07K1/10 , C07K14/575 , C07K1/04 , C07K1/08
摘要： An improved method for coupling carboxylic acids and amines is disclosed that includes the steps of combining a hyper-acid sensitive linker connecting an amine and a resin, a carboxylic acid, a carbodiimide, an activator additive, and a base, and carrying out the activation and coupling at a temperature greater than 30° C.

3. 发明申请

US20180066013A1 Use of Excess Carbodiimide for Peptide Synthesis at Elevated Temperatures 审中-公开
公开(公告)号：US20180066013A1
公开(公告)日：2018-03-08
申请号：US15686719
申请日：2017-08-25
申请人： CEM Corporation
发明人： Jonathan M. Collins , Sandeep K. Singh
IPC分类号： C07K1/107 , C07K1/08 , C07K1/06 , C07K1/04 , C07C267/00
CPC分类号： C07K1/1075 , C07C267/00 , C07K1/04 , C07K1/045 , C07K1/061 , C07K1/082 , C07K1/084 , C07K1/10
摘要： An improved method of coupling amino acids into peptides or peptidomimetics is disclosed in which the activation and coupling are carried out in the same vessel, in the presence of a carbodiimide in an amount greater than 1 equivalent as compared to the amino acid, in the presence of an activator additive, and at a temperature greater than 30° C.

4. 发明授权

US09921282B2 Method for determining fat or moisture content 有权
公开(公告)号：US09921282B2
公开(公告)日：2018-03-20
申请号：US13858991
申请日：2013-04-09
申请人： CEM Corporation
发明人： Michael J. Collins, Sr. , Jonathan M. Collins , Colin L. Simpson
IPC分类号： G01N24/08 , G01R33/44 , G01R33/31 , G01R33/46
CPC分类号： G01R33/44 , G01N24/08 , G01R33/31 , G01R33/4625
摘要： A method of measuring NMR response in an NMR instrument includes heating a sample at a heater temperature that is higher than the temperature of the interior of the NMR instrument, positioning the heated sample in the NMR instrument, and measuring the NMR response of the heat sample. Typically, the sample is dry and includes fat. Furthermore, a method of determining an amount of a component of a sample includes positioning a sample in an NMR instrument, applying a sequence of radio-frequency pulses to the sample, measuring the amplitudes of the signals produced by the application of the sequence of radio-frequency pulses, and determining the amount of a component in the sample using the measured amplitudes of the signals. The disclosed methods typically provide accurate analysis of samples in a shorter time period than traditional NMR techniques and solvent-based analysis techniques.

5. 发明申请

US20170369524A1 In-situ Solvent Recycling Process for Solid Phase Peptide Synthesis at Elevated Temperatures 审中-公开
公开(公告)号：US20170369524A1
公开(公告)日：2017-12-28
申请号：US15490090
申请日：2017-04-18
申请人： CEM Corporation
发明人： Jonathan M. Collins
IPC分类号： C07K1/04
CPC分类号： C07K1/04 , C07K1/045
摘要： An improvement in of deprotection in solid phase peptide synthesis is disclosed. The method includes the steps of adding the deprotection composition in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated amino acid from the preceding coupling cycle; and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle; and with the coupling solution at a temperature of at least 30° C.

6. 发明授权

US10239914B2 In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures 有权
公开(公告)号：US10239914B2
公开(公告)日：2019-03-26
申请号：US15490090
申请日：2017-04-18
申请人： CEM Corporation
发明人： Jonathan M. Collins
IPC分类号： C07K1/04
摘要： An improvement of deprotection in solid phase peptide synthesis is disclosed. The method includes the steps of adding the deprotection composition in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated amino acid from the preceding coupling cycle; and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle; and with the coupling solution at a temperature of at least 30° C.

7. 发明授权

US10125163B2 Solid phase peptide synthesis 有权
公开(公告)号：US10125163B2
公开(公告)日：2018-11-13
申请号：US15299931
申请日：2016-10-21
申请人： CEM Corporation
发明人： Jonathan M. Collins
IPC分类号： B01J19/12 , C07K1/04 , C07K1/107 , C07K1/14 , C07K1/06 , C07K14/575 , C07K14/605 , C07K14/815 , C07K14/635 , C07K14/59 , C07K14/705 , C07K14/645 , C07K14/005 , C12N7/00 , C07K14/47 , C07K7/08 , C07K7/16 , C07K14/46
摘要： An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.

8. 发明授权

US09969769B2 Coupling method for peptide synthesis at elevated temperatures 有权
公开(公告)号：US09969769B2
公开(公告)日：2018-05-15
申请号：US15647909
申请日：2017-07-12
申请人： CEM CORPORATION
发明人： Jonathan M. Collins , Sandeep Kumar Singh
IPC分类号： C07K1/00 , C07K1/08 , C07K1/04 , C07K14/575
CPC分类号： C07K1/006 , C07K1/04 , C07K1/045 , C07K1/08 , C07K1/084 , C07K1/10 , C07K14/57581
摘要： An improved method for coupling amino acids into peptides or peptidomimetics is disclosed that includes the steps of combining an amino acid, a carbodiimide, an activator additive, and a base at less than 1 equivalent compared to the amino acid to be activated; and carrying out the activation and coupling at a temperature greater than 30° C.

9. 发明申请

US20130265051A1 METHOD FOR DETERMINING FAT OR MOISTURE CONTENT 有权
标题翻译：用于测定脂肪或水分含量的方法
公开(公告)号：US20130265051A1
公开(公告)日：2013-10-10
申请号：US13858991
申请日：2013-04-09
申请人： CEM CORPORATION
发明人： Michael J. Collins, SR. , Jonathan M. Collins , Colin L. Simpson
IPC分类号： G01R33/44
CPC分类号： G01R33/44 , G01N24/08 , G01R33/31 , G01R33/4625
摘要： A method of measuring NMR response in an NMR instrument includes heating a sample at a heater temperature that is higher than the temperature of the interior of the NMR instrument, positioning the heated sample in the NMR instrument, and measuring the NMR response of the heat sample. Typically, the sample is dry and includes fat. Furthermore, a method of determining an amount of a component of a sample includes positioning a sample in an NMR instrument, applying a sequence of radio-frequency pulses to the sample, measuring the amplitudes of the signals produced by the application of the sequence of radio-frequency pulses, and determining the amount of a component in the sample using the measured amplitudes of the signals. The disclosed methods typically provide accurate analysis of samples in a shorter time period than traditional NMR techniques and solvent-based analysis techniques.
摘要翻译：在NMR仪器中测量NMR响应的方法包括在高于NMR仪器内部的温度的加热器温度下加热样品，将加热的样品定位在NMR仪器中，并测量热样品的NMR响应。通常，样品是干燥的并且包括脂肪。此外，确定样品的组分量的方法包括将样品定位在NMR仪器中，向样品施加一序列的射频脉冲，测量通过应用无线电序列产生的信号的振幅频率脉冲，并且使用测量的信号幅度来确定样本中的分量的量。所公开的方法通常在比传统NMR技术和基于溶剂的分析技术更短的时间段内提供对样品的精确分析。

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