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1. 发明授权

US11454792B2 Light microscope and method for providing structured illumination light 有权
公开(公告)号：US11454792B2
公开(公告)日：2022-09-27
申请号：US16610223
申请日：2018-04-24
申请人： Carl Zeiss Microscopy GmbH , LioniX International B.V.
发明人： Gerhard Krampert , Kai Wicker , Ralf Netz , Ronald Dekker , Edwin Jan Klein , Douwe Harmen Geuzebroek
IPC分类号： G02B21/00 , G02B27/58 , G01N21/64 , G02B21/36
摘要： A light microscope comprises: a structuring optical unit comprising a waveguide chip for providing a structured illumination; an input selection device for variably directing light to one of several inputs of the waveguide chip; the waveguide chip further comprising a light guide path following each of the inputs; each light guide path divides into several path divisions; and each path division leads to one output of the wave-guide chip. The outputs of the waveguide chip can be arranged at a pupil plane of the light microscope, and an exit direction of light from the outputs is transverse to a plane defined by the waveguide chip. A method for providing structured illumination light using the light microscope is also described.

2. 发明申请

US20150253559A1 OPTICAL ARRANGEMENT AND LIGHT MICROSCOPE 审中-公开
标题翻译：光学布置和光学显微镜
公开(公告)号：US20150253559A1
公开(公告)日：2015-09-10
申请号：US14425416
申请日：2013-08-02
申请人： Carl Zeiss Microscopy GmbH
发明人： Thomas Kalkbrenner , Gerhard Krampert , Ralf Netz
IPC分类号： G02B21/06 , G02B21/04 , G02B21/02 , G02B5/18 , G02B21/00
CPC分类号： G02B21/06 , G02B5/1814 , G02B21/0032 , G02B21/0076 , G02B21/0092 , G02B21/025 , G02B21/04 , G02B21/367 , G02B27/58
摘要： An optical arrangement for being positioned in a beam path of a light microscope, having at least a first and a second optical assembly for providing structured illumination light from incident light. The optical arrangement provides for light to be guided over different beam paths to the various optical assemblies and in the direction of a sample. Electronic control means are provided and designed to illuminate, in each case, a beam path from the different beam paths to different optical assemblies at a point in time, in that at least a first beam combination mirror is provided for guiding light coming from various optical assemblies to a common beam path in the direction of a sample. The first beam combination mirror has reflective areas on which only light from one of the two optical assemblies is incident and has the light-permeable areas of the beam combination mirror in which only light from the other of the optical assemblies is incident. The invention further relates to a light microscope having an optical arrangement according to the invention.
摘要翻译：一种用于定位在光学显微镜的光束路径中的光学装置，其具有至少第一和第二光学组件，用于提供来自入射光的结构化照明光。该光学装置使得光能够被引导到不同的光束路径到达各种光学组件和样本的方向。电子控制装置被提供和设计成在每种情况下照亮从不同光束路径到不同光学组件在一个时间点的光束路径，因为提供了至少第一光束组合镜来引导来自各种光学组件到样品方向上的共同光束路径。第一光束组合镜具有反射区域，其上只有来自两个光学组件中的一个的光入射，并且具有光束组合镜的透光区域，其中只有来自另一个光学组件的光入射。本发明还涉及具有根据本发明的光学装置的光学显微镜。

3. 发明授权

US10133046B2 Optical arrangement and light microscope 有权
公开(公告)号：US10133046B2
公开(公告)日：2018-11-20
申请号：US14425416
申请日：2013-08-02
申请人： Carl Zeiss Microscopy GmbH
发明人： Thomas Kalkbrenner , Gerhard Krampert , Ralf Netz
IPC分类号： G02B21/06 , G02B21/00 , G02B21/36 , G02B27/58 , G02B5/18 , G02B21/02 , G02B21/04
摘要： An optical arrangement for being positioned in a beam path of a light microscope, having at least a first and a second optical assembly for providing structured illumination light from incident light. The optical arrangement provides for light to be guided over different beam paths to the various optical assemblies and in the direction of a sample. Electronic control means are provided and designed to illuminate, in each case, a beam path from the different beam paths to different optical assemblies at a point in time, in that at least a first beam combination mirror is provided for guiding light coming from various optical assemblies to a common beam path in the direction of a sample. The first beam combination mirror has reflective areas on which only light from one of the two optical assemblies is incident and has the light-permeable areas of the beam combination mirror in which only light from the other of the optical assemblies is incident. The invention further relates to a light microscope having an optical arrangement according to the invention.

4. 发明申请

US20130314758A1 LIGHT SCANNING MICROSCOPE AND MICROSCOPY METHOD 有权
标题翻译：光扫描显微镜和微观方法
公开(公告)号：US20130314758A1
公开(公告)日：2013-11-28
申请号：US13902763
申请日：2013-05-24
申请人： Carl Zeiss Microscopy GmbH
发明人： Wibke Hellmich , Gerhard Krampert , Matthias Langhorst , Ralf Netz
IPC分类号： G02B21/00
CPC分类号： G02B21/0044 , G02B21/0052 , G02B21/008
摘要： A light scanning microscope with an illumination module generates several illumination beams and moves them, in each case as a spot, in a predefined region of a sample to excite sample radiation. A detector module for confocal detection of the sample radiation excited by each spot includes a first detector, an imaging lens system, having an optical axis, for imaging the predefined region along an imaging beam path running from the sample as far as the first detector, and a rotatable diaphragm with several pinholes located in a pinhole plane. The diaphragm, upon rotation, may be located at least partially in the imaging beam path for confocal detection. A second detector may be arranged outside of the imaging beam path. A first beam splitter may be arranged in the imaging beam path between the sample and the diaphragm. The beam splitter deflects sample radiation onto the second detector.
摘要翻译：具有照明模块的光扫描显微镜产生几个照明光束，并将它们在每种情况下作为点移动到样品的预定区域以激发样品辐射。用于由每个点激发的样品辐射的共焦检测的检测器模块包括具有光轴的第一检测器，成像透镜系统，用于沿着从样品运行的成像光束路径成像到第一检测器，以及具有位于针孔平面中的几个针孔的可旋转隔膜。膜片在旋转时可以至少部分地位于用于共焦检测的成像光束路径中。第二检测器可以布置在成像光束路径的外部。第一分束器可以布置在样品和隔膜之间的成像光束路径中。分束器将样品辐射器偏转到第二检测器上。

5. 发明申请

US20160003777A1 RECORDING DEVICE AND RECORDING METHOD 审中-公开
标题翻译：记录装置和记录方法
公开(公告)号：US20160003777A1
公开(公告)日：2016-01-07
申请号：US14771463
申请日：2014-02-14
申请人： CARL ZEISS AG , CARL ZEISS MICROSCOPY GMBH
发明人： Tobias Schmitt-Manderbach , Gerhard Krampert , Wibke Hellmich , Helmut Lippert
IPC分类号： G01N29/06
CPC分类号： G01N29/0654 , G01N29/2418 , G01N29/44
摘要： The invention relates to a recording device comprising an excitation module (2, 10; 9, 10) which stimulates the sample (3) for emitting pressure waves, an acoustic module (9, 10) for detecting the generated pressure waves, and a control module (10) which determines an acoustic image based on the data from the acoustic module (9, 10). Said recording device also comprises a reproduction module (5) for optically reproducing the sample (3) and the control module (10) determines a sample limit and/or a segment limit within the sample (3) based on the optical reproduction of the sample (3) and when the acoustic image is detected, the determined sample limit and/or segment limit are taken into consideration.
摘要翻译：本发明涉及一种记录装置，包括：激发模块（2,10; 9,10），其激发用于发射压力波的样品（3）;用于检测产生的压力波的声学模块（9,10）;以及控制模块（10），其基于来自声学模块（9,10）的数据确定声学图像。所述记录装置还包括用于光学地再现样品（3）的再现模块（5），并且控制模块（10）基于样品的光学再现来确定样品（3）内的样品极限和/或片段极限（3），并且当检测到声学图像时，考虑所确定的样本极限和/或分段极限。

6. 发明授权

US11614611B2 Segmented optical system for a lighting module for angle-resolved illumination 有权
公开(公告)号：US11614611B2
公开(公告)日：2023-03-28
申请号：US16469566
申请日：2017-12-18
申请人： Carl Zeiss Microscopy GmbH
发明人： Lars Stoppe , Matthias Hillenbrand , Uwe Wolf , Gerhard Krampert
IPC分类号： G02B21/12 , G02B21/08 , G02B3/00 , G02B5/04
摘要： An illumination module (101) for an optical apparatus comprises a light source unit (102), which is configured to selectively emit light along a multiplicity of beam paths (112) in each case. The illumination module (101) also comprises a multiplicity of optical elements (201-203) arranged with lateral offset from one another, wherein each optical element (201-203) of the multiplicity of optical elements (201-203) is configured to transform at least one corresponding beam path (112) of the multiplicity of beam paths.

7. 发明授权

US11598941B2 Method for operating a light microscope with structured illumination and optic arrangement 有权
公开(公告)号：US11598941B2
公开(公告)日：2023-03-07
申请号：US16423983
申请日：2019-05-28
申请人： Carl Zeiss Microscopy GmbH
发明人： Ralf Netz , Gerhard Krampert
IPC分类号： G02B21/00
摘要： A method for operating a light microscope with structured illumination includes: providing illumination patterns by means of a structuring device which splits impinging light into at least three coherent beam parts which correspond to a −1., 0., and +1. diffraction orders of light; generating different phases of the illumination patterns by setting different phase values for the beam parts with phase shifters; and recording at least one microscope image for each of the illumination patterns and calculating a high resolution image from the microscope images. Phase shifters are provided not only for the beam parts of the −1. and +1. diffraction orders but also at least one phase shifter for the beam part of the 0. diffraction order. At least two different phase values Φ0 are set with the at least one phase shifter for the 0. diffraction order to provide a plurality of illumination patterns with different phases.

8. 发明申请

US20200064609A1 Light Microscope and Method for Providing Structured Illumination Light 审中-公开
公开(公告)号：US20200064609A1
公开(公告)日：2020-02-27
申请号：US16610223
申请日：2018-04-24
申请人： Carl Zeiss Microscopy GmbH , LioniX International B.V.
发明人： Gerhard Krampert , Kai Wicker , Ralf Netz , Ronald Dekker , Edwin Jan Klein , Douwe Harmen Geuzebroek
IPC分类号： G02B21/00 , G02B27/58
摘要： A light microscope comprises: a structuring optical unit comprising a waveguide chip for providing a structured illumination; an input selection device for variably directing light to one of several inputs of the waveguide chip; the waveguide chip further comprising a light guide path following each of the inputs; each light guide path divides into several path divisions; and each path division leads to one output of the wave-guide chip. The outputs of the waveguide chip can be arranged at a pupil plane of the light microscope, and an exit direction of light from the outputs is transverse to a plane defined by the waveguide chip. A method for providing structured illumination light using the light microscope is also described.

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