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1. 发明申请

US20230133224A1 A SWAB AND CASE THEREOF, AND METHODS OF USING THE SAME 有权
公开(公告)号：US20230133224A1
公开(公告)日：2023-05-04
申请号：US17918843
申请日：2021-04-14
申请人： Daniel SHAHAF , Eyal BRESSLER
发明人： Daniel SHAHAF , Eyal BRESSLER
IPC分类号： G01N1/10 , B01L3/00
摘要： The present invention discloses, inter alia, swab, kit and a case, disclose a swab as defined above, administrable either or both into and onto a sample in a method comprising steps of providing the pouch-like envelope (1) with the opening (2), the inner surface (1i) and the at least one external surface (1e) with the at last one swabbing portion; inserting a handle into the swabbing portion; applying the swabbing portion either or both onto and into the substance; in-out rolling up the envelope so that the external portion hereto applied either or both onto and into the substance is position within the envelope; wherein at least one of the following s held true: the envelope characterized as a sleeve-like or sock-like elongated member having a main longitudinal axis, configured to be in-out rolled-up along the main longitudinal axis; and the envelope characterized as flexible pouch-like envelope, further characterized by being width-wise squeezable along an axis perpendicular to the main longitudinal axis thereby tightly encapsulated within at least two external case's walls. The present invention discloses a method for both sampling a substance and storing the same, characterized by steps: providing a pouch-like envelope (1), configured to be in-out rolled-up having an opening (2); the pouch comprises an inner surface (1i); and at least one external surface (1e) with at last one swabbing portion (3); the envelope either or both (a) characterized as a sleeve-like or sock-like elongated member having a main longitudinal axis, configured to be in-out rolled-up along the main longitudinal axis; and (b) flexible pouch-like envelope, characterized by being width-wise squeezable along an axis perpendicular to the main longitudinal axis thereby tightly encapsulated within two case's walls; inserting a handle into the swabbing portion; applying the swabbing portion either or both onto and into the substance; in-out rolling up the envelope so that the external portion hereto applied either or both onto and into the substance is position within the envelope; wherein at least one of the following is held true: the envelope characterized as a sleeve-like or sock-like elongated member having a main longitudinal axis, configured to be in-out rolled-up along the main longitudinal axis; and the envelope characterized as flexible pouch-like envelope, further characterized by being width-wise squeezable along an axis perpendicular to the main longitudinal axis thereby tightly encapsulated within at least two external case's walls.

2. 发明授权

US11639883B2 Method and apparatus for filtration of samples for online analyzers 有权
公开(公告)号：US11639883B2
公开(公告)日：2023-05-02
申请号：US16743330
申请日：2020-01-15
申请人： ECOLAB USA INC.
发明人： Darlington Mlambo , David R. Szymborski , David P. Workman , Michael J. Murcia
IPC分类号： G01N1/34 , C02F1/00 , G01N1/10 , G01N1/20 , C02F103/28 , C02F103/32 , C02F103/22
摘要： A filtration apparatus and methods of installing, using, and retracting the same. A filtration apparatus includes a compression gland, a ball valve, and a filter pipe. A distal portion of the filter pipe has one or more filtration holes. The filtration apparatus may be installed in a process pipe and the distal portion of the filter pipe may be disposed within the process pipe. The filter pipe can be easily retracted from the process pipe without interruption of the industrial process. The filtration apparatus can be automatically cleaned by compressed air or water.

3. 发明授权

US11633736B2 Optical reaction well for assay device 有权
公开(公告)号：US11633736B2
公开(公告)日：2023-04-25
申请号：US17040064
申请日：2019-03-22
申请人： TALIS BIOMEDICAL CORPORATION
发明人： Thomas H. Cauley, III
IPC分类号： B01L3/00 , G01N1/10 , B01F33/30 , B01F33/452 , B01J19/00
摘要： This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.

4. 发明授权

US11613427B2 Horizontal-flow-type apparatus for automatically transporting reagent cartridges 有权
公开(公告)号：US11613427B2
公开(公告)日：2023-03-28
申请号：US15768759
申请日：2016-10-28
申请人： BODITECH MED INC.
发明人： Byeong Chul Kim , Young Haeng Lee , Kyong Hwa Chong , Min Hwan Lee , Yu Jin Park
IPC分类号： B65G47/06 , B65G47/26 , B65G47/82 , G01N21/25 , G01N35/04 , G01N21/17 , G01N35/02 , G01N1/10 , G01N1/18 , G16H10/40 , G01N35/00 , G01N35/10
摘要： The present invention relates to a horizontal-flow-type apparatus for automatically transporting reagent cartridges. The apparatus includes: a magazine (110) in which a plurality of reagent cartridges (1) is stacked; a conveyer belt (120) having a plurality of separating projections (121) arranged in a conveying direction to horizontally separately convey the reagent cartridges (1); a driving motor (130) for driving the conveyer belt (120); a feeding unit (140) for feeding the reagent cartridges (1) stacked in the magazine (110) onto the conveyer belt (120); an examining unit (150) disposed over the front end of the conveyer belt (120) to examine the reagent cartridges (1); and reagent cartridge aligning members (161, 162) disposed in the conveying line of the conveyer belt (120), opposite to the examining unit (150), to align the reagent cartridges (1) in position.

5. 发明申请

US20230086247A1 System and Method for Separating and In-Situ Analyzing A Multiphase Immiscible Fluid Mixture 有权
公开(公告)号：US20230086247A1
公开(公告)日：2023-03-23
申请号：US17482098
申请日：2021-09-22
申请人： Saudi Arabian Oil Company
发明人： Naim Akmal , Ahmed Khalid Alqatari
IPC分类号： C02F1/469 , G01N1/10 , G01N33/18 , G01N1/38
摘要： A system separates and in-situ analyzes a discrete sample of multiphase fluid. The system includes a separation vessel having a first inner chamber for separating a discrete sample of multiphase fluid into liquid phases including an aqueous liquid phase and a nonporous liquid phase, and a built-in water analysis unit. The built-in water analysis unit includes an analytical cell disposed inside the first inner chamber of the separation vessel, the analytical cell having a second inner chamber, and at least one probe having a sensing area disposed in the second inner chamber for in-situ analysis of a sample of the aqueous liquid phase that is separated from the discrete sample of multiphase fluid in the first inner chamber and that is channeled to the second inner chamber from the first inner chamber for the in-situ analysis. The second inner chamber is defined inside the first inner chamber.

6. 发明授权

US11590496B2 Automated microscopic cell analysis 有权
公开(公告)号：US11590496B2
公开(公告)日：2023-02-28
申请号：US16803897
申请日：2020-02-27
申请人： Medica Corporation
发明人： Ronald Jones , Adrian Gropper , Robert Hagopian , Charles Rogers , Thomas Vitella , Tyler Cote , Donald Barry , Dirk Osterloh , Chen Yi
IPC分类号： G01N15/14 , G01N15/10 , B01L3/00 , G01N33/49 , G01N33/80 , G01N33/487 , G01N21/05 , G06V20/69 , G01N33/50 , G01N1/10 , G01N1/30
摘要： This disclosure describes single-use test cartridges, cell analyzer apparatus, and methods for automatically performing microscopic cell analysis tasks, such as counting and analyzing blood cells in biological samples. A small measured quantity of a biological sample, such as whole blood, is placed in a mixing bowl on the disposable test cartridge after being inserted into the cell analyzer. The analayzer also deposits a known amount of diluent/stain in the mixing bowl and mixes it with the blood. The analyzer takes a measured amount of the mixture and dispenses in a sample cup on the cartridge in fluid communication with an imaging chamber. The geometry of the imaging chamber is chosen to maintain the uniformity of the mixture, and to prevent cells from crowding or clumping as it is transferred into the imaging chamber by the analyzer. Images of all of the cellular components within the imaging chamber are counted and analyzed to obtain a complete blood count.

7. 发明授权

US11573156B2 Minimally invasive microsampler for intact removal of surface deposits and substrates 有权
公开(公告)号：US11573156B2
公开(公告)日：2023-02-07
申请号：US16248132
申请日：2019-01-15
申请人： WESTINGHOUSE ELECTRIC COMPANY LLC
发明人： Arash Parsi , William A. Byers
IPC分类号： G01N1/06 , G21C17/06 , G01N1/08 , G01N1/10
摘要： A method of sampling a multi-layered material and a micro-sampling tool are described. The sampling method includes penetrating a top surface of a material in a component of interest with a micro-cutting tool to a predetermined depth sufficient to include each layer of the multi-layered material and a portion of the base, without cutting through the full depth of the base, under-cutting from the depth of penetration through the base to define a micro-sample of the multi-layered material, and removing the micro-sample with each layer of the multi-layered material intact. The micro-sampler includes a cutting tool calibrated to cut to a depth no greater than 2 mm, and in some aspects, no greater than 200 microns into a multi-layered material, the material having a top surface and a metallic or ceramic base and a container for removing and storing a micro-sample cut from the material with each layer of the multi-layered material and a portion of the base intact.

8. 发明授权

US11549870B2 Cell preserving solution 有权
公开(公告)号：US11549870B2
公开(公告)日：2023-01-10
申请号：US16023772
申请日：2018-06-29
申请人： DNA Genotek, INC.
发明人： Youssef Biadillah , Stephen D. Andrews
IPC分类号： G01N1/30 , A61B10/00 , B01L3/00 , G01N1/10 , G01N1/00
摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

9. 发明授权

US11547301B2 Methods for collecting and testing bacteria containing samples from within the gastrointestinal tract 有权
公开(公告)号：US11547301B2
公开(公告)日：2023-01-10
申请号：US17197125
申请日：2021-03-10
申请人： Progenity, Inc.
发明人： Sharat Singh , Mitchell Lawrence Jones , Christopher Loren Wahl
IPC分类号： A61B10/00 , A61B5/00 , G01N21/76 , C12Q1/06 , G01N1/10 , G01N33/58 , C12Q1/04 , A61K45/06 , C12Q1/10 , A61B5/07 , C12M1/00 , C12N1/20 , G01N1/20 , G01N1/38 , A61K49/00 , G01N33/483 , G01N33/487 , A61B5/01 , A61B5/03 , A61B5/145 , A61B5/1455
摘要： The present disclosure relates to methods of collecting and testing bacteria containing samples from within the gastrointestinal (GI) tract of a subject. The methods may include disposing an ingestible device in the GI tract, collecting a bacteria-containing sample from the GI tract, selectively lysing eukaryotic cells in the sample by combining the sample with a dried reagent, exposing bacteria in the sample to resazurin in the ingestible device to produce resorufin, emitting light from the ingestible device, the emitted light being filtered through an optical filter to control for scatter so that the light interacts with the resorufin to produce fluorescence, and measuring a total fluorescence from the resorufin; or a rate of change of fluorescence from the resorufin as a function of time within the GI tract of the subject; and correlating the measured parameter to a number of viable bacterial cells in the sample.

10. 发明授权

US11536711B2 Measuring cartridge for measuring a liquid sample 有权
公开(公告)号：US11536711B2
公开(公告)日：2022-12-27
申请号：US16665868
申请日：2019-10-28
申请人： EXIAS Medical GmbH
发明人： Wolfgang Hofmann , Wolf-Dietrich Steinböck , Josef Hindinger
IPC分类号： G01N1/00 , G01N33/49 , C12M3/00 , G01N1/10 , G01N35/00 , B01L3/00
摘要： It is provided a measuring cartridge (1) for measuring at least one constituent of a liquid sample, in particular blood, and for performing quality control, the cartridge comprising: a casing (3) insertable into a reception opening (51) of a measuring instrument (50), the casing (3) at least partly surrounding an inner space (5); wherein the inner space contains: a measurement cell (7) comprising a reception space (9) for the sample and at least one sensor area (11) with which the sample is in contact when loaded into the reception space (9); plural quality control containers (13a,13b,13c) for respectively holding different quality control solutions (15a,15b,15c); a solution routing system (17) adapted to selectively route one of the quality control solutions (15a,15b,15c) from the respective quality control container (13a,13b,13c) into the reception space (9) of the measurement cell (7).

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