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1. 发明申请

US20110030803A1 Sample Preparation Dosing Unit 失效
标题翻译：样品制备单位
公开(公告)号：US20110030803A1
公开(公告)日：2011-02-10
申请号：US12849840
申请日：2010-08-04
申请人： Tobias Holenstein , Thomas Engel , Thomas Sidler , Adelrich Zuppiger , Carsten Haack , Alessandro D'Amore , Michael Meyberg , Tobias Greuter , Roland Stoeckli
发明人： Tobias Holenstein , Thomas Engel , Thomas Sidler , Adelrich Zuppiger , Carsten Haack , Alessandro D'Amore , Michael Meyberg , Tobias Greuter , Roland Stoeckli
IPC分类号： F17D3/00
CPC分类号： G01N35/10 , G01N1/38 , G01N35/08 , G01N35/1002 , G01N35/1065 , Y10T137/0318 , Y10T137/85978
摘要： A sample preparation dosing unit for liquid dosing is provided comprising an inlet port and an outlet port fluidically coupling the sample preparation dosing unit to a supply and target, respectively; a pump, fluidically arranged between the inlet port and the outlet port; an outlet flow restrictor with an outlet flow resistance, fluidically arranged between a pump outlet and outlet port; and a control arrangement with a branch, a control valve, and a control flow restrictor with a control flow resistance. The branch divides the flow at the pump outlet into an outlet flow through the outlet flow restrictor and into a control flow through the control flow restrictor. The control flow downstream of the control flow restrictor is fed, depending on the state of the control valve, either into the outlet port thereby merging with the outlet flow downstream of the outlet flow restrictor, or into a bypass conduit.
摘要翻译：提供了用于液体计量的样品制备剂量单元，其包括分别将样品制备剂量单元流体耦合到供给和靶标的入口端口和出口端口; 泵，流体地布置在入口和出口之间; 具有出口流动阻力的出口限流器，其流体地布置在泵出口和出口之间; 以及具有分支，控制阀和具有控制流阻的控制流量限制器的控制装置。分支将泵出口处的流分成通过出口限流器的出口流，并通过控制流限流器进入控制流。控制流量限制器下游的控制流根据控制阀的状态进入出口，从而与出口限流器下游的出口流合并，或者进入旁路管道。

2. 发明申请

US20100132487A1 PIPETTING DEVICE, MODULAR PIPETTING UNIT, PIPETTING SYSTEM AND METHOD FOR PIPETTING OF FLUID SAMPLES 有权
标题翻译：管道装置，模块化管道单元，管道系统和流体样品管道方法
公开(公告)号：US20100132487A1
公开(公告)日：2010-06-03
申请号：US12623785
申请日：2009-11-23
申请人： Carsten Haack , Thomas Engel , Tobias Holenstein
发明人： Carsten Haack , Thomas Engel , Tobias Holenstein
IPC分类号： B01L3/02 , G01N1/14
CPC分类号： B01L3/021 , B01L2400/0475 , G01N35/0099 , G01N35/1011 , G01N35/1072 , Y10T436/119163 , Y10T436/2575
摘要： A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.
摘要翻译：公开了一种具有模块化移液单元的移液装置，其包括用于移液流体样品的移液末端和用于将负压或正压转移到移液末端的泵管。移液末端和邻接移液头的泵管道的一部分相互限定用于接收流体样品的流体样品导管。模块化移液单元可拆卸地附接到用于定位模块化移液单元的自动定位装置。还公开了一种用于使用这种移液装置移液流体样品的系统和方法，其中以这样的方式进行流体样品的移液，使得每个吸取的流体样品体积小于流体样品导管的体积。

3. 发明授权

US08778281B2 Sample preparation dosing unit 失效
标题翻译：样品制备剂量单位
公开(公告)号：US08778281B2
公开(公告)日：2014-07-15
申请号：US12849840
申请日：2010-08-04
申请人： Tobias Holenstein , Thomas Engel , Thomas Sidler , Adelrich Zuppiger , Carsten Haack , Alessandro D'Amore , Michael Meyberg , Tobias Greuter , Roland Stoeckli
发明人： Tobias Holenstein , Thomas Engel , Thomas Sidler , Adelrich Zuppiger , Carsten Haack , Alessandro D'Amore , Michael Meyberg , Tobias Greuter , Roland Stoeckli
IPC分类号： B01L3/02 , G01N35/10 , G01N1/38
CPC分类号： G01N35/10 , G01N1/38 , G01N35/08 , G01N35/1002 , G01N35/1065 , Y10T137/0318 , Y10T137/85978
摘要： A sample preparation dosing unit for liquid dosing is provided comprising an inlet port and an outlet port fluidically coupling the sample preparation dosing unit to a supply and target, respectively; a pump, fluidically arranged between the inlet port and the outlet port; an outlet flow restrictor with an outlet flow resistance, fluidically arranged between a pump outlet and outlet port; and a control arrangement with a branch, a control valve, and a control flow restrictor with a control flow resistance. The branch divides the flow at the pump outlet into an outlet flow through the outlet flow restrictor and into a control flow through the control flow restrictor. The control flow downstream of the control flow restrictor is fed, depending on the state of the control valve, either into the outlet port thereby merging with the outlet flow downstream of the outlet flow restrictor, or into a bypass conduit.
摘要翻译：提供了用于液体计量的样品制备剂量单元，其包括分别将样品制备剂量单元流体耦合到供给和靶标的入口端口和出口端口; 泵，流体地布置在入口和出口之间; 具有出口流动阻力的出口限流器，其流体地布置在泵出口和出口之间; 以及具有分支，控制阀和具有控制流阻的控制流量限制器的控制装置。分支将泵出口处的流分成通过出口限流器的出口流，并通过控制流限流器进入控制流。控制流量限制器下游的控制流根据控制阀的状态进入出口，从而与出口限流器下游的出口流合并，或者进入旁路管道。

4. 发明授权

US08900878B2 Pipetting device, modular pipetting unit, pipetting system and method for pipetting of fluid samples 有权
标题翻译：移液装置，模块化移液单元，移液系统和流动样品移液方法
公开(公告)号：US08900878B2
公开(公告)日：2014-12-02
申请号：US12623785
申请日：2009-11-23
申请人： Carsten Haack , Thomas Engel , Tobias Holenstein
发明人： Carsten Haack , Thomas Engel , Tobias Holenstein
IPC分类号： G01N1/10 , B01L3/02 , G01N35/10 , G01N35/00
CPC分类号： B01L3/021 , B01L2400/0475 , G01N35/0099 , G01N35/1011 , G01N35/1072 , Y10T436/119163 , Y10T436/2575
摘要： A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.
摘要翻译：公开了一种具有模块化移液单元的移液装置，其包括用于移液流体样品的移液末端和用于将负压或正压转移到移液末端的泵管。移液末端和邻接移液头的泵管道的一部分相互限定用于接收流体样品的流体样品导管。模块化移液单元可拆卸地附接到用于定位模块化移液单元的自动定位装置。还公开了一种用于使用这种移液装置移液流体样品的系统和方法，其中以这样的方式进行流体样品的移液，使得每个吸取的流体样品体积小于流体样品导管的体积。

5. 发明授权

US08470267B2 Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus 有权
标题翻译：用于从含有所述颗粒的液体中分离磁性颗粒的装置以及适用于这种装置的容器阵列
公开(公告)号：US08470267B2
公开(公告)日：2013-06-25
申请号：US12294509
申请日：2007-03-21
申请人： Tobias Holenstein , Rolf Schneebeli , Renato Belz
发明人： Tobias Holenstein , Rolf Schneebeli , Renato Belz
IPC分类号： B03C1/12
CPC分类号： B03C1/02 , B01L3/5085 , B01L9/543 , B03C1/01 , B03C1/0332 , B03C1/12 , B03C1/288 , B03C2201/18 , G01N35/0098
摘要： An apparatus for separating magnetic particles from a liquid which contains said particles, said liquid being contained in an elongated vessel (11) having a length axis (12), said vessel being arranged in a vessel holder (13) with its length axis (12) in a substantially vertical position, said vessel (11) having a bottom and a tapered cross-section that diminishes towards the bottom of the vessel and a side wall (14) which has an outer surface which forms an angle with the length axis (12) of said vessel (11). This apparatus comprises a magnet (15) having a plane outer surface (16) and being adapted for being moved by transport means (17) along a motion path (25), said magnet (15) and said transport means (17) being so arranged with respect to said vessel (11) that over a portion of said motion path (25) said plane outer surface (16) of said magnet is in contact with a portion of said outer surface of said side wall (14) of said vessel (11), and transport means (17) for moving said magnet (15) between a first predetermined position and a second predetermined position along said motion path (25).
摘要翻译：一种用于从包含所述颗粒的液体中分离磁性颗粒的装置，所述液体包含在具有长度轴线（12）的细长容器（11）中，所述容器布置在容器保持器（13）中，其长度轴线（12 ），所述容器（11）具有朝向容器底部减小的底部和锥形横截面，以及具有与长度轴形成角度的外表面的侧壁（14） 12）。该装置包括具有平面外表面（16）并且适于由运输装置（17）沿着运动路径（25）移动的磁体（15），所述磁体（15）和所述传送装置（17）是如此相对于所述容器（11）布置在所述运动路径（25）的一部分上，所述磁体的所述平面外表面（16）与所述容器的所述侧壁（14）的所述外表面的一部分接触（11）和用于沿着所述运动路径（25）在所述第一预定位置和第二预定位置之间移动所述磁体（15）的传送装置（17）。

6. 发明申请

US20100284864A1 APPARATUS FOR SEPARATING MAGNETIC PARTICLES FROM LIQUIDS CONTAINING SAID PARTICLES, AND AN ARRAY OF VESSELS SUITABLE FOR USE WITH SUCH AN APPARATUS 有权
标题翻译：用于从含有颗粒的液体中分离磁性颗粒的装置和适用于这种装置的容器阵列
公开(公告)号：US20100284864A1
公开(公告)日：2010-11-11
申请号：US12294509
申请日：2007-03-21
申请人： Tobias Holenstein , Rolf Schneebeli , Renato Belz
发明人： Tobias Holenstein , Rolf Schneebeli , Renato Belz
IPC分类号： B03C1/12 , B01L9/00
CPC分类号： B03C1/02 , B01L3/5085 , B01L9/543 , B03C1/01 , B03C1/0332 , B03C1/12 , B03C1/288 , B03C2201/18 , G01N35/0098
摘要： An apparatus for separating magnetic particles from a liquid which contains said particles, said liquid being contained in an elongated vessel (11) having a length axis (12), said vessel being arranged in a vessel holder (13) with its length axis (12) in a substantially vertical position, said vessel (11) having a bottom and a tapered cross-section that diminishes towards the bottom of the vessel and a side wall (14) which has an outer surface which forms an angle with the length axis (12) of said vessel (11). This apparatus comprises a magnet (15) having a plane outer surface (16) and being adapted for being moved by transport means (17) along a motion path (25), said magnet (15) and said transport means (17) being so arranged with respect to said vessel (11) that over a portion of said motion path (25) said plane outer surface (16) of said magnet is in contact with a portion of said outer surface of said side wall (14) of said vessel (11), and transport means (17) for moving said magnet (15) between a first predetermined position and a second predetermined position along said motion path (25).
摘要翻译：一种用于从包含所述颗粒的液体中分离磁性颗粒的装置，所述液体包含在具有长度轴线（12）的细长容器（11）中，所述容器布置在容器保持器（13）中，其长度轴线（12 ），所述容器（11）具有朝向容器底部减小的底部和锥形横截面，以及具有与长度轴形成角度的外表面的侧壁（14） 12）。该装置包括具有平面外表面（16）并且适于由运输装置（17）沿着运动路径（25）移动的磁体（15），所述磁体（15）和所述传送装置（17）是如此相对于所述容器（11）布置在所述运动路径（25）的一部分上，所述磁体的所述平面外表面（16）与所述容器的所述侧壁（14）的所述外表面的一部分接触（11）和用于沿着所述运动路径（25）在所述第一预定位置和第二预定位置之间移动所述磁体（15）的传送装置（17）。

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