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1. 发明授权

US07844343B2 MRI-safe implantable medical device 有权
标题翻译： MRI安全可植入医疗器械
公开(公告)号：US07844343B2
公开(公告)日：2010-11-30
申请号：US10945739
申请日：2004-09-20
申请人： Carl D. Wahlstrand , Robert M. Skime , Gregory A. Hrdlicka , James M. Olsen , Stephen L. Bolea
发明人： Carl D. Wahlstrand , Robert M. Skime , Gregory A. Hrdlicka , James M. Olsen , Stephen L. Bolea
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/05 , A61N1/0534 , A61N1/0551 , A61N1/086 , A61N1/36071
摘要： A medical lead is provided for use in a pulse stimulation system of the type which includes a pulse generator for producing electrical stimulation therapy. The lead comprises an elongate insulating body and at least one electrical conductor within the insulating body. The conductor has a proximal end configured to be electrically coupled to the pulse generator and has a DC resistance in the range of 375-2000 ohms. At least one distal electrode is coupled to the conductor.
摘要翻译：提供了一种用于包括用于产生电刺激治疗的脉冲发生器的脉冲刺激系统的医疗引线。引线包括细长绝缘体和绝缘体内的至少一个电导体。导体具有被配置为电耦合到脉冲发生器的近端，并具有在375-2000欧姆范围内的直流电阻。至少一个远端电极耦合到导体。

2. 发明授权

US08620453B2 MRI-safe implantable medical device 有权
公开(公告)号：US08620453B2
公开(公告)日：2013-12-31
申请号：US12954563
申请日：2010-11-24
申请人： Carl D. Wahlstrand , Robert M. Skime , Gregory A. Hrdlicka , James M. Olsen , Stephen L. Bolea
发明人： Carl D. Wahlstrand , Robert M. Skime , Gregory A. Hrdlicka , James M. Olsen , Stephen L. Bolea
IPC分类号： A61N1/05
CPC分类号： A61N1/08 , A61N1/05 , A61N1/0534 , A61N1/0551 , A61N1/086 , A61N1/36071
摘要： A medical lead is provided for use in a pulse stimulation system of the type which includes a pulse generator for producing electrical stimulation therapy. The lead comprises an elongate insulating body and at least one electrical conductor within the insulating body. The conductor has a proximal end configured to be electrically coupled to the pulse generator and has a DC resistance in the range of 375-2000 ohms. At least one distal electrode is coupled to the conductor.

3. 发明申请

US20110071605A1 MRI-Safe Implantable Medical Device 有权
标题翻译： MRI安全可植入医疗器械
公开(公告)号：US20110071605A1
公开(公告)日：2011-03-24
申请号：US12954563
申请日：2010-11-24
申请人： Carl D. Wahlstrand , Robert M. Skime , Gregory A. Hrdlicka , James M. Olsen , Stephen L. Bolea
发明人： Carl D. Wahlstrand , Robert M. Skime , Gregory A. Hrdlicka , James M. Olsen , Stephen L. Bolea
IPC分类号： A61N1/05
CPC分类号： A61N1/08 , A61N1/05 , A61N1/0534 , A61N1/0551 , A61N1/086 , A61N1/36071
摘要： A medical lead is provided for use in a pulse stimulation system of the type which includes a pulse generator for producing electrical stimulation therapy. The lead comprises an elongate insulating body and at least one electrical conductor within the insulating body. The conductor has a proximal end configured to be electrically coupled to the pulse generator and has a DC resistance in the range of 375-2000 ohms. At least one distal electrode is coupled to the conductor.
摘要翻译：提供了一种用于包括用于产生电刺激治疗的脉冲发生器的脉冲刺激系统的医疗引线。引线包括细长绝缘体和绝缘体内的至少一个电导体。导体具有被配置为电耦合到脉冲发生器的近端，并具有在375-2000欧姆范围内的直流电阻。至少一个远端电极耦合到导体。

4. 发明授权

US07493159B2 Trial neuro stimulator with lead diagnostics 失效
标题翻译：试用神经刺激器与铅诊断
公开(公告)号：US07493159B2
公开(公告)日：2009-02-17
申请号：US10636487
申请日：2003-08-06
申请人： Gregory A. Hrdlicka , Robert M. Skime
发明人： Gregory A. Hrdlicka , Robert M. Skime
IPC分类号： A61N1/08
CPC分类号： A61N1/36014 , A61N1/37241 , A61N2001/083
摘要： A medical device known as a trial neuro stimulator with a diagnostics module to determine whether the therapy lead is operational for delivering stimulation therapy to improve operation in areas such as reliability and patient comfort is disclosed. The trial neuro stimulator is typically used to test the efficacy of neuro stimulation before implanting an implantable neuro stimulator in a patient. The trial neuro stimulator has a processor, memory, system reset, telemetry module, recharge module, power management module, power source, therapy module, therapy measurement module, and diagnostics module. The diagnostics module can be a lead sensor, a software detector using therapy lead measurements from the therapy measurement module, or, a combination of both the lead sensor and software detector to detect whether the therapy lead is operational. A method for diagnosing whether a therapy lead is operational is also disclosed.
摘要翻译：已知一种被称为具有诊断模块的试验性神经刺激器的医疗装置，其用于确定治疗引导是否可用于递送刺激治疗以改善诸如可靠性和患者舒适度的区域中的操作。试验性神经刺激器通常用于在植入可植入的神经刺激器在患者体内之前测试神经刺激的功效。试用神经刺激器具有处理器，存储器，系统复位，遥测模块，充电模块，电源管理模块，电源，治疗模块，治疗测量模块和诊断模块。诊断模块可以是引线传感器，使用来自治疗测量模块的治疗引线测量的软件检测器，或者是引导传感器和软件检测器的组合，以检测治疗引导线是否可操作。还公开了用于诊断治疗引线是否可操作的方法。

5. 发明授权

US08457744B2 Low-profile implantable medical device 有权
标题翻译：低调植入式医疗器械
公开(公告)号：US08457744B2
公开(公告)日：2013-06-04
申请号：US10730877
申请日：2003-12-09
申请人： Darren A. Janzig , Carl D. Wahlstrand , Paulette C. Olson , Robert M. Skime
发明人： Darren A. Janzig , Carl D. Wahlstrand , Paulette C. Olson , Robert M. Skime
IPC分类号： A61N1/08
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： Components of an implantable medical device are arranged to facilitate a low-profile housing. A circuit board within the housing carries integrated circuits and discrete components. In some embodiments, the integrated circuits and discrete components are located on first and second opposing surfaces of the circuit board, respectively. In some embodiments, the implantable medical device is implanted on a cranium of a patient and the housing is concave such that it substantially conforms to the cranium. In such embodiments, the integrated circuits and/or discrete components can be arranged on the circuit board according to height to better conform to the concavity of the housing. In some embodiments, the implantable medical device includes a telemetry coil that is positioned within the housing such that it occupies space that cannot be practically occupied by the circuit board.
摘要翻译：可植入医疗装置的部件被布置成便于小型外壳。外壳内的电路板承载集成电路和分立元件。在一些实施例中，集成电路和分立元件分别位于电路板的第一和第二相对表面上。在一些实施例中，将可植入医疗装置植入患者的颅骨上，并且所述外壳是凹形的，使得其基本上符合颅骨。在这样的实施例中，集成电路和/或分立组件可以根据高度布置在电路板上，以更好地符合壳体的凹面。在一些实施例中，可植入医疗装置包括位于壳体内的遥测线圈，使其占据不能被电路板实际占据的空间。

6. 发明申请

US20100049277A1 IMPLANTABLE NEUROSTIMULATOR DEVICE 有权
标题翻译：可植入神经细胞装置
公开(公告)号：US20100049277A1
公开(公告)日：2010-02-25
申请号：US12611504
申请日：2009-11-03
申请人： Carl D. Wahlstrand , Robert M. Skime
发明人： Carl D. Wahlstrand , Robert M. Skime
IPC分类号： A61N1/34 , A61N1/375
CPC分类号： A61N1/0504 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/0502 , A61N1/36071 , A61N1/3756
摘要： The disclosure describes an implantable neurostimulator device for delivery of neurostimulation to treat head, neck, or facial pain or tension, including pain or tension caused by occipital neuralgia. The device may be a neurostimulation device having a miniaturized housing with a low profile that permits subcutaneous implantation at a stimulation site directly adjacent a neuralgic region at the back of the neck of a patient. For example, the device may be subcutaneously implanted at the back of the neck of a patient to relieve symptoms of occipital neuralgia.
摘要翻译：本公开描述了用于递送神经刺激以治疗头部，颈部或面部疼痛或张力的可植入神经刺激器装置，包括由枕骨神经痛引起的疼痛或张力。该装置可以是具有小型化的壳体的神经刺激装置，其具有允许在紧邻患者颈部后方的神经痛区域的刺激部位皮下植入。例如，该装置可以皮下植入患者颈部的后部以减轻枕骨神经痛的症状。

7. 发明授权

US07647121B2 Therapy delivery mode selection 有权
标题翻译：治疗传递模式选择
公开(公告)号：US07647121B2
公开(公告)日：2010-01-12
申请号：US11687440
申请日：2007-03-16
申请人： Carl D. Wahlstrand , Robert M. Skime
发明人： Carl D. Wahlstrand , Robert M. Skime
IPC分类号： A61N1/36
CPC分类号： A61B5/053 , A61B5/04012 , A61B5/0402 , A61B5/103 , A61N1/36071 , A61N1/36521 , A61N1/37247 , G06F19/00 , G16H40/63
摘要： Techniques for selectably providing either constant voltage or constant current stimulation are described. A programming device provides a user interface by which a user selects either constant voltage or constant current stimulation, and selects either a voltage or current amplitude based on the selected stimulation mode. The programming device configures a medical device to provide the selected mode of stimulation at the selected amplitude. For example, when a medical device has constant voltage stimulation circuitry, e.g., circuitry including a voltage source, and the user selects constant current stimulation, the programming device configures the medical device to adjust the voltage amplitude based on a measured impedance to provide substantially constant current amplitude.
摘要翻译：描述了可选择地提供恒定电压或恒定电流刺激的技术。编程设备提供用户界面，用户通过该界面用户选择恒定电压或恒定电流刺激，并且基于所选择的刺激模式选择电压或电流幅度。编程设备配置医疗设备以在所选择的幅度提供所选择的刺激模式。例如，当医疗设备具有恒定电压刺激电路（例如，包括电压源的电路）并且用户选择恒定电流刺激时，编程设备配置医疗设备以基于测量的阻抗来调整电压幅度以提供基本上恒定的电流幅度。

8. 发明授权

US07596408B2 Implantable medical device with anti-infection agent 失效
标题翻译：具有抗感染剂的植入式医疗器械
公开(公告)号：US07596408B2
公开(公告)日：2009-09-29
申请号：US10837319
申请日：2004-04-30
申请人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
发明人： Ruchika Singhal , Darren A. Janzig , Carl D. Wahlstrand , Robert M. Skime , Paulette C. Olson , Erik R. Scott , James E. Randall
IPC分类号： A61N1/02
CPC分类号： A61N1/3754 , A61B5/076 , A61B2560/04 , A61L31/16 , A61L2300/404 , A61N1/3605 , A61N1/375
摘要： An implantable medical device with anti-infection agent. The implantable medical device may be configured for placement in the head of a patient and for monitoring or treatment of the brain. The implantable medical device may have a housing or it may have a housing and a member for providing a smooth interface between the device and the adjacent tissue. The anti-infection agent may be provided on or impregnated in the housing or the member. In some embodiments, the device includes a single module while in other embodiments a plurality of modules are coupled to provide a smaller profile. In some embodiments the implantable medical device may include both anti-infection and lubricious materials.
摘要翻译：具有抗感染剂的可植入医疗器械。可植入医疗装置可被配置用于放置在患者的头部并用于监测或治疗大脑。可植入医疗装置可以具有壳体，或者其可以具有壳体和用于在装置和相邻组织之间提供平滑界面的构件。抗感染剂可以设置在或浸渍在壳体或构件中。在一些实施例中，设备包括单个模块，而在其它实施例中，多个模块被耦合以提供较小的轮廓。在一些实施例中，可植入医疗装置可以包括抗感染和光滑材料。

9. 发明授权

US07596399B2 Implantation of implantable medical device 有权
标题翻译：植入式植入式医疗器械
公开(公告)号：US07596399B2
公开(公告)日：2009-09-29
申请号：US10835527
申请日：2004-04-29
申请人： Ruchika Singhal , Carl D. Wahlstrand , Robert M. Skime , Steven J. Urquhart
发明人： Ruchika Singhal , Carl D. Wahlstrand , Robert M. Skime , Steven J. Urquhart
IPC分类号： A61B5/04 , A61B8/00
CPC分类号： A61B5/6864 , A61B5/107 , A61B5/686 , A61B5/6868
摘要： In general, the invention is directed to strategies pertaining to implantation of an implantable medical device between a scalp and a skull of the patient. The invention pertains to collection of data such as data pertaining to the skull of the patient, the scalp of the patient, the vascular structure or neurological structures in the head of the patient, and the like. The data may be in the form of images, such as images generated by X-ray, magnetic resonance imaging, CT-scan and fluoroscopy. A surgeon can use the collected data to determine, for example, whether the patient is a candidate for a cranial implantation, whether the patient's skull and scalp can support the implantation, what configuration of device should be implanted, where the device should be implanted, and how the surgical incisions should be made.
摘要翻译：通常，本发明涉及关于在头皮和患者头骨之间植入可植入医疗装置的策略。本发明涉及诸如患者头骨，患者头皮，患者头部的血管结构或神经结构等数据的收集等。数据可以是图像的形式，例如通过X射线产生的图像，磁共振成像，CT扫描和荧光透视。外科医生可以使用收集的数据来确定例如患者是颅骨植入的候选者，患者的颅骨和头皮是否能够支撑植入，应植入装置的哪些配置，植入装置的位置，以及如何做外科切口。

10. 发明授权

US07392089B2 Reducing relative intermodule motion in a modular implantable medical device 失效
标题翻译：在模块化可植入医疗设备中减少相对模块间运动
公开(公告)号：US07392089B2
公开(公告)日：2008-06-24
申请号：US10731881
申请日：2003-12-09
申请人： Carl D. Wahlstrand , Darren A. Janzig , Robert M. Skime
发明人： Carl D. Wahlstrand , Darren A. Janzig , Robert M. Skime
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/3605 , A61N1/3754 , A61N1/3758
摘要： A modular implantable medical device includes a plurality of modules that are at least partially encapsulated by an overmold. The modules may be connected by coupling modules, which may be flexible to provide for one or more degrees of relative intermodular motion. The overmold may also be flexible. In order to reduce relative intermodule motion to acceptable direction and/or ranges, the overmold may include one or more motion reduction elements.
摘要翻译：模块化可植入医疗装置包括至少部分地由包覆成型包封的多个模块。模块可以通过耦合模块连接，耦合模块可以是柔性的，以提供一个或多个相对的模块间运动程度。包覆成型也可以是柔性的。为了将相对模块间运动减小到可接受的方向和/或范围，包覆模具可以包括一个或多个运动减少元件。

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