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1. 发明授权

US6066611A Bleaching compositions comprising protease enzymes 失效
标题翻译：包含蛋白酶的漂白组合物
公开(公告)号：US6066611A
公开(公告)日：2000-05-23
申请号：US848793
申请日：1997-05-01
申请人： Chanchal Kumar Ghosh , Michael Eugene Burns , David Neil DiGiulio , Edward Eugene Getty , Richard Timothy Hartshorn , Alan David Willey , Philip F. Brode , Bobby L. Barnett , Donn N. Rubingh
发明人： Chanchal Kumar Ghosh , Michael Eugene Burns , David Neil DiGiulio , Edward Eugene Getty , Richard Timothy Hartshorn , Alan David Willey , Philip F. Brode , Bobby L. Barnett , Donn N. Rubingh
IPC分类号： A61K8/41 , A61K8/49 , A61Q11/00 , C11D3/386 , C11D3/39 , G06Q40/04 , C11D3/28 , C11D3/395
CPC分类号： G06Q40/04 , A61K8/416 , A61K8/49 , A61K8/4906 , A61Q11/00 , C11D3/38609 , C11D3/3917 , C11D3/3945
摘要： The invention herein provides bleaching compositions comprising a protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin) and a bleaching agent.
摘要翻译：本发明提供了包含蛋白酶的漂白组合物，其是具有自然界中没有发现的氨基酸序列的羰基水解酶变体，其是通过用不同氨基酸替代前体羰基水解酶的多个氨基酸残基得到的，其中所述在前体酶中替换的多个氨基酸残基对应于与一个或多个以下残基组合的位置+76：+99，+ 101，+ 103，+ 104，+ 107，+ 123，+ 27，+ 105， +109，+126，+128，+135，+ 156，+166，+ 195，+ 197，+ 204，+ 206，+210，+216，+217，+218，+222，+260，+265 ，和/或+274，其中编号的位置对应于从解淀粉芽孢杆菌芽孢杆菌中天然存在的枯草杆菌蛋白酶或其它羰基水解酶或枯草杆菌蛋白酶（如枯草杆菌枯草杆菌蛋白酶）和漂白剂中的等同氨基酸残基。

2. 发明授权

US5677272A Bleaching compositions comprising protease enzymes 失效
标题翻译：包含蛋白酶的漂白组合物
公开(公告)号：US5677272A
公开(公告)日：1997-10-14
申请号：US322677
申请日：1994-10-13
申请人： Chanchal Kumar Ghosh , Michael Eugene Burns , David Neil DiGiulio , Edward Eugene Getty , Richard Timothy Hartshorn , Alan David Willey , Philip F. Brode , Bobby L. Barnett , Donn N. Rubingh
发明人： Chanchal Kumar Ghosh , Michael Eugene Burns , David Neil DiGiulio , Edward Eugene Getty , Richard Timothy Hartshorn , Alan David Willey , Philip F. Brode , Bobby L. Barnett , Donn N. Rubingh
IPC分类号： D06L3/00 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61K8/66 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C11D3/39 , C11D3/395 , C12N9/56 , C12N15/00 , C12N15/09 , C12N15/57 , C12R1/07 , C12S11/00 , D06L3/11 , G06Q40/04
CPC分类号： A61K8/24 , A61K8/22 , A61K8/23 , A61K8/416 , A61K8/42 , A61K8/463 , A61K8/466 , A61K8/49 , A61K8/4906 , A61K8/66 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C11D3/3907 , C11D3/3917 , G06Q40/04 , A61K2800/222 , A61K2800/86
摘要： The invention herein provides bleaching compositions comprising a protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions corresponds to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin) and a bleaching agent.
摘要翻译：本发明提供了包含蛋白酶的漂白组合物，其是具有自然界中没有发现的氨基酸序列的羰基水解酶变体，其是通过用不同氨基酸替代前体羰基水解酶的多个氨基酸残基得到的，其中所述在前体酶中替换的多个氨基酸残基对应于与一个或多个以下残基组合的位置+76：+99，+ 101，+ 103，+ 104，+ 107，+ 123，+ 27，+ 105， +109，+126，+128，+135，+ 156，+166，+ 195，+ 197，+ 204，+ 206，+210，+216，+217，+218，+222，+260，+265 ，和/或+274，其中编号的位置对应于从解淀粉芽孢杆菌芽孢杆菌中天然存在的枯草杆菌蛋白酶或其它羰基水解酶或枯草杆菌蛋白酶（如枯草杆菌枯草杆菌蛋白酶）和漂白剂中的等同氨基酸残基。

3. 发明授权

US06284246B1 Modified polypeptides with high activity and reduced allergenicity 失效
标题翻译：具有高活性和降低变应原性的改良多肽
公开(公告)号：US06284246B1
公开(公告)日：2001-09-04
申请号：US08903298
申请日：1997-07-30
申请人： David J. Weisgerber , Donn N. Rubingh
发明人： David J. Weisgerber , Donn N. Rubingh
IPC分类号： A61K600
CPC分类号： C11D3/38627 , A61K8/0208 , A61K8/66 , A61K8/86 , A61K47/60 , A61K2800/57 , A61K2800/70 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C11D3/386
摘要： The present invention relates to a modified polypeptide which has an enzymatic activity level of greater than about 70% of the parent polypeptide and an allergenic response level of less than about 33% of the parent polypeptide. Embodiments of the present invention relate to modified polypeptides with reduced allergenicity and high enzymatice activity comprising the formula: A-Bn wherein A is an enzyme, and mixtures thereof; B is a twin polymer moiety, having a total molecular weight of from about 0.5 kilodaltons (KD) to about 40 KD, having the formula conjugated to the enzyme; wherein R1 and R2 are essentially straight chain polymers, having a molecular weight ranging from about 0.25 KD to about 20 KD; wherein the ratio of the molecular weights of R1 and R2 is from about 1:10 to about 10:1; wherein X is a linking moiety which links the twin moeity to a single site on the enzyme; and n is the number of twin polymer moietis conjugated to the enzyme, and represents an integer from about 1 to about 15.
摘要翻译：本发明涉及一种修饰的多肽，其具有大于母体多肽的约70％的酶活性水平和低于亲本多肽的约33％的过敏反应水平。本发明的实施方案涉及具有降低的变应原性和高酶促活性的修饰多肽，其包含下式：其中A是酶及其混合物; B是具有约0.5千道尔顿（KD）至约40KD的总分子量的双聚合物部分，具有与酶结合的结合物; 其中R1和R2基本上是直链聚合物，其分子量范围为约0.25KD至约20KD; 其中R1和R2的分子量的比例为约1:10至约10:1; 其中X是连接部分，其将双重结合连接到酶上的单个位点; 并且n是与酶缀合的双重聚合物的数目，并且表示约1至约15的整数。

4. 发明授权

US4661288A Zwitterionic compounds having clay soil removal/anti/redeposition properties useful in detergent compositions 失效
标题翻译：具有洗涤剂组合物中有用的粘土去除/抗/再沉积性质的两性离子化合物
公开(公告)号：US4661288A
公开(公告)日：1987-04-28
申请号：US709614
申请日：1985-03-08
申请人： Donn N. Rubingh , Eugene P. Gosselink
发明人： Donn N. Rubingh , Eugene P. Gosselink
IPC分类号： C08G65/26 , C08G65/334 , C11D1/88 , C11D1/90 , C11D1/92 , C11D1/94 , C11D1/62 , C07C87/00 , C07C141/00 , C11D1/65 , C11D3/37
CPC分类号： C11D1/90 , C08G65/2624 , C08G65/263 , C08G65/3344 , C11D1/88 , C11D1/92 , C11D1/94
摘要： Water-soluble zwitterionic compounds having clay soil removal/anti-redeposition properties. The zwitterionic compounds are selected from monozwitterionic compounds, dizwitterionic compounds, polyzwitterionic compounds, and zwitterionic polymers. These zwitterionic compounds are useful in detergent compositions at from about 0.05 to about 95% by weight. In addition to the zwitterionic compounds, the detergent compositions further comprise from about 1 to about 75% by weight of a nonionic, anionic, ampholytic, zwitterionic, or cationic detergent surfactant or mixture thereof.
摘要翻译：具有粘土去除/抗再沉积性质的水溶性两性离子化合物。两性离子化合物选自单离子化合物，两性离子化合物，多分解性化合物和两性离子聚合物。这些两性离子化合物在洗涤剂组合物中的用量为约0.05-约95重量％。除了两性离子化合物之外，洗涤剂组合物还包含约1至约75重量％的非离子，阴离子，两性，两性离子或阳离子洗涤剂表面活性剂或其混合物。

5. 发明授权

US4659802A Cationic compounds having clay soil removal/anti-redeposition properties useful in detergent compositions 失效
标题翻译：具有可用于洗涤剂组合物中的粘土去除/抗再沉积性质的阳离子化合物
公开(公告)号：US4659802A
公开(公告)日：1987-04-21
申请号：US553551
申请日：1983-11-22
申请人： Donn N. Rubingh , Eugene P. Gosselink
发明人： Donn N. Rubingh , Eugene P. Gosselink
IPC分类号： C08G65/26 , C11D1/40 , C11D1/62 , C11D3/37
CPC分类号： C11D3/3723 , C08G65/2624 , C11D1/40 , C11D1/62
摘要： Water-soluble cationic compounds having clay soil removal/anti-redeposition properties. The cationic compounds are selected from ethoxylated cationic diamines, ethoxylated cationic polyamines, ethoxylated cationic polymers and mixtures thereof. These cationic compounds are useful in detergent compositions.
摘要翻译：具有粘土去除/抗再沉积性能的水溶性阳离子化合物。阳离子化合物选自乙氧基化阳离子二胺，乙氧基化阳离子多胺，乙氧基化阳离子聚合物及其混合物。这些阳离子化合物可用于洗涤剂组合物。

6. 发明授权

US4248729A Detergency booster 失效
标题翻译：洗涤助剂
公开(公告)号：US4248729A
公开(公告)日：1981-02-03
申请号：US968897
申请日：1978-12-13
申请人： Donn N. Rubingh , Theodore C. Stephens
发明人： Donn N. Rubingh , Theodore C. Stephens
IPC分类号： C11D1/72 , C11D1/83
CPC分类号： C11D1/72 , C11D1/83
摘要： Detergency boosters comprise certain nonionic surfactants. When used at particular concentrations in conjunction with commercial laundry detergents in laundering liquors of about 70.degree. C., and higher, followed by rinsing at about 66.degree. C., or lower, the boosters herein provide improved fabric cleaning benefits. The nonionic surfactant detergency boosters herein are the ethoxylated primary aliphatic alcohols characterized by an average aliphatic chain length in the range C.sub.12 -C.sub.13 and an average degree of ethoxylation of about 3.
摘要翻译：洗涤助剂包括某些非离子表面活性剂。当以约70℃以上的洗涤液与商业洗衣洗涤剂结合使用特定浓度，然后在约66℃或更低的温度下漂洗时，本发明的增效剂提供了改善的织物清洁效果。本文中非离子表面活性剂洗涤增效剂是乙氧基化的伯脂肪醇，其特征在于C12-C13的平均脂族链长度和平均乙氧基化度约为3。

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