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1. 发明申请

US20080160022A1 Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules 有权
标题翻译：使用可溶性CTLA4突变体分子保护同种异体胰岛移植的方法
公开(公告)号：US20080160022A1
公开(公告)日：2008-07-03
申请号：US11978701
申请日：2007-10-29
申请人： Christian P. Larsen , Thomas C. Pearson , Andrew B. Adams , Robert J. Peach , Peter S. Linsley , Joseph Roy Naemura , Jurgen Bajorath
发明人： Christian P. Larsen , Thomas C. Pearson , Andrew B. Adams , Robert J. Peach , Peter S. Linsley , Joseph Roy Naemura , Jurgen Bajorath
IPC分类号： A61K39/395 , A61P43/00
CPC分类号： C07K14/70521 , A61K31/436 , A61K39/39541 , A61K45/06 , C07K16/2866 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The present invention is a method of inhibiting islet cell transplant rejection particular, to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of soluble CTLA4 mutant molecule is L104EA29YIg.
摘要翻译：本发明是通过向受试者施用有效量的可溶性CTLA4突变体分子来特别地抑制胰岛细胞移植排斥的方法，以治疗糖尿病，例如1型和2型糖尿病。可溶性CTLA4突变体分子的一个实例是L104EA29YIg。

2. 发明授权

US07829534B2 Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules 有权
标题翻译：使用可溶性CTLA4突变体分子保护同种异体胰岛移植的方法
公开(公告)号：US07829534B2
公开(公告)日：2010-11-09
申请号：US11978701
申请日：2007-10-29
申请人： Christian P. Larsen , Thomas C. Pearson , Andrew B. Adams , Robert J. Peach , Peter S. Linsley , Joseph Roy Naemura , Jurgen Bajorath
发明人： Christian P. Larsen , Thomas C. Pearson , Andrew B. Adams , Robert J. Peach , Peter S. Linsley , Joseph Roy Naemura , Jurgen Bajorath
IPC分类号： A61K38/16 , C07K14/705 , C07K16/46
CPC分类号： C07K14/70521 , A61K31/436 , A61K39/39541 , A61K45/06 , C07K16/2866 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The present invention is a method of inhibiting islet cell transplant rejection particular, to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of soluble CTLA4 mutant molecule is L104EA29YIg.
摘要翻译：本发明是通过向受试者施用有效量的可溶性CTLA4突变体分子来特别地抑制胰岛细胞移植排斥的方法，以治疗糖尿病，例如1型和2型糖尿病。可溶性CTLA4突变体分子的一个实例是L104EA29YIg。

3. 发明授权

US07304033B2 Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules 有权
标题翻译：使用可溶性CTLA4突变体分子保护同种异体胰岛移植的方法
公开(公告)号：US07304033B2
公开(公告)日：2007-12-04
申请号：US10155514
申请日：2002-05-23
申请人： Christian P. Larsen , Thomas C. Pearson , Andrew B. Adams , Robert J. Peach , Peter S. Linsley , Joseph Roy Naemura , Jurgen Bajorath
发明人： Christian P. Larsen , Thomas C. Pearson , Andrew B. Adams , Robert J. Peach , Peter S. Linsley , Joseph Roy Naemura , Jurgen Bajorath
IPC分类号： A61K38/16 , C07K14/00
CPC分类号： C07K14/70521 , A61K31/436 , A61K39/39541 , A61K45/06 , C07K16/2866 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The present invention is a method of inhibiting islet cell transplant rejection, particularly to treat diabetes, such as type-1 and type-2 diabetes, by administering to a subject an effective amount of a soluble CTLA4 mutant molecule. One example of a soluble CTLA4 mutant molecule is L104EA29YIg.
摘要翻译：本发明是通过向受试者施用有效量的可溶性CTLA4突变体分子来抑制胰岛细胞移植排斥反应的方法，特别是治疗糖尿病，例如1型和2型糖尿病。可溶性CTLA4突变体分子的一个实例是L104EA29YIg。

4. 发明申请

US20090186037A1 METHODS FOR INHIBITING AN IMMUNE RESPONSE BY BLOCKING THE GP39/CD40 AND CTLA4/CD28/B7 PATHWAYS AND COMPOSITIONS FOR USE THEREWITH 审中-公开
标题翻译：通过阻断GP39 / CD40和CTLA4 / CD28 / B7途径和组合物来阻止免疫应答的方法
公开(公告)号：US20090186037A1
公开(公告)日：2009-07-23
申请号：US12207997
申请日：2008-09-10
申请人： Christian P. Larsen , Alejandro A. Aruffo , Diane L. Hollenbaugh , Peter S. Linsley , Jeffrey A. Ledbetter , Thomas C. Pearson
发明人： Christian P. Larsen , Alejandro A. Aruffo , Diane L. Hollenbaugh , Peter S. Linsley , Jeffrey A. Ledbetter , Thomas C. Pearson
IPC分类号： A61K39/395 , A61K38/16 , A61P37/06
CPC分类号： C07K16/2878 , A61K38/00 , A61K39/395 , C07K14/70521 , C07K14/70532 , C07K14/70575 , C07K14/70578 , C07K16/2818 , C07K16/2827 , C07K16/2875 , C07K2317/73 , A61K38/17 , A61K2300/00
摘要： The present invention provides a method for inhibiting an immune response and a method for inhibiting rejection of transplanted tissues. This method comprises preventing an endogenous molecule on a cell selected from the group consisting of gp39 and CD40 antigens from binding its endogenous ligand and preventing an endogenous molecule on a cell selected from the group consisting of CTLA4, CD28, and B7 antigens from binding its endogenous ligand. The prevention of such molecules from binding their ligand thereby blocks two independent signal pathways and inhibits the immune response resulting in transplanted tissue rejection.
摘要翻译：本发明提供抑制免疫应答的方法和抑制移植组织排斥的方法。该方法包括防止选自gp39和CD40抗原的细胞上的内源性分子与其内源性配体结合并防止选自CTLA4，CD28和B7抗原的细胞上的内源性分子结合其内源性配体。阻止这些分子结合其配体从而阻断两个独立的信号通路并抑制免疫应答导致移植组织排斥反应。

5. 发明授权

US5916560A Methods for inhibiting an immune response by blocking the GP39/CD40 and CTLA4/CD28/B7 pathways and compositions for use therewith 失效
公开(公告)号：US5916560A
公开(公告)日：1999-06-29
申请号：US821400
申请日：1997-03-20
申请人： Christian P. Larsen , Alejandro A. Aruffo , Diane L. Hollenbaugh , Peter S. Linsley , Jeffrey A. Ledbetter , Thomas C. Pearson
发明人： Christian P. Larsen , Alejandro A. Aruffo , Diane L. Hollenbaugh , Peter S. Linsley , Jeffrey A. Ledbetter , Thomas C. Pearson
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P37/06 , A61P43/00 , C07K14/705 , C07K16/28
CPC分类号： C07K16/2878 , A61K39/395 , C07K14/70521 , C07K14/70532 , C07K14/70575 , C07K14/70578 , C07K16/2818 , C07K16/2827 , C07K16/2875 , A61K38/00 , C07K2317/73
摘要： The present invention provides a method for inhibiting an immune reponse and a method for inhibiting rejection of transplanted tissues. This method comprises preventing an endogenous molecule on a cell selected from the group consisting of gp39 and CD40 antigens from binding its endogenous ligand and preventing an endogenous molecule on a cell selected from the group consisting of CTLA4, CD28, and B7 antigens from binding its endogenous ligand. The prevention of such molecules from binding their ligand thereby blocks two independent signal pathways and inhibits the immune response resulting in transplanted tissue rejection.

6. 发明授权

US06541725B2 Acoustical apparatus and method for sorting objects 失效
公开(公告)号：US06541725B2
公开(公告)日：2003-04-01
申请号：US09826518
申请日：2001-04-03
申请人： Thomas C. Pearson
发明人： Thomas C. Pearson
IPC分类号： B07C500
CPC分类号： B07C5/34 , B07C5/366 , Y10S209/932
摘要： An object, such as a pistachio nut, is sorted based on a given trait. The sorting process commences by bouncing the object off a body so that the object emits a sound. The sound emitted by the object is converted to an electrical signal which is analyzed to determine electrical characteristics that indicate the trait of the object. For example, the electrical signal can be integrated and a signal gradient produced to discriminate among signals from different classes of objects.

7. 发明授权

US5703784A Machine vision apparatus and method for sorting objects 失效
标题翻译：机器视觉设备和排序物体的方法
公开(公告)号：US5703784A
公开(公告)日：1997-12-30
申请号：US550310
申请日：1995-10-30
申请人： Thomas C. Pearson
发明人： Thomas C. Pearson
IPC分类号： B07C5/342 , G06K9/46 , G06F19/00
CPC分类号： G06K9/4604 , B07C5/3422 , B07C5/366
摘要： An object is sorted into different classes by producing a video image of the object. The signal level discontinuities in the image are evaluated by first deriving a video signal gradient of each pixel in the image. Then the number of pixels in three different signal gradient ranges are counted to produce count parameters which combined indicate the areas of differing contrast in the object. The count parameters are utilized in a pair of discriminate functions which define the two classes and solution of the discriminate functions are used to determine the probability that the object fits within one class. In response to the probability the object is directed along either a first path associated with one class or along a second path associated with the other class.
摘要翻译：通过产生对象的视频图像将对象分类到不同的类中。通过首先导出图像中的每个像素的视频信号梯度来评估图像中的信号电平不连续性。然后对三个不同的信号梯度范围中的像素数进行计数，以产生计数参数，这些参数组合表示物体中不同对比度的区域。计数参数用于定义两个类的一对鉴别函数，并且鉴别函数的解决方案用于确定对象适合于一个类的概率。响应于对象沿着与一个类相关联的第一路径或与另一类相关联的第二路径的概率来响应。

8. 发明授权

US07024942B1 Method and apparatus for non-destructive detection of pits and seed fragments in fruit 失效
标题翻译：水果中凹坑和种子碎片的无损检测方法和装置
公开(公告)号：US07024942B1
公开(公告)日：2006-04-11
申请号：US10842792
申请日：2004-05-10
申请人： Eric S. Jackson , Ronald P. Haff , Thomas C. Pearson
发明人： Eric S. Jackson , Ronald P. Haff , Thomas C. Pearson
IPC分类号： G01N3/08
CPC分类号： G01N3/08 , G01N33/025 , G01N2203/0019 , G01N2203/0676
摘要： An apparatus and method for the non-destructive detection of pits and pit fragments found in dried fruit has been developed. It utilizes a force transducer and a signal processor to determine whether or not pit or pit fragments are present in a fruit specimen, and is able to automatically separate specimens testing positive from the product stream.
摘要翻译：已经开发了用于在干果中发现的凹坑和坑碎片的非破坏性检测的装置和方法。它利用力传感器和信号处理器确定水果样本中是否存在坑或坑碎片，并且能够自动分离从产物流测试为阳性的标本。

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